{"id":"https://openalex.org/W4381664062","doi":"https://doi.org/10.1016/j.nbas.2023.100084","title":"Upregulation of endocytic protein expression in the Alzheimer\u2019s disease male human brain","display_name":"Upregulation of endocytic protein expression in the Alzheimer\u2019s disease male human brain","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4381664062","doi":"https://doi.org/10.1016/j.nbas.2023.100084","pmid":"https://pubmed.ncbi.nlm.nih.gov/37449017","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10336166"},"language":"en","primary_location":{"id":"doi:10.1016/j.nbas.2023.100084","doi":"https://doi.org/10.1016/j.nbas.2023.100084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbas.2023.100084","pdf_url":null,"source":{"id":"https://openalex.org/S4210227707","display_name":"Aging Brain","issn_l":"2589-9589","issn":["2589-9589"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Brain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.nbas.2023.100084","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006592797","display_name":"Mouhamed Alsaqati","orcid":"https://orcid.org/0000-0001-8276-8854","observed_orcids":["https://orcid.org/0000-0001-8276-8854"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mouhamed Alsaqati","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073194262","display_name":"Rhian S. Thomas","orcid":"https://orcid.org/0000-0002-7286-2764","observed_orcids":["https://orcid.org/0000-0002-7286-2764"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rhian S. Thomas","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045809090","display_name":"Emma J. Kidd","orcid":"https://orcid.org/0000-0001-5507-1170","observed_orcids":["https://orcid.org/0000-0001-5507-1170"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Emma J. Kidd","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK"],"raw_orcid":"https://orcid.org/0000-0001-5507-1170","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045809090"],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.9754,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.71278033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":null,"first_page":"100084","last_page":"100084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9259999990463257},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9430000185966492},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.8330000042915344},{"id":"https://openalex.org/keywords/caveolin-2","display_name":"caveolin-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bin1","display_name":"BIN1","score":0.8529999852180481},{"id":"https://openalex.org/keywords/picalm","display_name":"PICALM","score":0.9229999780654907},{"id":"https://openalex.org/keywords/rab5","display_name":"Rab5","score":0.6510000228881836},{"id":"https://openalex.org/keywords/ap2","display_name":"AP-2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gsk-3beta-phosphorylation","display_name":"GSK3\u03b2 phosphorylation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.7009999752044678},{"id":"https://openalex.org/keywords/bace1","display_name":"BACE1","score":0.8899999856948853},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/abeta42-40-ratio","display_name":"A\u03b242/A\u03b240 ratio","score":0.7739999890327454},{"id":"https://openalex.org/keywords/male-brain","display_name":"male brain","score":0.628000020980835},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.8781655430793762},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7973622679710388},{"id":"https://openalex.org/C63162447","wikidata":"https://www.wikidata.org/wiki/Q21100804","display_name":"Clathrin","level":4,"score":0.6625176072120667},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5422459840774536},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.4935864210128784},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.47990262508392334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47601136565208435},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44604599475860596},{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.41676560044288635},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4002561569213867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36734476685523987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18834733963012695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14327821135520935},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10929778218269348},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1047513484954834},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1016/j.nbas.2023.100084","doi":"https://doi.org/10.1016/j.nbas.2023.100084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbas.2023.100084","pdf_url":null,"source":{"id":"https://openalex.org/S4210227707","display_name":"Aging Brain","issn_l":"2589-9589","issn":["2589-9589"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Brain","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10336166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10336166","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10336166/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Brain","raw_type":"Text"},{"id":"pmid:37449017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37449017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging brain","raw_type":"Journal Article"},{"id":"pmh:oai:cronfa.swan.ac.uk:cronfa63878","doi":null,"is_oa":true,"landing_page_url":"https://cronfa.swan.ac.uk/Record/cronfa63878","pdf_url":"https://cronfa.swan.ac.uk/Record/cronfa63878/Download/63878__28369__3a81b5ee651f46eebfb0ae9a50265217.pdf","source":{"id":"https://openalex.org/S4306401612","display_name":"Cronfa (Swansea University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39586589","host_organization_name":"Swansea University","host_organization_lineage":["https://openalex.org/I39586589"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:160784","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/160784/1/Upregulation%20of%20endocytic%20protein%20expression%20in%20the%20Alzheimer%3Fs%20disease%20male%20human%20brain%20PUBLISHED%20VERSION.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/160784/1/Upregulation%20of%20endocytic%20protein%20expression%20in%20the%20Alzheimer%3Fs%20disease%20male%20human%20brain%20PUBLISHED%20VERSION.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:352a4772479b4f8ba9105e26164a4250","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/352a4772479b4f8ba9105e26164a4250","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging Brain, Vol 4, Iss , Pp 100084- (2023)","raw_type":"article"},{"id":"doi:10.25405/ncl.34474452","doi":"https://doi.org/10.25405/ncl.34474452","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34474452","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34474452.v1","doi":"https://doi.org/10.25405/ncl.34474452.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34474452.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1016/j.nbas.2023.100084","doi":"https://doi.org/10.1016/j.nbas.2023.100084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbas.2023.100084","pdf_url":null,"source":{"id":"https://openalex.org/S4210227707","display_name":"Aging Brain","issn_l":"2589-9589","issn":["2589-9589"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Brain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1286920112","display_name":null,"funder_award_id":"G0400074","funder_id":"https://openalex.org/F4320320295","funder_display_name":"Newcastle University"},{"id":"https://openalex.org/G239532143","display_name":null,"funder_award_id":"G0400074","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320312938","display_name":"BRACE","ror":"https://ror.org/03sq7pd48"},{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320319841","display_name":"Alzheimer's Research Trust","ror":"https://ror.org/02ymzm013"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320295","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70"},{"id":"https://openalex.org/F4320322155","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320335819","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381664062.pdf","grobid_xml":"https://content.openalex.org/works/W4381664062.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W52042314","https://openalex.org/W1516940938","https://openalex.org/W1598479263","https://openalex.org/W1620584505","https://openalex.org/W1680905070","https://openalex.org/W1939296414","https://openalex.org/W1946603937","https://openalex.org/W1965758080","https://openalex.org/W1966831629","https://openalex.org/W1968344841","https://openalex.org/W1973479349","https://openalex.org/W1975715283","https://openalex.org/W1979685042","https://openalex.org/W1989036097","https://openalex.org/W2001854231","https://openalex.org/W2015828388","https://openalex.org/W2016698723","https://openalex.org/W2016811754","https://openalex.org/W2020824841","https://openalex.org/W2023042376","https://openalex.org/W2028005779","https://openalex.org/W2028846933","https://openalex.org/W2030182984","https://openalex.org/W2032822445","https://openalex.org/W2032920422","https://openalex.org/W2033460128","https://openalex.org/W2040548499","https://openalex.org/W2047041100","https://openalex.org/W2052606088","https://openalex.org/W2052818071","https://openalex.org/W2054615702","https://openalex.org/W2060037872","https://openalex.org/W2061992397","https://openalex.org/W2062379645","https://openalex.org/W2068193781","https://openalex.org/W2068781633","https://openalex.org/W2071868039","https://openalex.org/W2075175573","https://openalex.org/W2076909215","https://openalex.org/W2080225612","https://openalex.org/W2082429191","https://openalex.org/W2088151512","https://openalex.org/W2090982126","https://openalex.org/W2094394444","https://openalex.org/W2096410114","https://openalex.org/W2096766291","https://openalex.org/W2104629568","https://openalex.org/W2108285073","https://openalex.org/W2119046783","https://openalex.org/W2121312696","https://openalex.org/W2133019124","https://openalex.org/W2136886662","https://openalex.org/W2142215500","https://openalex.org/W2152119060","https://openalex.org/W2167069331","https://openalex.org/W2169152986","https://openalex.org/W2194650865","https://openalex.org/W2252392053","https://openalex.org/W2416144820","https://openalex.org/W2471197622","https://openalex.org/W2491615326","https://openalex.org/W2513868860","https://openalex.org/W2549135004","https://openalex.org/W2604285326","https://openalex.org/W2711810487","https://openalex.org/W2752287204","https://openalex.org/W2782727085","https://openalex.org/W2799712080","https://openalex.org/W2807776100","https://openalex.org/W2888015172","https://openalex.org/W2974736094","https://openalex.org/W3003864134","https://openalex.org/W3006119534","https://openalex.org/W3012955650","https://openalex.org/W3035949793","https://openalex.org/W3045938554","https://openalex.org/W3090704421","https://openalex.org/W3092964313","https://openalex.org/W3108584570","https://openalex.org/W3135875197","https://openalex.org/W3158788824","https://openalex.org/W3198052269","https://openalex.org/W3214092816","https://openalex.org/W4214661923","https://openalex.org/W4220825176","https://openalex.org/W4225634431","https://openalex.org/W4295202935"],"related_works":["https://openalex.org/W2711810487","https://openalex.org/W1997795572","https://openalex.org/W2027007493","https://openalex.org/W2497959445","https://openalex.org/W2014035270","https://openalex.org/W1620584505","https://openalex.org/W4295202935","https://openalex.org/W2112222544","https://openalex.org/W1994447995","https://openalex.org/W2138941746"],"abstract_inverted_index":{"Amyloid-beta":[0],"(A\u03b2)":[1],"is":[2,12,27],"produced":[3],"from":[4,73],"amyloid":[5],"precursor":[6],"protein":[7,41,67],"(APP)":[8],"primarily":[9],"after":[10],"APP":[11,35],"internalised":[13],"by":[14],"endocytosis":[15,164],"and":[16,32,83,86,95,116,134,136,151],"clathrin-mediated":[17],"endocytic":[18,40],"processes":[19],"are":[20],"altered":[21,45],"in":[22,46,69,112,122,127,140,163,165,172],"Alzheimer's":[23],"disease":[24],"(AD).":[25],"There":[26],"also":[28],"evidence":[29],"that":[30,39],"cholesterol":[31],"flotillin":[33],"affect":[34],"endocytosis.":[36],"We":[37,65],"hypothesised":[38],"expression":[42,68],"would":[43],"be":[44,59],"the":[47,88,96,105,166,174],"brains":[48,142],"of":[49,98,177],"people":[50],"with":[51,75],"AD":[52,76,113,123,141,167],"compared":[53,66,77],"to":[54,61,78],"non-diseased":[55,80],"subjects":[56],"which":[57],"could":[58],"linked":[60],"increased":[62,103,121,175],"A\u03b2":[63,178],"generation.":[64],"frontal":[70],"cortex":[71],"samples":[72],"men":[74],"age-matched,":[79],"controls.":[81],"Soluble":[82],"insoluble":[84,106],"A\u03b240":[85],"A\u03b242,":[87],"soluble":[89],"A\u03b242/A\u03b240":[90],"ratio,":[91],"\u03b2CTF,":[92],"BACE1,":[93],"presenilin-1":[94],"ratio":[97,108],"phosphorylated:total":[99],"GSK3\u03b2":[100],"were":[101,119,138,153],"significantly":[102,110],"while":[104],"A\u03b242:A\u03b240":[107],"was":[109,145],"decreased":[111],"brains.":[114,124],"Total":[115],"phosphorylated":[117],"tau":[118],"markedly":[120],"Significant":[125],"increases":[126],"clathrin,":[128],"AP2,":[129],"PICALM":[130],"isoform":[131],"4,":[132],"Rab-5":[133],"caveolin-1":[135,150],"2":[137,152],"seen":[139],"but":[143],"BIN1":[144],"decreased.":[146,154],"However,":[147],"using":[148],"immunohistochemistry,":[149],"The":[155],"results":[156],"obtained":[157],"here":[158],"suggest":[159],"an":[160],"overall":[161],"increase":[162],"brain,":[168],"explaining,":[169],"at":[170],"least":[171],"part,":[173],"production":[176],"during":[179],"AD.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-06-23T00:00:00"}
