{"id":"https://openalex.org/W4381663410","doi":"https://doi.org/10.3390/biomedicines11061771","title":"Phytochemical Profiling and Anti-Fibrotic Activities of the Gemmotherapy Bud Extract of Corylus avellana in a Model of Liver Fibrosis on Diabetic Mice","display_name":"Phytochemical Profiling and Anti-Fibrotic Activities of the Gemmotherapy Bud Extract of Corylus avellana in a Model of Liver Fibrosis on Diabetic Mice","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381663410","doi":"https://doi.org/10.3390/biomedicines11061771","pmid":"https://pubmed.ncbi.nlm.nih.gov/37371866","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10296144"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines11061771","doi":"https://doi.org/10.3390/biomedicines11061771","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11061771","pdf_url":"https://www.mdpi.com/2227-9059/11/6/1771/pdf?version=1687315409","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/11/6/1771/pdf?version=1687315409","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019064842","display_name":"Cornel Balt\u0103","orcid":"https://orcid.org/0000-0001-5734-0071","observed_orcids":["https://orcid.org/0000-0001-5734-0071"]},"institutions":[{"id":"https://openalex.org/I4210106141","display_name":"Vasile Goldis Western University of Arad","ror":"https://ror.org/01e0stw12","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210106141"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Cornel Balta","raw_affiliation_strings":["\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania"],"raw_orcid":"https://orcid.org/0000-0001-5734-0071","affiliations":[{"raw_affiliation_string":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036010020","display_name":"Hildegard Herman","orcid":"https://orcid.org/0000-0002-6741-0245","observed_orcids":["https://orcid.org/0000-0002-6741-0245"]},"institutions":[{"id":"https://openalex.org/I4210106141","display_name":"Vasile Goldis Western University of Arad","ror":"https://ror.org/01e0stw12","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210106141"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Hildegard Herman","raw_affiliation_strings":["\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033469494","display_name":"Alina Ciceu","orcid":"https://orcid.org/0000-0001-6502-2655","observed_orcids":["https://orcid.org/0000-0001-6502-2655"]},"institutions":[{"id":"https://openalex.org/I4210106141","display_name":"Vasile Goldis Western University of Arad","ror":"https://ror.org/01e0stw12","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210106141"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Alina Ciceu","raw_affiliation_strings":["\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035519971","display_name":"Bianca Mladin","orcid":"https://orcid.org/0000-0001-7787-824X","observed_orcids":["https://orcid.org/0000-0001-7787-824X"]},"institutions":[{"id":"https://openalex.org/I4210106141","display_name":"Vasile Goldis Western University of Arad","ror":"https://ror.org/01e0stw12","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210106141"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Bianca Mladin","raw_affiliation_strings":["\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113847422","display_name":"Marcel Ro\u0219u","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106141","display_name":"Vasile Goldis Western University of Arad","ror":"https://ror.org/01e0stw12","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210106141"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Marcel Rosu","raw_affiliation_strings":["\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002960509","display_name":"Alciona Sasu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106141","display_name":"Vasile Goldis Western University of Arad","ror":"https://ror.org/01e0stw12","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210106141"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Alciona Sasu","raw_affiliation_strings":["\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068778175","display_name":"Victor Eduard Peteu","orcid":"https://orcid.org/0000-0002-4264-3739","observed_orcids":["https://orcid.org/0000-0002-4264-3739"]},"institutions":[{"id":"https://openalex.org/I4210114336","display_name":"Institutul National Victor Babes","ror":"https://ror.org/02h8ngt70","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210114336"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Victor Eduard Peteu","raw_affiliation_strings":["Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Babes National Institute of Pathology, 050096 Bucharest, Romania","institution_ids":["https://openalex.org/I4210114336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058157605","display_name":"Sorina Nicoleta Voicu","orcid":"https://orcid.org/0000-0002-0984-4766","observed_orcids":["https://orcid.org/0000-0002-0984-4766"]},"institutions":[{"id":"https://openalex.org/I141595442","display_name":"University of Bucharest","ror":"https://ror.org/02x2v6p15","country_code":"RO","type":"education","lineage":["https://openalex.org/I141595442"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Sorina Nicoleta Voicu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania","institution_ids":["https://openalex.org/I141595442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083116791","display_name":"Mihaela Bala\u0219","orcid":"https://orcid.org/0000-0001-9522-0118","observed_orcids":["https://orcid.org/0000-0001-9522-0118"]},"institutions":[{"id":"https://openalex.org/I141595442","display_name":"University of Bucharest","ror":"https://ror.org/02x2v6p15","country_code":"RO","type":"education","lineage":["https://openalex.org/I141595442"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Mihaela Balas","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania"],"raw_orcid":"https://orcid.org/0000-0001-9522-0118","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania","institution_ids":["https://openalex.org/I141595442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057251848","display_name":"Mihaela Gherghiceanu","orcid":"https://orcid.org/0000-0001-6117-4328","observed_orcids":["https://orcid.org/0000-0001-6117-4328"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]},{"id":"https://openalex.org/I4210114336","display_name":"Institutul National Victor Babes","ror":"https://ror.org/02h8ngt70","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210114336"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Mihaela Gherghiceanu","raw_affiliation_strings":["Department of Cellular and Molecular Biology and Histology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania","Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology and Histology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]},{"raw_affiliation_string":"Victor Babes National Institute of Pathology, 050096 Bucharest, Romania","institution_ids":["https://openalex.org/I4210114336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111877813","display_name":"Anca Dinischiotu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141595442","display_name":"University of Bucharest","ror":"https://ror.org/02x2v6p15","country_code":"RO","type":"education","lineage":["https://openalex.org/I141595442"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Anca Dinischiotu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania","institution_ids":["https://openalex.org/I141595442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017435057","display_name":"Neli-Kinga Ol\u00e1h","orcid":"https://orcid.org/0000-0001-5204-6885","observed_orcids":["https://orcid.org/0000-0001-5204-6885"]},"institutions":[{"id":"https://openalex.org/I4210106141","display_name":"Vasile Goldis Western University of Arad","ror":"https://ror.org/01e0stw12","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210106141"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Neli Kinga Olah","raw_affiliation_strings":["Faculty of Pharmacy, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041560971","display_name":"Anca Oana Hermenean","orcid":"https://orcid.org/0000-0001-8510-6653","observed_orcids":["https://orcid.org/0000-0001-8510-6653"]},"institutions":[{"id":"https://openalex.org/I4210106141","display_name":"Vasile Goldis Western University of Arad","ror":"https://ror.org/01e0stw12","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210106141"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Anca Hermenean","raw_affiliation_strings":["Faculty of Medicine, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania"],"raw_orcid":"https://orcid.org/0000-0001-8510-6653","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]},{"raw_affiliation_string":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University, 86 Rebreanu, 310414 Arad, Romania","institution_ids":["https://openalex.org/I4210106141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017435057"],"corresponding_institution_ids":["https://openalex.org/I4210106141"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":0.4836,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59145726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"6","first_page":"1771","last_page":"1771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corylus-avellana","display_name":"Corylus avellana","score":0.9959999918937683},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antifibrotic-activity","display_name":"antifibrotic activity","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tgf-beta1-smad-signaling-pathway","display_name":"TGF-\u03b21/Smad signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.7049999833106995},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hyperoside","display_name":"hyperoside","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chlorogenic-acid","display_name":"chlorogenic acid","score":0.9350000023841858},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.6890000104904175},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.8569999933242798},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.8100000023841858},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6072276830673218},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.6031709909439087},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5330551862716675},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5281871557235718},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.46489065885543823},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.4429779052734375},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.43583258986473083},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40204909443855286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32525283098220825},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32182562351226807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.267857164144516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2393316626548767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16721904277801514},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13113760948181152}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines11061771","doi":"https://doi.org/10.3390/biomedicines11061771","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11061771","pdf_url":"https://www.mdpi.com/2227-9059/11/6/1771/pdf?version=1687315409","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10296144","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10296144","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10296144/pdf/biomedicines-11-01771.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:37371866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37371866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a6b94c2cf7b941c7aa73d26f65e7e4cf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a6b94c2cf7b941c7aa73d26f65e7e4cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 11, Iss 6, p 1771 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines11061771","doi":"https://doi.org/10.3390/biomedicines11061771","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11061771","pdf_url":"https://www.mdpi.com/2227-9059/11/6/1771/pdf?version=1687315409","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329037","display_name":"Ministerul Cercet\u0103rii \u015fi Inov\u0103rii","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381663410.pdf","grobid_xml":"https://content.openalex.org/works/W4381663410.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W386759438","https://openalex.org/W1775749144","https://openalex.org/W1946251822","https://openalex.org/W1967847250","https://openalex.org/W1979851283","https://openalex.org/W1981046189","https://openalex.org/W2020960905","https://openalex.org/W2026383863","https://openalex.org/W2035542393","https://openalex.org/W2042641359","https://openalex.org/W2047580942","https://openalex.org/W2086732325","https://openalex.org/W2099157351","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2125297232","https://openalex.org/W2138275781","https://openalex.org/W2147934487","https://openalex.org/W2301719074","https://openalex.org/W2310491712","https://openalex.org/W2565367159","https://openalex.org/W2586982135","https://openalex.org/W2607364559","https://openalex.org/W2763336761","https://openalex.org/W2781934183","https://openalex.org/W2787976440","https://openalex.org/W2791463109","https://openalex.org/W2800750169","https://openalex.org/W2800934262","https://openalex.org/W2811269521","https://openalex.org/W2953681237","https://openalex.org/W2972905807","https://openalex.org/W3042620633","https://openalex.org/W3093312511","https://openalex.org/W3136084036","https://openalex.org/W3141576950","https://openalex.org/W3158304249","https://openalex.org/W3183465125","https://openalex.org/W4206014416","https://openalex.org/W4206242725","https://openalex.org/W4224983189","https://openalex.org/W6805963586"],"related_works":["https://openalex.org/W4295941399","https://openalex.org/W4321787592","https://openalex.org/W7134972060","https://openalex.org/W7220903254","https://openalex.org/W4389537598","https://openalex.org/W4312884562","https://openalex.org/W3101241035","https://openalex.org/W2029497004","https://openalex.org/W4283204385","https://openalex.org/W4317036502"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3],"aimed":[4],"to":[5,130],"explore":[6],"the":[7,11,77,90,155,159,168,172,192,218],"hepatoprotective":[8,200],"effects":[9,186],"of":[10,15,21,29,66,82,89,105,113,196,217],"gemmotherapy":[12,151,181],"bud":[13,78],"extract":[14,152,182],"Corylus":[16,179],"avellana":[17,180],"in":[18,57,76,136,167,191,209],"a":[19,52,64,142,207,215,223],"model":[20],"liver":[22,156,169,173,197,213],"fibrosis":[23,41],"on":[24,204],"diabetic":[25,59],"mice.":[26,60],"An":[27],"evaluation":[28],"total":[30],"flavonoids":[31],"and":[32,35,71,95,98,124,145,158,162,170,187,194,212,222],"polyphenols":[33],"contents":[34],"LC/MS":[36],"analyses":[37],"were":[38,74],"performed.":[39],"Experimental":[40],"was":[42],"induced":[43],"with":[44,150],"CCl4":[45,83],"(2":[46],"mL/kg":[47],"by":[48,141],"i.p.":[49],"injections":[50],"twice":[51],"week":[53],"for":[54],"7":[55,101],"weeks)":[56],"streptozotocin-induced":[58],"Our":[61,175],"results":[62,176],"showed":[63],"content":[65],"6\u20137%":[67],"flavonoids,":[68],"while":[69,118],"hyperoside":[70],"chlorogenic":[72],"acids":[73],"highlighted":[75],"extract.":[79],"Toxic":[80],"administration":[81],"increased":[84],"oxidative":[85,210],"stress,":[86],"mRNA":[87],"expression":[88],"transforming":[91],"growth":[92],"factor-\u03b21":[93],"(TGF-\u03b21)":[94],"Smad":[96,100],"2/3,":[97],"reduced":[99],"expression.":[102],"Furthermore,":[103],"up-regulation":[104,123],"\u03b1-smooth":[106],"muscle":[107],"actin":[108],"(\u03b1-SMA)":[109],"revealed":[110],"an":[111,131],"activation":[112],"hepatic":[114],"stellate":[115],"cells":[116],"(HSCs),":[117],"collagen":[119,165],"I":[120],"(Col":[121],"I)":[122],"matrix":[125,134],"metalloproteinases":[126],"(MMPs)":[127],"unbalance":[128],"led":[129],"altered":[132],"extracellular":[133],"enriched":[135],"collagen,":[137],"confirmed":[138],"as":[139],"well":[140],"trichrome":[143],"stain":[144],"electron":[146],"microscopy":[147],"analysis.":[148],"Treatment":[149],"significantly":[153,163],"restored":[154],"architecture":[157],"antioxidant":[160],"balance,":[161],"decreased":[164],"deposits":[166],"improved":[171],"function.":[174],"suggest":[177],"that":[178],"may":[183],"have":[184],"anti-fibrotic":[185],"could":[188],"be":[189],"useful":[190],"prevention":[193],"treatment":[195],"fibrosis.":[198],"The":[199],"mechanism":[201],"is":[202],"based":[203],"HSC":[205],"inhibition,":[206],"reduction":[208],"stress":[211],"damage,":[214],"downregulation":[216],"TGF-\u03b21/Smad":[219],"signaling":[220],"pathway":[221],"MMPs/TIMP":[224],"rebalance.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-23T00:00:00"}