{"id":"https://openalex.org/W4381663123","doi":"https://doi.org/10.3390/ijms241210378","title":"Lactobacillus fermentum HY7302 Improves Dry Eye Symptoms in a Mouse Model of Benzalkonium Chloride-Induced Eye Dysfunction and Human Conjunctiva Epithelial Cells","display_name":"Lactobacillus fermentum HY7302 Improves Dry Eye Symptoms in a Mouse Model of Benzalkonium Chloride-Induced Eye Dysfunction and Human Conjunctiva Epithelial Cells","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381663123","doi":"https://doi.org/10.3390/ijms241210378","pmid":"https://pubmed.ncbi.nlm.nih.gov/37373526","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10299454"},"language":"en","primary_location":{"id":"doi:10.3390/ijms241210378","doi":"https://doi.org/10.3390/ijms241210378","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241210378","pdf_url":"https://www.mdpi.com/1422-0067/24/12/10378/pdf?version=1687253635","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/12/10378/pdf?version=1687253635","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035852786","display_name":"Kippeum Lee","orcid":"https://orcid.org/0000-0002-1576-7373","observed_orcids":["https://orcid.org/0000-0002-1576-7373","https://orcid.org/0009-0003-4801-6052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kippeum Lee","raw_affiliation_strings":["R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-1576-7373","affiliations":[{"raw_affiliation_string":"R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110996502","display_name":"Ji Woong Jeong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji Woong Jeong","raw_affiliation_strings":["R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109956935","display_name":"Jae Jung Shim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae Jung Shim","raw_affiliation_strings":["R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017422415","display_name":"Hyun Sook Hong","orcid":"https://orcid.org/0000-0003-3659-1386","observed_orcids":["https://orcid.org/0000-0003-3659-1386"]},"institutions":[{"id":"https://openalex.org/I4210112503","display_name":"Kyung Hee University Medical Center","ror":"https://ror.org/01vbmek33","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Sook Hong","raw_affiliation_strings":["Kyung Hee Institute of Regenerative Medicine (KIRM), Medical Science Research Institute, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3659-1386","affiliations":[{"raw_affiliation_string":"Kyung Hee Institute of Regenerative Medicine (KIRM), Medical Science Research Institute, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I4210112503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112411108","display_name":"Joo Yun Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joo Yun Kim","raw_affiliation_strings":["R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110676055","display_name":"Jung Lyoul Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jung Lyoul Lee","raw_affiliation_strings":["R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24 Beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110676055","https://openalex.org/A5112411108"],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":4.6035,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.95769735,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"12","first_page":"10378","last_page":"10378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.8420000076293945},{"id":"https://openalex.org/keywords/benzalkonium-chloride","display_name":"benzalkonium chloride","score":0.9359999895095825},{"id":"https://openalex.org/keywords/conjunctival-epithelium","display_name":"conjunctival epithelium","score":0.7609999775886536},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ocular-surface-damage","display_name":"ocular surface damage","score":0.7089999914169312},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9049999713897705},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tear-film-break-up-time","display_name":"tear film break-up time","score":0.6909999847412109},{"id":"https://openalex.org/keywords/functional-food-supplement","display_name":"functional food supplement","score":0.6549999713897705},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2775919038","wikidata":"https://www.wikidata.org/wiki/Q108126784","display_name":"Benzalkonium chloride","level":2,"score":0.8684062361717224},{"id":"https://openalex.org/C2776503186","wikidata":"https://www.wikidata.org/wiki/Q2134039","display_name":"Lactobacillus fermentum","level":5,"score":0.7494514584541321},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.5493379831314087},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46666282415390015},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4481300115585327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43560606241226196},{"id":"https://openalex.org/C2778996431","wikidata":"https://www.wikidata.org/wiki/Q4849997","display_name":"Balanced salt solution","level":2,"score":0.434265673160553},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.42865681648254395},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.41804853081703186},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.41236722469329834},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40377578139305115},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.3468257784843445},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3455794155597687},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3365362882614136},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33559876680374146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3302192986011505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30795910954475403},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.2609051764011383},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.22771883010864258},{"id":"https://openalex.org/C2778985185","wikidata":"https://www.wikidata.org/wiki/Q1756682","display_name":"Lactobacillus plantarum","level":4,"score":0.22267308831214905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20394247770309448},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1816432774066925},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15440690517425537},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11372876167297363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001548","descriptor_name":"Benzalkonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013666","descriptor_name":"Tears","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052197","descriptor_name":"Limosilactobacillus fermentum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms241210378","doi":"https://doi.org/10.3390/ijms241210378","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241210378","pdf_url":"https://www.mdpi.com/1422-0067/24/12/10378/pdf?version=1687253635","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10299454","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10299454","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10299454/pdf/ijms-24-10378.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:37373526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37373526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms241210378","doi":"https://doi.org/10.3390/ijms241210378","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241210378","pdf_url":"https://www.mdpi.com/1422-0067/24/12/10378/pdf?version=1687253635","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381663123.pdf","grobid_xml":"https://content.openalex.org/works/W4381663123.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W156594437","https://openalex.org/W1542814291","https://openalex.org/W1595230652","https://openalex.org/W1964997797","https://openalex.org/W1973101750","https://openalex.org/W1976240497","https://openalex.org/W1983982734","https://openalex.org/W2013319326","https://openalex.org/W2018452537","https://openalex.org/W2052808939","https://openalex.org/W2071277764","https://openalex.org/W2071658063","https://openalex.org/W2119335900","https://openalex.org/W2149074973","https://openalex.org/W2245038877","https://openalex.org/W2442594135","https://openalex.org/W2523275226","https://openalex.org/W2568594876","https://openalex.org/W2594087437","https://openalex.org/W2594389980","https://openalex.org/W2597003311","https://openalex.org/W2737081537","https://openalex.org/W2773079918","https://openalex.org/W2799529947","https://openalex.org/W2902388601","https://openalex.org/W2903633547","https://openalex.org/W2985285467","https://openalex.org/W2988178326","https://openalex.org/W3012084215","https://openalex.org/W3014868659","https://openalex.org/W3017183170","https://openalex.org/W3032579201","https://openalex.org/W3047309411","https://openalex.org/W3109880004","https://openalex.org/W3110939505","https://openalex.org/W3117437033","https://openalex.org/W3172195964","https://openalex.org/W3188100986","https://openalex.org/W4224130009","https://openalex.org/W4253760541","https://openalex.org/W4253897310","https://openalex.org/W4280554329","https://openalex.org/W4283463916","https://openalex.org/W4283650450","https://openalex.org/W4284889544","https://openalex.org/W4311635686","https://openalex.org/W4317931847","https://openalex.org/W4318460049","https://openalex.org/W6606230181","https://openalex.org/W6718589015","https://openalex.org/W6734801527"],"related_works":["https://openalex.org/W4392983892","https://openalex.org/W4404393835","https://openalex.org/W3134433092","https://openalex.org/W4409261210","https://openalex.org/W4400091730","https://openalex.org/W4399729054","https://openalex.org/W7203738778","https://openalex.org/W1531451449","https://openalex.org/W2796493252","https://openalex.org/W2728863777"],"abstract_inverted_index":{"(1)":[0],"We":[1],"investigated":[2],"the":[3,6,22,58,64,87,101,128,132,142,151,157,172,196,211,216,237],"effects":[4],"of":[5,15,24,39,67,174,198,239],"Lactobacillus":[7],"fermentum":[8,228],"HY7302":[9,26,72,105,126,155,194,229],"(HY7302)":[10],"in":[11,113,131,160,165,215],"a":[12,28,96,117,166,249],"mouse":[13],"model":[14],"benzalkonium":[16],"chloride":[17],"(BAC)-induced":[18],"dry":[19,33,52,108,232,256],"eye,":[20,109],"and":[21,57,89,136,149,170,189,206,208,241,244],"possibility":[23],"using":[25,116],"as":[27,95,202,248],"food":[29,252],"supplement":[30],"for":[31,47],"preventing":[32],"eye.":[34],"(2)":[35],"The":[36,124],"ocular":[37],"surface":[38],"Balb/c":[40],"mice":[41],"was":[42,61,82,93],"exposed":[43],"to":[44,50,86,254],"0.2%":[45],"BAC":[46],"14":[48,77],"days":[49],"induce":[51],"eye":[53,233,257],"(n":[54,69],"=":[55,70,80],"8),":[56],"control":[59],"group":[60],"treated":[62],"with":[63],"same":[65],"amount":[66],"saline":[68],"8).":[71],"(1":[73],"\u00d7":[74],"109":[75],"CFU/kg/day,":[76],"days,":[78],"n":[79],"8)":[81],"orally":[83],"administered":[84],"daily":[85],"mice,":[88],"omega-3":[90],"(200":[91],"mg/kg/day)":[92],"used":[94,247],"positive":[97],"control.":[98],"To":[99],"understand":[100],"mechanisms":[102],"by":[103,235],"which":[104],"inhibits":[106],"BAC-induced":[107,129,158],"we":[110,224],"performed":[111],"an":[112],"vitro":[114],"study":[115],"human":[118],"conjunctival":[119,167,217],"cell":[120,168,218],"line":[121,169],"(clone-1-5c-4).":[122],"(3)":[123],"probiotic":[125],"improved":[127,150],"decreases":[130],"corneal":[133],"fluorescein":[134],"score":[135],"tear":[137,147],"break-up":[138],"time.":[139],"In":[140,221],"addition,":[141],"lactic":[143],"acid":[144],"bacteria":[145],"increased":[146],"production":[148,164,214],"detached":[152],"epithelium.":[153],"Moreover,":[154],"lowered":[156],"increases":[159],"reactive":[161],"oxygen":[162],"species":[163],"regulated":[171,210],"expression":[173,197,238],"several":[175],"apoptosis-related":[176],"factors,":[177,243],"including":[178],"phosphorylated":[179],"protein":[180,186],"kinase":[181],"B":[182],"(AKT),":[183],"B-cell":[184],"lymphoma":[185],"2":[187],"(Bcl-2),":[188],"activated":[190],"caspase":[191],"3.":[192],"Also,":[193],"alleviated":[195],"pro-inflammatory":[199,240],"cytokines,":[200],"such":[201],"interleukin-1\u03b2":[203],"(IL-1\u03b2),":[204],"IL-6,":[205],"IL-8,":[207],"also":[209],"matrix":[212],"metallopeptidase-9":[213],"line.":[219],"(4)":[220],"this":[222],"study,":[223],"showed":[225],"that":[226],"L.":[227],"helps":[230],"prevent":[231,255],"disease":[234],"regulating":[236],"apoptotic":[242],"could":[245],"be":[246],"new":[250],"functional":[251],"composition":[253],"disease.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-23T00:00:00"}
