{"id":"https://openalex.org/W4381662516","doi":"https://doi.org/10.3389/fnut.2023.1143613","title":"Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice","display_name":"Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice","publication_year":2023,"publication_date":"2023-06-21","ids":{"openalex":"https://openalex.org/W4381662516","doi":"https://doi.org/10.3389/fnut.2023.1143613","pmid":"https://pubmed.ncbi.nlm.nih.gov/37415911","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10322219"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2023.1143613","doi":"https://doi.org/10.3389/fnut.2023.1143613","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1143613","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2023.1143613/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnut.2023.1143613/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082325472","display_name":"Hyeyoon Eo","orcid":"https://orcid.org/0000-0002-1532-613X","observed_orcids":["https://orcid.org/0000-0002-1532-613X"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeyoon Eo","raw_affiliation_strings":["Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041428166","display_name":"Seong Hye Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Hye Kim","raw_affiliation_strings":["Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea","MThera Pharma Co., Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"MThera Pharma Co., Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052946793","display_name":"In Gyoung Ju","orcid":"https://orcid.org/0000-0001-9551-7528","observed_orcids":["https://orcid.org/0000-0001-9551-7528"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In Gyoung Ju","raw_affiliation_strings":["Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049214550","display_name":"Eugene Huh","orcid":"https://orcid.org/0009-0001-1090-1705","observed_orcids":["https://orcid.org/0009-0001-1090-1705"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eugene Huh","raw_affiliation_strings":["Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091149206","display_name":"Sinyeon Kim","orcid":"https://orcid.org/0000-0002-3987-910X","observed_orcids":["https://orcid.org/0000-0002-3987-910X"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sinyeon Kim","raw_affiliation_strings":["Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea","MThera Pharma Co., Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"MThera Pharma Co., Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017579044","display_name":"Jin Choi","orcid":"https://orcid.org/0000-0001-8517-8374","observed_orcids":["https://orcid.org/0000-0001-8517-8374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Gyu Choi","raw_affiliation_strings":["MThera Pharma Co., Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MThera Pharma Co., Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030773948","display_name":"Se Woong Kim","orcid":"https://orcid.org/0000-0002-9295-1393","observed_orcids":["https://orcid.org/0000-0002-9295-1393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Se Woong Kim","raw_affiliation_strings":["MThera Pharma Co., Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MThera Pharma Co., Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109410710","display_name":"Miwon Son","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miwon Son","raw_affiliation_strings":["MThera Pharma Co., Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MThera Pharma Co., Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041899584","display_name":"Myung Sook Oh","orcid":"https://orcid.org/0000-0001-8189-4066","observed_orcids":["https://orcid.org/0000-0001-8189-4066"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Myung Sook Oh","raw_affiliation_strings":["Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea","Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041899584"],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.3292,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75940594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"1143613","last_page":"1143613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.1843000054359436,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/longan","display_name":"longan","score":0.9179999828338623},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/binge-eating","display_name":"binge eating","score":0.8130000233650208},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.777999997138977},{"id":"https://openalex.org/keywords/pomc-neurons","display_name":"POMC neurons","score":0.8399999737739563},{"id":"https://openalex.org/keywords/agrp-neurons","display_name":"AgRP neurons","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6819999814033508},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7699999809265137},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.75},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7922612428665161},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7829368114471436},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6733450293540955},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6480997204780579},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.5902174711227417},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5649082660675049},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5605923533439636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5589125156402588},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.5454162359237671},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5245323777198792},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4476878345012665},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.43084925413131714},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.4148939847946167},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.41437527537345886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.298658549785614},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18324881792068481},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnut.2023.1143613","doi":"https://doi.org/10.3389/fnut.2023.1143613","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1143613","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2023.1143613/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10322219","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10322219","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10322219/pdf/fnut-10-1143613.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Nutr","raw_type":"Text"},{"id":"pmid:37415911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37415911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:df19e62eb4cb4d3f8b2441b52e245bc0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/df19e62eb4cb4d3f8b2441b52e245bc0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, Vol 10 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnut.2023.1143613","doi":"https://doi.org/10.3389/fnut.2023.1143613","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1143613","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2023.1143613/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5810739322","display_name":null,"funder_award_id":"2022R1A6A3A01087061","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6253507336","display_name":null,"funder_award_id":"2022R1A6A3A01087061","funder_id":"https://openalex.org/F4320321408","funder_display_name":"Ministry of Education"},{"id":"https://openalex.org/G8346938159","display_name":null,"funder_award_id":"S2938426","funder_id":"https://openalex.org/F4320334880","funder_display_name":"Small and Medium Business Administration"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321408","display_name":"Ministry of Education","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320334880","display_name":"Small and Medium Business Administration","ror":"https://ror.org/022c4zk48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381662516.pdf","grobid_xml":"https://content.openalex.org/works/W4381662516.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1546848728","https://openalex.org/W1967922632","https://openalex.org/W1975728315","https://openalex.org/W1982247506","https://openalex.org/W1984548515","https://openalex.org/W1996412403","https://openalex.org/W2000838615","https://openalex.org/W2014686926","https://openalex.org/W2038464101","https://openalex.org/W2068691622","https://openalex.org/W2070577415","https://openalex.org/W2100212168","https://openalex.org/W2105918486","https://openalex.org/W2108904801","https://openalex.org/W2112878443","https://openalex.org/W2113678374","https://openalex.org/W2130421120","https://openalex.org/W2131877042","https://openalex.org/W2160474662","https://openalex.org/W2162679859","https://openalex.org/W2169612876","https://openalex.org/W2170657882","https://openalex.org/W2299218994","https://openalex.org/W2411079969","https://openalex.org/W2411504116","https://openalex.org/W2586106736","https://openalex.org/W2604707508","https://openalex.org/W2769793959","https://openalex.org/W2792778713","https://openalex.org/W2797089588","https://openalex.org/W2802344459","https://openalex.org/W2805464289","https://openalex.org/W2891775020","https://openalex.org/W2913737818","https://openalex.org/W2972078765","https://openalex.org/W2972869264","https://openalex.org/W2972870117","https://openalex.org/W3000538903","https://openalex.org/W3035606353","https://openalex.org/W3115764654","https://openalex.org/W3130764305","https://openalex.org/W3144611280","https://openalex.org/W3164396775","https://openalex.org/W3184063921","https://openalex.org/W3184343015","https://openalex.org/W3196488689","https://openalex.org/W3200497610","https://openalex.org/W3216957364","https://openalex.org/W4210263313","https://openalex.org/W4224242780","https://openalex.org/W4280639616","https://openalex.org/W4288080792","https://openalex.org/W4307070336","https://openalex.org/W4309662537","https://openalex.org/W4310803791"],"related_works":["https://openalex.org/W7124457272","https://openalex.org/W7223134546","https://openalex.org/W2108932765","https://openalex.org/W4406352518","https://openalex.org/W6939143505","https://openalex.org/W7170213696","https://openalex.org/W4417422106","https://openalex.org/W2094079191","https://openalex.org/W3026908605","https://openalex.org/W4224436724"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"mellitus":[3],"(T2DM)":[4],"is":[5,66,186],"one":[6],"of":[7,19,33,102,108,155,162,199,214,231],"the":[8,197],"biggest":[9],"public":[10],"health":[11,62],"issues":[12],"worldwide":[13],"and":[14,28,47,54,77,122,135,160,194,206],"closely":[15],"related":[16],"to":[17,88],"development":[18],"other":[20],"chronic":[21],"diseases":[22],"such":[23],"as":[24,233,235],"cardiovascular":[25],"diseases,":[26],"cancer":[27],"neurodegenerative":[29],"diseases.":[30],"Considerable":[31],"percentage":[32],"T2DM":[34,110,232],"patients":[35,236],"undergo":[36],"have":[37],"suffered":[38],"from":[39],"binge":[40,78],"eating":[41,79],"disorder":[42,80],"which":[43,149,177],"exacerbates":[44],"insulin":[45,136],"resistance":[46],"metabolic":[48],"challenges.":[49],"Longan":[50],"(Dimocarpus":[51],"longan":[52,70,91],"L.)":[53],"its":[55],"constituents":[56],"are":[57],"reported":[58],"for":[59,229],"their":[60],"various":[61],"benefits.":[63],"However,":[64],"it":[65],"still":[67],"unknown":[68],"whether":[69,90],"fruit":[71,92],"supplementation":[72,95,116,170,201],"can":[73,96],"ameliorate":[74],"glucose":[75,120,133,195,204],"homeostasis":[76],"found":[81],"in":[82,106,138,151,180,191],"T2DM.":[83],"The":[84],"current":[85],"study":[86],"aimed":[87],"investigate":[89],"extract":[93],"(LE)":[94],"improve":[97],"diabetic":[98],"hyperglycemia":[99],"through":[100],"modulation":[101],"feeding":[103,207],"center":[104],"located":[105],"hypothalamus":[107],"db/db":[109,139,181],"mice.":[111,140,182],"As":[112,183],"a":[113,187,226],"result,":[114],"LE":[115,130,142,169,200,223],"ameliorated":[117],"fasting":[118],"blood":[119],"levels":[121,205],"reduced":[123,171],"excessive":[124],"epididymal":[125],"fat":[126],"accumulation.":[127],"In":[128],"addition,":[129],"administration":[131],"improved":[132],"tolerance":[134],"sensitivity":[137],"Especially,":[141],"supplemented":[143],"mice":[144],"showed":[145],"less":[146],"food":[147],"consumption":[148],"was":[150,178],"line":[152],"with":[153,237],"increase":[154],"pro-opiomelanocortin":[156],"(POMC)":[157],"neuronal":[158,166],"activities":[159],"decrease":[161],"agouti-related":[163],"peptide":[164],"(AgRP)":[165],"activities.":[167],"Furthermore,":[168],"hypothalamic":[172,215],"endoplasmic":[173],"reticulum":[174],"(ER)":[175],"stress":[176,185],"stimulated":[179],"ER":[184,216],"crucial":[188],"factor":[189],"involving":[190],"appetite":[192],"control":[193],"homeostasis,":[196],"effect":[198],"on":[202],"circulating":[203],"behavior":[208],"might":[209],"be":[210,225],"mediated":[211],"by":[212],"suppression":[213],"stress.":[217],"Collectively,":[218],"these":[219],"findings":[220],"suggest":[221],"that":[222],"could":[224],"potential":[227],"nutraceutical":[228],"improvement":[230],"well":[234],"satiety":[238],"issues.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-06-23T00:00:00"}