{"id":"https://openalex.org/W4381662228","doi":"https://doi.org/10.3390/biology12060890","title":"Xenopus laevis (Daudin, 1802) as a Model Organism for Bioscience: A Historic Review and Perspective","display_name":"Xenopus laevis (Daudin, 1802) as a Model Organism for Bioscience: A Historic Review and Perspective","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381662228","doi":"https://doi.org/10.3390/biology12060890","pmid":"https://pubmed.ncbi.nlm.nih.gov/37372174","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10295250"},"language":"en","primary_location":{"id":"doi:10.3390/biology12060890","doi":"https://doi.org/10.3390/biology12060890","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology12060890","pdf_url":"https://www.mdpi.com/2079-7737/12/6/890/pdf?version=1687334642","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4381662228"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-7737/12/6/890/pdf?version=1687334642","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055667657","display_name":"Rosa Carotenuto","orcid":"https://orcid.org/0000-0001-9207-9657","observed_orcids":["https://orcid.org/0000-0001-9207-9657"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rosa Carotenuto","raw_affiliation_strings":["Department of Biology, University of Naples Federico II, 80126 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9207-9657","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Naples Federico II, 80126 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057640198","display_name":"Maria Michela Pallotta","orcid":"https://orcid.org/0000-0001-7731-8621","observed_orcids":["https://orcid.org/0000-0001-7731-8621"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Michela Pallotta","raw_affiliation_strings":["Institute for Biomedical Technologies, National Research Council, 56124 Pisa, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7731-8621","affiliations":[{"raw_affiliation_string":"Institute for Biomedical Technologies, National Research Council, 56124 Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027673082","display_name":"Margherita Tussellino","orcid":"https://orcid.org/0000-0002-8338-9351","observed_orcids":["https://orcid.org/0000-0002-8338-9351"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Margherita Tussellino","raw_affiliation_strings":["Department of Biology, University of Naples Federico II, 80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Naples Federico II, 80126 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002841369","display_name":"Chiara Fogliano","orcid":"https://orcid.org/0000-0003-0868-2520","observed_orcids":["https://orcid.org/0000-0003-0868-2520"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Chiara Fogliano","raw_affiliation_strings":["Department of Biology, University of Naples Federico II, 80126 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0868-2520","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Naples Federico II, 80126 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002841369","https://openalex.org/A5055667657"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":0.895,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.69309538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"12","issue":"6","first_page":"890","last_page":"890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5327000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5327000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.2549000084400177,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.09830000251531601,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":1.0},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.7549999952316284},{"id":"https://openalex.org/keywords/3rs","display_name":"3Rs","score":0.75},{"id":"https://openalex.org/keywords/evolutionary-developmental-biology","display_name":"evolutionary developmental biology","score":0.7129999995231628},{"id":"https://openalex.org/keywords/toxicology","display_name":"toxicology","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ethology","display_name":"ethology","score":0.6800000071525574},{"id":"https://openalex.org/keywords/neurobiology","display_name":"neurobiology","score":0.9700000286102295},{"id":"https://openalex.org/keywords/endocrinology","display_name":"endocrinology","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-biology","display_name":"tumor biology","score":0.9900000095367432},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.9440000057220459},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.7559999823570251},{"id":"https://openalex.org/keywords/gametogenesis","display_name":"gametogenesis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metamorphosis","display_name":"metamorphosis","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9374082088470459},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.8809032440185547},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.7651885747909546},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.6065166592597961},{"id":"https://openalex.org/C136397037","wikidata":"https://www.wikidata.org/wiki/Q33753","display_name":"Metamorphosis","level":3,"score":0.6013302206993103},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.5874661207199097},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.5589799880981445},{"id":"https://openalex.org/C2781465898","wikidata":"https://www.wikidata.org/wiki/Q10908","display_name":"Amphibian","level":2,"score":0.5444775819778442},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.5145358443260193},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5007398128509521},{"id":"https://openalex.org/C39234202","wikidata":"https://www.wikidata.org/wiki/Q2904159","display_name":"Comparative biology","level":2,"score":0.459419310092926},{"id":"https://openalex.org/C175909808","wikidata":"https://www.wikidata.org/wiki/Q7155","display_name":"Ethology","level":2,"score":0.4545350670814514},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3862067461013794},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.33836081624031067},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32116907835006714},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.29292112588882446},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08560937643051147}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biology12060890","doi":"https://doi.org/10.3390/biology12060890","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology12060890","pdf_url":"https://www.mdpi.com/2079-7737/12/6/890/pdf?version=1687334642","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10295250","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10295250","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10295250/pdf/biology-12-00890.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology (Basel)","raw_type":"Text"},{"id":"pmid:37372174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37372174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0355b87f13c047aaaaf960c3642040e6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0355b87f13c047aaaaf960c3642040e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology, Vol 12, Iss 6, p 890 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biology12060890","doi":"https://doi.org/10.3390/biology12060890","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology12060890","pdf_url":"https://www.mdpi.com/2079-7737/12/6/890/pdf?version=1687334642","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381662228.pdf","grobid_xml":"https://content.openalex.org/works/W4381662228.grobid-xml"},"referenced_works_count":179,"referenced_works":["https://openalex.org/W74337203","https://openalex.org/W572929821","https://openalex.org/W1484821918","https://openalex.org/W1493507570","https://openalex.org/W1510228054","https://openalex.org/W1526675316","https://openalex.org/W1573687817","https://openalex.org/W1598710451","https://openalex.org/W1611891438","https://openalex.org/W1958044292","https://openalex.org/W1964609270","https://openalex.org/W1965536104","https://openalex.org/W1965682737","https://openalex.org/W1968487875","https://openalex.org/W1971236593","https://openalex.org/W1971581793","https://openalex.org/W1971747713","https://openalex.org/W1972336663","https://openalex.org/W1978030266","https://openalex.org/W1984491653","https://openalex.org/W1984552097","https://openalex.org/W1986942653","https://openalex.org/W1987672655","https://openalex.org/W1987924718","https://openalex.org/W1992342289","https://openalex.org/W1992553167","https://openalex.org/W1993154580","https://openalex.org/W1993662267","https://openalex.org/W1999411716","https://openalex.org/W1999966048","https://openalex.org/W2000413851","https://openalex.org/W2000735073","https://openalex.org/W2002725664","https://openalex.org/W2005943162","https://openalex.org/W2006566998","https://openalex.org/W2011037064","https://openalex.org/W2013327325","https://openalex.org/W2016942688","https://openalex.org/W2017331588","https://openalex.org/W2025339136","https://openalex.org/W2028962991","https://openalex.org/W2032532142","https://openalex.org/W2033251315","https://openalex.org/W2035983191","https://openalex.org/W2038008152","https://openalex.org/W2039355845","https://openalex.org/W2040363498","https://openalex.org/W2041547614","https://openalex.org/W2049936165","https://openalex.org/W2051783527","https://openalex.org/W2052813015","https://openalex.org/W2053651833","https://openalex.org/W2054433132","https://openalex.org/W2055711642","https://openalex.org/W2055950592","https://openalex.org/W2059172311","https://openalex.org/W2059598145","https://openalex.org/W2060722431","https://openalex.org/W2062259699","https://openalex.org/W2063856840","https://openalex.org/W2064439148","https://openalex.org/W2066109449","https://openalex.org/W2067139397","https://openalex.org/W2067862435","https://openalex.org/W2067978209","https://openalex.org/W2069312900","https://openalex.org/W2070908085","https://openalex.org/W2072114485","https://openalex.org/W2074731300","https://openalex.org/W2080842257","https://openalex.org/W2083356835","https://openalex.org/W2083517562","https://openalex.org/W2083998839","https://openalex.org/W2084665817","https://openalex.org/W2085767071","https://openalex.org/W2090322960","https://openalex.org/W2091989272","https://openalex.org/W2092061953","https://openalex.org/W2094018129","https://openalex.org/W2094278487","https://openalex.org/W2095277906","https://openalex.org/W2096211026","https://openalex.org/W2097860814","https://openalex.org/W2101929000","https://openalex.org/W2104276565","https://openalex.org/W2104406613","https://openalex.org/W2114713190","https://openalex.org/W2116903726","https://openalex.org/W2117280460","https://openalex.org/W2117692326","https://openalex.org/W2121358530","https://openalex.org/W2125727559","https://openalex.org/W2132963869","https://openalex.org/W2133378734","https://openalex.org/W2139814294","https://openalex.org/W2140466922","https://openalex.org/W2144316033","https://openalex.org/W2165243554","https://openalex.org/W2167586691","https://openalex.org/W2176079713","https://openalex.org/W2185020176","https://openalex.org/W2186372704","https://openalex.org/W2207649343","https://openalex.org/W2238514531","https://openalex.org/W2270589632","https://openalex.org/W2293902578","https://openalex.org/W2311801213","https://openalex.org/W2322460994","https://openalex.org/W2332733264","https://openalex.org/W2408485295","https://openalex.org/W2468835156","https://openalex.org/W2485024012","https://openalex.org/W2514139663","https://openalex.org/W2526108799","https://openalex.org/W2527259077","https://openalex.org/W2530781935","https://openalex.org/W2534919910","https://openalex.org/W2605356356","https://openalex.org/W2606979107","https://openalex.org/W2610637522","https://openalex.org/W2713158710","https://openalex.org/W2771054134","https://openalex.org/W2789998291","https://openalex.org/W2791934068","https://openalex.org/W2794504721","https://openalex.org/W2800885395","https://openalex.org/W2801718970","https://openalex.org/W2807974247","https://openalex.org/W2811087664","https://openalex.org/W2886224535","https://openalex.org/W2887491890","https://openalex.org/W2890575367","https://openalex.org/W2895907180","https://openalex.org/W2896176769","https://openalex.org/W2897152552","https://openalex.org/W2902163840","https://openalex.org/W2912826773","https://openalex.org/W2916913049","https://openalex.org/W2943822915","https://openalex.org/W2946771864","https://openalex.org/W2948591222","https://openalex.org/W2951599018","https://openalex.org/W2960167431","https://openalex.org/W2967490120","https://openalex.org/W2979319304","https://openalex.org/W2991596976","https://openalex.org/W2992737701","https://openalex.org/W2994705631","https://openalex.org/W2998494924","https://openalex.org/W3026347171","https://openalex.org/W3031842480","https://openalex.org/W3046766434","https://openalex.org/W3083458921","https://openalex.org/W3085563760","https://openalex.org/W3128706811","https://openalex.org/W3129791746","https://openalex.org/W3130792055","https://openalex.org/W3133908250","https://openalex.org/W3140680744","https://openalex.org/W3177963472","https://openalex.org/W3178738483","https://openalex.org/W3199960272","https://openalex.org/W3204062620","https://openalex.org/W3212726695","https://openalex.org/W4200035220","https://openalex.org/W4200091091","https://openalex.org/W4200264608","https://openalex.org/W4212893393","https://openalex.org/W4223636603","https://openalex.org/W4280545383","https://openalex.org/W4281259765","https://openalex.org/W4285386348","https://openalex.org/W4286251091","https://openalex.org/W4287952803","https://openalex.org/W4296248542","https://openalex.org/W4307343365","https://openalex.org/W4311697147","https://openalex.org/W4367841328","https://openalex.org/W4376598396"],"related_works":["https://openalex.org/W2609089391","https://openalex.org/W7135812416","https://openalex.org/W2106034774","https://openalex.org/W2489138667","https://openalex.org/W2339609698","https://openalex.org/W1592520209","https://openalex.org/W2059598145","https://openalex.org/W7003860358","https://openalex.org/W2333632279","https://openalex.org/W2186372704"],"abstract_inverted_index":{"In":[0],"vitro":[1,121],"systems":[2],"have":[3,172],"been":[4],"mainly":[5],"promoted":[6],"by":[7,12,119,189],"authorities":[8],"to":[9,60,85,92,108,148],"sustain":[10],"research":[11],"following":[13],"the":[14,45,61,75,93,106,114,140,156,174,179,185,199],"3Rs":[15],"principle,":[16],"but":[17],"continuously":[18],"increasing":[19],"amounts":[20],"of":[21,31,47,64,77,126,138,164,168,181,194],"evidence":[22],"point":[23],"out":[24],"that":[25,167,202],"in":[26,44,74,120,184],"vivo":[27],"experimentation":[28],"is":[29,39,205],"also":[30,69],"extreme":[32],"relevance.":[33],"Xenopus":[34],"laevis,":[35],"an":[36],"anuran":[37],"amphibian,":[38],"a":[40,71,87,161,206],"significant":[41],"model":[42,91,209],"organism":[43],"study":[46],"evolutionary":[48],"developmental":[49],"biology,":[50],"toxicology,":[51],"ethology,":[52],"neurobiology,":[53],"endocrinology,":[54],"immunology":[55],"and":[56,89,97,117,142,151],"tumor":[57],"biology;":[58],"thanks":[59],"recent":[62],"development":[63],"genome":[65,159],"editing,":[66],"it":[67],"has":[68],"acquired":[70],"relevant":[72],"position":[73],"field":[76],"genetics.":[78],"For":[79],"these":[80],"reasons,":[81],"X.":[82,157,182,203],"laevis":[83,158,183,204],"appears":[84],"be":[86],"powerful":[88],"alternative":[90,149],"zebrafish":[94],"for":[95,196,210],"environmental":[96],"biomedical":[98],"studies.":[99,213],"Its":[100],"life":[101],"cycle,":[102],"as":[103,105,131],"well":[104],"possibility":[107],"obtain":[109],"gametes":[110],"from":[111],"adults":[112],"during":[113],"whole":[115],"year":[116],"embryos":[118],"fertilization,":[122],"allows":[123],"experimental":[124],"studies":[125],"several":[127],"biological":[128],"endpoints,":[129],"such":[130],"gametogenesis,":[132],"embryogenesis,":[133],"larval":[134],"growth,":[135],"metamorphosis":[136],"and,":[137,187],"course,":[139],"young":[141],"adult":[143],"stages.":[144],"Moreover,":[145],"with":[146,166],"respect":[147],"invertebrate":[150],"even":[152],"vertebrate":[153],"animal":[154],"models,":[155],"displays":[160],"higher":[162],"degree":[163],"similarity":[165],"mammals.":[169],"Here,":[170],"we":[171],"reviewed":[173],"main":[175],"available":[176],"literature":[177],"on":[178],"use":[180],"biosciences":[186],"inspired":[188],"Feymann\u2019s":[190],"revised":[191],"view,":[192],"\u201cPlenty":[193],"room":[195],"biology":[197],"at":[198],"bottom\u201d,":[200],"suggest":[201],"very":[207],"useful":[208],"all":[211],"possible":[212]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2023-06-23T00:00:00"}
