{"id":"https://openalex.org/W4381620156","doi":"https://doi.org/10.1093/humrep/dead093.238","title":"O-197 Vertical transmission of maternal mitochondrial DNA via extracellular vesicles (EVs) modulates embryo bioenergetics during the periconceptional period","display_name":"O-197 Vertical transmission of maternal mitochondrial DNA via extracellular vesicles (EVs) modulates embryo bioenergetics during the periconceptional period","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4381620156","doi":"https://doi.org/10.1093/humrep/dead093.238"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/dead093.238","doi":"https://doi.org/10.1093/humrep/dead093.238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/dead093.238","pdf_url":"https://academic.oup.com/humrep/article-pdf/38/Supplement_1/dead093.238/50787167/dead093.238.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/humrep/article-pdf/38/Supplement_1/dead093.238/50787167/dead093.238.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038567260","display_name":"Felipe Vilella","orcid":"https://orcid.org/0000-0002-0039-9846","observed_orcids":["https://orcid.org/0000-0002-0039-9846"]},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F Vilella","raw_affiliation_strings":["Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain","institution_ids":["https://openalex.org/I4210158373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083459177","display_name":"David Bolumar","orcid":"https://orcid.org/0000-0002-6234-3821","observed_orcids":["https://orcid.org/0000-0002-6234-3821"]},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D Bolumar","raw_affiliation_strings":["Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain","institution_ids":["https://openalex.org/I4210158373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029688650","display_name":"Javier Moncayo","orcid":"https://orcid.org/0000-0002-3564-4063","observed_orcids":["https://orcid.org/0000-0002-3564-4063"]},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J Moncayo-Arlandi","raw_affiliation_strings":["Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain","institution_ids":["https://openalex.org/I4210158373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035199250","display_name":"Javier Gonz\u00e1lez-Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-9625-5264","observed_orcids":["https://orcid.org/0000-0002-9625-5264"]},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J Gonzalez-Fernandez","raw_affiliation_strings":["Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain","institution_ids":["https://openalex.org/I4210158373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004908327","display_name":"Ana Ochando","orcid":"https://orcid.org/0000-0001-5255-8813","observed_orcids":["https://orcid.org/0000-0001-5255-8813"]},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Ochando","raw_affiliation_strings":["Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain","institution_ids":["https://openalex.org/I4210158373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101818880","display_name":"Inmaculada Moreno","orcid":"https://orcid.org/0000-0001-6910-7509","observed_orcids":["https://orcid.org/0000-0001-6910-7509"]},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"I Moreno","raw_affiliation_strings":["Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Simon Foundation-INCLIVA Research Institute, Reproductive Medicine , Valencia, Spain","institution_ids":["https://openalex.org/I4210158373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009687333","display_name":"Carlos Mar\u00edn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Marin","raw_affiliation_strings":["Juno Genetics, Laboratory , Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juno Genetics, Laboratory , Valencia, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083937729","display_name":"Antonio Diez","orcid":"https://orcid.org/0000-0003-1045-0411","observed_orcids":["https://orcid.org/0000-0003-1045-0411"]},"institutions":[{"id":"https://openalex.org/I4210154725","display_name":"Igenomix","ror":"https://ror.org/04mjvsy78","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210154725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Diez","raw_affiliation_strings":["Igenomix, r&d , Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Igenomix, r&d , Valencia, Spain","institution_ids":["https://openalex.org/I4210154725"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090345459","display_name":"Carlos Sim\u00f3n","orcid":"https://orcid.org/0000-0003-0902-9531","observed_orcids":["https://orcid.org/0000-0003-0902-9531"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"C Simon","raw_affiliation_strings":["Carlos Simon Foundation-INCLIVA Research Institute- Department of Pediatrics- Obstetrics & Gynecology- Faculty of Medicine- University of Valencia. Valencia- Spain- Department of Obstetrics and Gynecology- Beth Israel Deaconess Medical Center- Harvard"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Simon Foundation-INCLIVA Research Institute- Department of Pediatrics- Obstetrics & Gynecology- Faculty of Medicine- University of Valencia. Valencia- Spain- Department of Obstetrics and Gynecology- Beth Israel Deaconess Medical Center- Harvard","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I16097986","https://openalex.org/I4210158373"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3752,"currency":"EUR","value_usd":4059},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vertical-transmission","display_name":"vertical transmission","score":0.6809999942779541},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.765999972820282},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9890000224113464},{"id":"https://openalex.org/keywords/endometrium","display_name":"endometrium","score":0.8059999942779541},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/trophoblast","display_name":"trophoblast","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.8790000081062317},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.7450000047683716},{"id":"https://openalex.org/keywords/oxygen-consumption-rate","display_name":"oxygen consumption rate","score":0.7260000109672546},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.6340000033378601},{"id":"https://openalex.org/keywords/microvesicles","display_name":"microvesicles","score":0.902999997138977},{"id":"https://openalex.org/keywords/apoptotic-bodies","display_name":"apoptotic bodies","score":0.9769999980926514},{"id":"https://openalex.org/keywords/periconceptional-period","display_name":"periconceptional period","score":0.734000027179718},{"id":"https://openalex.org/keywords/mitochondrial-clearance","display_name":"mitochondrial clearance","score":0.5809999704360962},{"id":"https://openalex.org/keywords/uterine-fluid","display_name":"uterine fluid","score":0.550000011920929},{"id":"https://openalex.org/keywords/maternal-fetal-communication","display_name":"maternal-fetal communication","score":0.42500001192092896},{"id":"https://openalex.org/keywords/mitochondrial-dna-copy-number","display_name":"mitochondrial DNA copy number","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.656469464302063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6260797381401062},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6180114150047302},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5366275906562805},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45631229877471924},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29391324520111084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15930268168449402},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.14399027824401855}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/humrep/dead093.238","doi":"https://doi.org/10.1093/humrep/dead093.238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/dead093.238","pdf_url":"https://academic.oup.com/humrep/article-pdf/38/Supplement_1/dead093.238/50787167/dead093.238.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/humrep/dead093.238","doi":"https://doi.org/10.1093/humrep/dead093.238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/dead093.238","pdf_url":"https://academic.oup.com/humrep/article-pdf/38/Supplement_1/dead093.238/50787167/dead093.238.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381620156.pdf","grobid_xml":"https://content.openalex.org/works/W4381620156.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4381800270","https://openalex.org/W4387664534","https://openalex.org/W4366683775","https://openalex.org/W3093294354","https://openalex.org/W2976129685","https://openalex.org/W3209624220","https://openalex.org/W7018819241","https://openalex.org/W3183272799","https://openalex.org/W4381620319","https://openalex.org/W4362670680"],"abstract_inverted_index":{"Abstract":[0],"Study":[1,141],"question":[2],"Does":[3],"maternal":[4,26,430,486],"endometrial":[5,155,298,311,320,342,399,416,466],"mitochondrial":[6,39,326],"(mt)":[7],"DNA":[8,123,219,228,353],"cargo":[9],"of":[10,25,52,121,170,239,279,319,325,334,361,363,384,389,435,463,475,485],"EVs":[11,30,73,100,151,200,240,304,349,391,400,417,431,490],"modulate":[12,432],"embryo":[13,16,266,335,438,471,499],"bioenergetics":[14,434],"during":[15,166,345,419,448],"implantation?":[17],"Summary":[18],"answer":[19],"We":[20,366],"demonstrate":[21],"the":[22,35,113,167,251,257,277,296,315,323,332,346,357,382,410,420,425,433,436,441,449,476,482,492,497,501],"vertical":[23,119,483],"transmission":[24,120,484],"mtDNA":[27,317,487],"within":[28,489],"endometrial-derived":[29],"and":[31,41,50,70,86,94,103,115,139,174,204,215,256,276,292,307,322,352,359,373,445,468],"their":[32,82,107,171],"uptake":[33,51],"by":[34,234,439],"trophoblast":[36],"which":[37,150,329],"reduces":[38],"respiration":[40],"ATP":[42,247,368,379],"production.":[43],"What":[44],"is":[45],"known":[46,59],"already":[47],"The":[48,118,281],"release":[49],"membrane-enclosed":[53],"compartments":[54],"with":[55,106,230,241,331,338,386,415,424],"specific":[56,339],"cargos,":[57],"commonly":[58],"as":[60,127],"EVs,":[61],"represents":[62],"a":[63,128,375,387,407,461,464,469],"novel":[64,129],"cell-to-cell":[65],"communication":[66],"mechanism":[67,133],"in":[68,149,179,341,370,378,409,412],"physiological":[69],"pathogenic":[71],"conditions.":[72],"are":[74],"generally":[75],"classified":[76,205],"into":[77,295],"three":[78,286],"populations":[79],"based":[80],"on":[81,112],"biogenetic":[83],"pathways,":[84],"composition,":[85],"physical":[87],"characteristics:":[88],"apoptotic":[89],"bodies":[90],"(ABs),":[91],"microvesicles":[92],"(MVs),":[93],"exosomes":[95],"(EXOs).":[96],"Among":[97],"other":[98],"contents,":[99],"contain":[101],"single-":[102],"double-stranded":[104],"DNA,":[105],"relative":[108],"abundance":[109],"varying":[110],"depending":[111],"cell":[114],"vesicle":[116],"type.":[117],"EV-associated":[122,227],"has":[124],"been":[125],"proposed":[126],"genetic":[130],"material":[131],"transfer":[132],"that":[134,303,481],"may":[135],"impact":[136],"genome":[137],"evolution":[138],"tumorigenesis.":[140],"design,":[142],"size,":[143],"duration":[144],"Prospective":[145],"observational":[146],"multicenter":[147],"analysis":[148],"were":[152,350,458],"obtained":[153,209,418,459],"from":[154,157,210],"fluid":[156],"healthy":[158],"donors":[159],"aged":[160],"18\u201335":[161],"years":[162],"(n":[163,193,244,271],"=":[164,194,245,272],"10)":[165],"receptive":[168,184,421],"phase":[169,422],"natural":[172],"cycle":[173],"under":[175],"hormonal":[176],"replacement":[177],"therapy":[178],"pre-receptive":[180,426],"(P":[181,185,189],"+":[182,186,190],"2),":[183],"5),":[187],"post-receptive":[188],"8)":[191],"stages":[192],"13).":[195],"Participants/materials,":[196],"setting,":[197],"methods":[198],"Endometrial":[199],"isolated":[201],"using":[202,223,250,460],"ultracentrifugation":[203],"according":[206],"to":[207,264,356,394,491],"`parameters":[208],"electron":[211],"microscopy,":[212],"Western":[213],"blotting,":[214],"size":[216],"distribution":[217],"analysis.":[218],"copy":[220],"number":[221,506],"identified":[222],"high":[224],"throughput":[225],"sequencing.":[226],"tagged":[229],"5-ethynyl-2\u2019-deoxyuridine":[231],"was":[232,354],"followed":[233],"confocal":[235],"imaging":[236],"after":[237],"co-incubation":[238],"murine":[242,364,371,470],"embryos":[243,372,385,396,413],"200).":[246],"levels":[248,380],"assessed":[249],"FLASC":[252],"luciferase":[253],"reporter":[254],"system,":[255],"Seahorse":[258],"XFE96":[259],"extracellular":[260],"flux":[261],"analyzer":[262],"used":[263],"measure":[265],"oxygen":[267,446],"consumption":[268,447],"rate":[269,444],"(OCR)":[270],"400).":[273],"Main":[274],"results":[275,457,479],"role":[278],"chance":[280],"human":[282,297,465],"endometrium":[283],"secretes":[284],"all":[285,390],"EV":[287],"types":[288,392],"-":[289,294],"ABs,":[290],"MVs,":[291],"EXOs":[293],"fluid.":[299],"Deep":[300],"sequencing":[301],"revealed":[302],"encapsulated":[305,488],"nuclear":[306],"mtDNA.":[308],"When":[309],"analyzing":[310],"biopsies,":[312],"we":[313,405],"observed":[314],"reduced":[316],"content":[318],"cells":[321],"activation":[324],"clearance":[327],"mechanisms,":[328],"coincided":[330],"time":[333],"implantation":[336,502],"together":[337],"enrichment":[340],"MVs":[343],"secreted":[344],"periconceptional":[347,450],"period.":[348,451],"internalized":[351],"transferred":[355],"cytoplasm":[358],"nuclei":[360],"trophectoderm":[362,493],"embryos.":[365],"analyzed":[367],"concentrations":[369],"found":[374],"significant":[376],"reduction":[377,408],"following":[381],"coculture":[383],"combination":[388,462],"compared":[393,423],"control":[395],"cultured":[397],"without":[398],"(p":[401],"<":[402],"0.001).":[403],"Finally,":[404],"demonstrated":[406],"OCR":[411],"treated":[414],"phase.":[427],"In":[428],"conclusion,":[429],"preimplantation":[437,498],"increasing":[440],"embryo's":[442],"metabolic":[443],"Limitations,":[452],"reasons":[453],"for":[454],"caution":[455],"These":[456],"model":[467],"model.":[472],"Wider":[473],"implications":[474],"findings":[477],"Our":[478],"suggest":[480],"might":[494],"energetically":[495],"assist":[496],"through":[500],"process.":[503],"Trial":[504],"registration":[505],"N/A":[507]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-06-23T00:00:00"}