{"id":"https://openalex.org/W4381615652","doi":"https://doi.org/10.1186/s12933-023-01879-4","title":"Tofogliflozin long-term effects on atherosclerosis progression and major clinical parameters in patients with type 2 diabetes mellitus lacking a history of cardiovascular disease: a 2-year extension study of the UTOPIA trial","display_name":"Tofogliflozin long-term effects on atherosclerosis progression and major clinical parameters in patients with type 2 diabetes mellitus lacking a history of cardiovascular disease: a 2-year extension study of the UTOPIA trial","publication_year":2023,"publication_date":"2023-06-22","ids":{"openalex":"https://openalex.org/W4381615652","doi":"https://doi.org/10.1186/s12933-023-01879-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/37349722","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10286339"},"language":"en","primary_location":{"id":"doi:10.1186/s12933-023-01879-4","doi":"https://doi.org/10.1186/s12933-023-01879-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-023-01879-4","pdf_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-023-01879-4","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-023-01879-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006471965","display_name":"Naoto Katakami","orcid":"https://orcid.org/0000-0001-9020-8320","observed_orcids":["https://orcid.org/0000-0001-9020-8320"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naoto Katakami","raw_affiliation_strings":["Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. katakami@endmet.med.osaka-u.ac.jp","Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. katakami@endmet.med.osaka-u.ac.jp","Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. katakami@endmet.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. katakami@endmet.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070216766","display_name":"Tomoya Mita","orcid":"https://orcid.org/0000-0002-4401-2965","observed_orcids":["https://orcid.org/0000-0002-4401-2965"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Mita","raw_affiliation_strings":["Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022551661","display_name":"Hidenori Yoshii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283298","display_name":"Juntendo Tokyo Koto Geriatric Medical Center","ror":"https://ror.org/01d6kr923","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283298"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Yoshii","raw_affiliation_strings":["Department of Medicine, Diabetology & Endocrinology, Juntendo Tokyo Koto Geriatric Medical Center, Koto-ku, Tokyo, 136-0075, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Diabetology & Endocrinology, Juntendo Tokyo Koto Geriatric Medical Center, Koto-ku, Tokyo, 136-0075, Japan","institution_ids":["https://openalex.org/I4405283298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079463427","display_name":"Toshihiko Shiraiwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshihiko Shiraiwa","raw_affiliation_strings":["Shiraiwa Medical Clinic, 4-10-24 Hozenji, Kashiwara, Osaka, 582-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiraiwa Medical Clinic, 4-10-24 Hozenji, Kashiwara, Osaka, 582-0005, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103144624","display_name":"Tetsuyuki Yasuda","orcid":"https://orcid.org/0000-0002-1128-8834","observed_orcids":["https://orcid.org/0000-0002-1128-8834","https://orcid.org/0000-0001-7018-4712"]},"institutions":[{"id":"https://openalex.org/I4210108563","display_name":"Osaka Police Hospital","ror":"https://ror.org/015x7ap02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108563"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuyuki Yasuda","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Osaka Police Hospital, 10-31, Kitayama-Cho, Tennoji-ku, Osaka, 543-0035, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Osaka Police Hospital, 10-31, Kitayama-Cho, Tennoji-ku, Osaka, 543-0035, Japan","institution_ids":["https://openalex.org/I4210108563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028248498","display_name":"Yosuke Okada","orcid":"https://orcid.org/0000-0003-4998-9078","observed_orcids":["https://orcid.org/0000-0003-4998-9078"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Okada","raw_affiliation_strings":["First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001269106","display_name":"Akira Kurozumi","orcid":"https://orcid.org/0000-0003-1768-3752","observed_orcids":["https://orcid.org/0000-0003-1768-3752"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Kurozumi","raw_affiliation_strings":["First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065280521","display_name":"Masahiro Hatazaki","orcid":"https://orcid.org/0009-0007-5529-2652","observed_orcids":["https://orcid.org/0009-0007-5529-2652"]},"institutions":[{"id":"https://openalex.org/I3019022944","display_name":"Osaka Prefectural Medical Center","ror":"https://ror.org/00vcb6036","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3019022944","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Hatazaki","raw_affiliation_strings":["Department of Diabetes and Endocrinology, Osaka General Medical Center, 3-1-56, Bandai-Higashi, Sumiyoshi-ku, Osaka, 558-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes and Endocrinology, Osaka General Medical Center, 3-1-56, Bandai-Higashi, Sumiyoshi-ku, Osaka, 558-8558, Japan","institution_ids":["https://openalex.org/I3019022944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024295858","display_name":"Hideaki Kaneto","orcid":"https://orcid.org/0000-0001-7898-1943","observed_orcids":["https://orcid.org/0000-0001-7898-1943"]},"institutions":[{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Kaneto","raw_affiliation_strings":["Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan","institution_ids":["https://openalex.org/I189996419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070116155","display_name":"Takeshi Osonoi","orcid":"https://orcid.org/0000-0002-5410-9277","observed_orcids":["https://orcid.org/0000-0002-5410-9277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Osonoi","raw_affiliation_strings":["Nakakinen Clinic, 745-5, Nakadai, Naka, Ibaraki, 311-0113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nakakinen Clinic, 745-5, Nakadai, Naka, Ibaraki, 311-0113, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103735051","display_name":"Tsunehiko Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113343","display_name":"Kansai Rosai Hospital","ror":"https://ror.org/024ran220","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210113343"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsunehiko Yamamoto","raw_affiliation_strings":["Diabetes and Endocrinology, Kansai Rosai Hospital, 3-1-69, Inabaso, Amagasaki, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology, Kansai Rosai Hospital, 3-1-69, Inabaso, Amagasaki, Hyogo, Japan","institution_ids":["https://openalex.org/I4210113343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111610562","display_name":"Nobuichi Kuribayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuichi Kuribayashi","raw_affiliation_strings":["Misaki Naika Clinic, 6-44-9, Futawa-Higashi, Funabashi, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Misaki Naika Clinic, 6-44-9, Futawa-Higashi, Funabashi, Chiba, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009702941","display_name":"Kazuhisa Maeda","orcid":"https://orcid.org/0000-0001-8126-0581","observed_orcids":["https://orcid.org/0000-0001-8126-0581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhisa Maeda","raw_affiliation_strings":["Kitasenri Maeda Clinic, 4-119, Furuedai, Suita, Osaka, 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasenri Maeda Clinic, 4-119, Furuedai, Suita, Osaka, 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005153787","display_name":"Hiroki Yokoyama","orcid":"https://orcid.org/0000-0003-1602-4050","observed_orcids":["https://orcid.org/0000-0003-1602-4050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroki Yokoyama","raw_affiliation_strings":["Jiyugaoka Medical Clinic, West 6, South 6-4-3, Obihiro, Hokkaido, 080-0016, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiyugaoka Medical Clinic, West 6, South 6-4-3, Obihiro, Hokkaido, 080-0016, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102262142","display_name":"Keisuke Kosugi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keisuke Kosugi","raw_affiliation_strings":["Kosugi Medical Clinic, 3-9, Tamatsukurimoto-Cho, Tennoji-ku, Osaka, 543-0014, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kosugi Medical Clinic, 3-9, Tamatsukurimoto-Cho, Tennoji-ku, Osaka, 543-0014, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034806440","display_name":"Kentaro Ohtoshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kentaro Ohtoshi","raw_affiliation_strings":["Otoshi Medical Clinic, 8-47, KakudachoOsaka Kita-ku, Osaka, 530-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otoshi Medical Clinic, 8-47, KakudachoOsaka Kita-ku, Osaka, 530-0017, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Isao Hayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isao Hayashi","raw_affiliation_strings":["Hayashi Clinic, 3-9-23, Koshienguchi, Nishinomiya, Hyogo, 663-8113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hayashi Clinic, 3-9-23, Koshienguchi, Nishinomiya, Hyogo, 663-8113, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023497800","display_name":"Satoru Sumitani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164826","display_name":"Nippon Life Hospital","ror":"https://ror.org/05kp9zx42","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210164826"]},{"id":"https://openalex.org/I4405285347","display_name":"Saiseikai Izuo Hospital","ror":"https://ror.org/058n7vg60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405285347"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Sumitani","raw_affiliation_strings":["Center for Diabetes and Endocrinology, Nippon Life Hospital, 2-1-54 Enokojima, Nishi-ku, Osaka, 550-0006, Japan","Department of Diabetology and Endocrinology, Pref Osaka Saiseikai Izuo Hospital, 3-4-5 Kitamura, Taisho, Osaka, 551-0032, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes and Endocrinology, Nippon Life Hospital, 2-1-54 Enokojima, Nishi-ku, Osaka, 550-0006, Japan","institution_ids":["https://openalex.org/I4210164826"]},{"raw_affiliation_string":"Department of Diabetology and Endocrinology, Pref Osaka Saiseikai Izuo Hospital, 3-4-5 Kitamura, Taisho, Osaka, 551-0032, Japan","institution_ids":["https://openalex.org/I4405285347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008847665","display_name":"Mamiko Tsugawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102296","display_name":"Ikeda Municipal Hospital","ror":"https://ror.org/00qezxe61","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102296"]},{"id":"https://openalex.org/I4405283158","display_name":"Meiwa Hospital","ror":"https://ror.org/0141nsn41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283158"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamiko Tsugawa","raw_affiliation_strings":["Department of Diabetes and Endocrinology, Meiwa Hospital, 4-31 Agenaruo, Nishinomiya, Hyogo, 663-8186, Japan","Department of Endocrinology and Metabolism, Ikeda Municipal Hospital, 3-1-18, Jonan, Ikeda, Osaka, 563-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes and Endocrinology, Meiwa Hospital, 4-31 Agenaruo, Nishinomiya, Hyogo, 663-8186, Japan","institution_ids":["https://openalex.org/I4405283158"]},{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Ikeda Municipal Hospital, 3-1-18, Jonan, Ikeda, Osaka, 563-8510, Japan","institution_ids":["https://openalex.org/I4210102296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036316783","display_name":"Kayoko Ryomoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112889","display_name":"Osaka Rosai Hospital","ror":"https://ror.org/02bj40x52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210112889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kayoko Ryomoto","raw_affiliation_strings":["Center for Diabetes Mellitus, Osaka Rosai Hospital, 1179-3 Nagasone-Cho, Kita-ku, Sakai, Osaka, 591-8025, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes Mellitus, Osaka Rosai Hospital, 1179-3 Nagasone-Cho, Kita-ku, Sakai, Osaka, 591-8025, Japan","institution_ids":["https://openalex.org/I4210112889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082832235","display_name":"Ken Kato","orcid":"https://orcid.org/0000-0002-1733-5072","observed_orcids":["https://orcid.org/0000-0002-1733-5072","https://orcid.org/0009-0001-9251-9306"]},"institutions":[{"id":"https://openalex.org/I4210090372","display_name":"Osaka National Hospital","ror":"https://ror.org/00b6s9f18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090372","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Kato","raw_affiliation_strings":["Diabetes Center, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Center, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan","institution_ids":["https://openalex.org/I4210090372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036241830","display_name":"Tadashi Nakamura","orcid":"https://orcid.org/0000-0002-0508-7876","observed_orcids":["https://orcid.org/0000-0002-0508-7876"]},"institutions":[{"id":"https://openalex.org/I4210138190","display_name":"Kawasaki Hospital","ror":"https://ror.org/03cfz7739","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210138190"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Nakamura","raw_affiliation_strings":["Department of Internal Medicine, Kawasaki Hospital, 3-3-1, Higashiyamacho, Kobe Hyogo-ku, Hyogo, 652-0042, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Kawasaki Hospital, 3-3-1, Higashiyamacho, Kobe Hyogo-ku, Hyogo, 652-0042, Japan","institution_ids":["https://openalex.org/I4210138190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104227164","display_name":"Satoshi Kawashima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Kawashima","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012506063","display_name":"Yasunori Sato","orcid":"https://orcid.org/0000-0002-7189-5126","observed_orcids":["https://orcid.org/0000-0002-7189-5126"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunori Sato","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043895658","display_name":"Hirotaka Watada","orcid":"https://orcid.org/0000-0001-5961-1816","observed_orcids":["https://orcid.org/0000-0001-5961-1816"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Watada","raw_affiliation_strings":["Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037246488","display_name":"Iichiro Shimomura","orcid":"https://orcid.org/0000-0002-0851-9603","observed_orcids":["https://orcid.org/0000-0002-0851-9603"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Iichiro Shimomura","raw_affiliation_strings":["Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"the UTOPIA study investigators","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the UTOPIA study investigators","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103119978","display_name":"Kota Komiyama","orcid":"https://orcid.org/0000-0002-0612-4130","observed_orcids":["https://orcid.org/0000-0002-0612-4130"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Komiyama","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070547255","display_name":"Tomoaki Shimizu","orcid":"https://orcid.org/0000-0001-5442-611X","observed_orcids":["https://orcid.org/0000-0001-5442-611X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Shimizu","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056410269","display_name":"Shinji Kamei","orcid":"https://orcid.org/0000-0002-3980-8619","observed_orcids":["https://orcid.org/0000-0002-3980-8619"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Kamei","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007642461","display_name":"Tomoe Kinoshita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Kinoshita","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084036501","display_name":"Masashi Shimoda","orcid":"https://orcid.org/0000-0002-4223-9613","observed_orcids":["https://orcid.org/0000-0002-4223-9613","https://orcid.org/0009-0003-3475-9701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Shimoda","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714639","display_name":"Makoto Saito","orcid":"https://orcid.org/0000-0001-9015-0050","observed_orcids":["https://orcid.org/0000-0001-9015-0050"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Saito","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Fujiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Fujiki","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040333756","display_name":"Yukari Fujita","orcid":"https://orcid.org/0000-0002-8847-5654","observed_orcids":["https://orcid.org/0000-0002-8847-5654","https://orcid.org/0009-0003-9656-1303"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Fujita","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Shimizu","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056345700","display_name":"Yutaka Umayahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Umayahara","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109349156","display_name":"Y. Irie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Irie","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Kataoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Kataoka","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109354541","display_name":"Yutaka Kiyohara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Kiyohara","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Ohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112889","display_name":"Osaka Rosai Hospital","ror":"https://ror.org/02bj40x52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210112889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ohashi","raw_affiliation_strings":["Center for Diabetes Mellitus, Osaka Rosai Hospital, 1179-3 Nagasone-Cho, Kita-ku, Sakai, Osaka, 591-8025, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes Mellitus, Osaka Rosai Hospital, 1179-3 Nagasone-Cho, Kita-ku, Sakai, Osaka, 591-8025, Japan","institution_ids":["https://openalex.org/I4210112889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036316783","display_name":"Kayoko Ryomoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210112889","display_name":"Osaka Rosai Hospital","ror":"https://ror.org/02bj40x52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210112889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Ryomoto","raw_affiliation_strings":["Center for Diabetes Mellitus, Osaka Rosai Hospital, 1179-3 Nagasone-Cho, Kita-ku, Sakai, Osaka, 591-8025, Japan","Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes Mellitus, Osaka Rosai Hospital, 1179-3 Nagasone-Cho, Kita-ku, Sakai, Osaka, 591-8025, Japan","institution_ids":["https://openalex.org/I4210112889"]},{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Takahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Takahi","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Fujishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Fujishima","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040333756","display_name":"Yukari Fujita","orcid":"https://orcid.org/0000-0002-8847-5654","observed_orcids":["https://orcid.org/0000-0002-8847-5654","https://orcid.org/0009-0003-9656-1303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086645806","display_name":"Atsunori Fukuhara","orcid":"https://orcid.org/0000-0002-6289-3778","observed_orcids":["https://orcid.org/0000-0002-6289-3778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Fukuhara","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Fukui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Fukui","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Hosokawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Hosokawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013468065","display_name":"Akihisa Imagawa","orcid":"https://orcid.org/0000-0002-4213-3229","observed_orcids":["https://orcid.org/0000-0002-4213-3229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Imagawa","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083356005","display_name":"Hiromi Iwahashi","orcid":"https://orcid.org/0000-0003-3275-6972","observed_orcids":["https://orcid.org/0000-0003-3275-6972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Iwahashi","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Mukai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Mukai","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Katsura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138190","display_name":"Kawasaki Hospital","ror":"https://ror.org/03cfz7739","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210138190"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Katsura","raw_affiliation_strings":["Department of Internal Medicine, Kawasaki Hospital, 3-3-1, Higashiyamacho, Kobe Hyogo-ku, Hyogo, 652-0042, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Kawasaki Hospital, 3-3-1, Higashiyamacho, Kobe Hyogo-ku, Hyogo, 652-0042, Japan","institution_ids":["https://openalex.org/I4210138190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033376925","display_name":"Dan Kawamori","orcid":"https://orcid.org/0000-0002-0149-8213","observed_orcids":["https://orcid.org/0000-0002-0149-8213"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"D. Kawamori","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083294804","display_name":"Tomohiko Kimura","orcid":"https://orcid.org/0000-0003-3986-9494","observed_orcids":["https://orcid.org/0000-0003-3986-9494"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Kimura","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Kobayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067533233","display_name":"Junji Kozawa","orcid":"https://orcid.org/0000-0001-9665-8947","observed_orcids":["https://orcid.org/0000-0001-9665-8947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Kozawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F. Kubo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Kubo","raw_affiliation_strings":["Kitasenri Maeda Clinic, 4-119, Furuedai, Suita, Osaka, 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasenri Maeda Clinic, 4-119, Furuedai, Suita, Osaka, 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045989814","display_name":"Norikazu Maeda","orcid":"https://orcid.org/0000-0002-7105-0836","observed_orcids":["https://orcid.org/0000-0002-7105-0836"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Maeda","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003580258","display_name":"Taka\u2010aki Matsuoka","orcid":"https://orcid.org/0000-0002-9952-9873","observed_orcids":["https://orcid.org/0000-0002-9952-9873","https://orcid.org/0000-0002-8948-1319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Matsuoka","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103167299","display_name":"Kazuo Miyashita","orcid":"https://orcid.org/0000-0001-5143-312X","observed_orcids":["https://orcid.org/0000-0001-5143-312X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Miyashita","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113798213","display_name":"S. Nakata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Nakata","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074726551","display_name":"Hiroyo Ninomiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Ninomiya","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003630359","display_name":"Hitoshi Nishizawa","orcid":"https://orcid.org/0000-0002-7845-9693","observed_orcids":["https://orcid.org/0000-0002-7845-9693"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Nishizawa","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110792494","display_name":"Y. Okuno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Okuno","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053734867","display_name":"Michio Otsuki","orcid":"https://orcid.org/0000-0001-5947-8621","observed_orcids":["https://orcid.org/0000-0001-5947-8621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Otsuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001502266","display_name":"Fumie Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F. Sakamoto","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114132529","display_name":"S Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Sasaki","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114013028","display_name":"I Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I. Sato","raw_affiliation_strings":["Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Shimo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Shimo","raw_affiliation_strings":["Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037246488","display_name":"Iichiro Shimomura","orcid":"https://orcid.org/0000-0002-0851-9603","observed_orcids":["https://orcid.org/0000-0002-0851-9603"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I. Shimomura","raw_affiliation_strings":["Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan","Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060704693","display_name":"Mitsuyoshi Takahara","orcid":"https://orcid.org/0000-0001-5105-041X","observed_orcids":["https://orcid.org/0000-0001-5105-041X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Takahara","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Takano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Takano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Tokunaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Tokunaga","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024481529","display_name":"Sae Uno","orcid":"https://orcid.org/0000-0003-0565-7311","observed_orcids":["https://orcid.org/0000-0003-0565-7311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Uno","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Yamaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Yamaoka","raw_affiliation_strings":["Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health, Keio University School of Medicine, 45 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075187976","display_name":"Sho Yoneda","orcid":"https://orcid.org/0000-0002-9165-3327","observed_orcids":["https://orcid.org/0000-0002-9165-3327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Yoneda","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078840076","display_name":"M. Hajime","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Hajime","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008230071","display_name":"Kenji Koikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Koikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068239361","display_name":"Fumi Kuno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Kuno","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047285396","display_name":"Kazuyuki Matsushita","orcid":"https://orcid.org/0000-0001-6742-0761","observed_orcids":["https://orcid.org/0000-0001-6742-0761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Matsushita","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065962304","display_name":"Manabu Narisawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Narisawa","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014535730","display_name":"Kazunari Tanaka","orcid":"https://orcid.org/0000-0001-9811-2665","observed_orcids":["https://orcid.org/0000-0001-9811-2665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Tanaka","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Sugai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Sugai","raw_affiliation_strings":["Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanda Naika Clinic, 5-21-3, Hannancho, Osaka Abeno-ku, Osaka, 545-0021, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084040621","display_name":"Katsuji Torimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Torimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5006471965"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":2.2943,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.89362635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"143","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tofogliflozin","display_name":"tofogliflozin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9760000109672546},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/atherosclerosis-progression","display_name":"atherosclerosis progression","score":0.972000002861023},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6869999766349792},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.753000020980835},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.796999990940094},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.6700000166893005},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.8100000023841858},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6290000081062317},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5929999947547913},{"id":"https://openalex.org/keywords/extension-study","display_name":"extension study","score":0.6830000281333923},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8933274149894714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7300223112106323},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.6016666889190674},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5633164644241333},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5492083430290222},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.5195856094360352},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4598925709724426},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.42924267053604126},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.42528098821640015},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42286697030067444},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3215498924255371},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1837742030620575}],"mesh":[{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014601","descriptor_name":"Utopias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055109","descriptor_name":"Ankle Brachial Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059168","descriptor_name":"Carotid Intima-Media Thickness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063177","descriptor_name":"Pulse Wave Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12933-023-01879-4","doi":"https://doi.org/10.1186/s12933-023-01879-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-023-01879-4","pdf_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-023-01879-4","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10286339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10286339","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10286339/pdf/12933_2023_Article_1879.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Diabetol","raw_type":"Text"},{"id":"pmid:37349722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37349722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular diabetology","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:doaj.org/article:8358aaeab0374c86b4c5f65e4528a3a5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8358aaeab0374c86b4c5f65e4528a3a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12933-023-01879-4","doi":"https://doi.org/10.1186/s12933-023-01879-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-023-01879-4","pdf_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-023-01879-4","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316238","display_name":"Kowa Company","ror":"https://ror.org/009z2z347"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381615652.pdf","grobid_xml":"https://content.openalex.org/works/W4381615652.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1835352130","https://openalex.org/W1969157512","https://openalex.org/W1974919082","https://openalex.org/W2033439327","https://openalex.org/W2052997601","https://openalex.org/W2066442598","https://openalex.org/W2072765033","https://openalex.org/W2073704832","https://openalex.org/W2074056350","https://openalex.org/W2104983588","https://openalex.org/W2122146058","https://openalex.org/W2134304394","https://openalex.org/W2138209376","https://openalex.org/W2138225782","https://openalex.org/W2140411181","https://openalex.org/W2144020184","https://openalex.org/W2146264128","https://openalex.org/W2166304122","https://openalex.org/W2167245776","https://openalex.org/W2171294019","https://openalex.org/W2182241779","https://openalex.org/W2310812385","https://openalex.org/W2341643234","https://openalex.org/W2416842703","https://openalex.org/W2590429728","https://openalex.org/W2592311396","https://openalex.org/W2606681868","https://openalex.org/W2626446274","https://openalex.org/W2750269437","https://openalex.org/W2753460738","https://openalex.org/W2755863750","https://openalex.org/W2791536956","https://openalex.org/W2799739525","https://openalex.org/W2808915250","https://openalex.org/W2939222610","https://openalex.org/W3022616650","https://openalex.org/W3041394830","https://openalex.org/W3074388173","https://openalex.org/W3120113718","https://openalex.org/W3190307997","https://openalex.org/W4210628871","https://openalex.org/W4280507712","https://openalex.org/W4306168413","https://openalex.org/W4307325168"],"related_works":["https://openalex.org/W3041394830","https://openalex.org/W3035157388","https://openalex.org/W3170895665","https://openalex.org/W6977415602","https://openalex.org/W2753460738","https://openalex.org/W6902224089","https://openalex.org/W3120113718","https://openalex.org/W4210628871","https://openalex.org/W6920919116","https://openalex.org/W6902258947"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1,38],"study":[2,45],"aimed":[3],"to":[4,156,214,221],"assess":[5],"the":[6,47,74,104,113,137,146,174,188,222,229,259],"long-term":[7,275],"effects":[8,277],"of":[9,34,46,103,248,269],"tofogliflozin,":[10],"a":[11,40,63,164,201,287],"sodium-glucose":[12],"cotransporter":[13],"2":[14,28,58],"(SGLT2)":[15],"inhibitor,":[16],"on":[17,278],"atherosclerosis":[18],"progression":[19],"and":[20,87,96,124,232,242,250,283],"major":[21],"clinical":[22],"parameters":[23],"in":[24,73,111,145,163,173,187,200,205],"patients":[25,60],"with":[26,266],"type":[27,57],"diabetes":[29,59],"lacking":[30],"an":[31],"apparent":[32],"history":[33],"cardiovascular":[35,97,280],"disease.":[36],"METHODS:":[37],"was":[39,263],"prospective":[41],"observational":[42],"2-year":[43,64],"extension":[44],"\"Using":[48],"TOfogliflozin":[49],"for":[50,56,89,167],"Possible":[51],"better":[52],"Intervention":[53],"against":[54],"Atherosclerosis":[55],"(UTOPIA)\"":[61],"trial,":[62],"randomized":[65],"intervention":[66],"study.":[67],"The":[68,100,246],"primary":[69],"endpoints":[70,80],"represented":[71],"changes":[72,147,206],"carotid":[75,106,270],"intima-media":[76],"thickness":[77],"(IMT).":[78],"Secondary":[79],"included":[81],"brachial-ankle":[82],"pulse":[83],"wave":[84],"velocity":[85],"(baPWV)":[86],"biomarkers":[88],"glucose":[90],"metabolism,":[91,93],"lipid":[92],"renal":[94],"function,":[95],"risks.":[98],"RESULTS:":[99],"mean":[101],"IMT":[102],"common":[105],"artery":[107],"(IMT-CCA)":[108],"significantly":[109,171,227,257],"decreased":[110],"both":[112],"tofogliflozin":[114,189,226],"(-":[115,128,191,207],"0.067":[116],"mm,":[117,130,149],"standard":[118],"error":[119],"0.009,":[120,132],"p":[121,133,158,182,196,217],"<":[122,134],"0.001)":[123,135],"conventional":[125,175,223],"treatment":[126,176,224],"groups":[127],"0.080":[129],"SE":[131],"throughout":[136],"follow-up":[138],"period;":[139],"however,":[140],"no":[141],"significant":[142,202],"intergroup":[143,203],"differences":[144],"(0.013":[148],"95%":[150,210],"confidence":[151],"interval":[152],"(CI)":[153],"-":[154,212,215],"0.012":[155],"0.037,":[157],"=":[159,183,197,218],"0.32)":[160],"were":[161],"observed":[162],"mixed-effects":[165],"model":[166],"repeated":[168],"measures.":[169],"baPWV":[170,284],"increased":[172],"group":[177,190],"(82.7":[178],"\u00b1":[179,193],"210.3":[180],"cm/s,":[181,195,209],"0.008)":[184],"but":[185,273],"not":[186,255,264],"17.5":[192],"221.3":[194],"0.54),":[198],"resulting":[199],"difference":[204],"100.2":[208],"CI":[211],"182.8":[213],"17.5,":[216],"0.018).":[219],"Compared":[220],"group,":[225],"improved":[228,267],"hemoglobin":[230],"A1c":[231],"high-density":[233],"lipoprotein":[234],"cholesterol":[235],"levels,":[236],"body":[237],"mass":[238],"index,":[239],"abdominal":[240],"circumference,":[241],"systolic":[243],"blood":[244],"pressure.":[245],"frequencies":[247],"total":[249],"serious":[251],"adverse":[252],"events":[253],"did":[254],"vary":[256],"between":[258],"groups.":[260],"CONCLUSIONS:":[261],"Tofogliflozin":[262],"associated":[265],"inhibition":[268],"wall":[271],"thickening":[272],"exerted":[274],"positive":[276],"various":[279],"risk":[281],"factors":[282],"while":[285],"showing":[286],"good":[288],"safety":[289],"profile.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-06-23T00:00:00"}