{"id":"https://openalex.org/W4381542486","doi":"https://doi.org/10.2218/gtopdb/f62/2023.1","title":"Tachykinin receptors in GtoPdb v.2023.1","display_name":"Tachykinin receptors in GtoPdb v.2023.1","publication_year":2023,"publication_date":"2023-04-26","ids":{"openalex":"https://openalex.org/W4381542486","doi":"https://doi.org/10.2218/gtopdb/f62/2023.1"},"language":"en","primary_location":{"id":"doi:10.2218/gtopdb/f62/2023.1","doi":"https://doi.org/10.2218/gtopdb/f62/2023.1","is_oa":true,"landing_page_url":"https://doi.org/10.2218/gtopdb/f62/2023.1","pdf_url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8709/11522","source":{"id":"https://openalex.org/S4210197557","display_name":"IUPHAR/BPS Guide to Pharmacology CITE","issn_l":"2633-1020","issn":["2633-1020"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321110","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/P4310321110"],"host_organization_lineage_names":["University of Edinburgh"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IUPHAR/BPS Guide to Pharmacology CITE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8709/11522","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018604241","display_name":"Jeffrey S. Barrett","orcid":"https://orcid.org/0000-0003-0879-1743","observed_orcids":["https://orcid.org/0000-0003-0879-1743"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Barrett","raw_affiliation_strings":["Children's Hospital of Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078856933","display_name":"Brenden Canning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenden Canning","raw_affiliation_strings":["Johns Hopkins"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031789645","display_name":"Joseph Coulson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph Coulson","raw_affiliation_strings":["University of Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048554642","display_name":"Erin Dombrowsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Dombrowsky","raw_affiliation_strings":["Children's Hospital of Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037161551","display_name":"Steven D. Douglas","orcid":"https://orcid.org/0000-0002-3748-3603","observed_orcids":["https://orcid.org/0000-0002-3748-3603"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Douglas","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001772015","display_name":"Tung Ming Fong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tung M. Fong","raw_affiliation_strings":["Vyluma Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vyluma Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066954770","display_name":"Christa Y. Heyward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christa Y. Heyward","raw_affiliation_strings":["Children's Hospital of Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053523675","display_name":"Susan E. Leeman","orcid":"https://orcid.org/0000-0003-2875-1394","observed_orcids":["https://orcid.org/0000-0003-2875-1394"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan E. Leeman","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080084180","display_name":"Pranela Remeshwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranela Remeshwar","raw_affiliation_strings":["University of Medicine and Dentistry of New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Medicine and Dentistry of New Jersey","institution_ids":["https://openalex.org/I4405286694"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1177,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35628479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2023","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tachykinin-receptors","display_name":"tachykinin receptors","score":1.0},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neurokinin-a","display_name":"neurokinin A","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neurokinin-b","display_name":"neurokinin B","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neuropeptide-k","display_name":"neuropeptide K","score":0.9390000104904175},{"id":"https://openalex.org/keywords/neuropeptide-gamma","display_name":"neuropeptide gamma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/receptor-pharmacology","display_name":"receptor pharmacology","score":0.6880000233650208},{"id":"https://openalex.org/keywords/receptor-nomenclature","display_name":"receptor nomenclature","score":0.6949999928474426},{"id":"https://openalex.org/keywords/aprepitant","display_name":"aprepitant","score":0.8230000138282776},{"id":"https://openalex.org/keywords/fosaprepitant","display_name":"fosaprepitant","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiemetics","display_name":"antiemetics","score":0.7390000224113464},{"id":"https://openalex.org/keywords/emetogenic-chemotherapy","display_name":"emetogenic chemotherapy","score":0.6940000057220459},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2781359426","wikidata":"https://www.wikidata.org/wiki/Q412604","display_name":"Neurokinin B","level":5,"score":0.9080902338027954},{"id":"https://openalex.org/C2777056410","wikidata":"https://www.wikidata.org/wiki/Q408566","display_name":"Neurokinin A","level":5,"score":0.8908595442771912},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.8260222673416138},{"id":"https://openalex.org/C2780574406","wikidata":"https://www.wikidata.org/wiki/Q621834","display_name":"Aprepitant","level":4,"score":0.817999005317688},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.6000826358795166},{"id":"https://openalex.org/C55938493","wikidata":"https://www.wikidata.org/wiki/Q426034","display_name":"Tachykinin receptor","level":5,"score":0.5762192010879517},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5719996094703674},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5706620216369629},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.517586350440979},{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.5156639814376831},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4823295772075653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3318156599998474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3100661039352417},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.2863389849662781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2741740942001343},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2218/gtopdb/f62/2023.1","doi":"https://doi.org/10.2218/gtopdb/f62/2023.1","is_oa":true,"landing_page_url":"https://doi.org/10.2218/gtopdb/f62/2023.1","pdf_url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8709/11522","source":{"id":"https://openalex.org/S4210197557","display_name":"IUPHAR/BPS Guide to Pharmacology CITE","issn_l":"2633-1020","issn":["2633-1020"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321110","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/P4310321110"],"host_organization_lineage_names":["University of Edinburgh"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IUPHAR/BPS Guide to Pharmacology CITE","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2218/gtopdb/f62/2023.1","doi":"https://doi.org/10.2218/gtopdb/f62/2023.1","is_oa":true,"landing_page_url":"https://doi.org/10.2218/gtopdb/f62/2023.1","pdf_url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8709/11522","source":{"id":"https://openalex.org/S4210197557","display_name":"IUPHAR/BPS Guide to Pharmacology CITE","issn_l":"2633-1020","issn":["2633-1020"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321110","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/P4310321110"],"host_organization_lineage_names":["University of Edinburgh"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IUPHAR/BPS Guide to Pharmacology CITE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381542486.pdf","grobid_xml":"https://content.openalex.org/works/W4381542486.grobid-xml"},"referenced_works_count":146,"referenced_works":["https://openalex.org/W73534840","https://openalex.org/W76344694","https://openalex.org/W1506118937","https://openalex.org/W1540911990","https://openalex.org/W1546069046","https://openalex.org/W1605277785","https://openalex.org/W1794360333","https://openalex.org/W1960003892","https://openalex.org/W1962105746","https://openalex.org/W1965597555","https://openalex.org/W1967930242","https://openalex.org/W1968134669","https://openalex.org/W1969267927","https://openalex.org/W1969487465","https://openalex.org/W1969666113","https://openalex.org/W1970160380","https://openalex.org/W1971695748","https://openalex.org/W1973830504","https://openalex.org/W1977366385","https://openalex.org/W1977865535","https://openalex.org/W1979924802","https://openalex.org/W1981312249","https://openalex.org/W1981748560","https://openalex.org/W1982969289","https://openalex.org/W1983214544","https://openalex.org/W1983869449","https://openalex.org/W1983991937","https://openalex.org/W1985247223","https://openalex.org/W1986858018","https://openalex.org/W1987910290","https://openalex.org/W1988933904","https://openalex.org/W1991782556","https://openalex.org/W1992675862","https://openalex.org/W1994663082","https://openalex.org/W1996205893","https://openalex.org/W2000582958","https://openalex.org/W2001782178","https://openalex.org/W2003557031","https://openalex.org/W2004094930","https://openalex.org/W2007589914","https://openalex.org/W2007737411","https://openalex.org/W2008901465","https://openalex.org/W2009302888","https://openalex.org/W2013475893","https://openalex.org/W2014917362","https://openalex.org/W2018809558","https://openalex.org/W2018968319","https://openalex.org/W2020596893","https://openalex.org/W2021760854","https://openalex.org/W2024878076","https://openalex.org/W2025928484","https://openalex.org/W2027220320","https://openalex.org/W2027251048","https://openalex.org/W2029202870","https://openalex.org/W2029724422","https://openalex.org/W2030025448","https://openalex.org/W2030618016","https://openalex.org/W2031749532","https://openalex.org/W2032703588","https://openalex.org/W2035207044","https://openalex.org/W2036176661","https://openalex.org/W2036819321","https://openalex.org/W2037860354","https://openalex.org/W2037925864","https://openalex.org/W2038169694","https://openalex.org/W2038227068","https://openalex.org/W2038574243","https://openalex.org/W2039878502","https://openalex.org/W2040300278","https://openalex.org/W2041160041","https://openalex.org/W2042312484","https://openalex.org/W2044485069","https://openalex.org/W2046519786","https://openalex.org/W2047636962","https://openalex.org/W2049441204","https://openalex.org/W2050984690","https://openalex.org/W2052360390","https://openalex.org/W2054782200","https://openalex.org/W2056542494","https://openalex.org/W2058041377","https://openalex.org/W2058155519","https://openalex.org/W2059096849","https://openalex.org/W2059175846","https://openalex.org/W2061277049","https://openalex.org/W2061623121","https://openalex.org/W2062083506","https://openalex.org/W2063566151","https://openalex.org/W2068214483","https://openalex.org/W2070500689","https://openalex.org/W2073862227","https://openalex.org/W2075839342","https://openalex.org/W2077380143","https://openalex.org/W2077918496","https://openalex.org/W2079973546","https://openalex.org/W2080275173","https://openalex.org/W2082093645","https://openalex.org/W2082345506","https://openalex.org/W2082858192","https://openalex.org/W2082884979","https://openalex.org/W2083357903","https://openalex.org/W2083646069","https://openalex.org/W2084299721","https://openalex.org/W2084311572","https://openalex.org/W2084366111","https://openalex.org/W2085753713","https://openalex.org/W2086402412","https://openalex.org/W2087086120","https://openalex.org/W2087242764","https://openalex.org/W2089155105","https://openalex.org/W2091535855","https://openalex.org/W2091833458","https://openalex.org/W2093238482","https://openalex.org/W2093531619","https://openalex.org/W2096842237","https://openalex.org/W2099336892","https://openalex.org/W2109897930","https://openalex.org/W2114168018","https://openalex.org/W2114655127","https://openalex.org/W2116982407","https://openalex.org/W2127828417","https://openalex.org/W2135025747","https://openalex.org/W2136718258","https://openalex.org/W2142914221","https://openalex.org/W2150837823","https://openalex.org/W2153532523","https://openalex.org/W2156480905","https://openalex.org/W2158429135","https://openalex.org/W2159080330","https://openalex.org/W2209063065","https://openalex.org/W2259854637","https://openalex.org/W2262787040","https://openalex.org/W2272838397","https://openalex.org/W2274270616","https://openalex.org/W2297332587","https://openalex.org/W2323130816","https://openalex.org/W2394850456","https://openalex.org/W2400978456","https://openalex.org/W2416289859","https://openalex.org/W2762721314","https://openalex.org/W2907640741","https://openalex.org/W2949784624","https://openalex.org/W3016345113","https://openalex.org/W3025963246","https://openalex.org/W4231948932","https://openalex.org/W4235556632","https://openalex.org/W4249605115"],"related_works":["https://openalex.org/W7092187785","https://openalex.org/W2973389676","https://openalex.org/W1998236817","https://openalex.org/W48422816","https://openalex.org/W4250362034","https://openalex.org/W2072300509","https://openalex.org/W87602577","https://openalex.org/W2093087429","https://openalex.org/W2082847226","https://openalex.org/W124171687"],"abstract_inverted_index":{"Tachykinin":[0],"receptors":[1],"(provisional":[2],"nomenclature":[3],"as":[4,23,35,96],"recommended":[5],"by":[6,11,102],"NC-IUPHAR":[7],"[91])":[8],"are":[9,56],"activated":[10],"the":[12,60,72,89,113],"endogenous":[13],"peptides":[14,65],"substance":[15,24],"P":[16],"(SP),":[17],"neurokinin":[18,26,30,36,49],"A":[19],"(NKA;":[20],"previously":[21,33],"known":[22,34],"K,":[25],"\u03b1,":[27],"neuromedin":[28,38],"L),":[29],"B":[31],"(NKB;":[32],"\u03b2,":[37],"K),":[39],"neuropeptide":[40,43],"K":[41],"and":[42,54,68,98,104,117],"\u03b3":[44],"(N-terminally":[45],"extended":[46],"forms":[47],"of":[48,59,66,91,115],"A).":[50],"The":[51],"neurokinins":[52],"(A":[53],"B)":[55],"mammalian":[57,67],"members":[58],"tachykinin":[61],"family,":[62],"which":[63],"includes":[64],"nonmammalian":[69],"origin":[70],"containing":[71],"consensus":[73],"sequence:":[74],"Phe-x-Gly-Leu-Met.":[75],"Marked":[76],"species":[77],"differences":[78],"in":[79,80,88,106],"vitro":[81],"pharmacology":[82],"exist":[83],"for":[84,112],"all":[85],"three":[86],"receptors,":[87],"context":[90],"nonpeptide":[92],"ligands.":[93],"Antagonists":[94],"such":[95],"aprepitant":[97],"fosaprepitant":[99],"were":[100],"approved":[101],"FDA":[103],"EMA,":[105],"combination":[107],"with":[108,120],"other":[109],"antiemetic":[110],"agents,":[111],"prevention":[114],"nausea":[116],"vomiting":[118],"associated":[119],"emetogenic":[121],"cancer":[122],"chemotherapy.":[123]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-22T00:00:00"}