{"id":"https://openalex.org/W4381469722","doi":"https://doi.org/10.1186/s12896-023-00785-7","title":"Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system","display_name":"Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381469722","doi":"https://doi.org/10.1186/s12896-023-00785-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/37340430","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10283290"},"language":"en","primary_location":{"id":"doi:10.1186/s12896-023-00785-7","doi":"https://doi.org/10.1186/s12896-023-00785-7","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12896-023-00785-7","pdf_url":"https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/s12896-023-00785-7","source":{"id":"https://openalex.org/S53489610","display_name":"BMC Biotechnology","issn_l":"1472-6750","issn":["1472-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/s12896-023-00785-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013652429","display_name":"Lena Mahmoudi Azar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3125175737","display_name":"Bezmi\u00e2lem Vak\u0131f \u00dcniversitesi","ror":"https://ror.org/04z60tq39","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125175737"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"Lena Mahmoudi Azar","raw_affiliation_strings":["Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Istanbul, 34820, Turkey","Department of Molecular Pathobiology, New York University College of Dentistry, New York, 10010, USA","NYU Pain Research Center, New York University College of Dentistry, New York, 10010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Istanbul, 34820, Turkey","institution_ids":["https://openalex.org/I3125175737"]},{"raw_affiliation_string":"Department of Molecular Pathobiology, New York University College of Dentistry, New York, 10010, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"NYU Pain Research Center, New York University College of Dentistry, New York, 10010, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026962740","display_name":"Elif Karaman","orcid":"https://orcid.org/0000-0001-6244-4668","observed_orcids":["https://orcid.org/0000-0001-6244-4668"]},"institutions":[{"id":"https://openalex.org/I3125175737","display_name":"Bezmi\u00e2lem Vak\u0131f \u00dcniversitesi","ror":"https://ror.org/04z60tq39","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125175737"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif Karaman","raw_affiliation_strings":["Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Istanbul, 34820, Turkey","Department of Biotechnology, Institute of Health Sciences, Bezmialem Vakif University, Fatih, Istanbul, 34093, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Istanbul, 34820, Turkey","institution_ids":["https://openalex.org/I3125175737"]},{"raw_affiliation_string":"Department of Biotechnology, Institute of Health Sciences, Bezmialem Vakif University, Fatih, Istanbul, 34093, Turkey","institution_ids":["https://openalex.org/I3125175737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092222018","display_name":"Burcu Beyaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Burcu Beyaz","raw_affiliation_strings":["Chemical and Biological Engineering, Ko\u00e7 University, Sariyer, Istanbul, 34450, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Engineering, Ko\u00e7 University, Sariyer, Istanbul, 34450, Turkey","institution_ids":["https://openalex.org/I1351752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092222019","display_name":"I\u015f\u0131lay G\u00f6ktan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"I\u015f\u0131lay G\u00f6ktan","raw_affiliation_strings":["Chemical and Biological Engineering, Ko\u00e7 University, Sariyer, Istanbul, 34450, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Engineering, Ko\u00e7 University, Sariyer, Istanbul, 34450, Turkey","institution_ids":["https://openalex.org/I1351752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004551276","display_name":"Alp Ertunga Ey\u00fcpo\u011flu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405392","display_name":"Bo\u011fazi\u00e7i University","ror":"https://ror.org/03z9tma90","country_code":"TR","type":"education","lineage":["https://openalex.org/I4405392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Alp Ertunga Ey\u00fcpo\u011flu","raw_affiliation_strings":["Department of of Molecular Biology and Genetics, Faculty of Arts and Sciences, Bogazici University, Istanbul, Sar\u0131yer, 34450, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of of Molecular Biology and Genetics, Faculty of Arts and Sciences, Bogazici University, Istanbul, Sar\u0131yer, 34450, Turkey","institution_ids":["https://openalex.org/I4405392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080669151","display_name":"Seda K\u0131z\u0131lel","orcid":"https://orcid.org/0000-0001-9092-2698","observed_orcids":["https://orcid.org/0000-0001-9092-2698"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seda Kizilel","raw_affiliation_strings":["Chemical and Biological Engineering, Ko\u00e7 University, Sariyer, Istanbul, 34450, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Engineering, Ko\u00e7 University, Sariyer, Istanbul, 34450, Turkey","institution_ids":["https://openalex.org/I1351752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061886998","display_name":"Batu Erman","orcid":"https://orcid.org/0000-0003-2180-7607","observed_orcids":["https://orcid.org/0000-0003-2180-7607"]},"institutions":[{"id":"https://openalex.org/I4405392","display_name":"Bo\u011fazi\u00e7i University","ror":"https://ror.org/03z9tma90","country_code":"TR","type":"education","lineage":["https://openalex.org/I4405392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Batu Erman","raw_affiliation_strings":["Department of of Molecular Biology and Genetics, Faculty of Arts and Sciences, Bogazici University, Istanbul, Sar\u0131yer, 34450, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of of Molecular Biology and Genetics, Faculty of Arts and Sciences, Bogazici University, Istanbul, Sar\u0131yer, 34450, Turkey","institution_ids":["https://openalex.org/I4405392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003591041","display_name":"Ahmet G\u00fcl","orcid":"https://orcid.org/0000-0001-8219-3720","observed_orcids":["https://orcid.org/0000-0001-8219-3720"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet G\u00fcl","raw_affiliation_strings":["Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih, Istanbul, 34134, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih, Istanbul, 34134, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":null,"display_name":"Serdar Uysal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3125175737","display_name":"Bezmi\u00e2lem Vak\u0131f \u00dcniversitesi","ror":"https://ror.org/04z60tq39","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125175737"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Serdar Uysal","raw_affiliation_strings":["Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Istanbul, 34820, Turkey. SUysal@bezmialem.edu.tr","Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Istanbul, 34820, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Istanbul, 34820, Turkey. SUysal@bezmialem.edu.tr","institution_ids":["https://openalex.org/I3125175737"]},{"raw_affiliation_string":"Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Istanbul, 34820, Turkey","institution_ids":["https://openalex.org/I3125175737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3125175737"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.3547,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47775129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"23","issue":"1","first_page":"15","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aspergillus-oryzae","display_name":"Aspergillus oryzae","score":0.9570000171661377},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.9319999814033508},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7360000014305115},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.6690000295639038},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/anakinra","display_name":"anakinra","score":0.6809999942779541},{"id":"https://openalex.org/keywords/industrial-scale-production","display_name":"industrial-scale production","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C149892131","wikidata":"https://www.wikidata.org/wiki/Q14914156","display_name":"Interleukin 1 receptor antagonist","level":5,"score":0.8814433813095093},{"id":"https://openalex.org/C2781204770","wikidata":"https://www.wikidata.org/wiki/Q22662068","display_name":"Aspergillus oryzae","level":3,"score":0.7742381691932678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7338590621948242},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.6276648640632629},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.604483962059021},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5927865505218506},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.45103415846824646},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4180164933204651},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.350288987159729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30125463008880615},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2537246644496918},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.22436583042144775},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08011096715927124}],"mesh":[{"descriptor_ui":"D001236","descriptor_name":"Aspergillus oryzae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001236","descriptor_name":"Aspergillus oryzae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12896-023-00785-7","doi":"https://doi.org/10.1186/s12896-023-00785-7","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12896-023-00785-7","pdf_url":"https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/s12896-023-00785-7","source":{"id":"https://openalex.org/S53489610","display_name":"BMC Biotechnology","issn_l":"1472-6750","issn":["1472-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10283290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10283290","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10283290/pdf/12896_2023_Article_785.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biotechnol","raw_type":"Text"},{"id":"pmid:37340430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37340430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0a4e30a6c21b43f6a76ed74cbb1d989a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0a4e30a6c21b43f6a76ed74cbb1d989a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Biotechnology, Vol 23, Iss 1, Pp 1-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12896-023-00785-7","doi":"https://doi.org/10.1186/s12896-023-00785-7","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12896-023-00785-7","pdf_url":"https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/s12896-023-00785-7","source":{"id":"https://openalex.org/S53489610","display_name":"BMC Biotechnology","issn_l":"1472-6750","issn":["1472-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3370568502","display_name":null,"funder_award_id":"20AG007","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"},{"id":"https://openalex.org/G4521885032","display_name":null,"funder_award_id":"20AG042 and 20AG007","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"},{"id":"https://openalex.org/F4320325050","display_name":"Bezmialem Vak\u0131f \u00dcniversitesi","ror":"https://ror.org/04z60tq39"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381469722.pdf","grobid_xml":"https://content.openalex.org/works/W4381469722.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1500774721","https://openalex.org/W1515994079","https://openalex.org/W1569828475","https://openalex.org/W1968157175","https://openalex.org/W1972152807","https://openalex.org/W1975044278","https://openalex.org/W1984026160","https://openalex.org/W1988473687","https://openalex.org/W1989459539","https://openalex.org/W1999388739","https://openalex.org/W2007210793","https://openalex.org/W2008406252","https://openalex.org/W2013819397","https://openalex.org/W2021359687","https://openalex.org/W2026667253","https://openalex.org/W2028693567","https://openalex.org/W2032140498","https://openalex.org/W2038796481","https://openalex.org/W2054110349","https://openalex.org/W2055099483","https://openalex.org/W2056756454","https://openalex.org/W2056995025","https://openalex.org/W2067420120","https://openalex.org/W2069805804","https://openalex.org/W2073598149","https://openalex.org/W2074393911","https://openalex.org/W2076578641","https://openalex.org/W2081414355","https://openalex.org/W2082067229","https://openalex.org/W2098343450","https://openalex.org/W2106853150","https://openalex.org/W2108829798","https://openalex.org/W2115596225","https://openalex.org/W2117439999","https://openalex.org/W2129195110","https://openalex.org/W2133557129","https://openalex.org/W2145866317","https://openalex.org/W2150107812","https://openalex.org/W2162300976","https://openalex.org/W2316302056","https://openalex.org/W2395462833","https://openalex.org/W2531211739","https://openalex.org/W2620096814","https://openalex.org/W2620755219","https://openalex.org/W2805429136","https://openalex.org/W2905094277","https://openalex.org/W2937670969","https://openalex.org/W2941098654","https://openalex.org/W3097506707","https://openalex.org/W3120697917","https://openalex.org/W3127398218","https://openalex.org/W3158621328","https://openalex.org/W4205581685"],"related_works":["https://openalex.org/W4250839714","https://openalex.org/W2978341968","https://openalex.org/W2028874446","https://openalex.org/W6977265931","https://openalex.org/W7208766652","https://openalex.org/W6888874041","https://openalex.org/W4400261174","https://openalex.org/W2299417763","https://openalex.org/W1968157175","https://openalex.org/W3177142620"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,140],"interleukin-1":[2,15],"receptor":[3],"antagonist":[4],"(IL-1Ra)":[5],"is":[6,27,100,199],"a":[7,47,55,110,134,170,184,204,226],"crucial":[8],"molecule":[9],"that":[10,97,217],"counteracts":[11],"the":[12,36,67,114,181,200],"effects":[13],"of":[14,25,32,113,137,144,183,203],"(IL-1)":[16],"by":[17,63],"binding":[18,116,173],"to":[19,53,229],"its":[20],"receptor.":[21],"A":[22],"high":[23],"concentration":[24,136],"IL-1Ra":[26,41,58,77,99,122,128,146,187,209,219],"required":[28],"for":[29,149,222],"complete":[30],"inhibition":[31],"IL-1":[33],"activity.":[34],"However,":[35],"currently":[37],"available":[38],"Escherichia":[39],"coli-expressed":[40],"(E.":[42],"coli":[43,125,166,231],"IL-1Ra,":[44,167],"Anakinra)":[45],"has":[46,220],"limited":[48],"half-life.":[49],"This":[50,178],"study":[51,112,179],"aims":[52],"produce":[54],"cost-effective,":[56],"functional":[57,185,206],"on":[59],"an":[60],"industrial":[61],"scale":[62],"expressing":[64],"it":[65],"in":[66,106,141,211],"pyrG":[68],"auxotroph":[69],"Aspergillus":[70],"oryzae.":[71,213],"RESULTS:":[72],"We":[73,108],"purified":[74],"A.":[75,212],"oryzae-expressed":[76],"(Asp.":[78],"IL-1Ra)":[79],"using":[80],"ion":[81],"exchange":[82],"and":[83,102,118,123,157,160,207],"size":[84],"exclusion":[85],"chromatography":[86],"(53":[87],"mg/L).":[88],"Sodium":[89],"dodecyl":[90],"sulfate-polyacrylamide":[91],"gel":[92],"electrophoresis":[93],"(SDS-PAGE)":[94],"analysis":[95],"revealed":[96],"Asp.":[98,121,127,145,186,218],"N-glycosylated":[101],"approximately":[103],"17":[104],"kDa":[105],"size.":[107],"conducted":[109],"comparative":[111],"bioactivity,":[115],"kinetics,":[117],"half-life":[119,143],"between":[120],"E.":[124,165,230],"IL-1Ra.":[126,232],"showed":[129,161],"good":[130],"bioactivity":[131],"even":[132],"at":[133],"low":[135],"0.5":[138],"nM.":[139],"vitro":[142],"was":[147],"determined":[148],"different":[150],"time":[151],"points":[152],"(0,":[153],"24,":[154],"48,":[155],"72,":[156],"96":[158],"h)":[159],"higher":[162],"stability":[163],"than":[164],"despite":[168],"exhibiting":[169],"100-fold":[171],"lower":[172],"affinity":[174],"(2":[175],"nM).":[176],"CONCLUSION:":[177],"reports":[180],"production":[182,224],"with":[188],"advantageous":[189],"stability,":[190],"without":[191],"extensive":[192],"downstream":[193],"processing.":[194],"To":[195],"our":[196],"knowledge,":[197],"this":[198],"first":[201],"report":[202],"recombinant":[205],"stable":[208],"expressed":[210],"Our":[214],"results":[215],"suggest":[216],"potential":[221],"industrial-scale":[223],"as":[225],"cost-effective":[227],"alternative":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-22T00:00:00"}
