{"id":"https://openalex.org/W4381461685","doi":"https://doi.org/10.22159/ijap.2023v15i3.47459","title":"PLACENTA EXTRACT-LOADED NOVASOME SIGNIFICANTLY IMPROVED HAIR GROWTH IN A RAT IN VIVO MODEL","display_name":"PLACENTA EXTRACT-LOADED NOVASOME SIGNIFICANTLY IMPROVED HAIR GROWTH IN A RAT IN VIVO MODEL","publication_year":2023,"publication_date":"2023-05-07","ids":{"openalex":"https://openalex.org/W4381461685","doi":"https://doi.org/10.22159/ijap.2023v15i3.47459"},"language":"en","primary_location":{"id":"doi:10.22159/ijap.2023v15i3.47459","doi":"https://doi.org/10.22159/ijap.2023v15i3.47459","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2023v15i3.47459","pdf_url":"https://journals.innovareacademics.in/index.php/ijap/article/download/47459/28046","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.innovareacademics.in/index.php/ijap/article/download/47459/28046","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043731723","display_name":"Ajeng Illastria Rosalina","orcid":"https://orcid.org/0000-0001-6184-4803","observed_orcids":["https://orcid.org/0000-0001-6184-4803"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"AJENG I. ROSALINA","raw_affiliation_strings":["Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-6184-4803","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082573415","display_name":"Iskandarsyah Iskandarsyah","orcid":"https://orcid.org/0000-0003-2095-2386","observed_orcids":["https://orcid.org/0000-0003-2095-2386"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"ISKANDARSYAH","raw_affiliation_strings":["Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080349519","display_name":"Erny Sagita","orcid":"https://orcid.org/0000-0001-8306-2431","observed_orcids":["https://orcid.org/0000-0001-8306-2431"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"ERNY SAGITA","raw_affiliation_strings":["Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-8306-2431","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I29617571"],"apc_list":null,"apc_paid":null,"fwci":0.4232,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.48748552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"138","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-growth","display_name":"hair growth","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nanocarrier-formulation","display_name":"nanocarrier formulation","score":0.628000020980835},{"id":"https://openalex.org/keywords/vesicle-loading","display_name":"vesicle loading","score":0.492000013589859},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7770000100135803},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.49900001287460327},{"id":"https://openalex.org/keywords/minoxidil","display_name":"minoxidil","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.7331901788711548},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.7035643458366394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.656686007976532},{"id":"https://openalex.org/C2779711729","wikidata":"https://www.wikidata.org/wiki/Q424165","display_name":"Minoxidil","level":2,"score":0.6467025279998779},{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.598835825920105},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5925965905189514},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5349608063697815},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.49013862013816833},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4737687408924103},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4632808566093445},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.43086540699005127},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4032335877418518},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2968739867210388},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18443763256072998},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.1806849241256714},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.1705857217311859},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.16717445850372314},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1606954038143158},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22159/ijap.2023v15i3.47459","doi":"https://doi.org/10.22159/ijap.2023v15i3.47459","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2023v15i3.47459","pdf_url":"https://journals.innovareacademics.in/index.php/ijap/article/download/47459/28046","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22159/ijap.2023v15i3.47459","doi":"https://doi.org/10.22159/ijap.2023v15i3.47459","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2023v15i3.47459","pdf_url":"https://journals.innovareacademics.in/index.php/ijap/article/download/47459/28046","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381461685.pdf","grobid_xml":"https://content.openalex.org/works/W4381461685.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1486648335","https://openalex.org/W1857568800","https://openalex.org/W1995800186","https://openalex.org/W2017501842","https://openalex.org/W2024651001","https://openalex.org/W2070700054","https://openalex.org/W2106961985","https://openalex.org/W2119280206","https://openalex.org/W2155142470","https://openalex.org/W2344698737","https://openalex.org/W2591708258","https://openalex.org/W2593339698","https://openalex.org/W2623556215","https://openalex.org/W2748925701","https://openalex.org/W2765109050","https://openalex.org/W2766482228","https://openalex.org/W2771286242","https://openalex.org/W2790157546","https://openalex.org/W2796533884","https://openalex.org/W2914096421","https://openalex.org/W2945782325","https://openalex.org/W2972633450","https://openalex.org/W3013081665","https://openalex.org/W3022403414","https://openalex.org/W3118838517","https://openalex.org/W3128430624","https://openalex.org/W3152931583","https://openalex.org/W3196501997","https://openalex.org/W3201610628","https://openalex.org/W3207872513","https://openalex.org/W4212801432","https://openalex.org/W4225529271","https://openalex.org/W4238661506","https://openalex.org/W4239486617"],"related_works":["https://openalex.org/W4401705867","https://openalex.org/W3128430624","https://openalex.org/W7213254083","https://openalex.org/W1987469513","https://openalex.org/W2231330625","https://openalex.org/W4415489459","https://openalex.org/W4404721288","https://openalex.org/W7124751772","https://openalex.org/W4386857430","https://openalex.org/W7160207564"],"abstract_inverted_index":{"Objective:":[0],"This":[1],"study":[2,142],"aims":[3],"to":[4,17,38,155],"improve":[5],"the":[6,40,46,50,58,96,115,147],"hair-growing":[7,152,191],"effect":[8,153,192],"of":[9,48,52,60,88,114],"bovine":[10],"placenta":[11],"extract":[12],"(PE)":[13],"by":[14,26,44,70],"loading":[15],"it":[16],"a":[18,165,171],"novasome":[19,23,86,118,125,149,178],"vesicle.":[20],"Methods:":[21],"PE-loaded":[22,66,85,148,156,176,196],"was":[24,36],"prepared":[25],"thin":[27],"layer":[28],"hydration":[29],"method.":[30],"A":[31,139],"23":[32],"full":[33],"factorial":[34],"design":[35],"used":[37],"obtain":[39],"most":[41,97,116],"optimum":[42,98,117],"formula":[43],"varying":[45],"type":[47,51],"surfactants,":[49],"free":[53],"fatty":[54],"acid":[55,93],"(FFA),":[56],"and":[57,62,80,107,129,158,185,195],"ratio":[59],"surfactants":[61],"FFA.":[63],"The":[64],"resulting":[65],"novasomes":[67],"were":[68],"characterized":[69],"entrapment":[71],"efficiency":[72],"(%EE),":[73],"particle":[74],"size":[75],"(PS),":[76],"polydispersity":[77],"index":[78],"(PDI),":[79],"zeta":[81],"potential":[82,166],"(ZP).":[83],"Results:":[84],"composed":[87],"Span":[89],"60:":[90],"cholesterol:":[91],"oleic":[92],"(10:10:3)":[94],"demonstrated":[95,150,189],"characteristics":[99,184],"with":[100,181],"PS":[101],"155.0":[102],"nm;":[103],"PDI":[104],"0.139;":[105],"ZP-63.73":[106],"EE":[108],"79.60%.":[109],"Transmission":[110],"electron":[111],"microscopy":[112],"(TEM)":[113],"revealed":[119],"non-aggregating":[120],"oligo-lamellar":[121],"nanovesicles.":[122],"In":[123,186],"addition,":[124],"showed":[126,145,179],"ultra-deformable":[127],"properties":[128],"good":[130,182],"stability":[131],"during":[132],"90":[133],"d":[134],"storage":[135],"at":[136],"4":[137],"\u00b0C.":[138],"hair":[140],"growth":[141],"in":[143,177],"rats":[144],"that":[146],"better":[151,190],"compared":[154],"liposome":[157],"minoxidil":[159,194],"2%":[160],"solution.":[161],"Conclusion:":[162],"Novasome":[163],"is":[164],"carrier":[167],"for":[168],"bringing":[169],"such":[170],"big":[172],"molecule":[173],"as":[174],"PE.":[175],"vesicles":[180],"physical":[183],"vivo":[187],"assessment":[188],"than":[193],"liposomes.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-05T08:02:43.246662","created_date":"2023-06-21T00:00:00"}