{"id":"https://openalex.org/W4381460059","doi":"https://doi.org/10.2218/gtopdb/f54/2023.1","title":"QRFP receptor in GtoPdb v.2023.1","display_name":"QRFP receptor in GtoPdb v.2023.1","publication_year":2023,"publication_date":"2023-04-26","ids":{"openalex":"https://openalex.org/W4381460059","doi":"https://doi.org/10.2218/gtopdb/f54/2023.1"},"language":"en","primary_location":{"id":"doi:10.2218/gtopdb/f54/2023.1","doi":"https://doi.org/10.2218/gtopdb/f54/2023.1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2218/gtopdb/f54/2023.1","pdf_url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8702/11501","source":{"id":"https://openalex.org/S4210197557","display_name":"IUPHAR/BPS Guide to Pharmacology CITE","issn_l":"2633-1020","issn":["2633-1020"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321110","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/P4310321110"],"host_organization_lineage_names":["University of Edinburgh"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IUPHAR/BPS Guide to Pharmacology CITE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8702/11501","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000591385","display_name":"Didier Bagnol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Didier Bagnol","raw_affiliation_strings":["Arena Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arena Pharmaceuticals","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004272341","display_name":"Tom I. Bonner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"id":"https://openalex.org/I4210160792","display_name":"National Institute of Mental Health","ror":"https://ror.org/04t0s7x83","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210103779","https://openalex.org/I4210160792"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tom I. Bonner","raw_affiliation_strings":["National Institute of Mental Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health","institution_ids":["https://openalex.org/I4210158500","https://openalex.org/I4210160792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023766496","display_name":"Myrna Carlebur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Myrna Carlebur","raw_affiliation_strings":["University of Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060689377","display_name":"Anthony P. Davenport","orcid":"https://orcid.org/0000-0002-2096-3117","observed_orcids":["https://orcid.org/0000-0002-2096-3117"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony P. Davenport","raw_affiliation_strings":["University of Cambridge"],"raw_orcid":"https://orcid.org/0000-0002-2096-3117","affiliations":[{"raw_affiliation_string":"University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059045245","display_name":"Stephen M. Foord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen M. Foord","raw_affiliation_strings":["GlaxoSmithKline"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071748316","display_name":"Shoji Fukusumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoji Fukusumi","raw_affiliation_strings":["University of Tsukuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tsukuba","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022575958","display_name":"Riccarda Granata","orcid":"https://orcid.org/0000-0003-4164-7313","observed_orcids":["https://orcid.org/0000-0003-4164-7313"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccarda Granata","raw_affiliation_strings":["University of Torino Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Torino Medical School","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061245649","display_name":"Dan Larhammar","orcid":"https://orcid.org/0000-0002-6736-0663","observed_orcids":["https://orcid.org/0000-0002-6736-0663"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dan Larhammar","raw_affiliation_strings":["Uppsala University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003657445","display_name":"J\u00e9r\u00f4me Leprince","orcid":"https://orcid.org/0000-0002-7814-9927","observed_orcids":["https://orcid.org/0000-0002-7814-9927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me Leprince","raw_affiliation_strings":["Normandy University"],"raw_orcid":"https://orcid.org/0000-0002-7814-9927","affiliations":[{"raw_affiliation_string":"Normandy University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019791662","display_name":"Janet J. Maguire","orcid":"https://orcid.org/0000-0002-9254-7040","observed_orcids":["https://orcid.org/0000-0002-9254-7040"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Janet J. Maguire","raw_affiliation_strings":["University of Cambridge"],"raw_orcid":"https://orcid.org/0000-0002-9254-7040","affiliations":[{"raw_affiliation_string":"University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031474690","display_name":"Stefany DePrato Primeaux","orcid":"https://orcid.org/0000-0002-4323-681X","observed_orcids":["https://orcid.org/0000-0002-4323-681X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefany D. Primeaux","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105885862","display_name":"Hubert Vaudry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hubert Vaudry","raw_affiliation_strings":["Normandy University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandy University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07500337,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2023","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.10050000250339508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orphan-gpcrs","display_name":"orphan G protein-coupled receptor","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gs-coupled-receptors","display_name":"Gs-coupled receptors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/peptide-receptors","display_name":"peptide receptors","score":0.6729999780654907},{"id":"https://openalex.org/keywords/signaling-bias","display_name":"signaling bias","score":0.7039999961853027},{"id":"https://openalex.org/keywords/receptor-mutations","display_name":"receptor mutations","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7185845375061035},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7007940411567688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5957158207893372},{"id":"https://openalex.org/C2779161069","wikidata":"https://www.wikidata.org/wiki/Q2496179","display_name":"Orphan receptor","level":4,"score":0.5031704306602478},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.47119781374931335},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.44911444187164307},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4394384026527405},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3498307466506958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3464553654193878},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33682531118392944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31650543212890625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2565608620643616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1014019250869751},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09386211633682251}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2218/gtopdb/f54/2023.1","doi":"https://doi.org/10.2218/gtopdb/f54/2023.1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2218/gtopdb/f54/2023.1","pdf_url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8702/11501","source":{"id":"https://openalex.org/S4210197557","display_name":"IUPHAR/BPS Guide to Pharmacology CITE","issn_l":"2633-1020","issn":["2633-1020"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321110","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/P4310321110"],"host_organization_lineage_names":["University of Edinburgh"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IUPHAR/BPS Guide to Pharmacology CITE","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2218/gtopdb/f54/2023.1","doi":"https://doi.org/10.2218/gtopdb/f54/2023.1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2218/gtopdb/f54/2023.1","pdf_url":"http://journals.ed.ac.uk/gtopdb-cite/article/download/8702/11501","source":{"id":"https://openalex.org/S4210197557","display_name":"IUPHAR/BPS Guide to Pharmacology CITE","issn_l":"2633-1020","issn":["2633-1020"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321110","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/P4310321110"],"host_organization_lineage_names":["University of Edinburgh"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IUPHAR/BPS Guide to Pharmacology CITE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381460059.pdf","grobid_xml":"https://content.openalex.org/works/W4381460059.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1841221756","https://openalex.org/W1969441974","https://openalex.org/W1969683051","https://openalex.org/W1996538291","https://openalex.org/W1998028045","https://openalex.org/W2026333686","https://openalex.org/W2029661560","https://openalex.org/W2044536055","https://openalex.org/W2045947576","https://openalex.org/W2050442804","https://openalex.org/W2086785253","https://openalex.org/W2092472523","https://openalex.org/W2097961893","https://openalex.org/W2116318587","https://openalex.org/W2119440196","https://openalex.org/W2131266487","https://openalex.org/W2158477075","https://openalex.org/W2166652281","https://openalex.org/W2625567569","https://openalex.org/W2898431958","https://openalex.org/W3154977798","https://openalex.org/W3185917247"],"related_works":["https://openalex.org/W2974781729","https://openalex.org/W2000300891","https://openalex.org/W2625567569","https://openalex.org/W2019788707","https://openalex.org/W4399810062","https://openalex.org/W4392210504","https://openalex.org/W4415266498","https://openalex.org/W3204019767","https://openalex.org/W4389408484","https://openalex.org/W1969441974"],"abstract_inverted_index":{"The":[0],"human":[1,152],"gene":[2],"encoding":[3],"the":[4,11,15,23,49,91,125,151],"QRFP":[5,16,112,153],"receptor":[6,17,33,113,154],"(nomenclature":[7],"as":[8,22,29,76,116],"agreed":[9],"by":[10,38,124],"NC-IUPHAR":[12],"Subcommittee":[13],"on":[14],"[19];":[18],"QRFPR,":[19],"formerly":[20],"known":[21],"Peptide":[24],"P518":[25],"receptor),":[26],"previously":[27],"designated":[28],"an":[30],"orphan":[31],"GPCR":[32,119],"was":[34,114,141],"identified":[35,115],"in":[36,90,150],"2001":[37],"Lee":[39],"et":[40],"al.":[41],"from":[42,60,67],"a":[43,54,81,117],"hypothalamus":[44],"cDNA":[45,51],"library":[46],"[17].":[47],"However,":[48,136],"reported":[50,143],"(AF411117)":[52],"is":[53],"chimera":[55],"with":[56,95],"bases":[57,64],"1-127":[58],"derived":[59,66],"chromosome":[61,68],"1":[62],"and":[63,107,130,138,158],"155-1368":[65],"4.":[69],"When":[70],"corrected,":[71],"QRFPR":[72],"(also":[73],"referred":[74],"to":[75,156],"SP9155":[77],"or":[78],"AQ27)":[79],"encodes":[80],"431":[82],"amino":[83],"acid":[84],"protein":[85],"that":[86],"shares":[87],"sequence":[88],"similarities":[89],"transmembrane":[92],"spanning":[93],"regions":[94],"other":[96],"peptide":[97],"receptors.":[98,111],"These":[99],"include":[100],"neuropeptide":[101,104],"FF2":[102],"(38%),":[103],"Y2":[105],"(37%)":[106],"galanin":[108],"Gal1":[109],"(35%)":[110],"Gs-coupled":[118],"[6,":[120,133],"14]":[121],"that's":[122],"activated":[123],"endogenous":[126],"peptides":[127],"QRFP43":[128],"(43RFa)":[129],"QRFP26":[131],"(26RFa)":[132],"14,":[134],"11].":[135],"Gq-":[137],"Gi/o-mediated":[139],"signaling":[140,161],"also":[142],"[11,":[144],"25].":[145],"Two":[146],"naturally":[147],"occurring":[148],"mutations":[149],"lead":[155],"distinct":[157],"opposite":[159],"26RFa-evoked":[160],"bias":[162],"[20].":[163]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-06-21T00:00:00"}