{"id":"https://openalex.org/W4381378424","doi":"https://doi.org/10.2337/db23-1225-p","title":"1225-P: Biomarkers in Prediabetes Reflecting Sex Varying Pathways of Cardiovascular Risk","display_name":"1225-P: Biomarkers in Prediabetes Reflecting Sex Varying Pathways of Cardiovascular Risk","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381378424","doi":"https://doi.org/10.2337/db23-1225-p"},"language":"en","primary_location":{"id":"doi:10.2337/db23-1225-p","doi":"https://doi.org/10.2337/db23-1225-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db23-1225-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035916657","display_name":"Yilin Yoshida","orcid":"https://orcid.org/0000-0003-0441-2697","observed_orcids":["https://orcid.org/0000-0003-0441-2697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YILIN YOSHIDA","raw_affiliation_strings":["New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Orleans, LA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059755912","display_name":"ZHIPENG CHEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ZHIPENG CHEN","raw_affiliation_strings":["New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Orleans, LA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020438554","display_name":"Changwei Li","orcid":"https://orcid.org/0000-0002-9203-304X","observed_orcids":["https://orcid.org/0000-0002-9203-304X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHANGWEI LI","raw_affiliation_strings":["New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Orleans, LA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034671525","display_name":"Vivian Andrew Fonseca","orcid":"https://orcid.org/0000-0002-3381-7151","observed_orcids":["https://orcid.org/0000-0002-3381-7151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VIVIAN FONSECA","raw_affiliation_strings":["New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Orleans, LA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051767029","display_name":"Franck Mauvais\u2010Jarvis","orcid":"https://orcid.org/0000-0002-0874-0754","observed_orcids":["https://orcid.org/0000-0002-0874-0754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FRANCK MAUVAIS-JARVIS","raw_affiliation_strings":["New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Orleans, LA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12645129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9480000138282776},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.7960000038146973},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.746999979019165},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.9089999794960022},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.7799999713897705},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.996999979019165},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6970000267028809},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7590000033378601},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.6740000247955322},{"id":"https://openalex.org/keywords/diabetes-progression","display_name":"diabetes progression","score":0.531000018119812},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.492000013589859},{"id":"https://openalex.org/keywords/atherosclerosis-risk-in-communities-study","display_name":"Atherosclerosis Risk in Communities Study","score":0.8090000152587891},{"id":"https://openalex.org/keywords/jackson-heart-study","display_name":"Jackson Heart Study","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.8277406096458435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8113142251968384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6965786814689636},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.6668000221252441},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5955173373222351},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.5778220295906067},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45957040786743164},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4346832036972046},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.370122492313385},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.3586800992488861},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.31141746044158936},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.27688851952552795}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db23-1225-p","doi":"https://doi.org/10.2337/db23-1225-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db23-1225-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4324140689","https://openalex.org/W4385235144","https://openalex.org/W2973799453","https://openalex.org/W7118685408","https://openalex.org/W2584665637","https://openalex.org/W4281752269","https://openalex.org/W2939934561","https://openalex.org/W2997312886","https://openalex.org/W2983007116","https://openalex.org/W2913470448"],"abstract_inverted_index":{"Background:":[0],"Women":[1],"with":[2,95,125,170,202],"diabetes":[3],"(DM)":[4],"had":[5,204,220,274,283],"higher":[6,15,165,198,205,221,275,284],"cardiovascular":[7],"risk":[8,17],"than":[9,168],"men,":[10],"partly":[11],"due":[12],"to":[13],"women\u2019s":[14],"cardiometabolic":[16],"factors":[18],"before":[19],"DM.":[20,268],"We":[21,36,54,97],"compared":[22],"sex":[23,63,246,251],"differences":[24,252],"in":[25,32,46,92,107,113,166,199,247,253,263,271],"biomarkers":[26,65],"that":[27],"reflect":[28],"distinct":[29],"pathophysiological":[30],"pathways":[31],"prediabetes":[33],"(PreDM).":[34],"Method:":[35],"conducted":[37],"a":[38],"cross-sectional":[39],"analysis":[40],"of":[41,68,102,321],"similarly":[42],"designed":[43],"Atherosclerosis":[44],"Risk":[45],"Communities":[47],"Study":[48],"and":[49,64,76,90,104,137,152,158,176,186,192,212,231,240,257,279,302],"the":[50,60,99,129],"Jackson":[51],"Heart":[52],"Study.":[53],"used":[55],"multivariable":[56],"linear":[57],"regressions":[58],"for":[59,79],"associations":[61],"between":[62],"(log(x))":[66],"representative":[67],"inflammation,":[69],"cardiac":[70,159],"injury/stress,":[71],"lipoprotein,":[72],"adipokine,":[73],"kidney":[74,285],"function,":[75],"glycemia":[77],"adjusted":[78,118],"age,":[80],"race,":[81],"BMI,":[82],"blood":[83],"pressure,":[84],"total":[85],"cholesterol,":[86],"smoking,":[87],"hypertensive":[88],"meds,":[89],"statins":[91],"CVD-free":[93],"individuals":[94],"PreDM.":[96,171,248],"evaluated":[98],"effect":[100],"modification":[101],"menopause":[103],"validated":[105],"results":[106],"those":[108],"who":[109,265],"progressed":[110],"into":[111],"DM":[112],"follow-up.":[114],"False":[115],"discovery":[116],"rate":[117],"multiple":[119],"comparisons.":[120],"Results:":[121],"In":[122],"5765":[123],"people":[124,264],"PreDM":[126,203],"at":[127],"baseline,":[128],"mean":[130],"age":[131],"was":[132],"54":[133],"y,":[134],"47%":[135],"women,":[136],"35%":[138],"non-Hispanic":[139],"Blacks.":[140],"Inflammatory":[141],"c-reactive":[142],"protein":[143],"(\u03b2":[144,149,155,161,173,181,189,194,209,215,224,228,234],"coefficient":[145],"0.3":[146,216],"P=5\u00d710-51),":[147],"fibrinogen":[148],"0.2":[150,156,174],"P=3\u00d710-12),":[151],"lymphocyte":[153],"count":[154],"P=7\u00d710-8),":[157],"NT-proBNT":[160],"0.6":[162,182,195],"P=1\u00d710-104)":[163],"were":[164,197,260],"women":[167,273],"men":[169,282],"Lipoprotein(a)":[172],"P=1\u00d710-10)":[175],"apolipoproteins":[177],"A1":[178],"(Apo":[179],"A1)":[180],"P=5":[183],"x":[184],"10-115),":[185],"adipokines,":[187,280],"leptin":[188],"1.1":[190],"P=3\u00d710-112)":[191],"adiponectin":[193],"P=6\u00d710-16)":[196],"women.":[200],"Men":[201],"random":[206],"urinary":[207],"creatinine":[208],"-0.6":[210],"P=2\u00d710-61)":[211],"reduced":[213],"eGFR":[214],"P=5\u00d710-29).":[217],"They":[218],"also":[219],"inflammatory":[222,277],"homocysteine":[223],"-0.5":[225],"P=2\u00d710-12),":[226],"triglycerides":[227],"-0.2":[229],"P<.0001),":[230],"Apo":[232,255],"B":[233],"-0.1":[235],"P<.0001).":[236],"Fructosamine,":[237],"glycated":[238],"albumin,":[239],"HbA1c":[241],"did":[242],"not":[243],"differ":[244],"by":[245],"Menopause":[249],"modifies":[250],"LDL-c,":[254],"B,":[256],"fibrinogen.":[258],"Results":[259],"generally":[261],"unchanged":[262],"later":[266],"became":[267],"Conclusion:":[269],"Overall,":[270],"PreDM,":[272],"vascular":[276],"markers":[278],"while":[281],"dysfunction":[286],"markers.":[287],"Disclosure":[288],"Y.Yoshida:":[289],"None.":[290,292,294,317],"Z.Chen:":[291],"C.Li:":[293],"V.Fonseca:":[295],"Consultant;":[296],"Abbott,":[297],"Corcept":[298],"Therapeutics,":[299],"Eli":[300],"Lilly":[301],"Company,":[303],"Other":[304],"Relationship;":[305],"BRAVO4HEALTH,":[306],"LLC,":[307],"Research":[308],"Support;":[309],"Fractyl":[310],"Health,":[311],"Inc.,":[312],"Stock/Shareholder;":[313],"Amgen":[314],"Inc.":[315],"F.Mauvais-jarvis:":[316],"Funding":[318],"National":[319],"Institutes":[320],"Health":[322],"(K12HD043451)":[323]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-06-21T00:00:00"}