{"id":"https://openalex.org/W4381377331","doi":"https://doi.org/10.2337/db23-60-or","title":"60-OR: A Pilot Study Evaluating an Insulin and Pramlintide Fully Closed-Loop Delivery System","display_name":"60-OR: A Pilot Study Evaluating an Insulin and Pramlintide Fully Closed-Loop Delivery System","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381377331","doi":"https://doi.org/10.2337/db23-60-or"},"language":"en","primary_location":{"id":"doi:10.2337/db23-60-or","doi":"https://doi.org/10.2337/db23-60-or","is_oa":false,"landing_page_url":"http://dx.doi.org/10.2337/db23-60-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014668215","display_name":"Madison Odabassian","orcid":"https://orcid.org/0009-0008-9866-7589","observed_orcids":["https://orcid.org/0009-0008-9866-7589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MADISON ODABASSIAN","raw_affiliation_strings":["Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montr\u00e9al, QC, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077247868","display_name":"Michael A. Tsoukas","orcid":"https://orcid.org/0000-0002-8326-7274","observed_orcids":["https://orcid.org/0000-0002-8326-7274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MICHAEL TSOUKAS","raw_affiliation_strings":["Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montr\u00e9al, QC, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004600356","display_name":"ELISA COHEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ELISA COHEN","raw_affiliation_strings":["Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montr\u00e9al, QC, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047498706","display_name":"Melissa\u2010Rosina Pasqua","orcid":"https://orcid.org/0000-0003-2389-9066","observed_orcids":["https://orcid.org/0000-0003-2389-9066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MELISSA-ROSINA PASQUA","raw_affiliation_strings":["Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montr\u00e9al, QC, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041606554","display_name":"Joanna Rutkowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOANNA RUTKOWSKI","raw_affiliation_strings":["Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montr\u00e9al, QC, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020314374","display_name":"Ahmad Haidar","orcid":"https://orcid.org/0000-0002-6700-0385","observed_orcids":["https://orcid.org/0000-0002-6700-0385","https://orcid.org/0000-0003-4730-5533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AHMAD HAIDAR","raw_affiliation_strings":["Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montr\u00e9al, QC, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1733,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44190119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"72","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/artificial-pancreas","display_name":"artificial pancreas","score":0.906000018119812},{"id":"https://openalex.org/keywords/pramlintide","display_name":"pramlintide","score":0.906000018119812},{"id":"https://openalex.org/keywords/insulin-aspart","display_name":"insulin aspart","score":0.8270000219345093},{"id":"https://openalex.org/keywords/time-in-range","display_name":"time in range","score":0.7440000176429749},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/insulin-dose-reduction","display_name":"insulin dose reduction","score":0.578000009059906},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2779908123","wikidata":"https://www.wikidata.org/wiki/Q2754775","display_name":"Insulin aspart","level":4,"score":0.9261449575424194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8181686401367188},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5033630728721619},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4709435701370239},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.42181161046028137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4195531904697418},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28758901357650757}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db23-60-or","doi":"https://doi.org/10.2337/db23-60-or","is_oa":false,"landing_page_url":"http://dx.doi.org/10.2337/db23-60-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415146344","https://openalex.org/W7163810504","https://openalex.org/W4281665492","https://openalex.org/W7014400723","https://openalex.org/W4387934425","https://openalex.org/W3202629367","https://openalex.org/W3001442615","https://openalex.org/W4399834251","https://openalex.org/W7063687319","https://openalex.org/W3131056140"],"abstract_inverted_index":{"We":[0],"conducted":[1],"a":[2,68,118,321],"randomized,":[3],"controlled,":[4],"pilot":[5,132,291],"study":[6,292],"to":[7,112,186,212,304],"eliminate":[8],"carbohydrate":[9,306],"counting":[10,307],"(CC)":[11],"in":[12,144,170,192,214,239,311,320],"adults":[13],"with":[14,60,155,178,205,222],"type":[15],"1":[16],"diabetes":[17],"using":[18],"an":[19,130],"automated":[20,297],"insulin":[21,83,92,106,199,249,283],"(insulin":[22],"aspart":[23,59,64,76,84,93,107,137,164,200,203,235,242,270,284],"and":[24,27,46,65,73,77,85,90,94,108,138,152,158,165,175,181,201,237,243,264,272,275,278,286,315,341,359],"faster":[25,58,63,75,136,202,241,269],"aspart)":[26],"pramlintide":[28,66,78,86,95,109,139,166],"dual-pump":[29],"fully":[30,296],"closed-loop":[31],"delivery":[32,299],"system.":[33],"The":[34,216,246],"interventions":[35,55,253],"included":[36],"5":[37],"arms":[38,204,236,288],"(n":[39],"=":[40],"11,":[41],"8":[42],"F,":[43],"A1C":[44],"7.4%)":[45],"participants":[47,116],"underwent":[48],"14":[49],"hours":[50],"of":[51,56,103],"outpatient,":[52],"free-living,":[53],"supervised":[54],"(i)":[57],"CC,":[61,72,89],"(ii)":[62],"at":[67],"1u:8\u00b5g":[69],"ratio":[70,208,225],"without":[71,80,88,97,308],"(iii)":[74],"(1:10)":[79,96],"CC":[81],"(iv)":[82],"(1:8)":[87],"(v)":[91],"CC.":[98],"One":[99],"participant":[100],"opted":[101],"out":[102],"the":[104,135,141,156,163,168,179,187,198,206,234,240,252,259,268,282,302,312],"two":[105],"arms.":[110,245],"Prior":[111],"each":[113,223],"dual-hormone":[114,298],"intervention,":[115],"had":[117],"2-4-day":[119],"drug":[120],"dose-escalation":[121],"period.":[122],"P-values":[123],"are":[124],"not":[125],"reported":[126],"as":[127],"this":[128],"is":[129],"underpowered":[131],"study.":[133,324],"During":[134,162],"interventions,":[140,167],"mean":[142,247],"time":[143,169,191,213,218,310],"target":[145,313],"range":[146,171,193],"(70-180":[147],"mg/dL)":[148],"was":[149,172,194,226,254],"69%":[150],"(24%)":[151],"77%":[153,176],"(13%)":[154],"1:8":[157,180,271,285],"1:10":[159,182,207,273,287],"ratios,":[160,183],"respectively.":[161,184,289],"71%":[173],"(15%)":[174],"(11%)":[177],"Compared":[185],"control":[188,244,260],"arm":[189],"where":[190],"72%":[195],"(26%),":[196],"both":[197],"provided":[209],"numerical":[210],"improvements":[211],"range.":[215],"median":[217],"spent":[219],"below":[220],"54mg/dL":[221],"respective":[224],"1.3%":[227],"(0,":[228,231],"4.5),":[229],"0.6%":[230],"2.4)":[232],"on":[233,258,267,281],"0.0%":[238],"total":[248],"used":[250],"throughout":[251],"38.2":[255],"(23.5)":[256,280],"units":[257],"arm,":[261],"31.8":[262],"(18.4)":[263],"32.5":[265],"(17.5)":[266],"respectively,":[274],"36.6":[276],"(26.9)":[277],"32.2":[279],"This":[290],"suggests":[293],"that":[294],"our":[295],"system":[300],"has":[301],"potential":[303],"alleviate":[305],"degrading":[309],"range;":[314],"it":[316],"will":[317],"be":[318],"investigated":[319],"larger":[322],"subsequent":[323],"Disclosure":[325],"M.Odabassian:":[326],"None.":[327,350,352,354],"M.Tsoukas:":[328],"Speaker's":[329],"Bureau;":[330],"Novo":[331],"Nordisk":[332],"Canada":[333],"Inc.,":[334,365,370],"Boehringer":[335],"Ingelheim":[336],"(Canada)":[337],"Ltd.,":[338],"Eli":[339,357],"Lilly":[340,358],"Company,":[342,360],"Janssen":[343],"Scientific":[344],"Affairs,":[345],"LLC,":[346],"AstraZeneca,":[347],"Sanofi.":[348],"E.Cohen:":[349],"M.Pasqua:":[351],"J.Rutkowski:":[353],"A.Haidar:":[355],"Consultant;":[356],"Other":[361],"Relationship;":[362],"Bigfoot":[363],"Biomedical,":[364],"Research":[366],"Support;":[367],"Adocia,":[368],"Dexcom,":[369],"Tandem":[371],"Diabetes":[372],"Care,":[373],"Inc.":[374]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-06-21T00:00:00"}