{"id":"https://openalex.org/W4381328453","doi":"https://doi.org/10.1097/gme.0000000000002210","title":"A phase 1/2, open-label, parallel group study to evaluate the safety and pharmacokinetics of DARE-HRT1 (80 \u03bcg estradiol/4 mg progesterone and 160 \u03bcg estradiol/8 mg progesterone intravaginal rings) over 12 weeks in healthy postmenopausal women","display_name":"A phase 1/2, open-label, parallel group study to evaluate the safety and pharmacokinetics of DARE-HRT1 (80 \u03bcg estradiol/4 mg progesterone and 160 \u03bcg estradiol/8 mg progesterone intravaginal rings) over 12 weeks in healthy postmenopausal women","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381328453","doi":"https://doi.org/10.1097/gme.0000000000002210","pmid":"https://pubmed.ncbi.nlm.nih.gov/37339390","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10389193"},"language":"en","primary_location":{"id":"doi:10.1097/gme.0000000000002210","doi":"https://doi.org/10.1097/gme.0000000000002210","is_oa":true,"landing_page_url":"https://doi.org/10.1097/gme.0000000000002210","pdf_url":null,"source":{"id":"https://openalex.org/S95311925","display_name":"Menopause The Journal of The North American Menopause Society","issn_l":"1072-3714","issn":["1072-3714","1530-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Menopause","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/gme.0000000000002210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031286794","display_name":"Andrea Ries Thurman","orcid":"https://orcid.org/0000-0001-9826-6664","observed_orcids":["https://orcid.org/0000-0001-9826-6664"]},"institutions":[{"id":"https://openalex.org/I4405268015","display_name":"Dar\u00e9 Bioscience, Inc. (United States)","ror":"https://ror.org/05cnefn88","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268015"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea Thurman","raw_affiliation_strings":["Dar\u00e9 Bioscience, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dar\u00e9 Bioscience, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4405268015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079344414","display_name":"Mary Louise Hull","orcid":"https://orcid.org/0000-0003-1813-3971","observed_orcids":["https://orcid.org/0000-0003-1813-3971"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. Louise Hull","raw_affiliation_strings":["PARC Clinical Research and Robinson Research Institute, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PARC Clinical Research and Robinson Research Institute, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000902840","display_name":"Bronwyn G. A. Stuckey","orcid":"https://orcid.org/0000-0002-9109-9864","observed_orcids":["https://orcid.org/0000-0002-9109-9864"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2802220196","display_name":"Sir Charles Gairdner Hospital","ror":"https://ror.org/01hhqsm59","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159","https://openalex.org/I2802220196","https://openalex.org/I4210133657","https://openalex.org/I4396570646"]},{"id":"https://openalex.org/I4210138241","display_name":"Keogh Institute for Medical Research","ror":"https://ror.org/03ddhm954","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210138241"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bronwyn Stuckey","raw_affiliation_strings":["Keogh Institute for Medical Research, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Keogh Institute for Medical Research, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands, Australia","institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2802220196","https://openalex.org/I4210138241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112976163","display_name":"Jessica Hatheway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268015","display_name":"Dar\u00e9 Bioscience, Inc. (United States)","ror":"https://ror.org/05cnefn88","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Hatheway","raw_affiliation_strings":["Dar\u00e9 Bioscience, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dar\u00e9 Bioscience, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4405268015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035996566","display_name":"Nadene Zack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268015","display_name":"Dar\u00e9 Bioscience, Inc. (United States)","ror":"https://ror.org/05cnefn88","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadene Zack","raw_affiliation_strings":["Dar\u00e9 Bioscience, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dar\u00e9 Bioscience, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4405268015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003470694","display_name":"Christine K. Mauck","orcid":"https://orcid.org/0000-0002-6662-1876","observed_orcids":["https://orcid.org/0000-0002-6662-1876","https://orcid.org/0000-0002-9066-7639"]},"institutions":[{"id":"https://openalex.org/I4405268015","display_name":"Dar\u00e9 Bioscience, Inc. (United States)","ror":"https://ror.org/05cnefn88","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Mauck","raw_affiliation_strings":["Dar\u00e9 Bioscience, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dar\u00e9 Bioscience, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4405268015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018390857","display_name":"David R. Friend","orcid":"https://orcid.org/0000-0002-8292-5466","observed_orcids":["https://orcid.org/0000-0002-8292-5466"]},"institutions":[{"id":"https://openalex.org/I4405268015","display_name":"Dar\u00e9 Bioscience, Inc. (United States)","ror":"https://ror.org/05cnefn88","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Friend","raw_affiliation_strings":["Dar\u00e9 Bioscience, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dar\u00e9 Bioscience, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4405268015"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031286794"],"corresponding_institution_ids":["https://openalex.org/I4405268015"],"apc_list":null,"apc_paid":null,"fwci":0.1876,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50497456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"30","issue":"8","first_page":"817","last_page":"823"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravaginal-ring","display_name":"intravaginal ring","score":0.921999990940094},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7429999709129333},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.972000002861023},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9110000133514404},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.6669999957084656},{"id":"https://openalex.org/keywords/endometrial-protection","display_name":"endometrial protection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.746999979019165},{"id":"https://openalex.org/keywords/menopausal-symptoms","display_name":"menopausal symptoms","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.839810311794281},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7784099578857422},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6251753568649292},{"id":"https://openalex.org/C2778656385","wikidata":"https://www.wikidata.org/wiki/Q414986","display_name":"Estrone","level":3,"score":0.5761826634407043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47314250469207764},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.4300040602684021},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.410503089427948},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3679739832878113}],"mesh":[{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004970","descriptor_name":"Estrone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1097/gme.0000000000002210","doi":"https://doi.org/10.1097/gme.0000000000002210","is_oa":true,"landing_page_url":"https://doi.org/10.1097/gme.0000000000002210","pdf_url":null,"source":{"id":"https://openalex.org/S95311925","display_name":"Menopause The Journal of The North American Menopause Society","issn_l":"1072-3714","issn":["1072-3714","1530-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Menopause","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10389193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10389193","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10389193/pdf/meno-30-817.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Menopause","raw_type":"Text"},{"id":"pmid:37339390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37339390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Menopause (New York, N.Y.)","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:pure.atira.dk:openaire/d6f5cf85-03ef-431f-a5a6-a714a68dc3cb","doi":null,"is_oa":true,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/d6f5cf85-03ef-431f-a5a6-a714a68dc3cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thurman, A, Hull, M L, Stuckey, B, Hatheway, J, Zack, N, Mauck, C & Friend, D 2023, 'A phase 1/2, open-label, parallel group study to evaluate the safety and pharmacokinetics of DARE-HRT1 (80 \u03bcg estradiol/4 mg progesterone and 160 \u03bcg estradiol/8 mg progesterone intravaginal rings) over 12 weeks in healthy postmenopausal women', Menopause (New York, N.Y.), vol. 30, no. 8, pp. 817-823. https://doi.org/10.1097/GME.0000000000002210","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/138889","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2440/138889","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1097/gme.0000000000002210","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1097/gme.0000000000002210","doi":"https://doi.org/10.1097/gme.0000000000002210","is_oa":true,"landing_page_url":"https://doi.org/10.1097/gme.0000000000002210","pdf_url":null,"source":{"id":"https://openalex.org/S95311925","display_name":"Menopause The Journal of The North American Menopause Society","issn_l":"1072-3714","issn":["1072-3714","1530-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Menopause","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381328453.pdf","grobid_xml":"https://content.openalex.org/works/W4381328453.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1930797507","https://openalex.org/W1981922048","https://openalex.org/W2088269104","https://openalex.org/W2141882752","https://openalex.org/W2162957019","https://openalex.org/W2204640292","https://openalex.org/W2466785413","https://openalex.org/W2731081721","https://openalex.org/W2735932918","https://openalex.org/W2935992304","https://openalex.org/W2948830396","https://openalex.org/W3092375876","https://openalex.org/W4234744513","https://openalex.org/W4236913514","https://openalex.org/W4237638199","https://openalex.org/W4283835704"],"related_works":["https://openalex.org/W3205672157","https://openalex.org/W4318930130","https://openalex.org/W4385650803","https://openalex.org/W4365458194","https://openalex.org/W2468144665","https://openalex.org/W60137103","https://openalex.org/W2084301284","https://openalex.org/W7217503406","https://openalex.org/W2017932891","https://openalex.org/W2926749471"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Primary":[1],"objectives":[2],"were":[3,52,123,130,135,153,183,206,215],"to":[4,55],"evaluate":[5],"the":[6,78,103,217,238],"safety":[7],"and":[8,97,102,114,134,155,158,163,168,185,188,193,198,208],"systemic":[9,100,212],"pharmacokinetics":[10],"(PK)":[11],"of":[12,111,235,240],"DARE-HRT1,":[13],"an":[14,48],"intravaginal":[15],"ring":[16],"(IVR),":[17],"which":[18,214],"releases":[19],"17\u03b22-Estradiol":[20],"(E2)":[21],"with":[22,47,62,72],"progesterone":[23],"(P4)":[24],"for":[25,80,166,196,237],"28":[26],"days":[27],"in":[28,42,99,211,216],"healthy":[29,44],"postmenopausal":[30,45],"women.":[31],"METHODS:":[32],"This":[33],"was":[34,90,117,161,191],"a":[35,85],"randomized,":[36],"open-label,":[37],"2-arm,":[38],"parallel":[39],"group":[40],"study":[41,231],"21":[43],"women":[46],"intact":[49],"uterus.":[50],"Women":[51],"randomized":[53],"(1:1)":[54],"either":[56],"DARE-HRT1":[57,67,121,204,236],"IVR1":[58,139,167,197],"(E2":[59,69],"80":[60],"\u03bcg/d":[61,71],"P4":[63,73,151,181,223],"4":[64],"mg/d)":[65],"or":[66,132],"IVR2":[68,141,169,199],"160":[70],"8":[74],"mg/d).":[75],"They":[76],"used":[77],"IVR":[79,87,122],"three":[81],"28-day":[82],"cycles,":[83],"inserting":[84],"new":[86],"monthly.":[88],"Safety":[89],"measured":[91],"by":[92],"treatment":[93,126,239],"emergent":[94,127],"adverse":[95,128],"events":[96,129],"changes":[98],"laboratories":[101],"endometrial":[104,226],"bilayer":[105],"width.":[106],"Baseline":[107],"adjusted":[108],"plasma":[109,147,180],"PK":[110],"E2,":[112],"P4,":[113],"estrone":[115],"(E1)":[116],"described.":[118],"RESULTS:":[119],"Both":[120,203],"safe.":[124],"All":[125],"mild":[131],"moderate":[133],"distributed":[136],"similarly":[137],"among":[138],"versus":[140],"users.":[142],"Month":[143,172],"3":[144,173],"median":[145,174],"maximum":[146],"(":[148,177],"Cmax":[149,159],")":[150,179],"concentrations":[152,182,224],"2.81":[154],"3.51":[156],"ng/mL":[157],"E2":[160,190,210],"42.95":[162],"77.27":[164],"pg/mL":[165,195],"groups,":[170],"respectively.":[171,201],"steady":[175],"state":[176],"Css":[178,189],"1.19":[184],"1.89":[186],"ng/mL,":[187],"20.73":[192],"38.16":[194],"users,":[200],"CONCLUSIONS:":[202],"IVRs":[205],"safe":[207],"released":[209],"concentrations,":[213],"low,":[218],"normal":[219],"premenopausal":[220],"range.":[221],"Systemic":[222],"predict":[225],"protection.":[227],"Data":[228],"from":[229],"this":[230],"support":[232],"further":[233],"development":[234],"menopausal":[241],"symptoms.":[242]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-21T00:00:00"}