{"id":"https://openalex.org/W4381309015","doi":"https://doi.org/10.1093/molbev/msad146","title":"The Ancestral Shape of the Access Proton Path of Mitochondrial ATP Synthases Revealed by a Split Subunit-a","display_name":"The Ancestral Shape of the Access Proton Path of Mitochondrial ATP Synthases Revealed by a Split Subunit-a","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4381309015","doi":"https://doi.org/10.1093/molbev/msad146","pmid":"https://pubmed.ncbi.nlm.nih.gov/37338543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10306403"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msad146","doi":"https://doi.org/10.1093/molbev/msad146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msad146","pdf_url":"https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msad146/50658955/msad146.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msad146/50658955/msad146.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059302456","display_name":"Jonathan E. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I3124161356","display_name":"University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice","ror":"https://ror.org/033n3pw66","country_code":"CZ","type":"education","lineage":["https://openalex.org/I3124161356"]},{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jonathan E Wong","raw_affiliation_strings":["Faculty of Science, University of South Bohemia , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic","Institute of Parasitology, Biology Centre, Czech Academy of Sciences , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, University of South Bohemia , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic","institution_ids":["https://openalex.org/I3124161356"]},{"raw_affiliation_string":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017181527","display_name":"Alena Z\u00edkov\u00e1","orcid":"https://orcid.org/0000-0002-8686-0225","observed_orcids":["https://orcid.org/0000-0002-8686-0225"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I3124161356","display_name":"University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice","ror":"https://ror.org/033n3pw66","country_code":"CZ","type":"education","lineage":["https://openalex.org/I3124161356"]},{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Alena Z\u00edkov\u00e1","raw_affiliation_strings":["Faculty of Science, University of South Bohemia , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic","Institute of Parasitology, Biology Centre, Czech Academy of Sciences , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, University of South Bohemia , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic","institution_ids":["https://openalex.org/I3124161356"]},{"raw_affiliation_string":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008204893","display_name":"Ond\u0159ej Gahura","orcid":"https://orcid.org/0000-0002-2925-4763","observed_orcids":["https://orcid.org/0000-0002-2925-4763"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Ond\u0159ej Gahura","raw_affiliation_strings":["Institute of Parasitology, Biology Centre, Czech Academy of Sciences , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-2925-4763","affiliations":[{"raw_affiliation_string":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences , \u010cesk\u00e9 Bud\u011bjovice , Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008204893"],"corresponding_institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"],"apc_list":{"value":3255,"currency":"USD","value_usd":3255},"apc_paid":{"value":3255,"currency":"USD","value_usd":3255},"fwci":0.3708,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.4490543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"40","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f1fo-atp-synthase","display_name":"F1FO-ATP synthase","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mitochondrial-atp-synthase","display_name":"mitochondrial ATP synthase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/subunit-a","display_name":"subunit a","score":0.7910000085830688},{"id":"https://openalex.org/keywords/n-terminal-alpha-helix","display_name":"N-terminal alpha-helix","score":0.7889999747276306},{"id":"https://openalex.org/keywords/gene-fragmentation","display_name":"gene fragmentation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.9020000100135803},{"id":"https://openalex.org/keywords/euglenozoa","display_name":"Euglenozoa","score":0.996999979019165},{"id":"https://openalex.org/keywords/alphaproteobacteria","display_name":"Alphaproteobacteria","score":0.9900000095367432},{"id":"https://openalex.org/keywords/endosymbiotic-origin-of-mitochondria","display_name":"endosymbiotic origin of mitochondria","score":0.8420000076293945},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7870335578918457},{"id":"https://openalex.org/C199733737","wikidata":"https://www.wikidata.org/wiki/Q4531856","display_name":"Endosymbiosis","level":5,"score":0.749225378036499},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.7386094331741333},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5791217088699341},{"id":"https://openalex.org/C119120687","wikidata":"https://www.wikidata.org/wiki/Q4654890","display_name":"ATP synthase gamma subunit","level":5,"score":0.5767771005630493},{"id":"https://openalex.org/C171357686","wikidata":"https://www.wikidata.org/wiki/Q910130","display_name":"Chemiosmosis","level":4,"score":0.5568364262580872},{"id":"https://openalex.org/C686708","wikidata":"https://www.wikidata.org/wiki/Q5423609","display_name":"F-ATPase","level":5,"score":0.5316040515899658},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.4958101212978363},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.48771199584007263},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.47535771131515503},{"id":"https://openalex.org/C2992012372","wikidata":"https://www.wikidata.org/wiki/Q412272","display_name":"Proton transport","level":3,"score":0.43623995780944824},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.4264916479587555},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.42395615577697754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4158655107021332},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3749145269393921},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3509542942047119},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27804848551750183},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12997817993164062},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10631603002548218},{"id":"https://openalex.org/C93829228","wikidata":"https://www.wikidata.org/wiki/Q165963","display_name":"Plastid","level":4,"score":0.07155647873878479},{"id":"https://openalex.org/C101692577","wikidata":"https://www.wikidata.org/wiki/Q337889","display_name":"Thylakoid","level":4,"score":0.0},{"id":"https://openalex.org/C69305403","wikidata":"https://www.wikidata.org/wiki/Q47263","display_name":"Chloroplast","level":3,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/molbev/msad146","doi":"https://doi.org/10.1093/molbev/msad146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msad146","pdf_url":"https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msad146/50658955/msad146.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"doi:10.1101/2023.02.25.530031","doi":"https://doi.org/10.1101/2023.02.25.530031","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.02.25.530031","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/23/2023.02.25.530031.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10306403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10306403","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10306403/pdf/msad146.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Evol","raw_type":"Text"},{"id":"pmid:37338543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37338543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/molbev/msad146","doi":"https://doi.org/10.1093/molbev/msad146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msad146","pdf_url":"https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msad146/50658955/msad146.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1059663884","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0/16_019","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"},{"id":"https://openalex.org/G1090217353","display_name":null,"funder_award_id":"0000759","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"},{"id":"https://openalex.org/G12500569","display_name":null,"funder_award_id":"CZ.02.1.01/0.0","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G176604203","display_name":null,"funder_award_id":"02.1.01/0.0/0.0","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G291036901","display_name":null,"funder_award_id":"CZ.02","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G2934980467","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0/16_019/0000759","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3086767680","display_name":"Mitoribosome in Trypanosoma brucei: biogenesis and unique traits of a divergent protein synthesis machine","funder_award_id":"GJ20-04150Y","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G325603504","display_name":"Mitochondrial signaling drives parasite differentiation","funder_award_id":"101044951","funder_id":"https://openalex.org/F4320338453","funder_display_name":"HORIZON EUROPE European Research Council"},{"id":"https://openalex.org/G3490171961","display_name":null,"funder_award_id":"CZ.02.1.01","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3622461675","display_name":null,"funder_award_id":"CZ.02.1.01","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3979014076","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0/ 16_019/0000759","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G4131035492","display_name":null,"funder_award_id":"CZ.02.1.01","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4445115756","display_name":null,"funder_award_id":"16_019/0000759","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"},{"id":"https://openalex.org/G5641063287","display_name":null,"funder_award_id":"CZ.02.1.01","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"},{"id":"https://openalex.org/G5916014575","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G700989975","display_name":null,"funder_award_id":"16_019/0000759","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7315588729","display_name":null,"funder_award_id":"02.1.01/0.0/0.0/16_019/0000759","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7363506711","display_name":null,"funder_award_id":"/16_019","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G836088697","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0/16 019/0000759","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321005","display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","ror":"https://ror.org/037n8p820"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338453","display_name":"HORIZON EUROPE European Research Council","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381309015.pdf","grobid_xml":"https://content.openalex.org/works/W4381309015.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1532669610","https://openalex.org/W1540116832","https://openalex.org/W1547153839","https://openalex.org/W1596316759","https://openalex.org/W1970664277","https://openalex.org/W1975304761","https://openalex.org/W2007858156","https://openalex.org/W2031546229","https://openalex.org/W2034528918","https://openalex.org/W2038575389","https://openalex.org/W2089606003","https://openalex.org/W2097870001","https://openalex.org/W2121395567","https://openalex.org/W2127786096","https://openalex.org/W2132926880","https://openalex.org/W2152917039","https://openalex.org/W2164825141","https://openalex.org/W2171692538","https://openalex.org/W2601868538","https://openalex.org/W2734356283","https://openalex.org/W2762478814","https://openalex.org/W2766352605","https://openalex.org/W2768385785","https://openalex.org/W2772989510","https://openalex.org/W2774777968","https://openalex.org/W2784674830","https://openalex.org/W2918063357","https://openalex.org/W2923457309","https://openalex.org/W2925284108","https://openalex.org/W2950629960","https://openalex.org/W2952197919","https://openalex.org/W2979715961","https://openalex.org/W2985267845","https://openalex.org/W3020272641","https://openalex.org/W3029090796","https://openalex.org/W3036067306","https://openalex.org/W3084135130","https://openalex.org/W3086511947","https://openalex.org/W3094245500","https://openalex.org/W3111481966","https://openalex.org/W3120675440","https://openalex.org/W3127231095","https://openalex.org/W3177828909","https://openalex.org/W3213569025","https://openalex.org/W4206320337","https://openalex.org/W4206945473","https://openalex.org/W4220668420","https://openalex.org/W4220999962","https://openalex.org/W4225253156","https://openalex.org/W4225906362","https://openalex.org/W4304163398","https://openalex.org/W4306407817","https://openalex.org/W4312114326","https://openalex.org/W4353056837","https://openalex.org/W4366417286"],"related_works":["https://openalex.org/W2772989510","https://openalex.org/W2047428998","https://openalex.org/W2025759141","https://openalex.org/W2550817899","https://openalex.org/W2026550766","https://openalex.org/W2100661426","https://openalex.org/W4366417286","https://openalex.org/W4304163398","https://openalex.org/W2577415744","https://openalex.org/W4206945473"],"abstract_inverted_index":{"The":[0,125],"passage":[1],"of":[2,16,21,33,54,61,73,85,93,118,129,153],"protons":[3,55],"across":[4,109],"membranes":[5],"through":[6],"F1Fo-ATP":[7],"synthases":[8,64],"spins":[9],"their":[10,39],"rotors":[11],"and":[12,31,36,38,52,78,99,111,146,160],"drives":[13],"the":[14,19,29,49,57,81,103,114,151,154,163],"synthesis":[15],"ATP.":[17],"While":[18],"principle":[20],"torque":[22],"generation":[23],"by":[24,68,169],"proton":[25,34,104,131,141],"transfer":[26],"is":[27,83,90],"known,":[28],"mechanisms":[30],"routes":[32,132],"access":[35,155],"release":[37],"evolution":[40],"are":[41,65,106],"not":[42,121],"fully":[43],"understood.":[44],"Here,":[45],"we":[46],"show":[47],"that":[48,89],"entry":[50,142],"site":[51,143],"path":[53],"in":[56,112,122,134,138,144,162],"lumenal":[58],"half":[59,156],"channel":[60,157],"mitochondrial":[62,145],"ATP":[63,148],"largely":[66],"defined":[67],"a":[69,91,139],"short":[70],"N-terminal":[71],"\u03b1-helix":[72,82,98,126],"subunit-a.":[74],"In":[75],"Trypanosoma":[76],"brucei":[77],"other":[79,100,123],"Euglenozoa,":[80],"part":[84],"another":[86],"polypeptide":[87],"chain":[88],"product":[92],"subunit-a":[94],"gene":[95],"fragmentation.":[96],"This":[97],"elements":[101],"forming":[102],"pathway":[105],"widely":[107],"conserved":[108],"eukaryotes":[110,159],"Alphaproteobacteria,":[113],"closest":[115],"extant":[116],"relatives":[117],"mitochondria,":[119],"but":[120],"bacteria.":[124],"blocks":[127],"one":[128],"two":[130],"found":[133],"Escherichia":[135],"coli,":[136],"resulting":[137],"single":[140],"alphaproteobacterial":[147],"synthases.":[149],"Thus,":[150],"shape":[152],"predates":[158],"originated":[161],"lineage":[164],"from":[165],"which":[166],"mitochondria":[167],"evolved":[168],"endosymbiosis.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-06-21T00:00:00"}
