{"id":"https://openalex.org/W4381308635","doi":"https://doi.org/10.1002/anie.202306274","title":"Synthetic Peptide Antibodies as TNF\u2010\u03b1 Inhibitors: Molecularly Imprinted Polymer Nanogels Neutralize the Inflammatory Activity of TNF\u2010\u03b1 in THP\u20101 Derived Macrophages","display_name":"Synthetic Peptide Antibodies as TNF\u2010\u03b1 Inhibitors: Molecularly Imprinted Polymer Nanogels Neutralize the Inflammatory Activity of TNF\u2010\u03b1 in THP\u20101 Derived Macrophages","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381308635","doi":"https://doi.org/10.1002/anie.202306274","pmid":"https://pubmed.ncbi.nlm.nih.gov/37338464"},"language":"en","primary_location":{"id":"doi:10.1002/anie.202306274","doi":"https://doi.org/10.1002/anie.202306274","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.202306274","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/hal-05409624v1/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072882656","display_name":"Claudia Herrera Le\u00f3n","orcid":"https://orcid.org/0000-0003-2804-6732","observed_orcids":["https://orcid.org/0000-0003-2804-6732"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claudia Herrera Le\u00f3n","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0003-2804-6732","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050757088","display_name":"Noel Angelo Kalacas","orcid":"https://orcid.org/0000-0002-3507-7724","observed_orcids":["https://orcid.org/0000-0002-3507-7724"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Noel Angelo Kalacas","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0002-3507-7724","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064543900","display_name":"Alejandra Mier","orcid":"https://orcid.org/0000-0002-7669-880X","observed_orcids":["https://orcid.org/0000-0002-7669-880X"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alejandra Mier","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0002-7669-880X","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051088114","display_name":"Peyman Sakhaii","orcid":"https://orcid.org/0000-0003-2557-7028","observed_orcids":["https://orcid.org/0000-0003-2557-7028"]},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peyman Sakhaii","raw_affiliation_strings":["Global CMC Early Development, Synthetics Platform, Sanofi-Aventis Deutschland GmbH, Industrial Park Hoechst, Building G849, 65926 Frankfurt/Main, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2557-7028","affiliations":[{"raw_affiliation_string":"Global CMC Early Development, Synthetics Platform, Sanofi-Aventis Deutschland GmbH, Industrial Park Hoechst, Building G849, 65926 Frankfurt/Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014521898","display_name":"Franck Merlier","orcid":"https://orcid.org/0000-0002-8895-8357","observed_orcids":["https://orcid.org/0000-0002-8895-8357"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Merlier","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0002-8895-8357","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068799810","display_name":"\u00c9lise Prost","orcid":"https://orcid.org/0000-0002-4806-9109","observed_orcids":["https://orcid.org/0000-0002-4806-9109"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elise Prost","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0002-4806-9109","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032225426","display_name":"Irene Maffucci","orcid":"https://orcid.org/0000-0002-4524-1137","observed_orcids":["https://orcid.org/0000-0002-4524-1137"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Irene Maffucci","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0002-4524-1137","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027390178","display_name":"Valentina Montagna","orcid":"https://orcid.org/0000-0003-0174-8400","observed_orcids":["https://orcid.org/0000-0003-0174-8400"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valentina Montagna","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0003-0174-8400","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088762019","display_name":"Helena Mora\u2010Rad\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helena Mora\u2010Rad\u00f3","raw_affiliation_strings":["Global CMC Early Development, Synthetics Platform, Sanofi-Aventis Deutschland GmbH, Industrial Park Hoechst, Building G849, 65926 Frankfurt/Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global CMC Early Development, Synthetics Platform, Sanofi-Aventis Deutschland GmbH, Industrial Park Hoechst, Building G849, 65926 Frankfurt/Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007383554","display_name":"Pradeep K. Dhal","orcid":"https://orcid.org/0000-0002-7059-855X","observed_orcids":["https://orcid.org/0000-0002-7059-855X"]},"institutions":[{"id":"https://openalex.org/I4210111804","display_name":"Sanofi (United States)","ror":"https://ror.org/027vj4x92","country_code":"US","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradeep K. Dhal","raw_affiliation_strings":["Global CMC Early Development, Synthetics Platform, Sanofi Global R&D, 350 Water Street, Cambridge, MA 02141 USA"],"raw_orcid":"https://orcid.org/0000-0002-7059-855X","affiliations":[{"raw_affiliation_string":"Global CMC Early Development, Synthetics Platform, Sanofi Global R&D, 350 Water Street, Cambridge, MA 02141 USA","institution_ids":["https://openalex.org/I4210111804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054803089","display_name":"Bernadette Tse Sum Bui","orcid":"https://orcid.org/0000-0002-4170-2303","observed_orcids":["https://orcid.org/0000-0002-4170-2303"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Bernadette Tse Sum Bui","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0002-4170-2303","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043319511","display_name":"Karsten Haupt","orcid":"https://orcid.org/0000-0001-6743-5066","observed_orcids":["https://orcid.org/0000-0001-6743-5066"]},"institutions":[{"id":"https://openalex.org/I102516824","display_name":"Universit\u00e9 de Technologie de Compi\u00e8gne","ror":"https://ror.org/04y5kwa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I102516824"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Karsten Haupt","raw_affiliation_strings":["CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France"],"raw_orcid":"https://orcid.org/0000-0001-6743-5066","affiliations":[{"raw_affiliation_string":"CNRS Enzyme and Cell Engineering Laboratory Universit\u00e9 de Technologie de Compi\u00e8gne  Rue du Docteur Schweitzer, CS 60319 60203 Compi\u00e8gne Cedex France","institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043319511","https://openalex.org/A5054803089"],"corresponding_institution_ids":["https://openalex.org/I102516824","https://openalex.org/I1294671590"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":3.8353,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.95460003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"62","issue":"34","first_page":"e202306274","last_page":"e202306274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecularly-imprinted-polymers","display_name":"molecularly imprinted polymers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/polymeric-nanogels","display_name":"polymer nanogels","score":0.8820000290870667},{"id":"https://openalex.org/keywords/synthetic-peptide-antibodies","display_name":"synthetic peptide antibodies","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/peptide-epitopes","display_name":"peptide epitopes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/anti-tnf-monoclonal-antibody","display_name":"anti-TNF monoclonal antibody","score":0.6880000233650208},{"id":"https://openalex.org/keywords/thp-1-macrophages","display_name":"THP-1 macrophages","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8389999866485596},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7514805793762207},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6534616947174072},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5490555763244629},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5263285040855408},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.517013669013977},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.49993062019348145},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47190219163894653},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4540347754955292},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41353681683540344},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26581141352653503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22153598070144653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20250603556632996}],"mesh":[{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080385","descriptor_name":"Nanogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082582","descriptor_name":"Molecularly Imprinted Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054802","descriptor_name":"Molecular Imprinting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/anie.202306274","doi":"https://doi.org/10.1002/anie.202306274","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.202306274","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:37338464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37338464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05409624v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05409624","pdf_url":"https://hal.science/hal-05409624v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Angewandte Chemie International Edition, 2023, 62 (34), pp.e202306274. &#x27E8;10.1002/anie.202306274&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-05409624v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05409624","pdf_url":"https://hal.science/hal-05409624v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Angewandte Chemie International Edition, 2023, 62 (34), pp.e202306274. &#x27E8;10.1002/anie.202306274&#x27E9;","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320322893","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266"},{"id":"https://openalex.org/F4320334498","display_name":"Sanofi-Aventis Deutschland","ror":"https://ror.org/03ytdtb31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381308635.pdf","grobid_xml":"https://content.openalex.org/works/W4381308635.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1501675811","https://openalex.org/W1968117332","https://openalex.org/W1972348350","https://openalex.org/W2010993726","https://openalex.org/W2024494874","https://openalex.org/W2029993898","https://openalex.org/W2046221052","https://openalex.org/W2054114268","https://openalex.org/W2061151008","https://openalex.org/W2061543974","https://openalex.org/W2070932113","https://openalex.org/W2074881372","https://openalex.org/W2076755375","https://openalex.org/W2096287192","https://openalex.org/W2098777254","https://openalex.org/W2100845577","https://openalex.org/W2111913995","https://openalex.org/W2127310510","https://openalex.org/W2143772891","https://openalex.org/W2147425799","https://openalex.org/W2263918696","https://openalex.org/W2282741333","https://openalex.org/W2902467987","https://openalex.org/W2911789924","https://openalex.org/W2912657837","https://openalex.org/W2912800487","https://openalex.org/W2942713732","https://openalex.org/W2945235170","https://openalex.org/W2954982313","https://openalex.org/W2965884920","https://openalex.org/W2969837335","https://openalex.org/W2982694101","https://openalex.org/W2999652302","https://openalex.org/W2999958881","https://openalex.org/W3046887530","https://openalex.org/W3134454558","https://openalex.org/W3146111873","https://openalex.org/W3161785094","https://openalex.org/W3186122668","https://openalex.org/W3207443835","https://openalex.org/W3209375789","https://openalex.org/W4200435261","https://openalex.org/W4280533962","https://openalex.org/W4282962750","https://openalex.org/W4317107450","https://openalex.org/W6602242674","https://openalex.org/W6632295051"],"related_works":["https://openalex.org/W4377107366","https://openalex.org/W2159512053","https://openalex.org/W3138874796","https://openalex.org/W2017203016","https://openalex.org/W1968261301","https://openalex.org/W4399364419","https://openalex.org/W4410357729","https://openalex.org/W4409334929","https://openalex.org/W4384701170","https://openalex.org/W7143487395"],"abstract_inverted_index":{"Tumor":[0],"Necrosis":[1],"Factor-\u03b1":[2],"(TNF-\u03b1)":[3],"is":[4,8,23],"a":[5,88,92,157],"cytokine":[6],"that":[7,168],"normally":[9],"produced":[10,24],"by":[11,46,79],"immune":[12],"cells":[13],"when":[14,19],"fighting":[15],"an":[16,63,96],"infection.":[17],"But,":[18],"too":[20],"much":[21],"TNF-\u03b1":[22,48,54,106,124,136,147,191],"as":[25,188],"in":[26,65,91,99,148],"autoimmune":[27],"diseases,":[28],"this":[29],"leads":[30],"to":[31,53,137,144,156,179],"unwanted":[32],"and":[33,49,84,109,122,128,130,173,177,183],"persistent":[34],"inflammation.":[35,59],"Anti-TNF-\u03b1":[36],"monoclonal":[37],"antibodies":[38,77],"have":[39],"revolutionized":[40],"the":[41,58,66,81,119,133,149,160,194],"therapy":[42],"of":[43,68,87,105,135,151,159,162,196],"these":[44],"disorders":[45],"blocking":[47],"preventing":[50],"its":[51,138],"binding":[52,134],"receptors,":[55],"thus":[56],"suppressing":[57],"Herein,":[60],"we":[61],"propose":[62],"alternative":[64],"form":[67],"molecularly":[69],"imprinted":[70],"polymer":[71],"nanogels":[72],"(MIP-NGs).":[73],"MIP-NGs":[74,117],"are":[75,171,185],"synthetic":[76,93],"obtained":[78],"nanomoulding":[80],"3-dimensional":[82],"shape":[83],"chemical":[85],"functionalities":[86],"desired":[89],"target":[90],"polymer.":[94],"Using":[95],"in-house":[97],"developed":[98],"silico":[100],"rational":[101],"approach,":[102],"epitope":[103],"peptides":[104],"were":[107,113,142],"generated":[108],"'synthetic":[110],"peptide":[111,121],"antibodies'":[112],"prepared.":[114],"The":[115],"resultant":[116],"bind":[118],"template":[120],"recombinant":[123],"with":[125],"high":[126],"affinity":[127],"selectivity,":[129],"can":[131],"block":[132],"receptor.":[139],"Consequently":[140],"they":[141],"applied":[143],"neutralize":[145],"pro-inflammatory":[146,163],"supernatant":[150],"human":[152],"THP-1":[153],"macrophages,":[154],"leading":[155],"downregulation":[158],"secretion":[161],"cytokines.":[164],"Our":[165],"results":[166],"suggest":[167],"MIP-NGs,":[169],"which":[170],"thermally":[172],"biochemically":[174],"more":[175],"stable":[176],"easier":[178],"manufacture":[180],"than":[181],"antibodies,":[182],"cost-effective,":[184],"very":[186],"promising":[187],"next":[189],"generation":[190],"inhibitors":[192],"for":[193],"treatment":[195],"inflammatory":[197],"diseases.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-06-21T00:00:00"}
