{"id":"https://openalex.org/W4381251007","doi":"https://doi.org/10.1021/acsomega.3c03160","title":"Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis","display_name":"Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis","publication_year":2023,"publication_date":"2023-06-19","ids":{"openalex":"https://openalex.org/W4381251007","doi":"https://doi.org/10.1021/acsomega.3c03160","pmid":"https://pubmed.ncbi.nlm.nih.gov/37426273","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10324384"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.3c03160","doi":"https://doi.org/10.1021/acsomega.3c03160","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c03160","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c03160","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c03160","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081487015","display_name":"Lijun Xue","orcid":"https://orcid.org/0000-0001-7793-3165","observed_orcids":["https://orcid.org/0000-0001-7793-3165"]},"institutions":[{"id":"https://openalex.org/I4405279148","display_name":"Pharmaron (China)","ror":"https://ror.org/012qm0r35","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405279148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Xue","raw_affiliation_strings":["Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China","institution_ids":["https://openalex.org/I4405279148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064754045","display_name":"Hangke Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279148","display_name":"Pharmaron (China)","ror":"https://ror.org/012qm0r35","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405279148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hangke Ma","raw_affiliation_strings":["Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China","institution_ids":["https://openalex.org/I4405279148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668788","display_name":"Weijie Liu","orcid":"https://orcid.org/0000-0003-3484-9347","observed_orcids":["https://orcid.org/0000-0003-3484-9347"]},"institutions":[{"id":"https://openalex.org/I4405279148","display_name":"Pharmaron (China)","ror":"https://ror.org/012qm0r35","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405279148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijie Liu","raw_affiliation_strings":["Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China","institution_ids":["https://openalex.org/I4405279148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079704580","display_name":"Nicolas Duchemin","orcid":"https://orcid.org/0000-0002-8035-0232","observed_orcids":["https://orcid.org/0000-0002-8035-0232"]},"institutions":[{"id":"https://openalex.org/I4210102587","display_name":"Pharmaron (United Kingdom)","ror":"https://ror.org/01fn7y155","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210102587","https://openalex.org/I4405279148"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicolas Duchemin","raw_affiliation_strings":["Pharmaron UK, Ltd., Innovation Park, West Cl, Hertford Road, Hoddesdon EN11 9FH, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaron UK, Ltd., Innovation Park, West Cl, Hertford Road, Hoddesdon EN11 9FH, U.K","institution_ids":["https://openalex.org/I4210102587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008926065","display_name":"Fanming Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279148","display_name":"Pharmaron (China)","ror":"https://ror.org/012qm0r35","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405279148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanming Zeng","raw_affiliation_strings":["Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China","institution_ids":["https://openalex.org/I4405279148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436783","display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0002-6509-8614","observed_orcids":["https://orcid.org/0000-0002-6509-8614"]},"institutions":[{"id":"https://openalex.org/I4405279148","display_name":"Pharmaron (China)","ror":"https://ror.org/012qm0r35","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405279148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China","institution_ids":["https://openalex.org/I4405279148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101935817","display_name":"Huanqing Zhang","orcid":"https://orcid.org/0000-0002-2495-8438","observed_orcids":["https://orcid.org/0000-0002-2495-8438"]},"institutions":[{"id":"https://openalex.org/I4405279148","display_name":"Pharmaron (China)","ror":"https://ror.org/012qm0r35","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405279148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanqing Zhang","raw_affiliation_strings":["Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China","institution_ids":["https://openalex.org/I4405279148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055653174","display_name":"Kexin Yang","orcid":"https://orcid.org/0009-0009-2321-7775","observed_orcids":["https://orcid.org/0009-0009-2321-7775"]},"institutions":[{"id":"https://openalex.org/I4405279148","display_name":"Pharmaron (China)","ror":"https://ror.org/012qm0r35","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405279148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kexin Yang","raw_affiliation_strings":["Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176 P. R. China","institution_ids":["https://openalex.org/I4405279148"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083197694","display_name":"Yun Jin Hu","orcid":"https://orcid.org/0000-0001-6943-2459","observed_orcids":["https://orcid.org/0000-0001-6943-2459"]},"institutions":[{"id":"https://openalex.org/I4405279148","display_name":"Pharmaron (China)","ror":"https://ror.org/012qm0r35","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405279148"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Jin Hu","raw_affiliation_strings":["Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China"],"raw_orcid":"https://orcid.org/0000-0001-6943-2459","affiliations":[{"raw_affiliation_string":"Pharmaron (Ningbo) Technology Development Co., Ltd., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315336 China","institution_ids":["https://openalex.org/I4405279148"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083197694"],"corresponding_institution_ids":["https://openalex.org/I4405279148"],"apc_list":{"value":1685,"currency":"USD","value_usd":1685},"apc_paid":{"value":1685,"currency":"USD","value_usd":1685},"fwci":0.8758,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63465363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"26","first_page":"24072","last_page":"24077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-encoded-libraries","display_name":"DNA-encoded libraries","score":0.8100000023841858},{"id":"https://openalex.org/keywords/library-synthesis","display_name":"library synthesis","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7637982368469238},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.5866093635559082},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.5330871939659119},{"id":"https://openalex.org/C2778701210","wikidata":"https://www.wikidata.org/wiki/Q28130034","display_name":"Constructive","level":3,"score":0.5290155410766602},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.524960994720459},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.5147140622138977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46742910146713257},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46076205372810364},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3900741636753082},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3790209889411926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27532756328582764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23380303382873535},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.18343642354011536},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.14526009559631348},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.06912294030189514}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/acsomega.3c03160","doi":"https://doi.org/10.1021/acsomega.3c03160","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c03160","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c03160","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10324384","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10324384","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10324384/pdf/ao3c03160.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:37426273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37426273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.3c03160","doi":"https://doi.org/10.1021/acsomega.3c03160","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c03160","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c03160","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324860","display_name":"Pharmaron","ror":"https://ror.org/012qm0r35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381251007.pdf","grobid_xml":"https://content.openalex.org/works/W4381251007.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W589574422","https://openalex.org/W1536174118","https://openalex.org/W1839106020","https://openalex.org/W1977275263","https://openalex.org/W1979740577","https://openalex.org/W1993105964","https://openalex.org/W2000520515","https://openalex.org/W2002789598","https://openalex.org/W2003657830","https://openalex.org/W2009054943","https://openalex.org/W2017423606","https://openalex.org/W2024499333","https://openalex.org/W2041752660","https://openalex.org/W2053021252","https://openalex.org/W2076134478","https://openalex.org/W2088388217","https://openalex.org/W2088997334","https://openalex.org/W2091473494","https://openalex.org/W2109129214","https://openalex.org/W2133437228","https://openalex.org/W2286829287","https://openalex.org/W2584580415","https://openalex.org/W2592709654","https://openalex.org/W2803083648","https://openalex.org/W2926778580","https://openalex.org/W2936336131","https://openalex.org/W2949220486","https://openalex.org/W2949246270","https://openalex.org/W2952263045","https://openalex.org/W2952887818","https://openalex.org/W2970782110","https://openalex.org/W3008886954","https://openalex.org/W3016708754","https://openalex.org/W3034612930","https://openalex.org/W3037518912","https://openalex.org/W3092211024","https://openalex.org/W3097831223","https://openalex.org/W3118421399","https://openalex.org/W3125195025","https://openalex.org/W3153905619","https://openalex.org/W3166642179","https://openalex.org/W3193325964","https://openalex.org/W4220938912","https://openalex.org/W4235147334","https://openalex.org/W4285263866","https://openalex.org/W4289518046","https://openalex.org/W4292939719","https://openalex.org/W4310572395","https://openalex.org/W4319985840","https://openalex.org/W4321605745","https://openalex.org/W4323825495"],"related_works":["https://openalex.org/W4399780855","https://openalex.org/W4382363626","https://openalex.org/W6955028564","https://openalex.org/W4410230565","https://openalex.org/W4224059954","https://openalex.org/W3011353733","https://openalex.org/W4295084867","https://openalex.org/W4405625078","https://openalex.org/W3188146132","https://openalex.org/W2810548458"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"A":[7],"novel":[8],"on-DNA":[9],"oxidative":[10],"disulfide":[11],"formation":[12],"method":[13],"has":[14],"been":[15],"developed.":[16],"Under":[17],"ambient":[18],"conditions,":[19],"the":[20],"methodology":[21],"showcased":[22],"wide":[23],"applicability":[24],"and":[25],"swift":[26],"implementation":[27],"in":[28],"routine":[29],"DNA-encoded":[30],"library":[31],"synthesis":[32],"to":[33],"access":[34],"pharmaceutically":[35],"relevant":[36],"motifs.":[37]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-20T00:00:00"}