{"id":"https://openalex.org/W4381140712","doi":"https://doi.org/10.1002/ajmg.b.32951","title":"Multi\u2010polygenic scores in psychiatry: From disorder specific to transdiagnostic perspectives","display_name":"Multi\u2010polygenic scores in psychiatry: From disorder specific to transdiagnostic perspectives","publication_year":2023,"publication_date":"2023-06-19","ids":{"openalex":"https://openalex.org/W4381140712","doi":"https://doi.org/10.1002/ajmg.b.32951","pmid":"https://pubmed.ncbi.nlm.nih.gov/37334623","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10803201"},"language":"en","primary_location":{"id":"doi:10.1002/ajmg.b.32951","doi":"https://doi.org/10.1002/ajmg.b.32951","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.b.32951","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.32951","source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.32951","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065756495","display_name":"Yingjie Shi","orcid":"https://orcid.org/0000-0003-1431-6340","observed_orcids":["https://orcid.org/0000-0003-1431-6340"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Yingjie Shi","raw_affiliation_strings":["Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-1431-6340","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017663367","display_name":"Emma Sprooten","orcid":"https://orcid.org/0000-0002-1691-9105","observed_orcids":["https://orcid.org/0000-0002-1691-9105"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Emma Sprooten","raw_affiliation_strings":["Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands","Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084206546","display_name":"Peter C.R. Mulders","orcid":"https://orcid.org/0000-0002-7867-5513","observed_orcids":["https://orcid.org/0000-0002-7867-5513"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter Mulders","raw_affiliation_strings":["Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022100446","display_name":"Janna Nonja Vrijsen","orcid":"https://orcid.org/0000-0002-7081-9893","observed_orcids":["https://orcid.org/0000-0002-7081-9893","https://orcid.org/0000-0003-0317-6696"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210157580","display_name":"Pro Persona","ror":"https://ror.org/04jy41s17","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210157580"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Janna Vrijsen","raw_affiliation_strings":["Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","Pro Persona Mental Health Care, Depression Expertise Centre, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]},{"raw_affiliation_string":"Pro Persona Mental Health Care, Depression Expertise Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210157580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082791385","display_name":"Janita Bralten","orcid":"https://orcid.org/0000-0003-1440-8675","observed_orcids":["https://orcid.org/0000-0003-1440-8675"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Janita Bralten","raw_affiliation_strings":["Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014114792","display_name":"Ditte Demontis","orcid":"https://orcid.org/0000-0001-9124-2766","observed_orcids":["https://orcid.org/0000-0001-9124-2766"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210127817","display_name":"Lundbeck Foundation","ror":"https://ror.org/03hz8wd80","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210127817"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ditte Demontis","raw_affiliation_strings":["Center for Genomics and Personalized Medicine, Aarhus, Denmark","Department of Biomedicine/Human Genetics, Aarhus University, Aarhus, Denmark","The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomics and Personalized Medicine, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Biomedicine/Human Genetics, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210127817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035161779","display_name":"Anders Dupont B\u00f8rglum","orcid":"https://orcid.org/0000-0001-8627-7219","observed_orcids":["https://orcid.org/0000-0001-8627-7219"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210127817","display_name":"Lundbeck Foundation","ror":"https://ror.org/03hz8wd80","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210127817"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders D. B\u00f8rglum","raw_affiliation_strings":["Center for Genomics and Personalized Medicine, Aarhus, Denmark","Department of Biomedicine/Human Genetics, Aarhus University, Aarhus, Denmark","The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomics and Personalized Medicine, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Biomedicine/Human Genetics, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210127817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018138876","display_name":"G. Bragi Walters","orcid":"https://orcid.org/0000-0002-5415-6487","observed_orcids":["https://orcid.org/0000-0002-5415-6487"]},"institutions":[{"id":"https://openalex.org/I1327191685","display_name":"deCODE Genetics (Iceland)","ror":"https://ror.org/04dzdm737","country_code":"IS","type":"company","lineage":["https://openalex.org/I1327191685"]},{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"G. Bragi Walters","raw_affiliation_strings":["Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland","deCODE Genetics  Reykjav\u00edk Iceland"],"raw_orcid":"https://orcid.org/0000-0002-5415-6487","affiliations":[{"raw_affiliation_string":"Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland","institution_ids":["https://openalex.org/I165368041"]},{"raw_affiliation_string":"deCODE Genetics  Reykjav\u00edk Iceland","institution_ids":["https://openalex.org/I1327191685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018239255","display_name":"K\u0101ri Stef\u00e1nsson","orcid":"https://orcid.org/0000-0003-1676-864X","observed_orcids":["https://orcid.org/0000-0003-1676-864X"]},"institutions":[{"id":"https://openalex.org/I1327191685","display_name":"deCODE Genetics (Iceland)","ror":"https://ror.org/04dzdm737","country_code":"IS","type":"company","lineage":["https://openalex.org/I1327191685"]},{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"Kari Stefansson","raw_affiliation_strings":["Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland","deCODE Genetics  Reykjav\u00edk Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland","institution_ids":["https://openalex.org/I165368041"]},{"raw_affiliation_string":"deCODE Genetics  Reykjav\u00edk Iceland","institution_ids":["https://openalex.org/I1327191685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025622161","display_name":"Philip van Eijndhoven","orcid":"https://orcid.org/0000-0003-3474-4326","observed_orcids":["https://orcid.org/0000-0003-3474-4326"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Philip van Eijndhoven","raw_affiliation_strings":["Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071538921","display_name":"Indira Tendolkar","orcid":"https://orcid.org/0000-0003-3171-3671","observed_orcids":["https://orcid.org/0000-0003-3171-3671"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Indira Tendolkar","raw_affiliation_strings":["Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038874292","display_name":"Barbara Franke","orcid":"https://orcid.org/0000-0003-4375-6572","observed_orcids":["https://orcid.org/0000-0003-4375-6572"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Barbara Franke","raw_affiliation_strings":["Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021197001","display_name":"Nina Roth Mota","orcid":"https://orcid.org/0000-0003-3504-759X","observed_orcids":["https://orcid.org/0000-0003-3504-759X"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nina Roth Mota","raw_affiliation_strings":["Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5065756495"],"corresponding_institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405261313"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":{"value":4330,"currency":"USD","value_usd":4330},"fwci":1.547,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82914791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"195","issue":"1","first_page":"e32951","last_page":"e32951"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.6620000004768372},{"id":"https://openalex.org/keywords/transdiagnostic-psychiatry","display_name":"transdiagnostic psychiatry","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dimensional-psychiatry","display_name":"dimensional psychiatry","score":0.7080000042915344},{"id":"https://openalex.org/keywords/research-domain-criteria","display_name":"Research Domain Criteria","score":0.9150000214576721},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6840000152587891},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7269999980926514},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.5879999995231628},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9919999837875366},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9909999966621399},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9120000004768372},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.9929999709129333},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.8809999823570251},{"id":"https://openalex.org/keywords/negative-valence-systems","display_name":"negative valence systems","score":0.8669999837875366},{"id":"https://openalex.org/keywords/social-sphere","display_name":"social sphere","score":0.414000004529953},{"id":"https://openalex.org/keywords/cognitive-domain","display_name":"cognitive domain","score":0.9509999752044678},{"id":"https://openalex.org/keywords/regulatory-regimes","display_name":"regulatory regimes","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6268688440322876},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.5463767647743225},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.49874353408813477},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.43645548820495605},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13482505083084106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08144450187683105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.045265793800354004},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011570","descriptor_name":"Psychiatry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011599","descriptor_name":"Psychopathology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/ajmg.b.32951","doi":"https://doi.org/10.1002/ajmg.b.32951","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.b.32951","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.32951","source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/2022.05.30.22275563","doi":"https://doi.org/10.1101/2022.05.30.22275563","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.05.30.22275563","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/05/31/2022.05.30.22275563.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:37334623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37334623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10803201","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10803201","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10803201/pdf/nihms-1952897.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Med Genet B Neuropsychiatr Genet","raw_type":"Text"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/301038","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2066/301038","pdf_url":"https://repository.ubn.ru.nl//bitstream/handle/2066/301038/301038.pdf","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1002/ajmg.b.32951","doi":"https://doi.org/10.1002/ajmg.b.32951","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.b.32951","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.32951","source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G120211565","display_name":"5/7 Psychiatric Genomics Consortium: Finding actionable variation","funder_award_id":"U01MH109514","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1571331078","display_name":null,"funder_award_id":"R344-2020-1060","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G1613426579","display_name":null,"funder_award_id":"667302","funder_id":"https://openalex.org/F4320311440","funder_display_name":"National Alliance for Research on Schizophrenia and Depression"},{"id":"https://openalex.org/G214445032","display_name":null,"funder_award_id":"R155-2014-1724","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G2783655308","display_name":null,"funder_award_id":"667302","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G3246699782","display_name":null,"funder_award_id":"R102\u2010A9118","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G352484845","display_name":null,"funder_award_id":"25034","funder_id":"https://openalex.org/F4320311440","funder_display_name":"National Alliance for Research on Schizophrenia and Depression"},{"id":"https://openalex.org/G3987400284","display_name":null,"funder_award_id":"R248\u20102017\u20102003","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G495187929","display_name":null,"funder_award_id":"EU\u2010H2020","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G5497799976","display_name":null,"funder_award_id":"R102-A9118, R155-2014-1724","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G6305174853","display_name":null,"funder_award_id":"and R248-2017-2003","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G6436024939","display_name":null,"funder_award_id":"NNF20OC0065561","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G6445013291","display_name":null,"funder_award_id":"847879","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G8306123767","display_name":null,"funder_award_id":"25034","funder_id":"https://openalex.org/F4320306147","funder_display_name":"Brain and Behavior Research Foundation"},{"id":"https://openalex.org/G84716273","display_name":null,"funder_award_id":"R102-A9118, R155-2014-1724, and R248-2017-2003","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G8858395165","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000900543","display_name":"2/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact","funder_award_id":"R01MH124851","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306147","display_name":"Brain and Behavior Research Foundation","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323698","display_name":"Radboud Universitair Medisch Centrum","ror":"https://ror.org/05wg1m734"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381140712.pdf","grobid_xml":"https://content.openalex.org/works/W4381140712.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1914301979","https://openalex.org/W1973792605","https://openalex.org/W1997338841","https://openalex.org/W2079375610","https://openalex.org/W2088477804","https://openalex.org/W2099231202","https://openalex.org/W2121487646","https://openalex.org/W2139852368","https://openalex.org/W2139870060","https://openalex.org/W2144044119","https://openalex.org/W2158282570","https://openalex.org/W2278265690","https://openalex.org/W2340656051","https://openalex.org/W2510973425","https://openalex.org/W2511515754","https://openalex.org/W2554593824","https://openalex.org/W2554756829","https://openalex.org/W2599264051","https://openalex.org/W2738082385","https://openalex.org/W2777388159","https://openalex.org/W2792082629","https://openalex.org/W2798099314","https://openalex.org/W2886752110","https://openalex.org/W2896481393","https://openalex.org/W2908945164","https://openalex.org/W2911487850","https://openalex.org/W2914482125","https://openalex.org/W2936793067","https://openalex.org/W2949479576","https://openalex.org/W2951553270","https://openalex.org/W2958615822","https://openalex.org/W2967846176","https://openalex.org/W2978740330","https://openalex.org/W2995971356","https://openalex.org/W3013660197","https://openalex.org/W3040213045","https://openalex.org/W3083437588","https://openalex.org/W3162259891","https://openalex.org/W3165642250","https://openalex.org/W3178295071","https://openalex.org/W3189197018","https://openalex.org/W3210901147","https://openalex.org/W4205415380","https://openalex.org/W4223520055","https://openalex.org/W4229010457","https://openalex.org/W4247665917","https://openalex.org/W4249930335","https://openalex.org/W4296843460","https://openalex.org/W4311347530"],"related_works":["https://openalex.org/W4411260254","https://openalex.org/W4316505388","https://openalex.org/W7119519449","https://openalex.org/W4414825524","https://openalex.org/W4403450345","https://openalex.org/W7213918291","https://openalex.org/W4285035039","https://openalex.org/W4414569249","https://openalex.org/W3024263474","https://openalex.org/W7143521402"],"abstract_inverted_index":{"Abstract":[0],"The":[1,48],"dense":[2],"co\u2010occurrence":[3],"of":[4,59,115,128,185,225,234,240],"psychiatric":[5,37,100,213,218,235,245],"disorders":[6,69,80,134],"questions":[7],"the":[8,31,126,140,150,160,166,173,182,205,209,216,223,226,231,238,241],"categorical":[9],"classification":[10],"tradition":[11],"and":[12,44,82,95,132,155,215,221,237],"motivates":[13],"efforts":[14],"to":[15,204],"establish":[16],"dimensional":[17,141,227],"constructs":[18],"with":[19,65,99,125],"neurobiological":[20],"foundations":[21],"that":[22],"transcend":[23],"diagnostic":[24],"boundaries.":[25],"In":[26,139],"this":[27],"study,":[28],"we":[29],"examined":[30],"genetic":[32,174,219,242],"liability":[33,243],"for":[34,120,176,244],"eight":[35],"major":[36,161],"disorder":[38,72],"phenotypes":[39],"under":[40],"both":[41,230],"a":[42,45,112],"disorder\u2010specific":[43],"transdiagnostic":[46],"framework.":[47,171],"study":[49,201],"sample":[50],"(":[51,135,189],"n":[52],"=":[53,192,195],"513)":[54],"was":[55,178],"deeply":[56],"phenotyped,":[57],"consisting":[58],"452":[60],"patients":[61,236],"from":[62,111],"tertiary":[63],"care":[64],"mood":[66,133],"disorders,":[67,76],"anxiety":[68],"(ANX),":[70],"attention\u2010deficit/hyperactivity":[71],"(ADHD),":[73],"autism":[74],"spectrum":[75],"and/or":[77],"substance":[78],"use":[79],"(SUD)":[81],"61":[83],"unaffected":[84],"comparison":[85],"individuals.":[86],"We":[87],"computed":[88],"subject\u2010specific":[89],"polygenic":[90],"risk":[91],"score":[92],"(PRS)":[93],"profiles":[94],"assessed":[96],"their":[97],"associations":[98],"diagnoses,":[101],"comorbidity":[102],"status,":[103],"as":[104,106],"well":[105],"cross\u2010disorder":[107],"behavioral":[108],"dimensions":[109],"derived":[110],"rich":[113],"battery":[114],"psychopathology":[116],"assessments.":[117],"High":[118],"PRSs":[119],"depression":[121,177],"were":[122,147],"unselectively":[123],"associated":[124],"diagnosis":[127],"SUD,":[129],"ADHD,":[130],"ANX,":[131],"p":[136,194],"<":[137],"1e\u20104).":[138],"approach,":[142],"four":[143],"distinct":[144],"functional":[145,162,183,232],"domains":[146,163],"uncovered,":[148],"namely":[149],"negative":[151,186],"valence,":[152],"social,":[153],"cognitive,":[154],"regulatory":[156],"systems,":[157],"closely":[158],"matching":[159],"proposed":[164],"by":[165],"Research":[167],"Domain":[168],"Criteria":[169],"(RDoC)":[170],"Critically,":[172],"predisposition":[175],"selectively":[179],"reflected":[180],"in":[181,229],"aspect":[184],"valence":[187],"systems":[188],"R":[190],"2":[191],"0.041,":[193],"5e\u20104)":[196],"but":[197],"not":[198],"others.":[199],"This":[200],"adds":[202],"evidence":[203],"ongoing":[206],"discussion":[207],"about":[208],"misalignment":[210],"between":[211],"current":[212],"nosology":[214],"underlying":[217],"etiology":[220],"underscores":[222],"effectiveness":[224],"approach":[228],"characterization":[233],"delineation":[239],"disorders.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-06-19T00:00:00"}