{"id":"https://openalex.org/W4381136734","doi":"https://doi.org/10.1002/jcp.31053","title":"The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targets","display_name":"The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targets","publication_year":2023,"publication_date":"2023-06-18","ids":{"openalex":"https://openalex.org/W4381136734","doi":"https://doi.org/10.1002/jcp.31053","pmid":"https://pubmed.ncbi.nlm.nih.gov/37334436"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.31053","doi":"https://doi.org/10.1002/jcp.31053","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.31053","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.31053","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4381136734"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.31053","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100454007","display_name":"Jie Liu","orcid":"https://orcid.org/0000-0001-6420-5177","observed_orcids":["https://orcid.org/0000-0001-6420-5177"]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Liu","raw_affiliation_strings":["Department of Dermatology, Skin Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Skin Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087256898","display_name":"Yongli Pan","orcid":"https://orcid.org/0000-0003-0473-3773","observed_orcids":["https://orcid.org/0000-0003-0473-3773"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yongli Pan","raw_affiliation_strings":["Department of Neurology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100743965","display_name":"Yuheng Liu","orcid":"https://orcid.org/0000-0001-5007-8533","observed_orcids":["https://orcid.org/0000-0001-5007-8533"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yuheng Liu","raw_affiliation_strings":["Department of Neurology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323729","display_name":"Wei Wei","orcid":"https://orcid.org/0000-0001-7843-6697","observed_orcids":["https://orcid.org/0000-0001-7843-6697"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wei Wei","raw_affiliation_strings":["Department of Neurology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoping Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoping Hu","raw_affiliation_strings":["Department of Dermatology, Skin Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Skin Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054866933","display_name":"Wenqiang Xin","orcid":"https://orcid.org/0000-0003-0231-6474","observed_orcids":["https://orcid.org/0000-0003-0231-6474"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wenqiang Xin","raw_affiliation_strings":["Department of Neurology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"],"raw_orcid":"https://orcid.org/0000-0003-0231-6474","affiliations":[{"raw_affiliation_string":"Department of Neurology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100442842","display_name":"Nan Chen","orcid":"https://orcid.org/0000-0001-8536-6631","observed_orcids":["https://orcid.org/0000-0001-8536-6631"]},"institutions":[{"id":"https://openalex.org/I4210160222","display_name":"Liaocheng People's Hospital","ror":"https://ror.org/052vn2478","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Nan Chen","raw_affiliation_strings":["Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng, China","institution_ids":["https://openalex.org/I4210160222"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100442842"],"corresponding_institution_ids":["https://openalex.org/I4210160222"],"apc_list":{"value":4940,"currency":"USD","value_usd":4940},"apc_paid":null,"fwci":0.6132,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.54395846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"238","issue":"8","first_page":"1693","last_page":"1715"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphatase-and-tensin-homolog","display_name":"phosphatase and tensin homolog","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8169999718666077},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.8980000019073486},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8679999709129333},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pten-mutation","display_name":"PTEN mutation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9869984984397888},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.8634870648384094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6429917812347412},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6293110847473145},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5428540706634521},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5350094437599182},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5094748139381409},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4532533288002014},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4346558153629303},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4191567897796631},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3531181812286377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35041290521621704},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3154216408729553},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2401120960712433},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.15036413073539734}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcp.31053","doi":"https://doi.org/10.1002/jcp.31053","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.31053","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.31053","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:37334436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37334436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/129127","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/129127","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal_article"}],"best_oa_location":{"id":"doi:10.1002/jcp.31053","doi":"https://doi.org/10.1002/jcp.31053","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.31053","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.31053","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381136734.pdf","grobid_xml":"https://content.openalex.org/works/W4381136734.grobid-xml"},"referenced_works_count":218,"referenced_works":["https://openalex.org/W10386318","https://openalex.org/W1526822145","https://openalex.org/W1531960008","https://openalex.org/W1582495617","https://openalex.org/W1752845679","https://openalex.org/W1756183899","https://openalex.org/W1927479387","https://openalex.org/W1935114338","https://openalex.org/W1939083266","https://openalex.org/W1964472375","https://openalex.org/W1965090530","https://openalex.org/W1966498224","https://openalex.org/W1968107667","https://openalex.org/W1972718275","https://openalex.org/W1979348895","https://openalex.org/W1984418041","https://openalex.org/W1988141599","https://openalex.org/W1988609792","https://openalex.org/W1988769784","https://openalex.org/W1989418405","https://openalex.org/W1990354097","https://openalex.org/W1991050083","https://openalex.org/W1991867384","https://openalex.org/W1992976746","https://openalex.org/W1996222881","https://openalex.org/W1996762696","https://openalex.org/W1999962445","https://openalex.org/W2005448885","https://openalex.org/W2006078179","https://openalex.org/W2006492820","https://openalex.org/W2010784970","https://openalex.org/W2011369410","https://openalex.org/W2013537373","https://openalex.org/W2014226478","https://openalex.org/W2014409330","https://openalex.org/W2017739035","https://openalex.org/W2020059026","https://openalex.org/W2020902595","https://openalex.org/W2021346058","https://openalex.org/W2022257653","https://openalex.org/W2025188980","https://openalex.org/W2025319925","https://openalex.org/W2026890342","https://openalex.org/W2028994134","https://openalex.org/W2029166421","https://openalex.org/W2029903254","https://openalex.org/W2031861741","https://openalex.org/W2033790217","https://openalex.org/W2035437790","https://openalex.org/W2036262371","https://openalex.org/W2038141559","https://openalex.org/W2039589725","https://openalex.org/W2039913198","https://openalex.org/W2040923206","https://openalex.org/W2043297692","https://openalex.org/W2043927273","https://openalex.org/W2047352825","https://openalex.org/W2048581134","https://openalex.org/W2048910214","https://openalex.org/W2049205984","https://openalex.org/W2049400611","https://openalex.org/W2060271784","https://openalex.org/W2064591654","https://openalex.org/W2066035908","https://openalex.org/W2067342462","https://openalex.org/W2067576594","https://openalex.org/W2067751798","https://openalex.org/W2067946759","https://openalex.org/W2070634275","https://openalex.org/W2074320863","https://openalex.org/W2074994749","https://openalex.org/W2075514051","https://openalex.org/W2076627331","https://openalex.org/W2077224617","https://openalex.org/W2078590818","https://openalex.org/W2080569014","https://openalex.org/W2083879234","https://openalex.org/W2083891373","https://openalex.org/W2086281394","https://openalex.org/W2086750497","https://openalex.org/W2086791464","https://openalex.org/W2087005086","https://openalex.org/W2087949287","https://openalex.org/W2094215712","https://openalex.org/W2097881410","https://openalex.org/W2099658407","https://openalex.org/W2102992903","https://openalex.org/W2103263826","https://openalex.org/W2107661677","https://openalex.org/W2109559424","https://openalex.org/W2111628123","https://openalex.org/W2112119769","https://openalex.org/W2117497402","https://openalex.org/W2119060677","https://openalex.org/W2119186515","https://openalex.org/W2120526616","https://openalex.org/W2124277850","https://openalex.org/W2125083914","https://openalex.org/W2127856718","https://openalex.org/W2129227644","https://openalex.org/W2129288956","https://openalex.org/W2131234404","https://openalex.org/W2131670056","https://openalex.org/W2136095930","https://openalex.org/W2136528920","https://openalex.org/W2140864342","https://openalex.org/W2141134269","https://openalex.org/W2142507343","https://openalex.org/W2142627514","https://openalex.org/W2143945587","https://openalex.org/W2148181678","https://openalex.org/W2148549145","https://openalex.org/W2150233389","https://openalex.org/W2150798124","https://openalex.org/W2151258296","https://openalex.org/W2152127384","https://openalex.org/W2153096480","https://openalex.org/W2153672941","https://openalex.org/W2154871907","https://openalex.org/W2156554006","https://openalex.org/W2156583045","https://openalex.org/W2158305336","https://openalex.org/W2158789461","https://openalex.org/W2159750196","https://openalex.org/W2161810908","https://openalex.org/W2162128794","https://openalex.org/W2162409477","https://openalex.org/W2162584257","https://openalex.org/W2165404212","https://openalex.org/W2167715370","https://openalex.org/W2170296344","https://openalex.org/W2171548830","https://openalex.org/W2171972386","https://openalex.org/W2173438131","https://openalex.org/W2176365353","https://openalex.org/W2213710063","https://openalex.org/W2315340994","https://openalex.org/W2328582512","https://openalex.org/W2374061524","https://openalex.org/W2384762556","https://openalex.org/W2410522613","https://openalex.org/W2413334570","https://openalex.org/W2432305911","https://openalex.org/W2529025963","https://openalex.org/W2550790189","https://openalex.org/W2553193004","https://openalex.org/W2557504094","https://openalex.org/W2576977194","https://openalex.org/W2580196525","https://openalex.org/W2587922577","https://openalex.org/W2592488370","https://openalex.org/W2594369714","https://openalex.org/W2594950847","https://openalex.org/W2600686170","https://openalex.org/W2605257455","https://openalex.org/W2614965957","https://openalex.org/W2732699482","https://openalex.org/W2743781704","https://openalex.org/W2746335001","https://openalex.org/W2754867682","https://openalex.org/W2759401232","https://openalex.org/W2766762285","https://openalex.org/W2767199072","https://openalex.org/W2769677993","https://openalex.org/W2772779917","https://openalex.org/W2773770165","https://openalex.org/W2788783025","https://openalex.org/W2792557374","https://openalex.org/W2796320234","https://openalex.org/W2810660714","https://openalex.org/W2883184095","https://openalex.org/W2883279334","https://openalex.org/W2883694743","https://openalex.org/W2887790253","https://openalex.org/W2891861371","https://openalex.org/W2896196924","https://openalex.org/W2901146277","https://openalex.org/W2913168520","https://openalex.org/W2924680674","https://openalex.org/W2934866207","https://openalex.org/W2939564206","https://openalex.org/W2945658350","https://openalex.org/W2947333108","https://openalex.org/W2953064112","https://openalex.org/W2967469449","https://openalex.org/W2969167544","https://openalex.org/W2972680580","https://openalex.org/W2972978175","https://openalex.org/W2984867222","https://openalex.org/W2985172783","https://openalex.org/W2986335853","https://openalex.org/W2994693285","https://openalex.org/W2997205599","https://openalex.org/W2999607433","https://openalex.org/W3001169602","https://openalex.org/W3007063303","https://openalex.org/W3012215321","https://openalex.org/W3015301267","https://openalex.org/W3018415286","https://openalex.org/W3027948868","https://openalex.org/W3034226330","https://openalex.org/W3046734733","https://openalex.org/W3073158550","https://openalex.org/W3082323898","https://openalex.org/W3082666061","https://openalex.org/W3126201942","https://openalex.org/W3137335307","https://openalex.org/W3189341011","https://openalex.org/W3206021083","https://openalex.org/W4205399187","https://openalex.org/W4221006434","https://openalex.org/W4225285753","https://openalex.org/W4226339216","https://openalex.org/W4243930828","https://openalex.org/W4247972276","https://openalex.org/W4253494562","https://openalex.org/W4297001205","https://openalex.org/W4310057048"],"related_works":["https://openalex.org/W2773474457","https://openalex.org/W2017739035","https://openalex.org/W1734521060","https://openalex.org/W2353488838","https://openalex.org/W2118263932","https://openalex.org/W4413779930","https://openalex.org/W2109559424","https://openalex.org/W4403733639","https://openalex.org/W2010784970","https://openalex.org/W2064220189"],"abstract_inverted_index":{"This":[0,140],"review":[1,141],"summarizes":[2],"the":[3,6,29,53,58,109,114,128,143,162],"implications":[4],"of":[5,31,68,113,124,146],"primary":[7],"tumor":[8,155],"suppressor":[9],"protein":[10],"phosphatase":[11],"and":[12,48,56,94,100,111,132,149],"tensin":[13],"homolog":[14],"(PTEN)":[15],"in":[16,52,57,106,127,134,154],"aggressive":[17],"cancer":[18,135],"development.":[19],"PTEN":[20,46,60,86,107,115,129,147,152],"interacts":[21],"with":[22],"other":[23],"cellular":[24],"proteins":[25],"or":[26,122],"factors":[27],"suggesting":[28],"existence":[30],"an":[32],"intricate":[33],"molecular":[34],"network":[35],"that":[36,45,85],"regulates":[37],"their":[38],"oncogenic":[39],"function.":[40,81],"Accumulating":[41],"evidence":[42],"has":[43],"shown":[44,84],"exists":[47],"plays":[49],"a":[50],"role":[51],"cytoplasmic":[54],"organelles":[55],"nucleus.":[59],"blocks":[61],"phosphoinositide":[62],"3-kinases":[63],"(PI3K)-protein":[64],"kinase":[65],"B-mammalian":[66],"target":[67],"rapamycin":[69],"signaling":[70],"pathway":[71],"by":[72],"dephosphorylating":[73],"phosphatidylinositol":[74],"(PI)-3,4,5-triphosphate":[75],"to":[76],"PI-4,5-bisphosphate":[77],"thus":[78],"counteracting":[79],"PI3K":[80],"Studies":[82],"have":[83],"expression":[87,148],"is":[88,137],"tightly":[89],"regulated":[90],"at":[91],"transcriptional,":[92],"posttranscriptional,":[93],"posttranslational":[95,101],"levels":[96],"(including":[97],"protein-protein":[98],"interactions":[99],"modifications).":[102],"Despite":[103],"recent":[104],"advances":[105],"research,":[108],"regulation":[110],"function":[112],"gene":[116,130],"remain":[117],"largely":[118],"unknown.":[119],"How":[120],"mutation":[121],"loss":[123],"specific":[125],"exons":[126],"occurs":[131],"involves":[133],"development":[136,156],"not":[138],"clear.":[139],"illustrates":[142],"regulatory":[144],"mechanisms":[145],"discusses":[150],"how":[151],"participates":[153],"and/or":[157],"suppression.":[158],"Future":[159],"prospects":[160],"for":[161],"clinical":[163],"applications":[164],"are":[165],"also":[166],"highlighted.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-06-19T00:00:00"}