{"id":"https://openalex.org/W4381050719","doi":"https://doi.org/10.14715/cmb/2023.69.4.9","title":"Effects of Pyrroloquinoline Quinone (PQQ) and Coenzyme Q10 on mitochondrial genes, mitomiRs and cellular properties in HepG2 cell line","display_name":"Effects of Pyrroloquinoline Quinone (PQQ) and Coenzyme Q10 on mitochondrial genes, mitomiRs and cellular properties in HepG2 cell line","publication_year":2023,"publication_date":"2023-04-30","ids":{"openalex":"https://openalex.org/W4381050719","doi":"https://doi.org/10.14715/cmb/2023.69.4.9","pmid":"https://pubmed.ncbi.nlm.nih.gov/37329547"},"language":"en","primary_location":{"id":"doi:10.14715/cmb/2023.69.4.9","doi":"https://doi.org/10.14715/cmb/2023.69.4.9","is_oa":true,"landing_page_url":"https://doi.org/10.14715/cmb/2023.69.4.9","pdf_url":"https://cellmolbiol.org/index.php/CMB/article/download/4741/2466","source":{"id":"https://openalex.org/S21749381","display_name":"Cellular and Molecular Biology","issn_l":"0145-5680","issn":["0145-5680","1165-158X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322765267","host_organization_name":"Cellular and Molecular Biology Association","host_organization_lineage":["https://openalex.org/P4322765267"],"host_organization_lineage_names":["Cellular and Molecular Biology Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://cellmolbiol.org/index.php/CMB/article/download/4741/2466","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018883605","display_name":"Muhammed Ali Nalbant","orcid":"https://orcid.org/0000-0002-4713-1492","observed_orcids":["https://orcid.org/0000-0002-4713-1492"]},"institutions":[{"id":"https://openalex.org/I169255954","display_name":"Bilecik \u015eeyh Edebali \u00dcniversitesi","ror":"https://ror.org/00dzfx204","country_code":"TR","type":"education","lineage":["https://openalex.org/I169255954"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Muhammed Ali  Nalbant","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Graduate Education Institute, Bilecik Seyh Edebali University, Bilecik, Turkey. mnalbant@bandirma.edu.tr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Graduate Education Institute, Bilecik Seyh Edebali University, Bilecik, Turkey. mnalbant@bandirma.edu.tr","institution_ids":["https://openalex.org/I169255954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028982308","display_name":"Onur Ero\u011flu","orcid":"https://orcid.org/0000-0002-3451-8540","observed_orcids":["https://orcid.org/0000-0002-3451-8540"]},"institutions":[{"id":"https://openalex.org/I169255954","display_name":"Bilecik \u015eeyh Edebali \u00dcniversitesi","ror":"https://ror.org/00dzfx204","country_code":"TR","type":"education","lineage":["https://openalex.org/I169255954"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Onur  Ero\u011flu","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science, Bilecik Seyh Edebali University, Bilecik, Turkey. onur.eroglu@bilecik.edu.tr","Biotechnology Research and Application Center, Bilecik \u015eeyh Edebali University, Bilecik, Turkey","Department of Molecular Biology and Genetics, Faculty of Science, Bilecik Seyh Edebali University, Bilecik, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Bilecik Seyh Edebali University, Bilecik, Turkey. onur.eroglu@bilecik.edu.tr","institution_ids":["https://openalex.org/I169255954"]},{"raw_affiliation_string":"Biotechnology Research and Application Center, Bilecik \u015eeyh Edebali University, Bilecik, Turkey","institution_ids":["https://openalex.org/I169255954"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Bilecik Seyh Edebali University, Bilecik, Turkey","institution_ids":["https://openalex.org/I169255954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I169255954"],"apc_list":null,"apc_paid":null,"fwci":0.3961,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.48182253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"69","issue":"4","first_page":"60","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrroloquinoline-quinone","display_name":"pyrroloquinoline quinone","score":0.996999979019165},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7799999713897705},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5320000052452087},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mir-15a","display_name":"miR-15a","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mir-16-1","display_name":"miR-16-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/mir-181c","display_name":"miR-181c","score":1.0},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6510000228881836},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/antioxidant-metabolism","display_name":"antioxidant metabolism","score":0.4830000102519989},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2778682154","wikidata":"https://www.wikidata.org/wiki/Q414583","display_name":"Pyrroloquinoline quinone","level":4,"score":0.9761074781417847},{"id":"https://openalex.org/C2779384338","wikidata":"https://www.wikidata.org/wiki/Q321285","display_name":"Coenzyme Q10","level":2,"score":0.8674596548080444},{"id":"https://openalex.org/C2780643102","wikidata":"https://www.wikidata.org/wiki/Q412382","display_name":"Quinone","level":2,"score":0.5699597001075745},{"id":"https://openalex.org/C14471203","wikidata":"https://www.wikidata.org/wiki/Q412832","display_name":"Coenzyme Q \u2013 cytochrome c reductase","level":4,"score":0.555614173412323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5318773984909058},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49894046783447266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49093344807624817},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.46749889850616455},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.46433910727500916},{"id":"https://openalex.org/C198352243","wikidata":"https://www.wikidata.org/wiki/Q37105","display_name":"Line (geometry)","level":2,"score":0.4163590371608734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36319130659103394},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35134562849998474},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15379461646080017},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.10988855361938477},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045542","descriptor_name":"PQQ Cofactor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045542","descriptor_name":"PQQ Cofactor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045542","descriptor_name":"PQQ Cofactor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050259","descriptor_name":"Genes, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.14715/cmb/2023.69.4.9","doi":"https://doi.org/10.14715/cmb/2023.69.4.9","is_oa":true,"landing_page_url":"https://doi.org/10.14715/cmb/2023.69.4.9","pdf_url":"https://cellmolbiol.org/index.php/CMB/article/download/4741/2466","source":{"id":"https://openalex.org/S21749381","display_name":"Cellular and Molecular Biology","issn_l":"0145-5680","issn":["0145-5680","1165-158X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322765267","host_organization_name":"Cellular and Molecular Biology Association","host_organization_lineage":["https://openalex.org/P4322765267"],"host_organization_lineage_names":["Cellular and Molecular Biology Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:37329547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37329547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},{"id":"pmh:oai:acikkaynak.bilecik.edu.tr:11552/3138","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11552/3138","pdf_url":"https://acikkaynak.bilecik.edu.tr/bitstreams/174967c0-17e8-4ecf-8d34-abd2c412e49a/download","source":{"id":"https://openalex.org/S7407055253","display_name":"Bilecik \u015eeyh Edebali University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},{"id":"pmh:oai:acikkaynak.bilecik.edu.tr:11552/3139","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11552/3139","pdf_url":"https://acikkaynak.bilecik.edu.tr/bitstreams/83bcb387-c62a-4dd3-9171-7fc61bac2d54/download","source":{"id":"https://openalex.org/S7407055253","display_name":"Bilecik \u015eeyh Edebali University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.14715/cmb/2023.69.4.9","doi":"https://doi.org/10.14715/cmb/2023.69.4.9","is_oa":true,"landing_page_url":"https://doi.org/10.14715/cmb/2023.69.4.9","pdf_url":"https://cellmolbiol.org/index.php/CMB/article/download/4741/2466","source":{"id":"https://openalex.org/S21749381","display_name":"Cellular and Molecular Biology","issn_l":"0145-5680","issn":["0145-5680","1165-158X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322765267","host_organization_name":"Cellular and Molecular Biology Association","host_organization_lineage":["https://openalex.org/P4322765267"],"host_organization_lineage_names":["Cellular and Molecular Biology Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381050719.pdf","grobid_xml":"https://content.openalex.org/works/W4381050719.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1970938389","https://openalex.org/W1997873957","https://openalex.org/W2123988303","https://openalex.org/W2153850374","https://openalex.org/W2155446034","https://openalex.org/W2166513441","https://openalex.org/W2323660874","https://openalex.org/W2593836423","https://openalex.org/W2774112395","https://openalex.org/W2902057744","https://openalex.org/W3002156037","https://openalex.org/W3006824993","https://openalex.org/W3025507183","https://openalex.org/W3176229378","https://openalex.org/W3202131782","https://openalex.org/W3205356733","https://openalex.org/W3215328491","https://openalex.org/W4244540255","https://openalex.org/W4292354307"],"related_works":["https://openalex.org/W4386193627","https://openalex.org/W2094439413","https://openalex.org/W2917445748","https://openalex.org/W2037309129","https://openalex.org/W2569582079","https://openalex.org/W3182264094","https://openalex.org/W2964111184","https://openalex.org/W2046994482","https://openalex.org/W4239738909","https://openalex.org/W2773585178"],"abstract_inverted_index":{"Our":[0],"study":[1],"aimed":[2],"to":[3,109,135,190,216],"reveal":[4],"the":[5,48,78,90,100,105,110,113,127,136,154,181,185,191,208,225],"effects":[6,49,62],"and":[7,17,34,36,54,60,71,122,131,149,200,221,231,238,247,256],"changes,":[8],"antioxidant":[9],"metabolism":[10],"(Oxidative":[11],"Stress),":[12],"inflammatory":[13],"response,":[14],"mitochondrial":[15,18,260],"biogenesis":[16],"dysfunction":[19],"characteristics":[20],"in":[21,29,58,85,153,178,184,207,253],"hepatocellular":[22,254],"carcinoma":[23,255],"cell":[24,64,67,132,156],"line":[25,157],"HepG2;":[26],"that":[27,41,119,146,196],"occur":[28],"genes":[30],"(NRF-1,":[31],"NRF-2,":[32],"NF\u03baB":[33],"PGC-1\u03b1)":[35],"miRNAs":[37],"(miR15-a,":[38],"miR16-1,":[39,229],"miR181-c)":[40],"can":[42,96],"control":[43,137,192],"related":[44],"features.":[45],"To":[46],"investigate":[47],"of":[50,87,94,112,180,228,235],"Pyrroloquinoline":[51,120,147,186,198,219,236],"quinone":[52,121,148,187,199,220,237],"(PQQ)":[53],"Coenzyme":[55,150],"Q10":[56,151],"(CoQ10)":[57],"HepG2,":[59],"their":[61],"on":[63,242],"viability,":[65],"lateral":[66],"migration,":[68],"gene":[69,170,183,214],"expression":[70,73,166,179,205,226],"miRNA":[72],"levels":[74,227],"were":[75],"investigated.":[76],"If":[77],"data":[79],"we":[80,117],"have":[81],"obtained":[82],"are":[83,249],"evaluated":[84],"terms":[86],"anti-cancer":[88],"effectiveness,":[89],"most":[91],"effective":[92,241],"use":[93,101,234],"CoQ10":[95,140,201,222,239],"be":[97],"defined":[98],"as":[99],"alone":[102],"rather":[103],"than":[104],"combined":[106,123,217],"use.":[107],"According":[108],"results":[111],"wound":[114,128],"healing":[115],"experiment,":[116],"determined":[118],"drug":[124],"application":[125,141,188,202],"increased":[126,158],"closure":[129],"area":[130],"proliferation":[133],"compared":[134,189,215],"group,":[138],"while":[139],"decreased":[142],"it.":[143],"We":[144,172,194],"found":[145,195],"exposure":[152],"HepG2":[155],"Peroxisome":[159],"proliferator-activated":[160],"receptor":[161],"gamma":[162],"coactivator":[163],"1-alpha":[164],"(PGC-1\u03b1)":[165],"but":[167],"not":[168],"NRF-1":[169],"expression.":[171],"reported":[173],"only":[174,197],"a":[175],"small":[176],"increase":[177,206],"NRF-2":[182],"group.":[193],"caused":[203],"more":[204],"Nuclear":[209],"Factor":[210],"kappa":[211],"B":[212],"(NF\u03baB)":[213],"application.":[218],"administration":[223],"down-regulated":[224],"miR15a":[230],"miR181c.":[232],"The":[233],"is":[240],"epigenetic":[243],"factors,":[244],"miR-15a,":[245],"miR-16-1":[246],"miR181c":[248],"important":[250],"candidate":[251],"biomarkers":[252],"diseases":[257],"accompanied":[258],"by":[259],"dysfunction.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-18T00:00:00"}