{"id":"https://openalex.org/W4380985673","doi":"https://doi.org/10.1515/cmb-2022-0148","title":"A comprehensive and detailed within-host modeling study involving crucial biomarkers and optimal drug regimen for type I Lepra reaction: A deterministic approach","display_name":"A comprehensive and detailed within-host modeling study involving crucial biomarkers and optimal drug regimen for type I Lepra reaction: A deterministic approach","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4380985673","doi":"https://doi.org/10.1515/cmb-2022-0148"},"language":"en","primary_location":{"id":"doi:10.1515/cmb-2022-0148","doi":"https://doi.org/10.1515/cmb-2022-0148","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cmb-2022-0148","pdf_url":"https://www.degruyter.com/document/doi/10.1515/cmb-2022-0148/pdf","source":{"id":"https://openalex.org/S4210220302","display_name":"Computational and Mathematical Biophysics","issn_l":"2544-7297","issn":["2544-7297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.degruyter.com/document/doi/10.1515/cmb-2022-0148/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Dinesh Nayak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4819740","display_name":"Sri Sathya Sai Institute of Higher Learning","ror":"https://ror.org/05arzt710","country_code":"IN","type":"education","lineage":["https://openalex.org/I4819740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dinesh Nayak","raw_affiliation_strings":["Department of Mathematics and Computer Science, Sri Sathya Sai Institute of Higher Learning - SSSIHL , Puttaparthi , 515134 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Sri Sathya Sai Institute of Higher Learning - SSSIHL , Puttaparthi , 515134 , India","institution_ids":["https://openalex.org/I4819740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110734312","display_name":"Bishal Chhetri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4819740","display_name":"Sri Sathya Sai Institute of Higher Learning","ror":"https://ror.org/05arzt710","country_code":"IN","type":"education","lineage":["https://openalex.org/I4819740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bishal Chhetri","raw_affiliation_strings":["Department of Mathematics and Computer Science, Sri Sathya Sai Institute of Higher Learning - SSSIHL , Puttaparthi , 515134 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Sri Sathya Sai Institute of Higher Learning - SSSIHL , Puttaparthi , 515134 , India","institution_ids":["https://openalex.org/I4819740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032064123","display_name":"Krishna Kiran Vamsi Dasu","orcid":"https://orcid.org/0000-0002-1296-0135","observed_orcids":["https://orcid.org/0000-0002-1296-0135"]},"institutions":[{"id":"https://openalex.org/I4819740","display_name":"Sri Sathya Sai Institute of Higher Learning","ror":"https://ror.org/05arzt710","country_code":"IN","type":"education","lineage":["https://openalex.org/I4819740"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Krishna Kiran Vamsi Dasu","raw_affiliation_strings":["Department of Mathematics and Computer Science, Sri Sathya Sai Institute of Higher Learning - SSSIHL , Puttaparthi , 515134 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Sri Sathya Sai Institute of Higher Learning - SSSIHL , Puttaparthi , 515134 , India","institution_ids":["https://openalex.org/I4819740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114036745","display_name":"Swapna Muthusamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163634","display_name":"Central Leprosy Teaching & Research Institute","ror":"https://ror.org/058t40d22","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I4210163634"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Swapna Muthusamy","raw_affiliation_strings":["Central Leprosy Teaching and Research Institute - CLTRI , Chennai , 603001 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Leprosy Teaching and Research Institute - CLTRI , Chennai , 603001 , India","institution_ids":["https://openalex.org/I4210163634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030587795","display_name":"Vijay Manohar Bhagat","orcid":"https://orcid.org/0000-0003-4852-2388","observed_orcids":["https://orcid.org/0000-0003-4852-2388"]},"institutions":[{"id":"https://openalex.org/I4210163634","display_name":"Central Leprosy Teaching & Research Institute","ror":"https://ror.org/058t40d22","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I4210163634"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijay M. Bhagat","raw_affiliation_strings":["Central Leprosy Teaching and Research Institute - CLTRI , Chennai , 603001 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Leprosy Teaching and Research Institute - CLTRI , Chennai , 603001 , India","institution_ids":["https://openalex.org/I4210163634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032064123"],"corresponding_institution_ids":["https://openalex.org/I4819740"],"apc_list":{"value":500,"currency":"EUR","value_usd":541},"apc_paid":{"value":500,"currency":"EUR","value_usd":541},"fwci":0.963,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70686116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.19179999828338623,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leprosy","display_name":"leprosy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/leprosy-reactions","display_name":"leprosy reactions","score":0.6290000081062317},{"id":"https://openalex.org/keywords/mycobacterium-leprae","display_name":"Mycobacterium leprae","score":0.9559999704360962},{"id":"https://openalex.org/keywords/within-host-dynamics","display_name":"within-host dynamics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bacterial-load","display_name":"bacterial load","score":0.925000011920929},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8870000243186951},{"id":"https://openalex.org/keywords/multidrug-therapy","display_name":"multidrug therapy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.7200000286102295},{"id":"https://openalex.org/keywords/sensitivity-analysis","display_name":"sensitivity analysis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/optimal-control","display_name":"optimal control","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2780695269","wikidata":"https://www.wikidata.org/wiki/Q36956","display_name":"Leprosy","level":2,"score":0.9160878658294678},{"id":"https://openalex.org/C2779823659","wikidata":"https://www.wikidata.org/wiki/Q155891","display_name":"Mycobacterium leprae","level":3,"score":0.806574821472168},{"id":"https://openalex.org/C101601086","wikidata":"https://www.wikidata.org/wiki/Q3753228","display_name":"Rank correlation","level":2,"score":0.5002021789550781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45968765020370483},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4380505084991455},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42729777097702026},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.42285606265068054},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4119794964790344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35356202721595764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19866803288459778},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19379815459251404},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15450650453567505},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1515/cmb-2022-0148","doi":"https://doi.org/10.1515/cmb-2022-0148","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cmb-2022-0148","pdf_url":"https://www.degruyter.com/document/doi/10.1515/cmb-2022-0148/pdf","source":{"id":"https://openalex.org/S4210220302","display_name":"Computational and Mathematical Biophysics","issn_l":"2544-7297","issn":["2544-7297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Biophysics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:29d01424425241cf874968f35a8acbb3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29d01424425241cf874968f35a8acbb3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Biophysics, Vol 11, Iss 1, Pp 124-243 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1515/cmb-2022-0148","doi":"https://doi.org/10.1515/cmb-2022-0148","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cmb-2022-0148","pdf_url":"https://www.degruyter.com/document/doi/10.1515/cmb-2022-0148/pdf","source":{"id":"https://openalex.org/S4210220302","display_name":"Computational and Mathematical Biophysics","issn_l":"2544-7297","issn":["2544-7297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Biophysics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380985673.pdf","grobid_xml":"https://content.openalex.org/works/W4380985673.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W45095440","https://openalex.org/W100464641","https://openalex.org/W155774906","https://openalex.org/W231975775","https://openalex.org/W288518295","https://openalex.org/W636564734","https://openalex.org/W1590063568","https://openalex.org/W1967940959","https://openalex.org/W1983611862","https://openalex.org/W1991209510","https://openalex.org/W1997646294","https://openalex.org/W2027011292","https://openalex.org/W2068604088","https://openalex.org/W2133748545","https://openalex.org/W2135326309","https://openalex.org/W2152803686","https://openalex.org/W2166565152","https://openalex.org/W2167267514","https://openalex.org/W2185118429","https://openalex.org/W2310586291","https://openalex.org/W2318260335","https://openalex.org/W2482777629","https://openalex.org/W2562621580","https://openalex.org/W2613166940","https://openalex.org/W2691066536","https://openalex.org/W2906800789","https://openalex.org/W3004586170","https://openalex.org/W3015016248","https://openalex.org/W3135275056","https://openalex.org/W3135791089","https://openalex.org/W3173884601","https://openalex.org/W3176025822","https://openalex.org/W3183139552","https://openalex.org/W4205904762","https://openalex.org/W4285280406","https://openalex.org/W4292429694","https://openalex.org/W4298426639"],"related_works":["https://openalex.org/W4301048565","https://openalex.org/W4312360002","https://openalex.org/W4391860310","https://openalex.org/W3176025822","https://openalex.org/W4407057869","https://openalex.org/W4396913415","https://openalex.org/W4366257097","https://openalex.org/W7204833195","https://openalex.org/W7162331652","https://openalex.org/W4387104786"],"abstract_inverted_index":{"Abstract":[0],"Leprosy":[1],"(Hansen\u2019s":[2],"disease)":[3],"is":[4],"an":[5,29],"infectious,":[6],"neglected":[7],"tropical":[8],"disease":[9],"caused":[10],"by":[11,57],"the":[12,48,74,84,89,95,103,122,139],"Mycobacterium":[13],"Leprae":[14],"(M.":[15],"Leprae).":[16],"About":[17],"2,02,189":[18],"new":[19],"cases":[20],"are":[21,28],"diagnosed":[22],"worldwide":[23],"each":[24],"year.":[25],"Lepra":[26],"reactions":[27,46],"off":[30],"shoot":[31],"of":[32,44,50,76,91,144],"leprosy":[33],"infection":[34],"causing":[35],"major":[36],"nerve":[37],"damage":[38],"leading":[39],"to":[40,72],"disability.":[41],"Early":[42],"detection":[43],"lepra":[45],"through":[47],"study":[49,143],"biomarkers":[51],"can":[52],"prevent":[53],"subsequent":[54],"disabilities.":[55],"Motivated":[56],"these":[58,145],"observations,":[59],"in":[60],"this":[61],"study,":[62],"we":[63,137],"have":[64],"proposed":[65],"and":[66,83,100,115,130,141],"analyzed":[67],"a":[68],"three-dimensional":[69],"mathematical":[70],"model":[71],"capture":[73],"dynamics":[75],"susceptible":[77],"schwann":[78,81],"cells,":[79,82],"infected":[80],"bacterial":[85],"load":[86],"based":[87],"on":[88],"pathogenesis":[90],"leprosy.":[92],"We":[93,119],"did":[94,138],"stability":[96],"analysis,":[97],"numerical":[98],"simulations,":[99],"also":[101],"performed":[102,121],"sensitivity":[104],"analysis":[105],"using":[106],"Spearman\u2019s":[107],"rank":[108,112],"correlation":[109,113],"coefficient,":[110,114],"partial":[111],"Sobol\u2019s":[116],"index":[117],"methods.":[118],"later":[120],"optimal":[123],"control":[124,134,147],"studies":[125],"with":[126],"both":[127],"multi-drug":[128],"therapy":[129],"steroid":[131],"interventions":[132],"as":[133],"variables.":[135],"Finally,":[136],"comparative":[140],"effectiveness":[142],"different":[146],"interventions.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-06-17T00:00:00"}
