{"id":"https://openalex.org/W4380880342","doi":"https://doi.org/10.1002/alz.062515","title":"Re\u2010evaluation of the genetic role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late\u2010onset Alzheimer disease","display_name":"Re\u2010evaluation of the genetic role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late\u2010onset Alzheimer disease","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4380880342","doi":"https://doi.org/10.1002/alz.062515"},"language":"en","primary_location":{"id":"doi:10.1002/alz.062515","doi":"https://doi.org/10.1002/alz.062515","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.062515","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.062515","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.062515","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027449459","display_name":"Kang-Hsien Fan","orcid":"https://orcid.org/0000-0003-0121-3959","observed_orcids":["https://orcid.org/0000-0003-0121-3959"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kang\u2010Hsien Fan","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006498638","display_name":"Muhammad Aslam","orcid":"https://orcid.org/0000-0003-1817-7894","observed_orcids":["https://orcid.org/0000-0003-1817-7894"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Muaaz Aslam","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001693516","display_name":"Lily Francis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Francis","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061219998","display_name":"Margaret Anne Bedison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A Bedison","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040234559","display_name":"Elizabeth Lawrence","orcid":"https://orcid.org/0000-0003-0934-6158","observed_orcids":["https://orcid.org/0000-0003-0934-6158","https://orcid.org/0000-0003-2983-2604"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth C Lawrence","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017112638","display_name":"Vibha Acharya","orcid":"https://orcid.org/0000-0001-6598-0052","observed_orcids":["https://orcid.org/0000-0001-6598-0052"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vibha Acharya","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053071315","display_name":"Beth Ellen Snitz","orcid":"https://orcid.org/0000-0002-9978-1374","observed_orcids":["https://orcid.org/0000-0002-9978-1374"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth E Snitz","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, Pittsburgh, PA  USA","University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, Pittsburgh, PA  USA","institution_ids":[]},{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068056679","display_name":"Mary Ganguli","orcid":"https://orcid.org/0000-0003-2762-7105","observed_orcids":["https://orcid.org/0000-0003-2762-7105"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ganguli","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084618289","display_name":"Steven Trent DeKosky","orcid":"https://orcid.org/0000-0003-3743-2758","observed_orcids":["https://orcid.org/0000-0003-3743-2758"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven T DeKosky","raw_affiliation_strings":["McKnight Brain Institute, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKnight Brain Institute, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619838","display_name":"Oscar L. L\u00f3pez","orcid":"https://orcid.org/0000-0002-8546-8256","observed_orcids":["https://orcid.org/0000-0002-8546-8256"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar L. Lopez","raw_affiliation_strings":["University of Pittsburgh Alzheimer\u2019s Disease Research Center, Pittsburgh, PA  USA","University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Alzheimer\u2019s Disease Research Center, Pittsburgh, PA  USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052349035","display_name":"Eleanor Feingold","orcid":"https://orcid.org/0000-0003-2898-6484","observed_orcids":["https://orcid.org/0000-0003-2898-6484"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleanor Feingold","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082479521","display_name":"M. Ilyas Kamboh","orcid":"https://orcid.org/0000-0002-3453-1438","observed_orcids":["https://orcid.org/0000-0002-3453-1438"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Ilyas Kamboh","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027449459"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10306027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.9269543886184692},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.648497462272644},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6090682744979858},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5944342613220215},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.5460982918739319},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49448561668395996},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4225388467311859},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.41721004247665405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4077087342739105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3725188076496124},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3322966694831848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3045930862426758},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.20251509547233582},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06886681914329529}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.062515","doi":"https://doi.org/10.1002/alz.062515","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.062515","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.062515","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.062515","doi":"https://doi.org/10.1002/alz.062515","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.062515","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.062515","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380880342.pdf","grobid_xml":"https://content.openalex.org/works/W4380880342.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4309477414","https://openalex.org/W2133286942","https://openalex.org/W2001642685","https://openalex.org/W2104722278","https://openalex.org/W2139824081","https://openalex.org/W4210432414","https://openalex.org/W1529356860","https://openalex.org/W2072637938","https://openalex.org/W1585653286","https://openalex.org/W2107094473"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"A":[2,153],"rare":[3],"missense":[4],"APOE":[5,125],"variant":[6],"(L28P;":[7],"APOE*4Pittsburgh)":[8],"has":[9,23,130],"been":[10,24,131],"reported":[11],"to":[12,81,121,237,254,261,311,347],"be":[13],"a":[14,44,203],"risk":[15,291],"factor":[16],"for":[17],"Alzheimer\u2019s":[18,70],"disease":[19],"(AD).":[20],"However,":[21],"sinceL28P":[22],"observed":[25,132,160],"only":[26,133,170],"among":[27,280],"APOE*4":[28,150,172],"carriers,":[29],"its":[30,57,349],"independent":[31,58,111,293],"genetic":[32,297],"association":[33,42],"is":[34,143,234,292,299],"uncertain.":[35],"In":[36],"this":[37,41,308],"study,":[38],"we":[39,117],"re\u2010evaluated":[40],"in":[43,83,91,134,138,161,167,317,339,352],"large":[45],"case\u2010control":[46,164],"sample":[47,97,244,257],"of":[48,68,113,155,205,232,259,265,278,287,294],"15,762":[49],"U.S.":[50],"Whites":[51],"aged":[52],"\u226560":[53],"years":[54],"and":[55,74,89,101,141,185,208,216,314,319,329,342],"investigated":[56],"effect.":[59],"Method":[60],"Samples":[61],"were":[62,159,202],"derived":[63],"from":[64,115],"three":[65,93],"sources:":[66],"University":[67],"Pittsburgh,":[69],"Disease":[71],"Sequencing":[72],"Project":[73],"the":[75,84,92,102,110,119,124,135,139,144,149,162,171,175,180,211,238,242,255,276,285,353],"Gingko":[76],"Evaluation":[77],"Memory":[78],"Study.":[79],"Due":[80],"variation":[82],"age":[85],"distribution":[86],"between":[87,179],"cases":[88,207],"controls":[90,209],"studies,":[94],"each":[95],"study":[96],"was":[98,191,220],"analyzed":[99],"separately,":[100],"results":[103],"then":[104],"combined":[105,163],"by":[106,301],"meta\u2010analysis.":[107],"To":[108],"distinguish":[109],"effect":[112,286],"L28P":[114,129,157,288],"APOE*4,":[116],"restricted":[118],"analysis":[120],"subjects":[122,282],"with":[123,210,241,273,325],"3/4":[126,142,212,281],"genotype,":[127],"as":[128,252],"heterozygous":[136],"state":[137],"APOE*4\u2010background":[140],"most":[145],"common":[146],"genotype":[147],"containing":[148,169],"allele.":[151],"Result":[152],"total":[154,204],"80":[156],"heterozygotes":[158],"sample,":[165],"all":[166],"those":[168],"allele,":[173],"confirming":[174],"complete":[176],"linkage":[177],"disequilibrium":[178],"two":[181],"sites.":[182],"The":[183,214,230],"age\u2010":[184,215],"sex\u2010adjusted":[186,217],"meta\u2010analysis":[187,218],"odds":[188],"ratio":[189],"(OR)":[190],"2.87":[192],"(95%":[193,222],"CI:":[194,223],"1.34":[195],"\u2013":[196,225],"6.13;":[197],"p":[198,227],"=":[199,228,250,269],"0.0066).":[200],"There":[201],"4,138":[206],"genotype.":[213],"OR":[219,264,277],"1.53":[221,279],"0.70":[224],"3.36;":[226],"0.28).":[229],"lack":[231],"significance":[233,351],"mainly":[235],"due":[236],"low":[239],"power":[240,247],"\u223c4,100":[243],"size":[245,258],"(12%":[246],"at":[248,267],"\u03b1":[249,268],"0.80),":[251],"compared":[253],"required":[256],"\u223c151,000":[260],"detect":[262],"an":[263,302],"1.5":[266],"0.80.":[270],"Conclusion":[271],"Even":[272],"non\u2010significant":[274],"p\u2010value,":[275],"suggests":[283],"that":[284,307],"on":[289],"AD":[290,354],"APOE*4.":[295],"Our":[296],"finding":[298,305],"reinforced":[300],"earlier":[303],"experimental":[304],"showing":[306],"mutation":[309],"leads":[310],"significant":[312],"structural":[313],"conformational":[315],"alterations":[316],"ApoE":[318],"can":[320],"induce":[321],"functional":[322,350],"defects":[323],"associated":[324],"neuronal":[326],"A\u03b242":[327],"accumulation":[328],"oxidative":[330],"stress":[331],"(J":[332],"Biol":[333],"Chem":[334],"2014;":[335],"289:12931).":[336],"Additional":[337],"studies":[338],"cell\u2010based":[340],"systems":[341],"animal":[343],"models":[344],"will":[345],"help":[346],"delineate":[348],"etiology.":[355]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-17T00:00:00"}
