{"id":"https://openalex.org/W4380875889","doi":"https://doi.org/10.1089/jop.2022.0186","title":"Effect of Treatment with Topical Azithromycin or Oral Doxycycline on Tear Film Thickness in Patients with Meibomian Gland Dysfunction: A Randomized Controlled Trial","display_name":"Effect of Treatment with Topical Azithromycin or Oral Doxycycline on Tear Film Thickness in Patients with Meibomian Gland Dysfunction: A Randomized Controlled Trial","publication_year":2023,"publication_date":"2023-06-16","ids":{"openalex":"https://openalex.org/W4380875889","doi":"https://doi.org/10.1089/jop.2022.0186","pmid":"https://pubmed.ncbi.nlm.nih.gov/37327369"},"language":"en","primary_location":{"id":"doi:10.1089/jop.2022.0186","doi":"https://doi.org/10.1089/jop.2022.0186","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jop.2022.0186","pdf_url":null,"source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007331938","display_name":"Andreas Schlatter","orcid":"https://orcid.org/0000-0003-2157-2203","observed_orcids":["https://orcid.org/0000-0003-2157-2203"]},"institutions":[{"id":"https://openalex.org/I4210101126","display_name":"Hanusch Hospital","ror":"https://ror.org/0163qhr63","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210101126"]},{"id":"https://openalex.org/I4210111130","display_name":"Vienna Institute for Research in Ocular Surgery","ror":"https://ror.org/022phs473","country_code":"AT","type":"facility","lineage":["https://openalex.org/I4210111130"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas Schlatter","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","VIROS\u2014Vienna Institute for Research in Ocular Surgery\u2014Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"VIROS\u2014Vienna Institute for Research in Ocular Surgery\u2014Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria","institution_ids":["https://openalex.org/I4210101126","https://openalex.org/I4210111130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021580652","display_name":"Nikolaus Hommer","orcid":"https://orcid.org/0000-0002-4116-1359","observed_orcids":["https://orcid.org/0000-0002-4116-1359"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Nikolaus Hommer","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013305347","display_name":"Martin Kallab","orcid":"https://orcid.org/0000-0002-7452-6334","observed_orcids":["https://orcid.org/0000-0002-7452-6334"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Martin Kallab","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019849165","display_name":"Hannes Stegmann","orcid":"https://orcid.org/0000-0003-2636-0218","observed_orcids":["https://orcid.org/0000-0003-2636-0218"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hannes Stegmann","raw_affiliation_strings":["Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria","Christian Doppler Laboratory for Ocular and Dermal Effects of Thiomers, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Christian Doppler Laboratory for Ocular and Dermal Effects of Thiomers, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112938215","display_name":"Kristina Zeller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101126","display_name":"Hanusch Hospital","ror":"https://ror.org/0163qhr63","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210101126"]},{"id":"https://openalex.org/I4210111130","display_name":"Vienna Institute for Research in Ocular Surgery","ror":"https://ror.org/022phs473","country_code":"AT","type":"facility","lineage":["https://openalex.org/I4210111130"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Kristina Zeller","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","VIROS\u2014Vienna Institute for Research in Ocular Surgery\u2014Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"VIROS\u2014Vienna Institute for Research in Ocular Surgery\u2014Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria","institution_ids":["https://openalex.org/I4210101126","https://openalex.org/I4210111130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090454655","display_name":"Stefan Palkovits","orcid":"https://orcid.org/0000-0002-0100-9862","observed_orcids":["https://orcid.org/0000-0002-0100-9862"]},"institutions":[{"id":"https://openalex.org/I4210101126","display_name":"Hanusch Hospital","ror":"https://ror.org/0163qhr63","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210101126"]},{"id":"https://openalex.org/I4210111130","display_name":"Vienna Institute for Research in Ocular Surgery","ror":"https://ror.org/022phs473","country_code":"AT","type":"facility","lineage":["https://openalex.org/I4210111130"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Stefan Palkovits","raw_affiliation_strings":["VIROS\u2014Vienna Institute for Research in Ocular Surgery\u2014Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VIROS\u2014Vienna Institute for Research in Ocular Surgery\u2014Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria","institution_ids":["https://openalex.org/I4210101126","https://openalex.org/I4210111130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021151100","display_name":"Oliver Findl","orcid":"https://orcid.org/0000-0002-1393-1598","observed_orcids":["https://orcid.org/0000-0002-1393-1598"]},"institutions":[{"id":"https://openalex.org/I4210101126","display_name":"Hanusch Hospital","ror":"https://ror.org/0163qhr63","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210101126"]},{"id":"https://openalex.org/I4210111130","display_name":"Vienna Institute for Research in Ocular Surgery","ror":"https://ror.org/022phs473","country_code":"AT","type":"facility","lineage":["https://openalex.org/I4210111130"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Oliver Findl","raw_affiliation_strings":["VIROS\u2014Vienna Institute for Research in Ocular Surgery\u2014Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VIROS\u2014Vienna Institute for Research in Ocular Surgery\u2014Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria","institution_ids":["https://openalex.org/I4210101126","https://openalex.org/I4210111130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019225873","display_name":"Ren\u00e9 Marcel Werkmeister","orcid":"https://orcid.org/0000-0002-5147-5714","observed_orcids":["https://orcid.org/0000-0002-5147-5714"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 M. Werkmeister","raw_affiliation_strings":["Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria","Christian Doppler Laboratory for Ocular and Dermal Effects of Thiomers, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Christian Doppler Laboratory for Ocular and Dermal Effects of Thiomers, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015017045","display_name":"Leopold F. Schmetterer","orcid":"https://orcid.org/0000-0002-7189-1707","observed_orcids":["https://orcid.org/0000-0002-7189-1707"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210165657","display_name":"Institute of Molecular and Clinical Ophthalmology Basel","ror":"https://ror.org/05e715194","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210165657"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","CH","SG"],"is_corresponding":false,"raw_author_name":"Leopold Schmetterer","raw_affiliation_strings":["Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria","Christian Doppler Laboratory for Ocular and Dermal Effects of Thiomers, Vienna, Austria","Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","School of Chemical and Biological Engineering, Nanyang Technological University, Singapore, Singapore","Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore","Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland","Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore","SERI-NTU Advanced Ocular Engineering (STANCE), Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Christian Doppler Laboratory for Ocular and Dermal Effects of Thiomers, Vienna, Austria","institution_ids":[]},{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore","institution_ids":["https://openalex.org/I2799299286","https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland","institution_ids":["https://openalex.org/I4210165657"]},{"raw_affiliation_string":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"SERI-NTU Advanced Ocular Engineering (STANCE), Singapore, Singapore","institution_ids":["https://openalex.org/I172675005","https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060581148","display_name":"Gerhard Garh\u00f6fer","orcid":"https://orcid.org/0000-0001-5547-5669","observed_orcids":["https://orcid.org/0000-0001-5547-5669"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gerhard Garh\u00f6fer","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012595826","display_name":"Doreen Schmidl","orcid":"https://orcid.org/0000-0001-5664-7768","observed_orcids":["https://orcid.org/0000-0001-5664-7768"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Doreen Schmidl","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5012595826"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":null,"apc_paid":null,"fwci":2.64,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.8873614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"39","issue":"6","first_page":"371","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meibomian-gland-dysfunction","display_name":"meibomian gland dysfunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-doxycycline","display_name":"oral doxycycline","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tear-film-thickness","display_name":"tear film thickness","score":0.996999979019165},{"id":"https://openalex.org/keywords/ocular-surface-disease","display_name":"ocular surface disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ocular-surface-disease-index","display_name":"Ocular Surface Disease Index","score":0.753000020980835},{"id":"https://openalex.org/keywords/ultrahigh-resolution-optical-coherence-tomography","display_name":"ultrahigh-resolution optical coherence tomography","score":0.8069999814033508},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.4569999873638153},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.9371145367622375},{"id":"https://openalex.org/C2778907293","wikidata":"https://www.wikidata.org/wiki/Q165399","display_name":"Azithromycin","level":3,"score":0.9341194033622742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9208053946495056},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6091870665550232},{"id":"https://openalex.org/C2777165675","wikidata":"https://www.wikidata.org/wiki/Q1425513","display_name":"Meibomian gland","level":3,"score":0.5856987833976746},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5356796383857727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46770593523979187},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.44308900833129883},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3541509807109833},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3520745038986206},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.19974195957183838},{"id":"https://openalex.org/C2781302119","wikidata":"https://www.wikidata.org/wiki/Q48228","display_name":"Eyelid","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000080343","descriptor_name":"Meibomian Gland Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008537","descriptor_name":"Meibomian Glands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013666","descriptor_name":"Tears","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017963","descriptor_name":"Azithromycin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/jop.2022.0186","doi":"https://doi.org/10.1089/jop.2022.0186","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jop.2022.0186","pdf_url":null,"source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:37327369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37327369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/227699","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10356/227699","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1172081258","https://openalex.org/W1557398606","https://openalex.org/W1970613833","https://openalex.org/W1973048725","https://openalex.org/W1973475258","https://openalex.org/W1981351886","https://openalex.org/W1993900282","https://openalex.org/W2006063667","https://openalex.org/W2033018935","https://openalex.org/W2034672829","https://openalex.org/W2039492593","https://openalex.org/W2050149948","https://openalex.org/W2061620519","https://openalex.org/W2073220200","https://openalex.org/W2090310190","https://openalex.org/W2091630088","https://openalex.org/W2116923399","https://openalex.org/W2117679883","https://openalex.org/W2130789099","https://openalex.org/W2163785631","https://openalex.org/W2282249952","https://openalex.org/W2590631861","https://openalex.org/W2738160893","https://openalex.org/W2769455967","https://openalex.org/W2934752296","https://openalex.org/W2940998200","https://openalex.org/W2996584653","https://openalex.org/W3041109863","https://openalex.org/W3045258900","https://openalex.org/W3048968848","https://openalex.org/W3048972440","https://openalex.org/W3092207694","https://openalex.org/W3093991642","https://openalex.org/W3096433658","https://openalex.org/W3110195347","https://openalex.org/W3114137509","https://openalex.org/W4242429602"],"related_works":["https://openalex.org/W4385666733","https://openalex.org/W2940998200","https://openalex.org/W3017706301","https://openalex.org/W2006063667","https://openalex.org/W4387243309","https://openalex.org/W2894469259","https://openalex.org/W4409021306","https://openalex.org/W7219227508","https://openalex.org/W2061620519","https://openalex.org/W2737996304"],"abstract_inverted_index":{"Purpose:This":[0],"prospective,":[1],"randomized,":[2],"observer-masked,":[3],"parallel-group":[4],"study":[5,67],"aimed":[6],"to":[7,41,180,194],"compare":[8],"the":[9,66,85,102,149,158,177,181],"effect":[10],"of":[11,26,58,65,119,167,184,188],"topical":[12,44],"azithromycin":[13,45,150,190],"and":[14,22,24,116,131,165],"oral":[15,47],"doxycycline":[16,159],"on":[17],"tear":[18],"film":[19],"thickness":[20],"(TFT)":[21],"signs":[23,118,137,164],"symptoms":[25,166],"ocular":[27,110],"surface":[28,111],"disease":[29,112],"(OSD)":[30],"in":[31,70,84,90,123,148,157,169],"patients":[32,81,170],"with":[33,74,98,171,173,198],"meibomian":[34],"gland":[35],"dysfunction":[36],"(MGD).":[37],"Methods:Patients":[38],"were":[39,61,82,154],"randomized":[40],"either":[42],"receive":[43],"or":[46],"doxycycline.":[48],"After":[49],"a":[50],"baseline":[51],"visit,":[52],"three":[53],"follow-up":[54],"visits":[55],"at":[56],"intervals":[57],"2":[59],"weeks":[60],"scheduled.":[62],"Main":[63],"outcome":[64],"was":[68],"change":[69],"TFT":[71,87],"as":[72],"measured":[73],"ultrahigh":[75],"resolution":[76],"optical":[77],"coherence":[78],"tomography.":[79],"Results:Twenty":[80],"included":[83],"analysis.":[86],"significantly":[88,121],"increased":[89],"both":[91,124],"groups":[92,103,125],"(P":[93,104,126],"=":[94,105,127,133],"0.028":[95],"vs.":[96,138],"baseline)":[97],"no":[99,174],"difference":[100,175],"between":[101,176],"0.096).":[106],"As":[107],"secondary":[108],"outcomes,":[109],"index":[113],"(OSDI)":[114],"score":[115],"composite":[117],"OSD":[120,136,168],"decreased":[122],"0.023":[128],"for":[129,135],"OSDI":[130],"P":[132],"0.016":[134],"baseline).":[139],"While":[140],"eye-related":[141],"adverse":[142],"events":[143],"(AEs)":[144],"occurred":[145],"more":[146,155],"frequently":[147],"group,":[151],"systemic":[152,185],"AEs":[153],"common":[156],"group.":[160],"Conclusions:Both":[161],"treatments":[162],"improved":[163],"MGD":[172],"groups.":[178],"Due":[179],"higher":[182],"frequency":[183],"side":[186],"effects":[187],"doxycycline,":[189],"eye":[191],"drops":[192],"seem":[193],"be":[195],"an":[196],"alternative":[197],"comparable":[199],"efficacy.":[200],"Clinical":[201],"Trial":[202],"Registration":[203],"number:":[204],"NCT03162497.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-06-17T00:00:00"}