{"id":"https://openalex.org/W4380795177","doi":"https://doi.org/10.1161/circ.146.suppl_1.14044","title":"Abstract 14044: Leveraging Multi-Omics to Identify Biologically-Informed Clusters of Individuals With Differing Underlying Disease Risk Mechanisms Using an Innovative Network Modelling Approach","display_name":"Abstract 14044: Leveraging Multi-Omics to Identify Biologically-Informed Clusters of Individuals With Differing Underlying Disease Risk Mechanisms Using an Innovative Network Modelling Approach","publication_year":2022,"publication_date":"2022-11-08","ids":{"openalex":"https://openalex.org/W4380795177","doi":"https://doi.org/10.1161/circ.146.suppl_1.14044"},"language":"en","primary_location":{"id":"doi:10.1161/circ.146.suppl_1.14044","doi":"https://doi.org/10.1161/circ.146.suppl_1.14044","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.146.suppl_1.14044","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050693295","display_name":"Minoo Bagheri Naraghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minoo Bagheri Naraghi","raw_affiliation_strings":["Medicine, Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066281730","display_name":"Bertrand De Meulder","orcid":"https://orcid.org/0000-0002-2108-7657","observed_orcids":["https://orcid.org/0000-0002-2108-7657"]},"institutions":[{"id":"https://openalex.org/I4387930247","display_name":"European Institute for Systems Biology and Medicine","ror":"https://ror.org/04f927797","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4387930247"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bertrand De Meulder","raw_affiliation_strings":["Association EISBM, Vourles, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association EISBM, Vourles, France","institution_ids":["https://openalex.org/I4387930247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079561527","display_name":"Jeffrey S. Annis","orcid":"https://orcid.org/0000-0002-3097-4186","observed_orcids":["https://orcid.org/0000-0002-3097-4186"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Annis","raw_affiliation_strings":["Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010818326","display_name":"Evan L. Brittain","orcid":"https://orcid.org/0000-0001-5843-3392","observed_orcids":["https://orcid.org/0000-0001-5843-3392"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Brittain","raw_affiliation_strings":["Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102887489","display_name":"Jonathan D. Mosley","orcid":"https://orcid.org/0000-0001-6421-2887","observed_orcids":["https://orcid.org/0000-0001-6421-2887"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Mosley","raw_affiliation_strings":["Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078392652","display_name":"Jane F. Ferguson","orcid":"https://orcid.org/0000-0001-6896-1025","observed_orcids":["https://orcid.org/0000-0001-6896-1025"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane F Ferguson","raw_affiliation_strings":["Medicine, Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.22269999980926514,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.8410000205039978},{"id":"https://openalex.org/keywords/endotypes","display_name":"endotypes","score":0.5960000157356262},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/similarity-network-fusion","display_name":"similarity network fusion","score":0.8420000076293945},{"id":"https://openalex.org/keywords/consensus-clustering","display_name":"consensus clustering","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-risk-prediction","display_name":"genetic risk prediction","score":0.5479999780654907},{"id":"https://openalex.org/keywords/metabolites","display_name":"metabolites","score":0.5450000166893005},{"id":"https://openalex.org/keywords/proteins","display_name":"proteins","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.859000027179718},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":1.0},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":1.0},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6353074908256531},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.5532945394515991},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5511335134506226},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5455098748207092},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.474148690700531},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4679272174835205},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.46557921171188354},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4516417980194092},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.45069605112075806},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.45031240582466125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4182455241680145},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.4152785837650299},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23737996816635132},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20313572883605957},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1832977533340454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1556050181388855},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14604434370994568},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.1169734001159668},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.146.suppl_1.14044","doi":"https://doi.org/10.1161/circ.146.suppl_1.14044","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.146.suppl_1.14044","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404080925","https://openalex.org/W7220701703","https://openalex.org/W4308258969","https://openalex.org/W3147556802","https://openalex.org/W7204138899","https://openalex.org/W7124765846","https://openalex.org/W4367664918","https://openalex.org/W7160107246","https://openalex.org/W3173949147","https://openalex.org/W3187854016"],"abstract_inverted_index":{"Background:":[0],"The":[1,58,99,154,240],"rates":[2],"of":[3,43,54,62,71,84,102,124,134,196,201,212,228,237],"known":[4,117],"cardiometabolic":[5,55,110,238],"risk":[6,18,52,118,233,251],"elevation":[7],"are":[8,16,193],"highly":[9],"variable":[10],"among":[11],"patients":[12],"suggesting":[13],"that":[14,24],"there":[15],"other":[17],"mediators":[19],"underlying":[20],"diseases.":[21,125,199,239],"We":[22,143],"hypothesized":[23],"using":[25,89,112,138],"cutting-edge":[26],"and":[27,64,73,140,171,175,191,230,235],"innovative":[28,241],"multi-omics":[29,222],"integrative":[30],"network":[31,91],"analysis":[32,127],"in":[33,77,93],"conjunction":[34,94],"with":[35,95,108,162,169,178,206],"the":[36,68,132,197,216],"consensus":[37,96],"clustering":[38,97,223],"approach":[39],"would":[40],"identify":[41,121],"clusters":[42,101,146,188,203],"individuals":[44,103,229],"which":[45,148],"may":[46],"represent":[47],"novel":[48,220,232],"functional":[49],"and/or":[50],"pathophysiological":[51],"mechanisms":[53,211],"disorders.":[56],"Methods:":[57],"genetically":[59],"predicted":[60],"levels":[61],"metabolites":[63],"proteins":[65],"constructed":[66],"from":[67],"GWAS":[69],"data":[70,86],"Framingham/Malm\u00f6":[72],"KORA-TWINS":[74],"were":[75,87,104,157],"imputed":[76],"13,562":[78],"BioVU":[79],"participants.":[80],"These":[81],"2":[82,168,190],"layers":[83],"omics":[85],"integrated":[88],"similarity":[90],"fusion":[92],"approaches.":[98],"identified":[100,144,225],"tested":[105],"for":[106,116,159],"associations":[107,156],"14":[109],"diseases":[111,213],"logistic":[113],"regression":[114],"adjusting":[115],"factors":[119],"to":[120,131,215],"endotypic":[122,194],"determinants":[123,195],"Pathway":[126],"comparing":[128],"each":[129],"cluster":[130,160,167,176],"rest":[133],"participants":[135],"was":[136,150,204],"performed":[137],"Reactome":[139],"MetaboAnalyst.":[141],"Results:":[142],"5":[145],"across":[147],"LDL-C":[149],"significantly":[151],"(p=0.001)":[152],"different.":[153],"significant":[155],"found":[158],"1":[161,185],"coronary":[163],"artery":[164],"disease":[165,181],"(p=0.04),":[166],"cardiomyopathy(p=0.004)":[170],"atrial":[172],"fibrillation":[173],"(p=0.03)":[174,182],"4":[177,192],"congenital":[179],"heart":[180],"[":[183],"Fig":[184],"].":[186],"Thus,":[187],"1,":[189],"above":[198],"Each":[200],"these":[202],"associated":[205],"distinct":[207],"pathways":[208],"indicating":[209],"candidate":[210],"related":[214],"clusters.":[217],"Conclusions:":[218],"This":[219],"discovery-oriented":[221],"method":[224],"biologically-related":[226],"subgroups":[227],"revealed":[231],"mechanism":[234],"biomarkers":[236],"network-based":[242],"models":[243],"advance":[244],"precision":[245],"medicine":[246],"by":[247],"enabling":[248],"future":[249],"prognostic":[250],"prediction":[252],"tools.":[253]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-06-16T00:00:00"}