{"id":"https://openalex.org/W4380793985","doi":"https://doi.org/10.1161/circ.146.suppl_1.11374","title":"Abstract 11374: Aspirin for Primary Prevention of Cardiovascular Events in Patients With Elevated Lipoprotein(a): The Multi-Ethnic Study of Atherosclerosis","display_name":"Abstract 11374: Aspirin for Primary Prevention of Cardiovascular Events in Patients With Elevated Lipoprotein(a): The Multi-Ethnic Study of Atherosclerosis","publication_year":2022,"publication_date":"2022-11-08","ids":{"openalex":"https://openalex.org/W4380793985","doi":"https://doi.org/10.1161/circ.146.suppl_1.11374"},"language":"en","primary_location":{"id":"doi:10.1161/circ.146.suppl_1.11374","doi":"https://doi.org/10.1161/circ.146.suppl_1.11374","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.146.suppl_1.11374","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086030104","display_name":"Harpreet Singh Bhatia","orcid":"https://orcid.org/0000-0002-3964-2989","observed_orcids":["https://orcid.org/0000-0002-3964-2989"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harpreet S Bhatia","raw_affiliation_strings":["Univ of California San Diego, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California San Diego, San Diego, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033165442","display_name":"Patrick James Trainor","orcid":"https://orcid.org/0000-0002-3012-9716","observed_orcids":["https://orcid.org/0000-0002-3012-9716"]},"institutions":[{"id":"https://openalex.org/I10052268","display_name":"New Mexico State University","ror":"https://ror.org/00hpz7z43","country_code":"US","type":"education","lineage":["https://openalex.org/I10052268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Trainor","raw_affiliation_strings":["New Mexico State Univ, Silver City, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Mexico State Univ, Silver City, NM","institution_ids":["https://openalex.org/I10052268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033546833","display_name":"Samantha M. Carlisle","orcid":"https://orcid.org/0000-0002-8968-4300","observed_orcids":["https://orcid.org/0000-0002-8968-4300"]},"institutions":[{"id":"https://openalex.org/I10052268","display_name":"New Mexico State University","ror":"https://ror.org/00hpz7z43","country_code":"US","type":"education","lineage":["https://openalex.org/I10052268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Carlisle","raw_affiliation_strings":["New Mexico State Univ, Las Cruces, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Mexico State Univ, Las Cruces, NM","institution_ids":["https://openalex.org/I10052268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073734270","display_name":"Michael Y. Tsai","orcid":"https://orcid.org/0000-0001-7553-3408","observed_orcids":["https://orcid.org/0000-0001-7553-3408"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Y Tsai","raw_affiliation_strings":["UNIVERSITY MINNESOTA, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY MINNESOTA, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002475361","display_name":"Michael H. Criqui","orcid":"https://orcid.org/0000-0003-0425-9661","observed_orcids":["https://orcid.org/0000-0003-0425-9661"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H Criqui","raw_affiliation_strings":["UCSD, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017391708","display_name":"Andrew Paul DeFilippis","orcid":"https://orcid.org/0000-0002-5135-9748","observed_orcids":["https://orcid.org/0000-0002-5135-9748"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew P Defilippis","raw_affiliation_strings":["Vanderbilt Univ Med Cente, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med Cente, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091030211","display_name":"Sotirios Tsimikas","orcid":"https://orcid.org/0000-0001-9834-9494","observed_orcids":["https://orcid.org/0000-0001-9834-9494"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sotirios Tsimikas","raw_affiliation_strings":["UNIV CALIFORNIA SAN DIEGO, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIV CALIFORNIA SAN DIEGO, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.8870000243186951},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.8019999861717224},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6320000290870667},{"id":"https://openalex.org/keywords/multi-ethnic-study-of-atherosclerosis","display_name":"Multi-Ethnic Study of Atherosclerosis","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.9473737478256226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9423737525939941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6798866391181946},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6521600484848022},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5098916292190552},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5055558681488037},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5006759166717529},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4679841995239258},{"id":"https://openalex.org/C2993857929","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Primary prevention","level":3,"score":0.4263717532157898},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3701944947242737},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3305119276046753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.146.suppl_1.11374","doi":"https://doi.org/10.1161/circ.146.suppl_1.11374","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.146.suppl_1.11374","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391388162","https://openalex.org/W4409254528","https://openalex.org/W4413773638","https://openalex.org/W4386367277","https://openalex.org/W4385446620","https://openalex.org/W4404246725","https://openalex.org/W7155183976","https://openalex.org/W7127881065","https://openalex.org/W4320185814","https://openalex.org/W7152684360"],"abstract_inverted_index":{"Introduction:":[0],"There":[1],"is":[2],"a":[3,41,70,144,152,178,227],"lack":[4],"of":[5,53,59,147,215,253],"effective":[6],"therapies":[7],"for":[8,17,114],"reducing":[9],"risk":[10,76,116,149],"in":[11,33,181,230,233,249],"people":[12,34],"with":[13,35,112,128,135,140,151,177,186,196,200,210,226,235,251],"elevated":[14,36,141,187,236],"Lp(a),":[15],"especially":[16],"primary":[18],"prevention.":[19],"We":[20,39,63,78],"aimed":[21],"to":[22],"evaluate":[23],"the":[24,50,81],"association":[25,82],"between":[26,83],"aspirin":[27,65,84,137,156,174,201,216,254],"use":[28,85,157,202,217,223],"and":[29,67,86,103,132,162,246],"cardiovascular":[30,61],"events":[31,91,166,183,232],"(CVD)":[32],"Lp(a).":[37],"Methods:":[38],"performed":[40],"prospective":[42],"cohort":[43,121],"study":[44,120],"using":[45,69,107],"data":[46],"from":[47,49,206],"participants":[48,234],"Multi-Ethnic":[51],"Study":[52],"Atherosclerosis":[54],"(MESA)":[55],"who":[56],"were":[57],"free":[58],"baseline":[60,99,136,239],"disease.":[62],"matched":[64],"users":[66],"non-users":[68],"propensity":[71,172],"score":[72],"based":[73],"on":[74],"CVD":[75,115,148],"factors.":[77,117],"then":[79],"evaluated":[80],"coronary":[87],"heart":[88],"disease":[89],"(CHD)":[90],"(CHD":[92],"death,":[93],"non-fatal":[94],"myocardial":[95],"infarction)":[96],"stratified":[97],"by":[98],"Lp(a)":[100,129,142,188,197,211,237],"level":[101],"(above":[102],"below":[104],"50":[105],"mg/dL)":[106],"Cox":[108],"proportional":[109],"hazards":[110],"models":[111],"adjustment":[113],"Results:":[118],"Our":[119],"included":[122],"6,632":[123],"participants,":[124],"including":[125],"1,138":[126],"(20%)":[127],">50":[130,198],"mg/dL":[131,199,213],"1,592":[133],"(24%)":[134],"use.":[138,255],"Participants":[139],"had":[143,203],"higher":[145,164],"burden":[146],"factors,":[150],"trend":[153],"toward":[154],"greater":[155],"(25.7%":[158],"vs":[159,168],"23.6%,":[160],"p=0.10)":[161],"significantly":[163],"CHD":[165,182,207,231],"(9.0%":[167],"7.3%,":[169],"p=0.03).":[170,194],"After":[171],"matching,":[173],"was":[175,224],"associated":[176,225],"significant":[179,228],"reduction":[180,229],"among":[184],"those":[185,209],"(HR":[189],"0.54,":[190],"95%":[191],"CI":[192],"0.32-0.94,":[193],"Those":[195],"similar":[204],"freedom":[205],"as":[208],"\u226450":[212],"regardless":[214],"(":[218],"Figure":[219],").":[220],"Conclusions:":[221],"Aspirin":[222],"without":[238],"CVD.":[240],"These":[241],"results":[242],"are":[243],"hypothesis":[244],"generating":[245],"require":[247],"confirmation":[248],"studies":[250],"randomization":[252]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-06-16T00:00:00"}
