{"id":"https://openalex.org/W4380686018","doi":"https://doi.org/10.3390/microorganisms11061573","title":"The Mycobacterium smegmatis HesB Protein, MSMEG_4272, Is Required for In Vitro Growth and Iron Homeostasis","display_name":"The Mycobacterium smegmatis HesB Protein, MSMEG_4272, Is Required for In Vitro Growth and Iron Homeostasis","publication_year":2023,"publication_date":"2023-06-14","ids":{"openalex":"https://openalex.org/W4380686018","doi":"https://doi.org/10.3390/microorganisms11061573","pmid":"https://pubmed.ncbi.nlm.nih.gov/37375075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10301553"},"language":"en","primary_location":{"id":"doi:10.3390/microorganisms11061573","doi":"https://doi.org/10.3390/microorganisms11061573","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms11061573","pdf_url":"https://www.mdpi.com/2076-2607/11/6/1573/pdf?version=1686721111","source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-2607/11/6/1573/pdf?version=1686721111","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015701535","display_name":"Nandi Niemand Wolhuter","orcid":"https://orcid.org/0000-0002-5638-1469","observed_orcids":["https://orcid.org/0000-0002-5638-1469"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Nandi Niemand Wolhuter","raw_affiliation_strings":["NRF/DSI Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa"],"raw_orcid":"https://orcid.org/0000-0002-5638-1469","affiliations":[{"raw_affiliation_string":"NRF/DSI Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019216322","display_name":"Lerato Ngakane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Lerato Ngakane","raw_affiliation_strings":["NRF/DSI Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NRF/DSI Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038793327","display_name":"Timothy J. de Wet","orcid":"https://orcid.org/0000-0002-3978-5322","observed_orcids":["https://orcid.org/0000-0002-3978-5322"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Timothy J. de Wet","raw_affiliation_strings":["Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa","SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, University of Cape Town, Cape Town 7925, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"raw_affiliation_string":"SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, University of Cape Town, Cape Town 7925, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021801489","display_name":"Robin M. Warren","orcid":"https://orcid.org/0000-0001-5741-7358","observed_orcids":["https://orcid.org/0000-0001-5741-7358"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Robin M. Warren","raw_affiliation_strings":["NRF/DSI Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NRF/DSI Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010572343","display_name":"Monique J. Williams","orcid":"https://orcid.org/0000-0002-6701-8403","observed_orcids":["https://orcid.org/0000-0002-6701-8403"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Monique J. Williams","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Cape Town, Cape Town 7700, South Africa","NRF/DSI Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Cape Town, Cape Town 7700, South Africa","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"NRF/DSI Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010572343"],"corresponding_institution_ids":["https://openalex.org/I10947320","https://openalex.org/I157614274","https://openalex.org/I26092322"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03984804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"6","first_page":"1573","last_page":"1573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.350600004196167,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.350600004196167,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.24570000171661377,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.2451000064611435,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/iron-sulfur-cluster-assembly","display_name":"iron-sulfur cluster assembly","score":0.8989999890327454},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/essential-genes","display_name":"essential genes","score":0.4659999907016754},{"id":"https://openalex.org/keywords/growth-defects","display_name":"growth defects","score":0.6510000228881836},{"id":"https://openalex.org/keywords/isoniazid-susceptibility","display_name":"isoniazid susceptibility","score":0.9929999709129333},{"id":"https://openalex.org/keywords/succinate-dehydrogenase","display_name":"succinate dehydrogenase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/aconitase","display_name":"aconitase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/crispri-knockdown","display_name":"CRISPRi knockdown","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2777204207","wikidata":"https://www.wikidata.org/wiki/Q606230","display_name":"Mycobacterium smegmatis","level":4,"score":0.6440733671188354},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4833514392375946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46308642625808716},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.43806788325309753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39558330178260803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3905480206012726},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3727622628211975},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3686911463737488},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.13590139150619507},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07966193556785583},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/microorganisms11061573","doi":"https://doi.org/10.3390/microorganisms11061573","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms11061573","pdf_url":"https://www.mdpi.com/2076-2607/11/6/1573/pdf?version=1686721111","source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10301553","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10301553","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10301553/pdf/microorganisms-11-01573.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"Text"},{"id":"pmid:37375075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37375075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:01f8473fcf27444c885685b4787a2a8a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/01f8473fcf27444c885685b4787a2a8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microorganisms, Vol 11, Iss 6, p 1573 (2023)","raw_type":"article"},{"id":"pmh:oai:scholar.sun.ac.za:10019.1/135099","doi":null,"is_oa":false,"landing_page_url":"https://scholar.sun.ac.za/handle/10019.1/135099","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3390/microorganisms11061573","doi":"https://doi.org/10.3390/microorganisms11061573","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms11061573","pdf_url":"https://www.mdpi.com/2076-2607/11/6/1573/pdf?version=1686721111","source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.40450000762939453,"display_name":"Zero hunger"},{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G10360874","display_name":null,"funder_award_id":"41744","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G6069715653","display_name":null,"funder_award_id":"91424","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"},{"id":"https://openalex.org/F4320322697","display_name":"Harry Crossley Foundation","ror":"https://ror.org/03t1asa17"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380686018.pdf","grobid_xml":"https://content.openalex.org/works/W4380686018.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1555806273","https://openalex.org/W1657643071","https://openalex.org/W1839665474","https://openalex.org/W1846680989","https://openalex.org/W1995220081","https://openalex.org/W1995348107","https://openalex.org/W1997266605","https://openalex.org/W2000959843","https://openalex.org/W2002507236","https://openalex.org/W2005692769","https://openalex.org/W2010961029","https://openalex.org/W2016397232","https://openalex.org/W2017263653","https://openalex.org/W2020983758","https://openalex.org/W2030983914","https://openalex.org/W2031389000","https://openalex.org/W2035816996","https://openalex.org/W2035839314","https://openalex.org/W2036027341","https://openalex.org/W2043223529","https://openalex.org/W2047142948","https://openalex.org/W2051317564","https://openalex.org/W2055531830","https://openalex.org/W2059831206","https://openalex.org/W2067576392","https://openalex.org/W2074698591","https://openalex.org/W2084612893","https://openalex.org/W2088444276","https://openalex.org/W2090079874","https://openalex.org/W2097062730","https://openalex.org/W2110595170","https://openalex.org/W2128482141","https://openalex.org/W2129593385","https://openalex.org/W2132196608","https://openalex.org/W2137912205","https://openalex.org/W2144097910","https://openalex.org/W2145008535","https://openalex.org/W2149776132","https://openalex.org/W2153878038","https://openalex.org/W2158023121","https://openalex.org/W2160407391","https://openalex.org/W2165626042","https://openalex.org/W2332014868","https://openalex.org/W2521602802","https://openalex.org/W2586637020","https://openalex.org/W2783582167","https://openalex.org/W2795798455","https://openalex.org/W2845745072","https://openalex.org/W2995059681","https://openalex.org/W3007507919","https://openalex.org/W4223905184","https://openalex.org/W4249215296"],"related_works":["https://openalex.org/W2995059681","https://openalex.org/W3085942008","https://openalex.org/W2078567653","https://openalex.org/W3021397364","https://openalex.org/W4394717095","https://openalex.org/W2747853342","https://openalex.org/W4223905184","https://openalex.org/W2129120626","https://openalex.org/W3099054812","https://openalex.org/W3031801962"],"abstract_inverted_index":{"A-type":[0],"carrier":[1],"(ATC)":[2],"proteins":[3],"are":[4],"proposed":[5],"to":[6,33,40,96],"function":[7],"in":[8,59,68,79,125,136],"the":[9,34,54,103,106,126],"biogenesis":[10],"of":[11,22,37,65,105,128,139],"Fe-S":[12,107],"clusters,":[13],"although":[14],"their":[15],"exact":[16],"role":[17,124],"remains":[18],"controversial.":[19],"The":[20,82],"genome":[21],"Mycobacterium":[23],"smegmatis":[24],"encodes":[25],"a":[26,69,123],"single":[27],"ATC":[28],"protein,":[29],"MSMEG_4272,":[30],"which":[31,76],"belongs":[32],"HesB/YadR/YfhF":[35],"family":[36],"proteins.":[38],"Attempts":[39],"generate":[41],"an":[42],"MSMEG_4272":[43,66,121],"deletion":[44],"mutant":[45],"by":[46],"two-step":[47],"allelic":[48],"exchange":[49],"were":[50,114],"unsuccessful,":[51],"suggesting":[52],"that":[53,120],"gene":[55],"is":[56,133],"essential":[57],"for":[58,135],"vitro":[60,137],"growth.":[61,145],"CRISPRi-mediated":[62],"transcriptional":[63],"knock-down":[64],"resulted":[67],"growth":[70,138],"defect":[71],"under":[72,90],"standard":[73],"culture":[74],"conditions,":[75],"was":[77],"exacerbated":[78],"mineral-defined":[80],"media.":[81],"knockdown":[83],"strain":[84],"displayed":[85],"reduced":[86],"intracellular":[87,129],"iron":[88,130],"levels":[89,131],"iron-replete":[91],"conditions":[92],"and":[93,100,112,132],"increased":[94],"susceptibility":[95],"clofazimine,":[97],"2,3-dimethoxy-1,4-naphthoquinone":[98],"(DMNQ),":[99],"isoniazid,":[101],"while":[102],"activity":[104],"containing":[108],"enzymes,":[109],"succinate":[110],"dehydrogenase,":[111],"aconitase":[113],"not":[115],"affected.":[116],"This":[117],"study":[118],"suggests":[119],"plays":[122],"regulation":[127],"required":[134],"M.":[140],"smegmatis,":[141],"particularly":[142],"during":[143],"exponential":[144]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-06-15T00:00:00"}
