{"id":"https://openalex.org/W4380537372","doi":"https://doi.org/10.1073/pnas.2304055120","title":"Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes","display_name":"Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes","publication_year":2023,"publication_date":"2023-06-13","ids":{"openalex":"https://openalex.org/W4380537372","doi":"https://doi.org/10.1073/pnas.2304055120","pmid":"https://pubmed.ncbi.nlm.nih.gov/36993702"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2304055120","doi":"https://doi.org/10.1073/pnas.2304055120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2304055120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2304055120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078651983","display_name":"Yi Sun","orcid":"https://orcid.org/0000-0002-7821-4346","observed_orcids":["https://orcid.org/0000-0002-7821-4346"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Sun","raw_affiliation_strings":["Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090920800","display_name":"Michael C. Young","orcid":"https://orcid.org/0000-0002-8420-2149","observed_orcids":["https://orcid.org/0000-0002-8420-2149"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Young","raw_affiliation_strings":["Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":"https://orcid.org/0000-0002-8420-2149","affiliations":[{"raw_affiliation_string":"Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063512021","display_name":"Claire H. Woodward","orcid":"https://orcid.org/0000-0002-0373-6318","observed_orcids":["https://orcid.org/0000-0002-0373-6318"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire H. Woodward","raw_affiliation_strings":["Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":"https://orcid.org/0000-0002-0373-6318","affiliations":[{"raw_affiliation_string":"Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000272523","display_name":"Julia N. Danon","orcid":"https://orcid.org/0000-0001-6971-6582","observed_orcids":["https://orcid.org/0000-0001-6971-6582"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia N. Danon","raw_affiliation_strings":["Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014955406","display_name":"Hau V. Truong","orcid":"https://orcid.org/0000-0002-0059-2793","observed_orcids":["https://orcid.org/0000-0002-0059-2793"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hau V. Truong","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":"https://orcid.org/0000-0002-0059-2793","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076220245","display_name":"S. K. Gupta","orcid":"https://orcid.org/0000-0002-2151-9018","observed_orcids":["https://orcid.org/0000-0002-2151-9018"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sagar Gupta","raw_affiliation_strings":["Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":"https://orcid.org/0000-0002-2151-9018","affiliations":[{"raw_affiliation_string":"Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079637189","display_name":"Trenton J. Winters","orcid":"https://orcid.org/0000-0001-8922-3013","observed_orcids":["https://orcid.org/0000-0001-8922-3013"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trenton J. Winters","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":"https://orcid.org/0000-0001-8922-3013","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006783362","display_name":"Joan Font-Burgada","orcid":"https://orcid.org/0000-0003-3372-418X","observed_orcids":["https://orcid.org/0000-0003-3372-418X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Font-Burgada","raw_affiliation_strings":["Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA 19111"],"raw_orcid":"https://orcid.org/0000-0003-3372-418X","affiliations":[{"raw_affiliation_string":"Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA 19111","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070112401","display_name":"George M. Burslem","orcid":"https://orcid.org/0000-0002-2812-983X","observed_orcids":["https://orcid.org/0000-0002-2812-983X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Burslem","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":"https://orcid.org/0000-0002-2812-983X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028334734","display_name":"Nikolaos G. Sgourakis","orcid":"https://orcid.org/0000-0003-3655-3902","observed_orcids":["https://orcid.org/0000-0003-3655-3902"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolaos G. Sgourakis","raw_affiliation_strings":["Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":"https://orcid.org/0000-0003-3655-3902","affiliations":[{"raw_affiliation_string":"Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5316,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.91289442,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"120","issue":"25","first_page":"e2304055120","last_page":"e2304055120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hla-allotypes","display_name":"HLA allotypes","score":0.7950000166893005},{"id":"https://openalex.org/keywords/peptide-loading","display_name":"peptide loading","score":0.7670000195503235},{"id":"https://openalex.org/keywords/disulfide-bond-engineering","display_name":"disulfide bond engineering","score":0.8820000290870667},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.7419999837875366},{"id":"https://openalex.org/keywords/peptide-exchange","display_name":"peptide exchange","score":0.4169999957084656},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.5180000066757202},{"id":"https://openalex.org/keywords/antigen-discovery","display_name":"antigen identification","score":0.41200000047683716},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.7540000081062317},{"id":"https://openalex.org/keywords/structure-guided-design","display_name":"structure-guided design","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6697104573249817},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6416252255439758},{"id":"https://openalex.org/C197695756","wikidata":"https://www.wikidata.org/wiki/Q1750372","display_name":"MHC restriction","level":5,"score":0.6041165590286255},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.580315113067627},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5694283246994019},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5647251605987549},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.48205265402793884},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4372224509716034},{"id":"https://openalex.org/C2910492473","wikidata":"https://www.wikidata.org/wiki/Q18026920","display_name":"HLA-B Antigens","level":4,"score":0.411693274974823},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.38067349791526794},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3327443599700928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3239143490791321},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.252541184425354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23736664652824402},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2134890854358673},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12944063544273376}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.2304055120","doi":"https://doi.org/10.1073/pnas.2304055120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2304055120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2023.03.18.533266","doi":"https://doi.org/10.1101/2023.03.18.533266","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.03.18.533266","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/18/2023.03.18.533266.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:36993702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36993702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37310998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37310998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10288639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10288639","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10288639/pdf/pnas.202304055.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10055308","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10055308","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2304055120","doi":"https://doi.org/10.1073/pnas.2304055120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2304055120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1233929309","display_name":null,"funder_award_id":"U01-DK112217","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G156276794","display_name":null,"funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1653713024","display_name":null,"funder_award_id":"R35-GM142505","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2099282922","display_name":null,"funder_award_id":"R35GM125034","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2595820228","display_name":null,"funder_award_id":"R01 AI143997","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4915533436","display_name":null,"funder_award_id":"T32GM132039","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G603226791","display_name":null,"funder_award_id":"5R35GM125034","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6223919579","display_name":null,"funder_award_id":"T32GM132039","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G6921937552","display_name":null,"funder_award_id":"5U01DK112217","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7457220623","display_name":null,"funder_award_id":"5R01AI143997","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000016740","display_name":null,"funder_award_id":"T32GM132039","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000136449","display_name":null,"funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000865034","display_name":"Editing Acetylation and Protein Homeostasis","funder_award_id":"5r35gm142505-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1496724330","https://openalex.org/W1971395758","https://openalex.org/W1975767181","https://openalex.org/W1979391589","https://openalex.org/W1990675281","https://openalex.org/W1991869086","https://openalex.org/W1993238707","https://openalex.org/W1995138538","https://openalex.org/W1998260902","https://openalex.org/W2001081076","https://openalex.org/W2006629564","https://openalex.org/W2014569071","https://openalex.org/W2018454859","https://openalex.org/W2019519304","https://openalex.org/W2023967363","https://openalex.org/W2040783956","https://openalex.org/W2046407551","https://openalex.org/W2050717189","https://openalex.org/W2051152071","https://openalex.org/W2057843569","https://openalex.org/W2067069532","https://openalex.org/W2072408048","https://openalex.org/W2085331797","https://openalex.org/W2085450869","https://openalex.org/W2092792420","https://openalex.org/W2097602001","https://openalex.org/W2101553545","https://openalex.org/W2102237050","https://openalex.org/W2111441225","https://openalex.org/W2134182833","https://openalex.org/W2137447323","https://openalex.org/W2145831493","https://openalex.org/W2147514865","https://openalex.org/W2150482345","https://openalex.org/W2159454255","https://openalex.org/W2161756346","https://openalex.org/W2165885799","https://openalex.org/W2173369751","https://openalex.org/W2204515846","https://openalex.org/W2267250079","https://openalex.org/W2268382786","https://openalex.org/W2284191436","https://openalex.org/W2586332244","https://openalex.org/W2597129987","https://openalex.org/W2640667059","https://openalex.org/W2761298339","https://openalex.org/W2761385332","https://openalex.org/W2802471001","https://openalex.org/W2803075628","https://openalex.org/W2847857000","https://openalex.org/W2850163413","https://openalex.org/W2887527620","https://openalex.org/W2890033924","https://openalex.org/W2955168413","https://openalex.org/W2963290778","https://openalex.org/W2963509805","https://openalex.org/W2987147436","https://openalex.org/W2992070886","https://openalex.org/W2992159714","https://openalex.org/W3011061234","https://openalex.org/W3017134886","https://openalex.org/W3017816722","https://openalex.org/W3020858248","https://openalex.org/W3120392574","https://openalex.org/W3177579389","https://openalex.org/W3182639224","https://openalex.org/W4200059396","https://openalex.org/W4308637256","https://openalex.org/W4321766556","https://openalex.org/W4387491415"],"related_works":["https://openalex.org/W2089872551","https://openalex.org/W2011835836","https://openalex.org/W2176905394","https://openalex.org/W1939527068","https://openalex.org/W1840653008","https://openalex.org/W2023967363","https://openalex.org/W4281625971","https://openalex.org/W2761385332","https://openalex.org/W2070684866","https://openalex.org/W2161221618"],"abstract_inverted_index":{"Abstract":[0],"The":[1,168],"polymorphic":[2,244],"nature":[3],"and":[4,14,32,54,135,164,200,234,278,293,305,335,347],"intrinsic":[5],"instability":[6],"of":[7,41,105,128,137,151,221,227,242,286,354,367],"class":[8],"I":[9],"major":[10],"histocompatibility":[11],"complex":[12],"(MHC-I)":[13],"MHC-like":[15],"molecules":[16,99,175,266,325],"loaded":[17,115],"with":[18,116,208,267,298],"suboptimal":[19],"peptides,":[20],"metabolites,":[21],"or":[22],"glycolipids":[23],"presents":[24],"a":[25,177,213,225,257,318,327,374],"fundamental":[26],"challenge":[27],"for":[28,64,216,260],"identifying":[29],"disease-relevant":[30],"antigens":[31],"antigen-specific":[33],"T":[34],"cell":[35],"receptors":[36],"(TCRs),":[37],"hindering":[38],"the":[39,47,52,67,81,111,126,129,133,138,152,160,240,299,351,365],"development":[40],"autologous":[42],"therapeutics.":[43],"Here,":[44],"we":[45,124],"leverage":[46],"positive":[48,287],"allosteric":[49,288],"coupling":[50],"between":[51,290],"peptide":[53,153,183,291],"light":[55],"chain":[56,70,301],"(\u03b2":[57],"2":[58,61,83,147,295,314],"microglobulin,":[59],"\u03b2":[60,146,294,313],"m)":[62],"subunits":[63],"binding":[65,154,292],"to":[66,86,110,118,156,181,229,321,363],"MHC-I":[68,91,98,139,174,219,265,324,355],"heavy":[69,300],"(HC)":[71],"through":[72],"an":[73,332],"engineered":[74],"disulfide":[75,130,170],"bond":[76,131,171],"bridging":[77],"conserved":[78],"epitopes":[79],"across":[80,185],"HC/\u03b2":[82],"m":[84,148,296,315],"interface,":[85],"generate":[87],"conformationally":[88,262],"stable,":[89,263],"open":[90,97,179,264,333],"molecules.":[92,203,252],"Biophysical":[93],"characterization":[94],"shows":[95],"that":[96,310],"are":[100],"properly":[101],"folded":[102],"protein":[103],"complexes":[104],"enhanced":[106,222,268],"thermal":[107],"stability":[108],"compared":[109],"wild":[112],"type,":[113],"when":[114],"low-":[117],"intermediate-affinity":[119],"peptides.":[120],"Using":[121],"solution":[122,303],"NMR,":[123],"characterize":[125],"effects":[127,158],"on":[132,159],"conformation":[134,180,334],"dynamics":[136],"structure,":[140],"ranging":[141],"from":[142,194,340],"local":[143],"changes":[144],"in":[145,176,239,326,373],"interacting":[149],"sites":[150],"groove":[155],"long-range":[157],"\u03b1":[161,165],"2-1":[162],"helix":[163],"3":[166],"domain.":[167],"interchain":[169],"stabilizes":[172],"empty":[173,323],"peptide-receptive,":[178],"promote":[182],"exchange":[184,270,371],"multiple":[186],"human":[187],"leucocyte":[188],"antigen":[189],"(HLA)":[190],"allotypes,":[191,246],"covering":[192],"representatives":[193],"five":[195,273],"HLA-A,":[196,274],"six":[197],"HLA-B":[198,276],"supertypes,":[199,277],"oligomorphic":[201,250,279],"HLA-Ib":[202,280],"Our":[204,343],"structural":[205,346],"design,":[206],"combined":[207],"conditional":[209],"\u03b2-peptide":[210],"ligands,":[211],"provides":[212,345],"universal":[214,369],"platform":[215],"generating":[217,261],"ready-to-load":[218],"systems":[220,372],"stability,":[223],"enabling":[224],"range":[226],"approaches":[228],"screen":[230],"antigenic":[231],"epitope":[232],"libraries":[233],"probe":[235],"polyclonal":[236],"TCR":[237],"repertoires":[238],"context":[241],"highly":[243],"HLA-I":[245],"as":[247,249,317],"well":[248],"nonclassical":[251],"Significance":[253],"Statement":[254],"We":[255,282,308],"outline":[256],"structure-guided":[258],"approach":[259],"ligand":[269,370],"kinetics":[271],"spanning":[272],"all":[275],"allotypes.":[281],"present":[283],"direct":[284],"evidence":[285],"cooperativity":[289],"association":[297],"by":[302,330],"NMR":[304],"HDX-MS":[306],"spectroscopy.":[307],"demonstrate":[309],"covalently":[311],"linked":[312],"serves":[316],"conformational":[319,352],"chaperone":[320],"stabilize":[322],"peptide-receptive":[328],"state,":[329],"inducing":[331],"preventing":[336],"intrinsically":[337],"unstable":[338],"heterodimers":[339],"irreversible":[341],"aggregation.":[342],"study":[344],"biophysical":[348],"insights":[349],"into":[350],"properties":[353],"ternary":[356],"complexes,":[357],"which":[358],"can":[359],"be":[360],"further":[361],"applied":[362],"improve":[364],"design":[366],"ultra-stable,":[368],"pan-HLA":[375],"allelic":[376],"setting.":[377]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
