{"id":"https://openalex.org/W4380434440","doi":"https://doi.org/10.1055/s-0043-1769023","title":"Intravenous trough level guided dose intensification of ustekinumab for refractory severe pyoderma gangrenosum \u2013 a literature review","display_name":"Intravenous trough level guided dose intensification of ustekinumab for refractory severe pyoderma gangrenosum \u2013 a literature review","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4380434440","doi":"https://doi.org/10.1055/s-0043-1769023"},"language":"de","primary_location":{"id":"doi:10.1055/s-0043-1769023","doi":"https://doi.org/10.1055/s-0043-1769023","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0043-1769023","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"F. Strasser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Strasser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035565611","display_name":"Karin Steidl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Steidl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M. Franzoi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Franzoi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092150851","display_name":"F. Hohenwarter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Hohenwarter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086979123","display_name":"Hans-Peter Gr\u00f6chenig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. P. Gr\u00f6chenig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"05","first_page":"e184","last_page":"e184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12328","display_name":"Autoimmune and Inflammatory Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12328","display_name":"Autoimmune and Inflammatory Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyoderma-gangrenosum","display_name":"pyoderma gangrenosum","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ustekinumab","display_name":"ustekinumab","score":1.0},{"id":"https://openalex.org/keywords/dose-intensification","display_name":"dose intensification","score":0.8140000104904175},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.6949999928474426},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.8769999742507935},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8970000147819519},{"id":"https://openalex.org/keywords/neutrophilic-dermatosis","display_name":"neutrophilic dermatosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/drug-monitoring","display_name":"drug monitoring","score":0.39800000190734863},{"id":"https://openalex.org/keywords/refractory-disease","display_name":"refractory disease","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2780520777","wikidata":"https://www.wikidata.org/wiki/Q1526459","display_name":"Pyoderma gangrenosum","level":3,"score":0.9842913150787354},{"id":"https://openalex.org/C2778975655","wikidata":"https://www.wikidata.org/wiki/Q420305","display_name":"Ustekinumab","level":4,"score":0.9371232390403748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8371753692626953},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7301080226898193},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.637965202331543},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6329842805862427},{"id":"https://openalex.org/C2909108646","wikidata":"https://www.wikidata.org/wiki/Q1514476","display_name":"Neutrophilic dermatosis","level":4,"score":0.5569571256637573},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.43900784850120544},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3353123664855957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22739610075950623},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0043-1769023","doi":"https://doi.org/10.1055/s-0043-1769023","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0043-1769023","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W3117032355"],"related_works":["https://openalex.org/W3209560388","https://openalex.org/W2111493645","https://openalex.org/W4377293837","https://openalex.org/W2771393606","https://openalex.org/W2504248367","https://openalex.org/W2904466270","https://openalex.org/W2899733537","https://openalex.org/W4388671629","https://openalex.org/W4252916022","https://openalex.org/W3164408333"],"abstract_inverted_index":{"Introduction":[0],"Pyoderma":[1],"gangrenosum":[2,259],"(PG)":[3],"is":[4,38],"a":[5,44,77,92,238],"neutrophilic":[6],"dermatosis,":[7],"which":[8],"can":[9],"occur":[10],"as":[11],"an":[12,252],"extraintestinal":[13],"manifestation":[14],"in":[15,79,104,110,176,183,200],"inflammatory":[16],"bowel":[17],"disease":[18,49],"(IBD).":[19],"Regarding":[20],"treatment,":[21],"evidence":[22,169],"exists":[23],"for":[24,71,112,170,254],"ustekinumab":[25,264],"(UST)":[26],"[":[27,186],"1":[28,187],"].":[29,188],"However,":[30],"management":[31],"of":[32,43,257],"PG":[33,54,84,105,115,172,201,211,236],"occurrence":[34],"during":[35],"UST":[36,64,118,137,175,196,207,247],"treatment":[37,116,173],"not":[39,191],"clear.":[40],"We":[41,108,133,189],"report":[42],"30-year-old":[45],"woman":[46],"with":[47,117,174,267],"Crohn\u2019s":[48],"(CD),":[50],"who":[51],"developed":[52],"severe":[53,255],"on":[55],"the":[56,120,142,226],"right":[57],"leg.":[58],"She":[59],"was":[60,90,213,230],"receiving":[61],"subcutaneous":[62],"(s.c.)":[63],"at":[65],"90":[66],"mg":[67,136],"every":[68],"4":[69,139,151,223],"weeks":[70,140,154,224,242],"CD":[72],"maintenance":[73],"therapy":[74],"but":[75],"had":[76],"decline":[78],"serum":[80,206],"trough":[81,93,127,157,197,208,265],"concentration":[82,209],"before":[83,161,210],"onset.":[85,244],"Our":[86,165],"aim":[87],"to":[88,220],"investigate":[89],"whether":[91],"level":[94,198],"guided":[95],"dose":[96,248],"intensification":[97,249],"via":[98],"intravenous":[99,131],"re-induction":[100,217],"would":[101],"be":[102,251],"effective":[103],"treatment.":[106,202],"Methods":[107],"searched":[109],"PubMed":[111],"data":[113,194],"regarding":[114,195],"using":[119],"terms":[121],"\u201custekinumab":[122,126,130],"and":[123,129,152,229],"pyoderma":[124,258],"gangrenosum\u201d,":[125],"levels\u201d":[128],"re-induction\u201d.":[132],"administered":[134],"130":[135],"intravenously":[138],"after":[141,225,233,243],"last":[143],"s.c.":[144],"injection,":[145],"followed":[146],"by":[147],"two":[148],"more":[149],"infusions":[150],"8":[153,184,234],"afterwards.":[155],"Serum":[156],"levels":[158,266],"were":[159],"measured":[160],"each":[162],"infusion.":[163],"Results":[164],"literature":[166],"review":[167],"included":[168],"successful":[171],"9":[177],"IBD":[178],"patients":[179],"achieving":[180],"complete":[181,239],"remission":[182,240],"cases":[185,256],"did":[190],"find":[192],"any":[193],"measurements":[199],"In":[203],"our":[204],"patient":[205],"onset":[212],"1.93":[214],"\u00b5g/ml.":[215],"During":[216],"it":[218],"increased":[219],"8.35":[221],"\u00b5g/ml":[222,232],"first":[227],"infusion":[228],"7.28":[231],"weeks.":[235],"showed":[237],"20":[241],"Conclusion":[245],"Intravenous":[246],"could":[250],"option":[253],"although":[260],"further":[261],"studies":[262],"correlating":[263],"clinical":[268],"response":[269],"are":[270],"needed.":[271],"Publication":[272],"History":[273],"Article":[274],"published":[275],"online:":[276],"24":[277],"May":[278],"2023":[279],"\u00a9":[280],"2023.":[281],"Thieme.":[282],"All":[283],"rights":[284],"reserved.":[285],"Georg":[286],"Thieme":[287],"Verlag":[288],"R\u00fcdigerstra\u00dfe":[289],"14,":[290],"70469":[291],"Stuttgart,":[292],"Germany":[293]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-06-14T00:00:00"}
