{"id":"https://openalex.org/W4380360477","doi":"https://doi.org/10.1093/neuonc/noad073.103","title":"DIPG-56. PEDIATRIC GLIOMAS EXHIBIT A UNIQUE LIPID METABOLIC PHENOTYPE DISTINCT FROM ADULT GBMS","display_name":"DIPG-56. PEDIATRIC GLIOMAS EXHIBIT A UNIQUE LIPID METABOLIC PHENOTYPE DISTINCT FROM ADULT GBMS","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4380360477","doi":"https://doi.org/10.1093/neuonc/noad073.103"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad073.103","doi":"https://doi.org/10.1093/neuonc/noad073.103","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.103","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i26/50575262/noad073.103.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i26/50575262/noad073.103.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jennifer Salinas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Salinas","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088148851","display_name":"Jenna K. Minami","orcid":"https://orcid.org/0000-0003-4686-7948","observed_orcids":["https://orcid.org/0000-0003-4686-7948"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna Minami","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060762596","display_name":"Nicholas A. Bayley","orcid":"https://orcid.org/0000-0003-0489-0592","observed_orcids":["https://orcid.org/0000-0003-0489-0592"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Bayley","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074625242","display_name":"Christopher Tse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Tse","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057643976","display_name":"Henan Zhu","orcid":"https://orcid.org/0000-0003-1617-0146","observed_orcids":["https://orcid.org/0000-0003-1617-0146"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henan Zhu","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092146798","display_name":"Hong A. Tum","orcid":"https://orcid.org/0009-0006-8077-1535","observed_orcids":["https://orcid.org/0009-0006-8077-1535"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Tum","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063511816","display_name":"Timothy Francis Cloughesy","orcid":"https://orcid.org/0000-0002-8656-7483","observed_orcids":["https://orcid.org/0000-0002-8656-7483"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Cloughesy","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079316205","display_name":"Linda M. Liau","orcid":"https://orcid.org/0000-0002-4053-0052","observed_orcids":["https://orcid.org/0000-0002-4053-0052"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Liau","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022247782","display_name":"Thomas G. Graeber","orcid":"https://orcid.org/0000-0001-8574-9181","observed_orcids":["https://orcid.org/0000-0001-8574-9181"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Graber","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004206249","display_name":"David A. Nathanson","orcid":"https://orcid.org/0000-0002-4919-9159","observed_orcids":["https://orcid.org/0000-0002-4919-9159"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Nathanson","raw_affiliation_strings":["UCLA , Los Angeles , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA , Los Angeles , USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":{"value":4612,"currency":"USD","value_usd":4612},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_1","first_page":"i26","last_page":"i26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3034999966621399,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-glioma","display_name":"pediatric glioma","score":0.875},{"id":"https://openalex.org/keywords/idh-wildtype-glioblastoma","display_name":"IDH-wildtype glioblastoma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.9100000262260437},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.847000002861023},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.9919999837875366},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.6909999847412109},{"id":"https://openalex.org/keywords/metabolic-vulnerability","display_name":"metabolic vulnerability","score":0.7710000276565552},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7314639091491699},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7286834716796875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5092331171035767},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5051212906837463},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4691191017627716},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34151047468185425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27457568049430847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.249171644449234}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad073.103","doi":"https://doi.org/10.1093/neuonc/noad073.103","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.103","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i26/50575262/noad073.103.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10260162","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10260162","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10260162/pdf/noad073.103.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noad073.103","doi":"https://doi.org/10.1093/neuonc/noad073.103","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.103","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i26/50575262/noad073.103.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380360477.pdf","grobid_xml":"https://content.openalex.org/works/W4380360477.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6977554713","https://openalex.org/W4402945480","https://openalex.org/W4408429443","https://openalex.org/W2442561753","https://openalex.org/W2566680996","https://openalex.org/W4404238085","https://openalex.org/W7164203081","https://openalex.org/W4416140173","https://openalex.org/W7001135098","https://openalex.org/W7140416795"],"abstract_inverted_index":{"Abstract":[0],"Pediatric":[1],"and":[2,12,36,43,51,82,142],"adult":[3,41,130,141],"IDH-wildtype":[4],"gliomas":[5,45,58,76,98,127],"(GBM)":[6],"differ":[7],"in":[8],"both":[9,40],"their":[10],"clinical":[11],"molecular":[13,35],"characteristics.":[14],"However,":[15],"whether":[16],"distinct":[17,137],"metabolic":[18,95,138],"vulnerabilities":[19],"exist":[20],"between":[21],"these":[22,134],"two":[23],"types":[24],"of":[25,39,70,92,100,102,118,125],"malignant":[26],"brain":[27,111],"tumors":[28],"is":[29],"unknown.":[30],"Here,":[31],"we":[32],"performed":[33],"integrated":[34],"lipidomic":[37],"profiling":[38],"IDHwt":[42,57,131],"pediatric":[44,75,97,126,143,152],"to":[46,129,150],"identify":[47,136],"distinguishable":[48],"lipid":[49,63,79,119],"phenotypes":[50],"consequent":[52],"vulnerabilities.":[53],"This":[54],"analysis":[55],"revealed":[56],"have":[59],"heightened":[60],"de":[61],"novo":[62],"biosynthetic":[64,80],"programs":[65,139],"with":[66],"an":[67],"elevated":[68],"abundance":[69],"triacylglycerides":[71],"(TAGs).":[72],"By":[73],"contrast,":[74],"exhibited":[77],"lower":[78],"capacity":[81],"contained":[83],"a":[84,90],"higher":[85],"enrichment":[86],"for":[87,113],"phospholipids.":[88],"As":[89],"consequence":[91],"this":[93],"unique":[94],"program,":[96],"relied":[99],"uptake":[101],"environmental":[103],"complex":[104],"fatty":[105],"acids":[106],"derived":[107],"from":[108],"normal":[109],"resident":[110],"cells":[112],"growth.":[114,154],"Accordingly,":[115],"therapeutic":[116],"abrogation":[117],"scavenging":[120],"pathways":[121],"selectively":[122],"inhibited":[123],"proliferation":[124],"compared":[128],"counterparts.":[132],"Together,":[133],"studies":[135],"among":[140],"gliomas,":[144],"revealing":[145],"new":[146],"therapeutically":[147],"actionable":[148],"targets":[149],"slow":[151],"glioma":[153]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-13T00:00:00"}
