{"id":"https://openalex.org/W4380359786","doi":"https://doi.org/10.1093/neuonc/noad073.068","title":"DIPG-21. LINKING DETERMINATION OF CELL FATE IN THE DEVELOPING CENTRAL NERVOUS SYSTEM TO DIFFUSE MIDLINE GLIOMA","display_name":"DIPG-21. LINKING DETERMINATION OF CELL FATE IN THE DEVELOPING CENTRAL NERVOUS SYSTEM TO DIFFUSE MIDLINE GLIOMA","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4380359786","doi":"https://doi.org/10.1093/neuonc/noad073.068","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10260029"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad073.068","doi":"https://doi.org/10.1093/neuonc/noad073.068","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.068","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i17/50575222/noad073.068.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i17/50575222/noad073.068.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056312959","display_name":"Liam M. Furst","orcid":"https://orcid.org/0000-0003-3505-2233","observed_orcids":["https://orcid.org/0000-0003-3505-2233"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Liam Furst","raw_affiliation_strings":["Department of Paediatrics, University of Melbourne, Parkville, Australia","Murdoch Children\u2019s Research Institute , Parkville , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Melbourne, Parkville, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Murdoch Children\u2019s Research Institute , Parkville , Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082204478","display_name":"Enola Roussel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Enola Roussel","raw_affiliation_strings":["Department of Paediatrics, University of Melbourne, Parkville, Australia","Murdoch Children\u2019s Research Institute , Parkville , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Melbourne, Parkville, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Murdoch Children\u2019s Research Institute , Parkville , Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062788575","display_name":"Ryan F. Leung","orcid":"https://orcid.org/0000-0001-8546-0185","observed_orcids":["https://orcid.org/0000-0001-8546-0185"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ryan Leung","raw_affiliation_strings":["Department of Paediatrics, University of Melbourne, Parkville, Australia","Murdoch Children\u2019s Research Institute , Parkville , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Melbourne, Parkville, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Murdoch Children\u2019s Research Institute , Parkville , Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053415970","display_name":"Ankita M. George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ankita George","raw_affiliation_strings":["Murdoch Children\u2019s Research Institute , Parkville , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Murdoch Children\u2019s Research Institute , Parkville , Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005525867","display_name":"Ron Firestein","orcid":"https://orcid.org/0000-0002-5255-1838","observed_orcids":["https://orcid.org/0000-0002-5255-1838"]},"institutions":[{"id":"https://openalex.org/I2802600346","display_name":"Hudson Institute of Medical Research","ror":"https://ror.org/0083mf965","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I2802600346"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ron Firestein","raw_affiliation_strings":["Hudson Institute of Medical Research , Clayton , Australia","Monash University , Clayton , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hudson Institute of Medical Research , Clayton , Australia","institution_ids":["https://openalex.org/I2802600346"]},{"raw_affiliation_string":"Monash University , Clayton , Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078868987","display_name":"Maree C. Faux","orcid":"https://orcid.org/0000-0001-7770-6683","observed_orcids":["https://orcid.org/0000-0001-7770-6683"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Maree Faux","raw_affiliation_strings":["Department of Paediatrics, University of Melbourne, Parkville, Australia","Murdoch Children\u2019s Research Institute , Parkville , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Melbourne, Parkville, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Murdoch Children\u2019s Research Institute , Parkville , Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066504355","display_name":"David D. Eisenstat","orcid":"https://orcid.org/0000-0002-5976-0798","observed_orcids":["https://orcid.org/0000-0002-5976-0798"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Eisenstat","raw_affiliation_strings":["Department of Paediatrics, University of Melbourne, Parkville, Australia","Murdoch Children\u2019s Research Institute , Parkville , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Melbourne, Parkville, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Murdoch Children\u2019s Research Institute , Parkville , Australia","institution_ids":["https://openalex.org/I4210150290"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":{"value":4612,"currency":"USD","value_usd":4612},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_1","first_page":"i17","last_page":"i17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dlx2","display_name":"Dlx2","score":0.972000002861023},{"id":"https://openalex.org/keywords/h3k27m-mutation","display_name":"H3K27M mutation","score":0.718999981880188},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.8420000076293945},{"id":"https://openalex.org/keywords/homeodomain-transcription-factor","display_name":"homeodomain transcription factor","score":0.6200000047683716},{"id":"https://openalex.org/keywords/olig2","display_name":"Olig2","score":0.7480000257492065},{"id":"https://openalex.org/keywords/nkx2-2","display_name":"Nkx2.2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/plp1","display_name":"PLP1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/histone-h3-variant","display_name":"histone H3 variant","score":0.5419999957084656},{"id":"https://openalex.org/keywords/epigenetic-dysregulation","display_name":"epigenetic dysregulation","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2779055221","wikidata":"https://www.wikidata.org/wiki/Q18035130","display_name":"OLIG2","level":5,"score":0.7693027257919312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6785094141960144},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.638190507888794},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4686265289783478},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4496746361255646},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.42483675479888916},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3870677351951599},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.38535502552986145},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36851775646209717},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.33428525924682617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26643800735473633},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2111228108406067},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19912967085838318},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.15647009015083313},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08899599313735962},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.08137056231498718},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad073.068","doi":"https://doi.org/10.1093/neuonc/noad073.068","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.068","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i17/50575222/noad073.068.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10260029","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10260029","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10260029/pdf/noad073.068.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noad073.068","doi":"https://doi.org/10.1093/neuonc/noad073.068","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.068","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i17/50575222/noad073.068.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380359786.pdf","grobid_xml":"https://content.openalex.org/works/W4380359786.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388588683","https://openalex.org/W7165796250","https://openalex.org/W4399788039","https://openalex.org/W2899929689","https://openalex.org/W4404237043","https://openalex.org/W3111311155","https://openalex.org/W2883882405","https://openalex.org/W2809620633","https://openalex.org/W4229081379","https://openalex.org/W7204231809"],"abstract_inverted_index":{"Abstract":[0],"Diffuse":[1],"midline":[2],"glioma,":[3],"K27-altered":[4],"(DMG)":[5],"is":[6,53],"a":[7,54,66,123,150,272,280],"treatment":[8],"resistant,":[9],"uniformly":[10],"fatal":[11],"cancer":[12],"that":[13,22,58],"arises":[14],"predominantly":[15],"in":[16,32,87,90,102,112,118,131,152,158,181,217,261,266,269,295],"children.":[17],"Next-generation":[18],"sequencing":[19],"has":[20],"revealed":[21],"the":[23,248,277],"majority":[24],"of":[25,77,93,122,135,145,189,201,208,226,243,258,279],"patients":[26],"with":[27,241],"DMG":[28,128,166,222,263],"harbor":[29],"K27M":[30],"mutations":[31],"canonical":[33],"histone":[34,227],"variants":[35],"H3.1":[36],"and":[37,44,64,81,115,138,141,155,176,215,219,233,268,291],"H3.3,":[38],"leading":[39],"to":[40,95,287],"global":[41,143],"epigenetic":[42],"dysregulation":[43],"an":[45,170,202],"oligodendrocyte":[46],"precursor":[47],"cell":[48,62,69,167,183,196,223,288],"(OPC)":[49],"transcriptional":[50],"profile.":[51],"DLX2":[52,75,94,174,190,209,259],"homeobox":[55,281],"transcription":[56,282],"factor":[57,283],"directly":[59],"represses":[60],"OPC":[61,88,234,245],"fate":[63,70,179,289],"promotes":[65],"GABAergic":[67],"interneuron":[68],"during":[71],"neurogenesis.":[72],"We":[73],"identified":[74],"occupancy":[76],"early":[78],"(Olig2,":[79],"Nkx2.2)":[80],"late":[82],"(Myt1,":[83],"Plp1)":[84],"genes":[85,236,246],"required":[86,284],"differentiation":[89],"vivo.":[91,119],"Co-expression":[92],"target":[96],"sequences":[97],"reduced":[98],"reporter":[99],"gene":[100],"expression":[101,117,134,175,210,260],"vitro.":[103,159],"The":[104,256],"Dlx1/Dlx2":[105,249],"double":[106],"knockout":[107,188,218],"(DKO)":[108],"mouse":[109,251],"showed":[110,169],"increases":[111],"Olig2,":[113],"Nkx2.2,":[114,142],"Plp-1":[116],"Transient":[120],"over-expression":[121],"Dlx2-GFP":[124],"construct":[125],"into":[126],"murine":[127],"cells":[129,264],"resulted":[130],"significant":[132],"increased":[133],"Gad1/2":[136],"isoforms":[137],"decreased":[139],"Olig2":[140],"restoration":[144],"H3K27me3,":[146],"as":[147,149,252],"well":[148],"reduction":[151],"migration,":[153],"invasion,":[154],"colony":[156],"formation":[157],"An":[160],"RNAseq":[161],"database":[162],"containing":[163],"45":[164],"human":[165,221,262],"lines":[168,184,197],"inverse":[171],"correlation":[172],"between":[173],"OLIG1/2.":[177],"Cell":[178],"changes":[180],"DLX2high/OLIG1/2low":[182],"were":[185],"evaluated":[186],"by":[187,213,254],"using":[191],"CRISPR/Cas9.":[192],"Concurrently,":[193],"OLIG1/2high/DLX2low":[194],"expressing":[195],"underwent":[198],"stable":[199],"transfection":[200],"DLX2-mCherry":[203],"overexpression":[204],"construct.":[205],"Successful":[206],"alteration":[207],"was":[211],"confirmed":[212],"qPCR":[214],"immunoblot":[216],"overexpressing":[220],"lines.":[224],"Analysis":[225],"H3":[228],"marks":[229],"(K27me3,":[230],"K27ac),":[231],"K27M,":[232],"signature":[235],"will":[237],"be":[238],"presented":[239],"along":[240],"comparison":[242],"altered":[244],"from":[247],"DKO":[250],"determined":[253],"RNAseq.":[255],"manipulation":[257],"both":[265],"vitro":[267],"vivo":[270],"provides":[271],"model":[273],"system":[274],"for":[275,285],"assessing":[276],"contribution":[278],"neurogenesis":[286],"regulation":[290],"effects":[292],"on":[293],"tumorigenicity":[294],"DMG.":[296]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-06-13T00:00:00"}
