{"id":"https://openalex.org/W4380354552","doi":"https://doi.org/10.1093/neuonc/noad073.173","title":"HGG-24. A NOVEL ONCOGENIC ROLE FOR MENIN IN GLIOMA","display_name":"HGG-24. A NOVEL ONCOGENIC ROLE FOR MENIN IN GLIOMA","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4380354552","doi":"https://doi.org/10.1093/neuonc/noad073.173"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad073.173","doi":"https://doi.org/10.1093/neuonc/noad073.173","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.173","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i45/50575402/noad073.173.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i45/50575402/noad073.173.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100719504","display_name":"Yanhong Yang","orcid":"https://orcid.org/0000-0002-3923-5523","observed_orcids":["https://orcid.org/0000-0002-3923-5523"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanhong Yang","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center , New York , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center , New York , USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089346436","display_name":"Yuhki Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhki Saito","raw_affiliation_strings":["The Rockefeller University , New York , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University , New York , USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010141544","display_name":"Elena Goldberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Goldberg","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center , New York , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center , New York , USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089099493","display_name":"Zaki Abou-Mrad","orcid":"https://orcid.org/0000-0001-6387-8396","observed_orcids":["https://orcid.org/0000-0001-6387-8396"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaki Abou Mrad","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center , New York , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center , New York , USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090666103","display_name":"Alexandra Giantini-Larsen","orcid":"https://orcid.org/0000-0002-9545-8502","observed_orcids":["https://orcid.org/0000-0002-9545-8502"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Giantini Larsen","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center , New York , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center , New York , USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092145562","display_name":"Greta Ghita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39694355","display_name":"Hunter College","ror":"https://ror.org/00g2xk477","country_code":"US","type":"education","lineage":["https://openalex.org/I39694355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greta Ghita","raw_affiliation_strings":["Hunter College , New York , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunter College , New York , USA","institution_ids":["https://openalex.org/I39694355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081823120","display_name":"Viviane S. Tabar","orcid":"https://orcid.org/0000-0002-1284-1670","observed_orcids":["https://orcid.org/0000-0002-1284-1670"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viviane Tabar","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center , New York , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center , New York , USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":{"value":4612,"currency":"USD","value_usd":4612},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_1","first_page":"i45","last_page":"i45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/menin","display_name":"menin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/men1","display_name":"MEN1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oncogenic-role","display_name":"oncogenic role","score":0.7139999866485596},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/hmgn1","display_name":"HMGN1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/h3k27-acetylation","display_name":"H3K27 acetylation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/menin-inhibitors","display_name":"menin inhibitors","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pediatric-glioma","display_name":"pediatric glioma","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2779469564","wikidata":"https://www.wikidata.org/wiki/Q1920577","display_name":"MEN1","level":4,"score":0.6786539554595947},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6688421964645386},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6522312164306641},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.5948960781097412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5848191380500793},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5173172950744629},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.46280306577682495},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.43349942564964294},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.4109407067298889},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3039034605026245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2796594202518463},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.08277586102485657},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08228302001953125},{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad073.173","doi":"https://doi.org/10.1093/neuonc/noad073.173","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.173","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i45/50575402/noad073.173.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10259963","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10259963","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10259963/pdf/noad073.173.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noad073.173","doi":"https://doi.org/10.1093/neuonc/noad073.173","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.173","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i45/50575402/noad073.173.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380354552.pdf","grobid_xml":"https://content.openalex.org/works/W4380354552.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2965791261","https://openalex.org/W2153837873","https://openalex.org/W1989534627","https://openalex.org/W4398142361","https://openalex.org/W4409691530","https://openalex.org/W2137876306","https://openalex.org/W4408960166","https://openalex.org/W2438598737","https://openalex.org/W7135037062","https://openalex.org/W7165800271"],"abstract_inverted_index":{"Abstract":[0],"High-grade":[1],"gliomas":[2],"(HGGs)":[3],"represent":[4],"the":[5,27,43,83,151,176,253],"most":[6],"common":[7],"subtype":[8],"of":[9,30,68,79,93,106,111,115,118,126,214,220,224,231,255],"primary":[10,33],"malignant":[11],"tumors":[12],"from":[13,32,56],"brain":[14,34],"or":[15],"spinal":[16],"cord.":[17],"With":[18],"about":[19],"18":[20],"months":[21],"overall":[22],"survival":[23],"time,":[24],"HGGs":[25,88,216],"is":[26,154,200,241],"leading":[28],"cause":[29],"death":[31],"tumor.":[35],"Survival":[36],"outcomes":[37],"have":[38],"not":[39,155],"improved":[40],"significantly":[41],"over":[42],"past":[44],"two":[45],"decades":[46],"despite":[47],"major":[48],"research":[49],"and":[50,66,143,180,209,222,262],"therapeutic":[51,244,265],"discovery":[52],"efforts.":[53],"Previous":[54],"work":[55,240,251],"our":[57,160],"lab":[58],"suggested":[59],"a":[60,75,91,112,167,194,201],"role":[61,78,125,169,254],"for":[62],"menin":[63,80,127,135,165,197,248],"in":[64,86,131,170,228,258],"initiation":[65],"maintenance":[67],"pediatric":[69],"high-grade":[70],"glioma.":[71,158],"Here":[72],"we":[73,102,148,183],"describe":[74],"critical":[76,168],"oncogenic":[77,124],"(encoded":[81],"by":[82,246],"MEN1":[84,107,221],"gene)":[85],"maintaining":[87,171],"proliferation.":[89],"Using":[90,178],"panel":[92],"early":[94],"passage":[95],"HGG":[96],"lines":[97],"harboring":[98],"diverse":[99],"genomic":[100,120],"alterations,":[101],"demonstrate":[103],"that":[104,150,164,218],"silencing":[105,223],"blocks":[108],"proliferation":[109,261],"(60%-80%)":[110],"subset":[113],"(8/12)":[114],"HGGs,":[116],"independent":[117],"their":[119],"alteration":[121],"profile.":[122],"An":[123],"has":[128],"been":[129],"described":[130],"MLL-rearrangement":[132],"leukemia,":[133],"where":[134],"complexes":[136],"with":[137,157,206,234],"MLL":[138],"to":[139],"affect":[140],"H3K4":[141],"trimethylation":[142],"activate":[144],"leukemogenic":[145],"genes.":[146],"However,":[147],"found":[149],"menin-MLL":[152],"interaction":[153],"associated":[156,205,233],"Instead,":[159],"mechanistic":[161],"studies":[162,213],"suggest":[163],"plays":[166],"H3K27":[172,210],"acetylation":[173],"marks":[174],"across":[175],"genome.":[177],"immunoprecipitation":[179],"mass":[181],"spectrometry,":[182],"identified":[184],"HMGN1":[185,199,225],"(high":[186],"mobility":[187],"group":[188],"nucleosome-binding":[189],"domain":[190],"1":[191],"protein)":[192],"as":[193],"putative":[195],"novel":[196,247,264],"partner.":[198],"chromatin":[202,207],"remodeling":[203,257],"protein":[204],"accessibility":[208],"acetylation.":[211],"Transcriptional":[212],"patient-derived":[215],"revealed":[217],"knockout":[219],"both":[226],"resulted":[227],"broad":[229],"repression":[230],"genes":[232],"proliferative":[235],"tumor":[236],"progenitor":[237],"clusters.":[238],"Ongoing":[239],"aimed":[242],"at":[243],"targeting":[245],"inhibitors.":[249],"Our":[250],"demonstrates":[252],"epigenetic":[256],"controlling":[259],"glioma":[260],"identifying":[263],"targets.":[266]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-13T00:00:00"}
