{"id":"https://openalex.org/W4380302425","doi":"https://doi.org/10.1093/neuonc/noad073.209","title":"IMMU-22. ALLOGENEIC NK CELLS SECRETING IL15 AND RESISTANT TO TGF-\u03b2 Show Antitumor Activity Against Gliobastoma","display_name":"IMMU-22. ALLOGENEIC NK CELLS SECRETING IL15 AND RESISTANT TO TGF-\u03b2 Show Antitumor Activity Against Gliobastoma","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4380302425","doi":"https://doi.org/10.1093/neuonc/noad073.209"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad073.209","doi":"https://doi.org/10.1093/neuonc/noad073.209","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.209","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i54/50575510/noad073.209.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i54/50575510/noad073.209.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031647936","display_name":"Nethaji Muniraj","orcid":"https://orcid.org/0000-0002-3820-2148","observed_orcids":["https://orcid.org/0000-0002-3820-2148"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nethaji Muniraj","raw_affiliation_strings":["Children\u2019s National Hospital , Washington DC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital , Washington DC , USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081407458","display_name":"Kajal Chaudhry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kajal Chaudhry","raw_affiliation_strings":["Children\u2019s National Hospital , Washington DC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital , Washington DC , USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021745903","display_name":"Joshua Terao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Terao","raw_affiliation_strings":["Children\u2019s National Hospital , Washington DC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital , Washington DC , USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112015986","display_name":"Luke Barron","orcid":"https://orcid.org/0000-0002-8660-3069","observed_orcids":["https://orcid.org/0000-0002-8660-3069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke Barron","raw_affiliation_strings":["Catamaran Bio , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catamaran Bio , Boston, MA , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087525727","display_name":"Vipin Suri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vipin Suri","raw_affiliation_strings":["Catamaran Bio , Boston, MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catamaran Bio , Boston, MA , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006134549","display_name":"Catherine M. Bollard","orcid":"https://orcid.org/0000-0001-5140-9090","observed_orcids":["https://orcid.org/0000-0001-5140-9090"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Bollard","raw_affiliation_strings":["Children\u2019s National Hospital , Washington DC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital , Washington DC , USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033997937","display_name":"Carolina Colli Cruz","orcid":"https://orcid.org/0000-0001-7065-3769","observed_orcids":["https://orcid.org/0000-0001-7065-3769"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conrad Russell Cruz","raw_affiliation_strings":["Children\u2019s National Hospital , Washington DC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital , Washington DC , USA","institution_ids":["https://openalex.org/I1336742384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":{"value":4612,"currency":"USD","value_usd":4612},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_1","first_page":"i54","last_page":"i54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allogeneic-natural-killer-cells","display_name":"allogeneic natural killer cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.878000020980835},{"id":"https://openalex.org/keywords/tgf-beta-resistance","display_name":"TGF-beta resistance","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cord-blood-nk-cells","display_name":"cord blood NK cells","score":0.7400000095367432},{"id":"https://openalex.org/keywords/nk-cell-engineering","display_name":"NK cell engineering","score":0.6460000276565552},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tumor-clearance","display_name":"tumor clearance","score":0.597000002861023},{"id":"https://openalex.org/keywords/cytokine-toxicity","display_name":"cytokine toxicity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nk-cell-persistence","display_name":"NK cell persistence","score":0.7580000162124634},{"id":"https://openalex.org/keywords/suicide-gene","display_name":"suicide gene","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C206191192","wikidata":"https://www.wikidata.org/wiki/Q17149636","display_name":"NK-92","level":5,"score":0.536088764667511},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.51910400390625},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5118386149406433},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.46861228346824646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45050764083862305},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.4422478675842285},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.43990689516067505},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43389129638671875},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.4224960505962372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3767431676387787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3351742625236511},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3196004629135132},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3172965347766876},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2877084016799927},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24349886178970337},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad073.209","doi":"https://doi.org/10.1093/neuonc/noad073.209","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.209","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i54/50575510/noad073.209.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10260151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10260151","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10260151/pdf/noad073.209.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noad073.209","doi":"https://doi.org/10.1093/neuonc/noad073.209","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad073.209","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i54/50575510/noad073.209.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380302425.pdf","grobid_xml":"https://content.openalex.org/works/W4380302425.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362596625","https://openalex.org/W3216930338","https://openalex.org/W197552348","https://openalex.org/W4391932922","https://openalex.org/W7219912590","https://openalex.org/W2572765595","https://openalex.org/W3007918417","https://openalex.org/W2482107139","https://openalex.org/W4387183474","https://openalex.org/W6926880971"],"abstract_inverted_index":{"Abstract":[0],"INTRODUCTION":[1],"High":[2],"grade":[3],"brain":[4,232],"cancers,":[5],"like":[6],"most":[7],"solid":[8],"tumors,":[9],"often":[10],"relapse":[11],"and":[12,29,54,64,69,91,130,258],"are":[13,268],"resistant":[14],"to":[15,20,26,37,51,66,104,174,273,288],"current":[16],"therapies.":[17],"Limited":[18],"efficacy":[19],"cell":[21,78,84,119,140,162,203,228],"therapy":[22],"may":[23],"be":[24],"related":[25],"intratumoral":[27],"heterogeneity":[28],"the":[30,82,106,113,151,184,212,231,263],"suppressive":[31,256],"tumor":[32,48,187,246],"microenvironment.":[33],"Hence,":[34],"we":[35,142,172,286],"aimed":[36],"modify":[38],"allogeneic":[39,117],"natural":[40],"killer":[41],"(NK)":[42],"cells,":[43],"which":[44],"can":[45],"recognize":[46],"expressed":[47],"stress":[49],"ligands,":[50],"resist":[52],"TGF-\u03b2":[53,257],"secrete":[55],"IL15.":[56,266],"METHODS":[57],"Cord":[58],"blood-derived":[59],"NK":[60,77,118,126,161,165,169,202,219,227,249],"cells":[61,98,127,166,250],"were":[62,87,99,209,240,251,259],"expanded":[63],"modified":[65],"express":[67],"IL15":[68,129,278],"a":[70,290],"dominant":[71],"negative":[72],"receptor":[73],"(DNR)":[74],"against":[75,81,254],"TGF-\u03b2.":[76],"product":[79],"activity":[80],"GBM":[83],"line":[85],"U87MG":[86],"evaluated":[88],"in":[89,92,148,183,211,230],"vitro":[90],"vivo.":[93],"The":[94],"behavior":[95],"of":[96,111,115,186,207,214,261],"these":[97,294],"also":[100],"analyzed":[101],"ex":[102],"vivo,":[103],"evaluate":[105],"impact":[107],"(including":[108],"potential":[109],"toxicity)":[110],"increasing":[112],"potency":[114],"this":[116,284],"product.":[120],"RESULTS":[121],"While":[122],"animals":[123],"injected":[124],"with":[125,159,198,217,226],"secreting":[128,262],"expressing":[131],"DNR":[132],"successfully":[133],"cleared":[134],"tumors":[135],"6":[136],"days":[137],"after":[138],"T":[139],"infusion,":[141],"did":[143],"not":[144],"observe":[145],"significant":[146],"differences":[147],"survival":[149],"between":[150],"groups":[152],"(no":[153],"treatment":[154,192],"control":[155,193],"mice":[156,194,196,215],"vs":[157,163,167,195],"treated":[158,197,216],"mock-transduced":[160,199],"DNR-transduced":[164],"IL-15/DNR-transduced":[168,201,218],"cells).":[170],"Therefore,":[171],"sought":[173],"determine":[175,274],"whether":[176,275],"cytokine-related":[177],"toxicity":[178,276,285],"was":[179],"responsible":[180],"for":[181],"death":[182],"setting":[185],"clearance.":[188],"We":[189,243,267],"compared":[190],"no":[191,237],"or":[200],"products.":[204],"Elevated":[205],"levels":[206,224],"IL-15":[208,223],"detected":[210],"plasma":[213],"cells.":[220],"These":[221],"elevated":[222],"corresponded":[225],"persistence":[229],"measured":[233],"by":[234],"ddPCR.":[235],"However,":[236],"other":[238],"cytokines":[239],"upregulated.":[241],"CONCLUSIONS":[242],"observed":[244],"improved":[245],"clearance":[247],"when":[248],"both":[252],"protected":[253],"immune":[255],"capable":[260],"stimulatory":[264],"cytokine":[265],"currently":[269],"performing":[270],"additional":[271],"experiments":[272],"from":[277],"secretion":[279],"occurs.":[280],"To":[281],"potentially":[282],"mitigate":[283],"plan":[287],"engineer":[289],"suicide":[291],"gene":[292],"into":[293],"constructs.":[295]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-06-13T00:00:00"}
