{"id":"https://openalex.org/W4380265489","doi":"https://doi.org/10.34172/jre.2023.25095","title":"Phytochemicals with sodium-glucose co-transporter inhibitory effects for the management of diabetes; a narrative review on recent findings","display_name":"Phytochemicals with sodium-glucose co-transporter inhibitory effects for the management of diabetes; a narrative review on recent findings","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4380265489","doi":"https://doi.org/10.34172/jre.2023.25095"},"language":"en","primary_location":{"id":"doi:10.34172/jre.2023.25095","doi":"https://doi.org/10.34172/jre.2023.25095","is_oa":true,"landing_page_url":"https://doi.org/10.34172/jre.2023.25095","pdf_url":"https://jrenendo.com/PDF/jre-9-e25095.pdf","source":{"id":"https://openalex.org/S4210226273","display_name":"Journal of Renal Endocrinology","issn_l":"2423-6438","issn":["2423-6438"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Renal Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jrenendo.com/PDF/jre-9-e25095.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101668539","display_name":"Mehrnaz Salehi","orcid":"https://orcid.org/0000-0002-1967-203X","observed_orcids":["https://orcid.org/0000-0002-1967-203X"]},"institutions":[{"id":"https://openalex.org/I127908078","display_name":"Shahrekord University","ror":"https://ror.org/051rngw70","country_code":"IR","type":"education","lineage":["https://openalex.org/I127908078"]},{"id":"https://openalex.org/I170350485","display_name":"Shahrekord University of Medical Sciences","ror":"https://ror.org/0506tgm76","country_code":"IR","type":"education","lineage":["https://openalex.org/I170350485"]},{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mehrnaz Salehi","raw_affiliation_strings":["Anatomical and Clinical Pathologist, Mazandaran University of Medical Science, Mazandaran, Iran","School of Medicine, Shahrekord University of Medical Science, Shahrekord, Iran"],"raw_orcid":"https://orcid.org/0000-0002-1967-203X","affiliations":[{"raw_affiliation_string":"Anatomical and Clinical Pathologist, Mazandaran University of Medical Science, Mazandaran, Iran","institution_ids":["https://openalex.org/I88085062"]},{"raw_affiliation_string":"School of Medicine, Shahrekord University of Medical Science, Shahrekord, Iran","institution_ids":["https://openalex.org/I127908078","https://openalex.org/I170350485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092139669","display_name":"Najmeh Rayatpisheh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127908078","display_name":"Shahrekord University","ror":"https://ror.org/051rngw70","country_code":"IR","type":"education","lineage":["https://openalex.org/I127908078"]},{"id":"https://openalex.org/I170350485","display_name":"Shahrekord University of Medical Sciences","ror":"https://ror.org/0506tgm76","country_code":"IR","type":"education","lineage":["https://openalex.org/I170350485"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Najmeh Rayatpisheh","raw_affiliation_strings":["School of Medicine, Shahrekord University of Medical Science, Shahrekord, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Shahrekord University of Medical Science, Shahrekord, Iran","institution_ids":["https://openalex.org/I127908078","https://openalex.org/I170350485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144071099","display_name":"Mahsa Salehi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127908078","display_name":"Shahrekord University","ror":"https://ror.org/051rngw70","country_code":"IR","type":"education","lineage":["https://openalex.org/I127908078"]},{"id":"https://openalex.org/I170350485","display_name":"Shahrekord University of Medical Sciences","ror":"https://ror.org/0506tgm76","country_code":"IR","type":"education","lineage":["https://openalex.org/I170350485"]},{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahsa Salehi","raw_affiliation_strings":["Anatomical and Clinical Pathologist, Mazandaran University of Medical Science, Mazandaran, Iran","School of Medicine, Shahrekord University of Medical Science, Shahrekord, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomical and Clinical Pathologist, Mazandaran University of Medical Science, Mazandaran, Iran","institution_ids":["https://openalex.org/I88085062"]},{"raw_affiliation_string":"School of Medicine, Shahrekord University of Medical Science, Shahrekord, Iran","institution_ids":["https://openalex.org/I127908078","https://openalex.org/I170350485"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072272330","display_name":"Hossein Mardanparvar","orcid":"https://orcid.org/0000-0001-7455-5373","observed_orcids":["https://orcid.org/0000-0001-7455-5373"]},"institutions":[{"id":"https://openalex.org/I4210128695","display_name":"Hormozgan University of Medical Sciences","ror":"https://ror.org/037wqsr57","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210128695"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Mardanparvar","raw_affiliation_strings":["Department of Nursing, Faculty of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran"],"raw_orcid":"https://orcid.org/0000-0001-7455-5373","affiliations":[{"raw_affiliation_string":"Department of Nursing, Faculty of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran","institution_ids":["https://openalex.org/I4210128695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101668539"],"corresponding_institution_ids":["https://openalex.org/I127908078","https://openalex.org/I170350485","https://openalex.org/I88085062"],"apc_list":null,"apc_paid":null,"fwci":0.062,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.12187334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":null,"first_page":"e25095","last_page":"e25095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.8809999823570251},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.968999981880188},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.859000027179718},{"id":"https://openalex.org/keywords/antidiabetic-plants","display_name":"antidiabetic plants","score":0.6570000052452087},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.718999981880188},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.8528250455856323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8250664472579956},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.6625354886054993},{"id":"https://openalex.org/C2780485761","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Blood sugar","level":3,"score":0.46122556924819946},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.42074042558670044},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.41558706760406494},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41260573267936707},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35665762424468994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3446129560470581},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24046632647514343}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.34172/jre.2023.25095","doi":"https://doi.org/10.34172/jre.2023.25095","is_oa":true,"landing_page_url":"https://doi.org/10.34172/jre.2023.25095","pdf_url":"https://jrenendo.com/PDF/jre-9-e25095.pdf","source":{"id":"https://openalex.org/S4210226273","display_name":"Journal of Renal Endocrinology","issn_l":"2423-6438","issn":["2423-6438"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Renal Endocrinology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.34172/jre.2023.25095","doi":"https://doi.org/10.34172/jre.2023.25095","is_oa":true,"landing_page_url":"https://doi.org/10.34172/jre.2023.25095","pdf_url":"https://jrenendo.com/PDF/jre-9-e25095.pdf","source":{"id":"https://openalex.org/S4210226273","display_name":"Journal of Renal Endocrinology","issn_l":"2423-6438","issn":["2423-6438"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Renal Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322245","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380265489.pdf","grobid_xml":"https://content.openalex.org/works/W4380265489.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W56821845","https://openalex.org/W220367320","https://openalex.org/W1498081846","https://openalex.org/W1502472986","https://openalex.org/W1883072153","https://openalex.org/W1964666590","https://openalex.org/W1964971448","https://openalex.org/W1980555036","https://openalex.org/W1996200878","https://openalex.org/W2006966362","https://openalex.org/W2015335287","https://openalex.org/W2024372370","https://openalex.org/W2026609170","https://openalex.org/W2028165126","https://openalex.org/W2034486758","https://openalex.org/W2045712031","https://openalex.org/W2049435714","https://openalex.org/W2063209889","https://openalex.org/W2066175993","https://openalex.org/W2075957866","https://openalex.org/W2089506867","https://openalex.org/W2142360957","https://openalex.org/W2147802246","https://openalex.org/W2154910753","https://openalex.org/W2169403426","https://openalex.org/W2344863995","https://openalex.org/W2513874912","https://openalex.org/W2524889084","https://openalex.org/W2809305468","https://openalex.org/W2809312083","https://openalex.org/W2917363032","https://openalex.org/W2945792041","https://openalex.org/W2977247321","https://openalex.org/W3011304075","https://openalex.org/W3127141806","https://openalex.org/W3165373898","https://openalex.org/W3183822960","https://openalex.org/W3184295085","https://openalex.org/W3213932487","https://openalex.org/W4200026682","https://openalex.org/W4200595023","https://openalex.org/W4211020598","https://openalex.org/W4220765841","https://openalex.org/W4290999921","https://openalex.org/W4294128061","https://openalex.org/W4295780107","https://openalex.org/W4306816561"],"related_works":["https://openalex.org/W4206478008","https://openalex.org/W4404831603","https://openalex.org/W2513874912","https://openalex.org/W1921682233","https://openalex.org/W4289527926","https://openalex.org/W1848569896","https://openalex.org/W7214887296","https://openalex.org/W6902335433","https://openalex.org/W2805392868","https://openalex.org/W4236829012"],"abstract_inverted_index":{"Diabetes":[0,15,34],"mellitus":[1],"is":[2,19],"a":[3],"chronic":[4,103],"condition":[5],"suffering":[6],"millions":[7],"of":[8,69,133,147,157,173],"people":[9,27],"worldwide.":[10],"According":[11],"to":[12,101,125,153,168],"the":[13,75,117,134,145,155,170],"International":[14],"Federation":[16],"(IDF),":[17],"it":[18,48],"estimated":[20],"that":[21],"by":[22,31,116],"2045":[23],"about":[24],"783":[25],"million":[26],"will":[28],"be":[29,36],"affected":[30],"this":[32],"disease.":[33],"can":[35],"treated":[37],"today":[38],"with":[39,159],"various":[40],"hypoglycemic":[41],"drugs,":[42,72],"including":[43],"metformin":[44],"and":[45,63,108],"sulfonylureas.":[46],"However,":[47],"has":[49,113],"unwanted":[50],"side":[51,128],"effects,":[52,129],"such":[53,73,105],"as":[54,74,82,106],"nausea,":[55],"diarrhea,":[56],"hypothyroidism,":[57],"weight":[58],"gain,":[59],"liver":[60],"failure,":[61],"tachycardia,":[62],"lactic":[64],"acidosis.":[65],"A":[66],"newer":[67],"group":[68],"oral":[70],"diabetes":[71,112,165],"sodium-glucose":[76],"co-transporter":[77],"inhibitors":[78],"(SGLTi),":[79],"are":[80,123,136],"recognized":[81],"useful":[83],"in":[84,89,166],"treating":[85],"blood":[86],"sugar":[87],"levels":[88],"diabetic":[90,178],"patients.":[91,179],"Natural":[92],"phytochemicals":[93,158],"derived":[94,137],"from":[95,139],"plants":[96,140],"have":[97,126],"long":[98],"been":[99,114],"used":[100],"treat":[102],"diseases":[104],"diabetes,":[107],"traditional":[109],"phytotherapy":[110],"for":[111,177],"recommended":[115],"world":[118],"health":[119],"organization.":[120],"Herbal":[121],"medicines":[122],"believed":[124],"fewer":[127],"so":[130],"nearly":[131],"80%":[132],"drugs":[135],"directly":[138],"or":[141],"modified":[142],"plants.":[143],"Given":[144],"importance":[146],"these":[148],"results,":[149],"we":[150],"were":[151],"inspired":[152],"investigate":[154],"impact":[156],"his":[160],"SGLT2":[161],"inhibitory":[162],"effects":[163],"on":[164],"order":[167],"develop":[169],"next":[171],"generation":[172],"safer":[174],"therapeutic":[175],"strategies":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-12T00:00:00"}
