{"id":"https://openalex.org/W4380185692","doi":"https://doi.org/10.1055/s-0043-1767200","title":"The PHORECAST (Hamburg HPV Oropharyngeal Cancer Screening Study) \u2013 A current update and outlook","display_name":"The PHORECAST (Hamburg HPV Oropharyngeal Cancer Screening Study) \u2013 A current update and outlook","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4380185692","doi":"https://doi.org/10.1055/s-0043-1767200"},"language":"en","primary_location":{"id":"doi:10.1055/s-0043-1767200","doi":"https://doi.org/10.1055/s-0043-1767200","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0043-1767200","pdf_url":null,"source":{"id":"https://openalex.org/S140305009","display_name":"Laryngo-Rhino-Otologie","issn_l":"0935-8943","issn":["0935-8943","1438-8685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laryngo-Rhino-Otologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034001854","display_name":"Benjamin Becker","orcid":"https://orcid.org/0000-0002-8496-7731","observed_orcids":["https://orcid.org/0000-0002-8496-7731"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benjamin Becker","raw_affiliation_strings":["Universit\u00e4tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075136596","display_name":"Sophie Anna Hoffmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sophie Anna Hoffmann","raw_affiliation_strings":["Universit\u00e4tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112575023","display_name":"Lea Schroeder","orcid":"https://orcid.org/0009-0004-6049-6375","observed_orcids":["https://orcid.org/0009-0004-6049-6375"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lea Schr\u00f6der","raw_affiliation_strings":["Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yassin Hussein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yassin Hussein","raw_affiliation_strings":["Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg City Health Study, Epidemiologisches Studienzentrum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg City Health Study, Epidemiologisches Studienzentrum","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048036585","display_name":"Elina Larissa Petersen","orcid":"https://orcid.org/0000-0002-1235-5066","observed_orcids":["https://orcid.org/0000-0002-1235-5066"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elina Petersen","raw_affiliation_strings":["Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg City Health Study, Epidemiologisches Studienzentrum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg City Health Study, Epidemiologisches Studienzentrum","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015522685","display_name":"Christian Stephan Betz","orcid":"https://orcid.org/0000-0003-3188-1026","observed_orcids":["https://orcid.org/0000-0003-3188-1026","https://orcid.org/0000-0002-7717-7387"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Betz","raw_affiliation_strings":["Universit\u00e4tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077355814","display_name":"Thorsten Rieckmann","orcid":"https://orcid.org/0000-0001-8426-107X","observed_orcids":["https://orcid.org/0000-0001-8426-107X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten Rieckmann","raw_affiliation_strings":["Universit\u00e4tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde","Universit\u00e4tsklinikum Hamburg-Eppendorf, Labor f\u00fcr Strahlenbiologie und Experimentelle Radioonkologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Labor f\u00fcr Strahlenbiologie und Experimentelle Radioonkologie","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080937699","display_name":"Tim Waterboer","orcid":"https://orcid.org/0000-0002-0616-6963","observed_orcids":["https://orcid.org/0000-0002-0616-6963"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Waterboer","raw_affiliation_strings":["Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12097521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"S 02","first_page":"S229","last_page":"S229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/serological-screening","display_name":"serological screening","score":0.6740000247955322},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7559999823570251},{"id":"https://openalex.org/keywords/asymptomatic-cancer","display_name":"asymptomatic cancer","score":0.6290000081062317},{"id":"https://openalex.org/keywords/head-and-neck-cancer-screening","display_name":"head and neck cancer screening","score":0.6420000195503235},{"id":"https://openalex.org/keywords/hamburg-city-health-study","display_name":"Hamburg City Health Study","score":0.7210000157356262},{"id":"https://openalex.org/keywords/multiplex-serology","display_name":"multiplex serology","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6376290321350098},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5841224193572998},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5338476896286011},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.42236292362213135},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3982466757297516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33470261096954346},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0043-1767200","doi":"https://doi.org/10.1055/s-0043-1767200","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0043-1767200","pdf_url":null,"source":{"id":"https://openalex.org/S140305009","display_name":"Laryngo-Rhino-Otologie","issn_l":"0935-8943","issn":["0935-8943","1438-8685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laryngo-Rhino-Otologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296167684","https://openalex.org/W4395036060","https://openalex.org/W3172107752","https://openalex.org/W4382200680","https://openalex.org/W3043229782","https://openalex.org/W3042624105","https://openalex.org/W3172586569","https://openalex.org/W2598719214","https://openalex.org/W7208725179","https://openalex.org/W4409633222"],"abstract_inverted_index":{"Introduction":[0],"Despite":[1],"the":[2,14,53,70,93,168,171],"rising":[3],"incidence":[4],"of":[5,45,167,170,191,217,251],"oropharyngeal":[6],"cancer":[7],"attributable":[8],"to":[9,31,91,125,238],"human":[10],"papillomaviruses":[11],"(HPV-OPC)":[12],"over":[13],"last":[15],"decades,":[16],"early":[17,25,110,213,220,244],"detection":[18],"is":[19,67,174],"still":[20],"challenging.":[21],"Antibodies":[22],"against":[23],"HPV16":[24,103,137,201,219],"proteins":[26],"are":[27,204],"detectable":[28,189],"years":[29],"prior":[30],"HPV-OPC":[32,42,121,153,230],"diagnosis.":[33],"Our":[34],"proof-of-concept":[35],"study":[36,66,78],"allowed":[37,224],"identifying":[38,225],"three":[39],"stage":[40,228],"I":[41,229],"patients,":[43],"out":[44],"eleven":[46],"participants":[47,83,99,134,186,199],"considered":[48,116],"at":[49,106,117,242],"high":[50,118],"risk":[51,119],"within":[52,69],"Hamburg":[54],"City":[55],"Health":[56],"Study":[57],"(HCHS)":[58],"until":[59],"June":[60],"2022.":[61],"Patients":[62],"and":[63,105,123,128,149,173,180,193,232,248],"methods":[64],"The":[65,184,197],"embedded":[68],"HCHS,":[71],"a":[72],"single":[73,136,200],"center,":[74],"prospective,":[75],"epidemiologic":[76],"cohort":[77],"that":[79],"started":[80],"enrolling":[81],"45.000":[82],"(45-74":[84],"years)":[85],"in":[86,212],"2016.":[87],"Using":[88],"multiplex":[89],"serology":[90],"analyze":[92],"first":[94],"4,424":[95],"participants\u2019":[96],"sera,":[97],"11":[98],"(0.3%)":[100],"seropositive":[101,203],"for":[102,120,176,206],"E6":[104,138,202],"least":[107],"one":[108,143],"additional":[109],"protein":[111],"(E1,":[112],"E2,":[113],"E7)":[114],"were":[115,135],"development":[122],"invited":[124],"non-invasive":[126],"head":[127],"neck":[129],"follow-up":[130],"(FU)":[131],"exams.":[132],"24":[133,198],"seropositive.":[139],"Results":[140],"Currently":[141],"(10/2022)":[142],"more":[144],"female":[145],"participant":[146,159],"was":[147],"identified":[148],"treated":[150],"with":[151,162,182],"asymptomatic":[152,163,227],"(cT2":[154],"cN1":[155],"cM0).":[156],"One":[157],"male":[158],"presented":[160],"(11/2022)":[161],"progressive":[164],"asymmetric":[165],"hyperplasia":[166],"base":[169],"tongue":[172],"planned":[175,205],"magnetic":[177],"resonance":[178],"imaging":[179],"panendoscopy":[181],"biopsy.":[183],"remaining":[185],"showed":[187],"no":[188],"signs":[190],"cancer,":[192],"undergo":[194],"regular":[195],"FU.":[196],"FU":[207],"including":[208],"anogenital":[209],"examination":[210],"beginning":[211],"2023.":[214],"Conclusion":[215],"Detection":[216],"multiple":[218],"antibodies":[221],"so":[222],"far":[223],"four":[226],"patients":[231,241],"might":[233],"be":[234],"an":[235,243],"innovative":[236],"method":[237],"identify":[239],"such":[240],"stage,":[245],"reduce":[246],"morbidity":[247],"improve":[249],"quality":[250],"life.":[252],"Publication":[253],"History":[254],"Article":[255],"published":[256],"online:":[257],"12":[258],"May":[259],"2023":[260],"Georg":[261],"Thieme":[262],"Verlag":[263],"R\u00fcdigerstra\u00dfe":[264],"14,":[265],"70469":[266],"Stuttgart,":[267],"Germany":[268]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-06-11T00:00:00"}
