{"id":"https://openalex.org/W4380090616","doi":"https://doi.org/10.1111/imr.13231","title":"Good CARMA : Turning bad tumor\u2010resident myeloid cells good with chimeric antigen receptor macrophages","display_name":"Good CARMA : Turning bad tumor\u2010resident myeloid cells good with chimeric antigen receptor macrophages","publication_year":2023,"publication_date":"2023-06-09","ids":{"openalex":"https://openalex.org/W4380090616","doi":"https://doi.org/10.1111/imr.13231","pmid":"https://pubmed.ncbi.nlm.nih.gov/37295964"},"language":"en","primary_location":{"id":"doi:10.1111/imr.13231","doi":"https://doi.org/10.1111/imr.13231","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imr.13231","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imr.13231","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imr.13231","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000266658","display_name":"Christopher M. Snyder","orcid":"https://orcid.org/0000-0003-1370-7198","observed_orcids":["https://orcid.org/0000-0003-1370-7198"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Snyder","raw_affiliation_strings":["Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039491957","display_name":"Saar I. Gill","orcid":"https://orcid.org/0000-0001-7946-7778","observed_orcids":["https://orcid.org/0000-0001-7946-7778"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saar I. Gill","raw_affiliation_strings":["Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA","Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-7946-7778","affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039491957"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4530,"currency":"USD","value_usd":4530},"apc_paid":null,"fwci":0.3326,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.33302469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"320","issue":"1","first_page":"236","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-macrophages","display_name":"chimeric antigen receptor macrophages","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9190000295639038},{"id":"https://openalex.org/keywords/macrophage-repolarization","display_name":"macrophage repolarization","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8820000290870667},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.5509999990463257},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/macrophage-plasticity","display_name":"macrophage plasticity","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6304698586463928},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5683809518814087},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5493552088737488},{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.526441216468811},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5232055187225342},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5055580139160156},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5039791464805603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5003643035888672},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4860092103481293},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4687754213809967},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4494086802005768},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4472009539604187},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4376469850540161},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43402808904647827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41667357087135315},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41197696328163147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3283073306083679},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21303272247314453},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20431318879127502},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1579938530921936},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15262430906295776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14699548482894897}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/imr.13231","doi":"https://doi.org/10.1111/imr.13231","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imr.13231","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imr.13231","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:37295964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37295964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/imr.13231","doi":"https://doi.org/10.1111/imr.13231","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imr.13231","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imr.13231","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380090616.pdf","grobid_xml":"https://content.openalex.org/works/W4380090616.grobid-xml"},"referenced_works_count":163,"referenced_works":["https://openalex.org/W982662479","https://openalex.org/W1107917109","https://openalex.org/W1666037483","https://openalex.org/W1926179112","https://openalex.org/W1940048983","https://openalex.org/W1963904011","https://openalex.org/W1965130745","https://openalex.org/W1969057487","https://openalex.org/W1972808685","https://openalex.org/W1980763172","https://openalex.org/W1981755236","https://openalex.org/W1999124123","https://openalex.org/W2005334224","https://openalex.org/W2017056838","https://openalex.org/W2043850625","https://openalex.org/W2043980011","https://openalex.org/W2043991982","https://openalex.org/W2047564123","https://openalex.org/W2049469024","https://openalex.org/W2061123122","https://openalex.org/W2067256262","https://openalex.org/W2069554621","https://openalex.org/W2076734829","https://openalex.org/W2084909479","https://openalex.org/W2100039832","https://openalex.org/W2102032120","https://openalex.org/W2106102605","https://openalex.org/W2113544323","https://openalex.org/W2117034500","https://openalex.org/W2127898787","https://openalex.org/W2131464730","https://openalex.org/W2132564070","https://openalex.org/W2133346943","https://openalex.org/W2134167421","https://openalex.org/W2140347191","https://openalex.org/W2142530756","https://openalex.org/W2143766145","https://openalex.org/W2159137725","https://openalex.org/W2159560463","https://openalex.org/W2163035374","https://openalex.org/W2163175900","https://openalex.org/W2165275387","https://openalex.org/W2174080440","https://openalex.org/W2176714462","https://openalex.org/W2179454156","https://openalex.org/W2293645537","https://openalex.org/W2301044272","https://openalex.org/W2331667420","https://openalex.org/W2340110554","https://openalex.org/W2401143451","https://openalex.org/W2471840718","https://openalex.org/W2520601585","https://openalex.org/W2524516638","https://openalex.org/W2528574508","https://openalex.org/W2559092619","https://openalex.org/W2605540758","https://openalex.org/W2606222190","https://openalex.org/W2615301036","https://openalex.org/W2649656222","https://openalex.org/W2749550628","https://openalex.org/W2750254726","https://openalex.org/W2756859243","https://openalex.org/W2770003411","https://openalex.org/W2779155953","https://openalex.org/W2782080447","https://openalex.org/W2783304391","https://openalex.org/W2795318100","https://openalex.org/W2797407068","https://openalex.org/W2797866384","https://openalex.org/W2801309958","https://openalex.org/W2810715813","https://openalex.org/W2884417934","https://openalex.org/W2885957766","https://openalex.org/W2890042587","https://openalex.org/W2895245013","https://openalex.org/W2897460617","https://openalex.org/W2910435913","https://openalex.org/W2910735802","https://openalex.org/W2913136103","https://openalex.org/W2914311347","https://openalex.org/W2916860038","https://openalex.org/W2919508314","https://openalex.org/W2934055254","https://openalex.org/W2943781197","https://openalex.org/W2945697388","https://openalex.org/W2949407488","https://openalex.org/W2957498182","https://openalex.org/W2959497269","https://openalex.org/W2971468927","https://openalex.org/W2972291002","https://openalex.org/W2975360268","https://openalex.org/W2976957583","https://openalex.org/W2979129329","https://openalex.org/W2982216374","https://openalex.org/W2991009389","https://openalex.org/W2997652717","https://openalex.org/W3002759430","https://openalex.org/W3004611567","https://openalex.org/W3005777482","https://openalex.org/W3006438030","https://openalex.org/W3006614516","https://openalex.org/W3009334726","https://openalex.org/W3009920944","https://openalex.org/W3014808794","https://openalex.org/W3021224081","https://openalex.org/W3021413923","https://openalex.org/W3026228757","https://openalex.org/W3036265910","https://openalex.org/W3043725858","https://openalex.org/W3043942728","https://openalex.org/W3048665145","https://openalex.org/W3094167654","https://openalex.org/W3096942492","https://openalex.org/W3097012221","https://openalex.org/W3097015693","https://openalex.org/W3106079805","https://openalex.org/W3112396245","https://openalex.org/W3118518279","https://openalex.org/W3119086885","https://openalex.org/W3131164337","https://openalex.org/W3134349159","https://openalex.org/W3136452579","https://openalex.org/W3137708660","https://openalex.org/W3146001933","https://openalex.org/W3150063851","https://openalex.org/W3163238461","https://openalex.org/W3163913184","https://openalex.org/W3165476047","https://openalex.org/W3171491383","https://openalex.org/W3173233941","https://openalex.org/W3178484180","https://openalex.org/W3179409394","https://openalex.org/W3203575974","https://openalex.org/W3208430261","https://openalex.org/W3214546142","https://openalex.org/W4200451376","https://openalex.org/W4206107105","https://openalex.org/W4206662285","https://openalex.org/W4210343276","https://openalex.org/W4220973444","https://openalex.org/W4224441524","https://openalex.org/W4225329042","https://openalex.org/W4225736964","https://openalex.org/W4280541127","https://openalex.org/W4283264926","https://openalex.org/W4287510340","https://openalex.org/W4297907002","https://openalex.org/W4306708247","https://openalex.org/W4306843924","https://openalex.org/W4307208803","https://openalex.org/W4307994194","https://openalex.org/W4308988935","https://openalex.org/W4309740791","https://openalex.org/W4313556841","https://openalex.org/W4321004466","https://openalex.org/W4321373233","https://openalex.org/W4321480081","https://openalex.org/W4321611362","https://openalex.org/W4321611431","https://openalex.org/W4322767854","https://openalex.org/W4323539126","https://openalex.org/W4360599541","https://openalex.org/W4361214122"],"related_works":["https://openalex.org/W7203502098","https://openalex.org/W4295086777","https://openalex.org/W3203266881","https://openalex.org/W3196510371","https://openalex.org/W2913136103","https://openalex.org/W7116364765","https://openalex.org/W4206602777","https://openalex.org/W4412002759","https://openalex.org/W4385898089","https://openalex.org/W4379507930"],"abstract_inverted_index":{"In":[0,31,129],"religious":[1],"philosophy,":[2],"the":[3,8,32,39,44,75,118,139,145],"concept":[4],"of":[5,10,34,43,111,142,147],"karma":[6],"represents":[7],"effect":[9],"one's":[11,17],"past":[12],"and":[13,29,53,79,134],"present":[14],"actions":[15],"on":[16],"future.":[18],"Macrophages":[19,64],"are":[20,37,59,70,84],"highly":[21],"plastic":[22],"cells":[23,124],"with":[24],"myriad":[25],"roles":[26],"in":[27,101,138],"health":[28],"disease.":[30],"setting":[33],"cancer,":[35],"macrophages":[36,58,96,112,143],"among":[38],"most":[40],"plentiful":[41],"members":[42],"immune":[45],"microenvironment":[46,77],"where":[47],"they":[48,83],"generally":[49],"support":[50],"tumor":[51,76],"growth":[52],"restrain":[54],"antitumor":[55],"immunity.":[56],"However,":[57],"not":[60],"necessarily":[61],"born":[62],"bad.":[63],"or":[65,93],"their":[66,115,127],"immediate":[67],"progenitors,":[68],"monocytes,":[69],"induced":[71],"to":[72,74,91,104,125],"traffic":[73],"(TME)":[78],"during":[80],"this":[81,130],"process":[82],"polarized":[85],"toward":[86],"a":[87],"tumor-promoting":[88],"phenotype.":[89],"Efforts":[90],"deplete":[92],"repolarize":[94],"tumor-associated":[95],"(TAM)":[97],"for":[98,144],"therapeutic":[99],"benefit":[100],"cancer":[102],"have":[103],"date":[105],"disappointed.":[106],"By":[107],"contrast,":[108],"genetic":[109,140],"engineering":[110,141],"followed":[113],"by":[114],"transit":[116],"into":[117],"TME":[119],"may":[120],"allow":[121],"these":[122],"impressionable":[123],"mend":[126],"ways.":[128],"review,":[131],"we":[132],"summarize":[133],"discuss":[135],"recent":[136],"advances":[137],"treatment":[146],"cancer.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-10T00:00:00"}