{"id":"https://openalex.org/W4380090577","doi":"https://doi.org/10.3390/cancers15123117","title":"Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A","display_name":"Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A","publication_year":2023,"publication_date":"2023-06-08","ids":{"openalex":"https://openalex.org/W4380090577","doi":"https://doi.org/10.3390/cancers15123117","pmid":"https://pubmed.ncbi.nlm.nih.gov/37370727","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10296593"},"language":"en","primary_location":{"id":"doi:10.3390/cancers15123117","doi":"https://doi.org/10.3390/cancers15123117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15123117","pdf_url":"https://www.mdpi.com/2072-6694/15/12/3117/pdf?version=1686533640","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/15/12/3117/pdf?version=1686533640","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078015259","display_name":"Omid Fotouhi","orcid":"https://orcid.org/0000-0003-0019-0230","observed_orcids":["https://orcid.org/0000-0003-0019-0230"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Omid Fotouhi","raw_affiliation_strings":["Department of Urology, Medical Center-University of Freiburg, 79016 Freiburg, Germany","German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","Department of Urology, Medical Center-University of Freiburg, 79106 Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0019-0230","affiliations":[{"raw_affiliation_string":"Department of Urology, Medical Center-University of Freiburg, 79016 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Department of Urology, Medical Center-University of Freiburg, 79106 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072357730","display_name":"Sheikh Nizamuddin","orcid":"https://orcid.org/0000-0002-4586-5898","observed_orcids":["https://orcid.org/0000-0002-4586-5898","https://orcid.org/0000-0002-1125-5872"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sheikh Nizamuddin","raw_affiliation_strings":["Department of Urology, Medical Center-University of Freiburg, 79016 Freiburg, Germany","German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","Department of Urology, Medical Center-University of Freiburg, 79106 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Medical Center-University of Freiburg, 79016 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Department of Urology, Medical Center-University of Freiburg, 79106 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018660368","display_name":"Stephanie Falk","orcid":"https://orcid.org/0000-0002-3340-4461","observed_orcids":["https://orcid.org/0000-0002-3340-4461"]},"institutions":[{"id":"https://openalex.org/I4210164321","display_name":"Max Planck Institute of Immunobiology and Epigenetics","ror":"https://ror.org/058xzat49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephanie Falk","raw_affiliation_strings":["Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany","Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3340-4461","affiliations":[{"raw_affiliation_string":"Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany","institution_ids":["https://openalex.org/I4210164321"]},{"raw_affiliation_string":"Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany","institution_ids":["https://openalex.org/I4210164321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050843400","display_name":"Oliver Schilling","orcid":"https://orcid.org/0000-0001-7678-7653","observed_orcids":["https://orcid.org/0000-0001-7678-7653"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Schilling","raw_affiliation_strings":["German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","Institute for Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany","Institute for Surgical Pathology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, 79106 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Institute for Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Institute for Surgical Pathology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, 79106 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051457514","display_name":"Ruth Kn\u00fcchel","orcid":"https://orcid.org/0000-0002-4987-701X","observed_orcids":["https://orcid.org/0000-0002-4987-701X"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ruth Kn\u00fcchel-Clarke","raw_affiliation_strings":["Institute of Pathology, University Hospital RWTH Aachen, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Hospital RWTH Aachen, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078157555","display_name":"Martin Lothar Biniossek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin L. Biniossek","raw_affiliation_strings":["Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany","Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058519318","display_name":"H. T. Marc Timmers","orcid":"https://orcid.org/0000-0001-7062-1417","observed_orcids":["https://orcid.org/0000-0001-7062-1417"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"H.Th. Marc Timmers","raw_affiliation_strings":["Department of Urology, Medical Center-University of Freiburg, 79016 Freiburg, Germany","German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","Department of Urology, Medical Center-University of Freiburg, 79106 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Medical Center-University of Freiburg, 79016 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Department of Urology, Medical Center-University of Freiburg, 79106 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5058519318"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I17937529","https://openalex.org/I2801240073","https://openalex.org/I4391767962"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.5407,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.55218746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"15","issue":"12","first_page":"3117","last_page":"3117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7770000100135803},{"id":"https://openalex.org/keywords/exon-14","display_name":"exon 14","score":0.7329999804496765},{"id":"https://openalex.org/keywords/nuclear-localization-signal","display_name":"nuclear localization signal","score":0.9909999966621399},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mll3","display_name":"MLL3","score":0.9010000228881836},{"id":"https://openalex.org/keywords/kmt2d","display_name":"KMT2D","score":0.996999979019165},{"id":"https://openalex.org/keywords/chromatin-binding","display_name":"chromatin binding","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9399999976158142},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.8453000783920288},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.7806159257888794},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7500259876251221},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7311080694198608},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6876703500747681},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6449437141418457},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5811684727668762},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5107293128967285},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4635677933692932},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.4282695949077606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41262978315353394},{"id":"https://openalex.org/C73758832","wikidata":"https://www.wikidata.org/wiki/Q7578564","display_name":"Splicing factor","level":5,"score":0.4109395742416382},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3196726441383362},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.31407952308654785},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.242348313331604},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1813981533050537}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers15123117","doi":"https://doi.org/10.3390/cancers15123117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15123117","pdf_url":"https://www.mdpi.com/2072-6694/15/12/3117/pdf?version=1686533640","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"doi:10.1101/2023.04.20.536794","doi":"https://doi.org/10.1101/2023.04.20.536794","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.04.20.536794","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/04/20/2023.04.20.536794.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10296593","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10296593","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10296593/pdf/cancers-15-03117.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:37370727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37370727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers15123117","doi":"https://doi.org/10.3390/cancers15123117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15123117","pdf_url":"https://www.mdpi.com/2072-6694/15/12/3117/pdf?version=1686533640","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G181390637","display_name":null,"funder_award_id":"SFB\u00a0992","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G312682041","display_name":null,"funder_award_id":"SFB850","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3158133374","display_name":"Epigenetic Complex Assembly in Space and Time","funder_award_id":"ANR-19-CE12-0029","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5169843119","display_name":"SFB 992: Medizinische Epigenetik (MEDEP)  Von grundlegenden Mechanismen zu klinischen Anwendungen","funder_award_id":"192904750","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6881367434","display_name":null,"funder_award_id":"SFB850 subproject B9","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321013","display_name":"Radboud Universiteit","ror":"https://ror.org/016xsfp80"},{"id":"https://openalex.org/F4320321421","display_name":"Albert-Ludwigs-Universit\u00e4t Freiburg","ror":"https://ror.org/0245cg223"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380090577.pdf","grobid_xml":"https://content.openalex.org/works/W4380090577.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1980255776","https://openalex.org/W2003847336","https://openalex.org/W2007139310","https://openalex.org/W2008735740","https://openalex.org/W2022300004","https://openalex.org/W2049991359","https://openalex.org/W2053964757","https://openalex.org/W2081495471","https://openalex.org/W2086554513","https://openalex.org/W2088170764","https://openalex.org/W2108196925","https://openalex.org/W2114843025","https://openalex.org/W2118998259","https://openalex.org/W2128551987","https://openalex.org/W2149441684","https://openalex.org/W2155804510","https://openalex.org/W2157495337","https://openalex.org/W2159885528","https://openalex.org/W2170551349","https://openalex.org/W2176981778","https://openalex.org/W2412836466","https://openalex.org/W2463195069","https://openalex.org/W2463295652","https://openalex.org/W2544360569","https://openalex.org/W2586325036","https://openalex.org/W2600167055","https://openalex.org/W2612976808","https://openalex.org/W2763670669","https://openalex.org/W2789761553","https://openalex.org/W2795877840","https://openalex.org/W2803792092","https://openalex.org/W2899203682","https://openalex.org/W2902745704","https://openalex.org/W2914682245","https://openalex.org/W2926880969","https://openalex.org/W3008113983","https://openalex.org/W3016842444","https://openalex.org/W3027413721","https://openalex.org/W3029661147","https://openalex.org/W3046528824","https://openalex.org/W3089588325","https://openalex.org/W3089590915","https://openalex.org/W3091186260","https://openalex.org/W3091873072","https://openalex.org/W3127641096","https://openalex.org/W3199764951","https://openalex.org/W3206935098","https://openalex.org/W4285089388"],"related_works":["https://openalex.org/W2789761553","https://openalex.org/W2926397425","https://openalex.org/W2050083560","https://openalex.org/W4411453838","https://openalex.org/W7095517903","https://openalex.org/W4380149627","https://openalex.org/W2354535014","https://openalex.org/W2908989229","https://openalex.org/W2038046438","https://openalex.org/W2914682245"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,64],"UTX/KDM6A":[3,46,203],"histone":[4,206],"H3K27":[5,207],"demethylase":[6,208],"plays":[7,210,311],"an":[8,211,312],"important":[9,212,313],"role":[10,213,275,314],"in":[11,17,30,49,54,88,93,214,246,250,257,279,315],"development":[12,216],"and":[13,53,60,91,151,154,168,175,193,209,217,261,267,285],"is":[14,204,248],"frequently":[15],"mutated":[16],"cancers":[18],"such":[19,220],"as":[20,221],"urothelial":[21,222],"cancer.":[22,223,269],"Despite":[23],"many":[24],"studies":[25],"on":[26],"UTX":[27,68,100,145,162,180,192,232,255,288,309],"proteins,":[28],"variations":[29],"mRNA":[31],"splicing":[32,47,185,236,299,307],"have":[33],"been":[34],"overlooked.":[35],"Methods":[36],"Using":[37,137],"Nanopore":[38],"sequencing,":[39],"we":[40,141],"present":[41],"a":[42,107,205,226,239,241,251,274],"comprehensive":[43],"analysis":[44,272],"of":[45,67,83,119,159,191,231,254,308],"events":[48],"human":[50,218],"cell":[51,94,259],"lines":[52,260],"tissue":[55],"samples":[56],"from":[57,263],"bladder":[58,89,265,268],"cancer":[59],"normal":[61,264],"epithelium.":[62],"Results":[63],"central":[65],"region":[66,227,278,300],"mRNAs":[69,86,181],"encoded":[70],"by":[71,98],"exons":[72,166,229],"12":[73],"to":[74,81,113,133,171,281,294],"17":[75],"undergoes":[76,234],"extensive":[77,183,235],"alternative":[78,184,298,306],"splicing.":[79],"Up":[80],"half":[82],"all":[84,144],"stable":[85],"(8-48%":[87],"tissues":[90,262],"18-58%":[92],"lines)":[95],"are":[96],"represented":[97],"the":[99,114,120,134,149,160,188,282,297],"canonical":[101,121,135],"isoform":[102,131],"lacking":[103],"exon":[104,129],"14":[105,167],"encoding":[106],"nuclear":[108,242],"localization":[109,118,190,243],"sequence,":[110],"hence":[111],"localize":[112],"nucleus,":[115],"unlike":[116],"cytonuclear":[117],"isoform.":[122],"Chromatin":[123],"association":[124],"was":[125,289],"also":[126,290],"higher":[127],"for":[128,276],"14-containing":[130],"compared":[132],"UTX.":[136],"quantitative":[138],"mass":[139],"spectrometry,":[140],"found":[142],"that":[143,186,233,305],"isoforms":[146],"integrated":[147],"into":[148],"MLL3":[150],"MLL4,":[152],"PR-DUB":[153,174,284],"MiDAC":[155,176,286],"complexes.":[156,200,287],"Interestingly,":[157],"one":[158],"novel":[161],"isoforms,":[163],"which":[164],"lacks":[165],"16,":[169],"fails":[170],"interact":[172],"with":[173,196],"complex":[177],"members.":[178],"Conclusion":[179],"undergo":[182],"controls":[187],"subcellular":[189],"its":[194,316],"interactions":[195],"other":[197],"chromatin":[198,295],"regulatory":[199],"Simple":[201],"Summary":[202],"mammalian":[215],"diseases":[219],"We":[224],"identified":[225],"encompassing":[228],"12-17":[230],"events.":[237],"As":[238],"result,":[240],"sequence":[244],"located":[245],"exon14":[247],"missing":[249],"considerable":[252],"part":[253],"transcripts":[256,310],"different":[258],"epithelium":[266],"Mass":[270],"spectrometry":[271],"showed":[273,304],"this":[277],"binding":[280],"epigenetic":[283],"more":[291],"extensively":[292],"bound":[293],"when":[296],"presented.":[301],"Our":[302],"study":[303],"functions.":[317]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-06-10T00:00:00"}
