{"id":"https://openalex.org/W4380090168","doi":"https://doi.org/10.3390/molecules28124643","title":"Terpinen-4-ol Induces Ferroptosis of Glioma Cells via Downregulating JUN Proto-Oncogene","display_name":"Terpinen-4-ol Induces Ferroptosis of Glioma Cells via Downregulating JUN Proto-Oncogene","publication_year":2023,"publication_date":"2023-06-08","ids":{"openalex":"https://openalex.org/W4380090168","doi":"https://doi.org/10.3390/molecules28124643","pmid":"https://pubmed.ncbi.nlm.nih.gov/37375197","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10301057"},"language":"en","primary_location":{"id":"doi:10.3390/molecules28124643","doi":"https://doi.org/10.3390/molecules28124643","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules28124643","pdf_url":"https://www.mdpi.com/1420-3049/28/12/4643/pdf?version=1686216544","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/28/12/4643/pdf?version=1686216544","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075563091","display_name":"Wenpeng Cao","orcid":"https://orcid.org/0000-0002-7345-755X","observed_orcids":["https://orcid.org/0000-0002-7345-755X"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenpeng Cao","raw_affiliation_strings":["Department of Anatomy, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China"],"raw_orcid":"https://orcid.org/0000-0002-7345-755X","affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101903762","display_name":"Yumei Li","orcid":"https://orcid.org/0000-0001-9618-3865","observed_orcids":["https://orcid.org/0000-0001-9618-3865"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yumei Li","raw_affiliation_strings":["Department of Anatomy, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China"],"raw_orcid":"https://orcid.org/0000-0001-9618-3865","affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031875987","display_name":"Zhirui Zeng","orcid":"https://orcid.org/0000-0001-9547-9074","observed_orcids":["https://orcid.org/0000-0001-9547-9074"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhirui Zeng","raw_affiliation_strings":["Department of Physiology, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China"],"raw_orcid":"https://orcid.org/0000-0001-9547-9074","affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046964574","display_name":"Shan Lei","orcid":"https://orcid.org/0000-0003-3789-4186","observed_orcids":["https://orcid.org/0000-0003-3789-4186"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shan Lei","raw_affiliation_strings":["Department of Physiology, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China"],"raw_orcid":"https://orcid.org/0000-0003-3789-4186","affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medicine, Guizhou Medical University, Guiyang 550025, China","institution_ids":["https://openalex.org/I149137203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031875987","https://openalex.org/A5046964574"],"corresponding_institution_ids":["https://openalex.org/I149137203"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2558},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2558},"fwci":1.5504,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.83286993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"28","issue":"12","first_page":"4643","last_page":"4643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/terpinen-4-ol","display_name":"terpinen-4-ol","score":1.0},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5019999742507935},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6150000095367432},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.45500001311302185},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.9361743330955505},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6271101832389832},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6163965463638306},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5692765712738037},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5370492339134216},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5082120895385742},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5028249621391296},{"id":"https://openalex.org/C128473837","wikidata":"https://www.wikidata.org/wiki/Q7863603","display_name":"U87","level":3,"score":0.4972670376300812},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4654209315776825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4464688003063202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4332472085952759},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.427490770816803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11938655376434326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09191352128982544},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05943658947944641}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016758","descriptor_name":"Genes, jun","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules28124643","doi":"https://doi.org/10.3390/molecules28124643","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules28124643","pdf_url":"https://www.mdpi.com/1420-3049/28/12/4643/pdf?version=1686216544","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10301057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10301057","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:37375197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37375197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3f75977891954f9d8ae44e95fca64a79","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3f75977891954f9d8ae44e95fca64a79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 28, Iss 12, p 4643 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules28124643","doi":"https://doi.org/10.3390/molecules28124643","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules28124643","pdf_url":"https://www.mdpi.com/1420-3049/28/12/4643/pdf?version=1686216544","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3705161266","display_name":null,"funder_award_id":"20NSP020","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3814519508","display_name":null,"funder_award_id":"82160567","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5613535124","display_name":null,"funder_award_id":"gzwkj (2021-522)","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6726976857","display_name":null,"funder_award_id":"19NSP034","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8564838731","display_name":null,"funder_award_id":"ZK (2023) General 313","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320317797","display_name":"Health Commission of Guizhou Province","ror":"https://ror.org/027yzwq33"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380090168.pdf","grobid_xml":"https://content.openalex.org/works/W4380090168.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1489790004","https://openalex.org/W2098692163","https://openalex.org/W2154049977","https://openalex.org/W2287212130","https://openalex.org/W2607129810","https://openalex.org/W2622809964","https://openalex.org/W2793640805","https://openalex.org/W2903902570","https://openalex.org/W2939322913","https://openalex.org/W2954576837","https://openalex.org/W2995204555","https://openalex.org/W3038112528","https://openalex.org/W3126254925","https://openalex.org/W3144002437","https://openalex.org/W3177905799","https://openalex.org/W3183799519","https://openalex.org/W3198930705","https://openalex.org/W3207114410","https://openalex.org/W3214546142","https://openalex.org/W4220667062","https://openalex.org/W4220689328","https://openalex.org/W4221031965","https://openalex.org/W4223517351","https://openalex.org/W4280507305","https://openalex.org/W4283078991","https://openalex.org/W4283318274","https://openalex.org/W4283644146","https://openalex.org/W4296693425","https://openalex.org/W4297486068","https://openalex.org/W4317555078","https://openalex.org/W4318263613","https://openalex.org/W4318817212","https://openalex.org/W4321445965","https://openalex.org/W4322775359","https://openalex.org/W4327811619","https://openalex.org/W4360945134"],"related_works":["https://openalex.org/W4414189228","https://openalex.org/W4409521617","https://openalex.org/W7165877837","https://openalex.org/W4393085172","https://openalex.org/W4414189234","https://openalex.org/W4403531396","https://openalex.org/W7164538871","https://openalex.org/W4381715144","https://openalex.org/W4206163244","https://openalex.org/W4402561890"],"abstract_inverted_index":{"According":[0],"to":[1,13,39],"previous":[2],"research,":[3],"turmeric":[4],"seeds":[5],"exhibit":[6],"anti-inflammatory,":[7],"anti-malignancy,":[8],"and":[9,49,59,74,105,117,137,139,153,156,179,227,231],"anti-aging":[10],"properties":[11,143],"due":[12],"an":[14,57],"abundance":[15],"of":[16,69,79,84,95,119,125,144,169,198],"terpinen-4-ol":[17],"(T4O).":[18],"Although":[19],"it":[20],"is":[21],"still":[22],"unclear":[23],"how":[24],"T4O":[25,70,80,147,163,175,189,207,218,232],"works":[26],"on":[27,81],"glioma":[28,44,85,145,150,161,171,186,241],"cells,":[29],"limited":[30],"data":[31,212],"exist":[32],"regarding":[33],"its":[34,182,220],"specific":[35],"effects.":[36],"In":[37],"order":[38],"determine":[40],"whether":[41],"or":[42],"not":[43],"cell":[45,86,151,229],"lines":[46],"U251,":[47],"U87,":[48],"LN229":[50],"are":[51],"viable,":[52],"CCK8":[53],"was":[54,64,89],"used":[55],"as":[56,236],"assay":[58,63],"a":[60,102,237],"colony":[61,154],"formation":[62,155],"performed":[65],"using":[66],"different":[67],"concentrations":[68],"(0,":[71],"1,":[72],"2,":[73],"4":[75],"\u03bcM).":[76],"The":[77,188,196],"effect":[78],"the":[82,92,96,113,123,126,132,140,160,165,170,185,203,215],"proliferation":[83,168],"line":[87],"U251":[88],"detected":[90],"through":[91,194,206],"subcutaneous":[93,166],"implantation":[94],"tumor":[97,167],"model.":[98],"Through":[99],"high-throughput":[100],"sequencing,":[101],"bioinformatic":[103],"analysis,":[104],"real-time":[106],"quantitative":[107],"polymerase":[108],"chain":[109],"reactions,":[110],"we":[111,130],"identified":[112],"key":[114],"signaling":[115],"pathways":[116],"targets":[118],"T4O.":[120],"Finally,":[121],"for":[122,240],"measurement":[124],"cellular":[127],"ferroptosis":[128,158,201,226],"levels,":[129],"examined":[131],"relationship":[133],"between":[134],"T4O,":[135],"ferroptosis,":[136],"JUN":[138,177,199],"malignant":[141],"biological":[142],"cells.":[146,162,187],"significantly":[148,180],"inhibited":[149,164,191],"growth":[152],"induced":[157],"in":[159,173,184,202],"cells":[172,204],"vivo.":[174],"suppressed":[176,200],"transcription":[178,193],"reduced":[181],"expression":[183],"treatment":[190],"GPX4":[192],"JUN.":[195],"overexpression":[197],"rescued":[205],"treatment.":[208,242],"Taken":[209],"together,":[210],"our":[211],"suggest":[213],"that":[214],"natural":[216],"product":[217],"exerts":[219],"anti-cancer":[221],"effects":[222],"by":[223],"inducing":[224],"JUN/GPX4-dependent":[225],"inhibiting":[228],"proliferation,":[230],"will":[233],"hope-fully":[234],"serve":[235],"prospective":[238],"compound":[239]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-10T00:00:00"}
