{"id":"https://openalex.org/W4380052257","doi":"https://doi.org/10.3389/fcell.2023.1082213","title":"The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation","display_name":"The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation","publication_year":2023,"publication_date":"2023-06-08","ids":{"openalex":"https://openalex.org/W4380052257","doi":"https://doi.org/10.3389/fcell.2023.1082213","pmid":"https://pubmed.ncbi.nlm.nih.gov/37163088"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2023.1082213","doi":"https://doi.org/10.3389/fcell.2023.1082213","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1082213","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2023.1082213/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2023.1082213/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055981997","display_name":"Emily Fern\u00e1ndez-Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Fern\u00e1ndez Garc\u00eda","raw_affiliation_strings":["Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041497513","display_name":"Usha Paudel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Usha Paudel","raw_affiliation_strings":["Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051260812","display_name":"Michael Noji","orcid":"https://orcid.org/0000-0002-6996-5367","observed_orcids":["https://orcid.org/0000-0002-6996-5367"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Noji","raw_affiliation_strings":["Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","Department of Medicine, Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Medicine, Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071347274","display_name":"Caitlyn E. Bowman","orcid":"https://orcid.org/0000-0003-2310-581X","observed_orcids":["https://orcid.org/0000-0003-2310-581X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlyn E. Bowman","raw_affiliation_strings":["Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Medicine, Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Medicine, Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065125959","display_name":"Jason Robert Pitarresi","orcid":"https://orcid.org/0000-0001-9549-4768","observed_orcids":["https://orcid.org/0000-0001-9549-4768"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R. Pitarresi","raw_affiliation_strings":["Division of Hematology/Oncology, Departments of Medicine and Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA","Division of Digestive and Liver Diseases, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Departments of Medicine and Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, United States","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158402561","display_name":"Anil K. Rustgi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil K. Rustgi","raw_affiliation_strings":["Division of Digestive and Liver Diseases, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA","Division of Hematology/Oncology, Departments of Medicine and Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Departments of Medicine and Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104753400","display_name":"Kathryn E. Wellen","orcid":"https://orcid.org/0000-0002-2281-0042","observed_orcids":["https://orcid.org/0000-0002-2281-0042"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn E. Wellen","raw_affiliation_strings":["Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007124467","display_name":"Zoltan Pierre Arany","orcid":"https://orcid.org/0000-0003-1368-2453","observed_orcids":["https://orcid.org/0000-0003-1368-2453"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zolt Arany","raw_affiliation_strings":["Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Medicine, Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Medicine, Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086313737","display_name":"Jillian Weissenrieder","orcid":"https://orcid.org/0000-0002-8096-5421","observed_orcids":["https://orcid.org/0000-0002-8096-5421"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jillian S. Weissenrieder","raw_affiliation_strings":["Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030221375","display_name":"J. Kevin Foskett","orcid":"https://orcid.org/0000-0002-8854-0268","observed_orcids":["https://orcid.org/0000-0002-8854-0268"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Kevin Foskett","raw_affiliation_strings":["Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030221375"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":2.6815,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.92014587,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"11","issue":null,"first_page":"1082213","last_page":"1082213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.046300001442432404,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.03929999843239784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-calcium-uniporter","display_name":"mitochondrial calcium uniporter","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mcu","display_name":"MCU","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mitochondrial-calcium-uptake","display_name":"mitochondrial calcium uptake","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.859000027179718},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.6380000114440918},{"id":"https://openalex.org/keywords/spheroid-formation","display_name":"spheroid formation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/glutaminolysis","display_name":"glutaminolysis","score":1.0},{"id":"https://openalex.org/keywords/transformed-fibroblasts","display_name":"transformed fibroblasts","score":0.8610000014305115},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.6438276171684265},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.6417032480239868},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6393671631813049},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6372433304786682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5654726028442383},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.548459529876709},{"id":"https://openalex.org/C35341161","wikidata":"https://www.wikidata.org/wiki/Q289992","display_name":"Uniporter","level":4,"score":0.4999399185180664},{"id":"https://openalex.org/C88099638","wikidata":"https://www.wikidata.org/wiki/Q412856","display_name":"Pyruvate dehydrogenase complex","level":3,"score":0.46923428773880005},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4325886070728302},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4159565567970276},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3419530391693115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3221074938774109},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2114275097846985},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.12229418754577637},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fcell.2023.1082213","doi":"https://doi.org/10.3389/fcell.2023.1082213","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1082213","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2023.1082213/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.04.26.538295","doi":"https://doi.org/10.1101/2023.04.26.538295","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.04.26.538295","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/04/28/2023.04.26.538295.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37163088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37163088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37363724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37363724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10168388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10168388","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10168388/pdf/nihpp-2023.04.26.538295v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10285664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10285664","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10285664/pdf/fcell-11-1082213.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cb28ae95e890444195d1c0db4283eafa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cb28ae95e890444195d1c0db4283eafa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 11 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2023.1082213","doi":"https://doi.org/10.3389/fcell.2023.1082213","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1082213","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2023.1082213/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1025384971","display_name":null,"funder_award_id":"R01DK060694","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1240806148","display_name":null,"funder_award_id":"T32-HL007843","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2266079415","display_name":null,"funder_award_id":"HEK293T","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2548302533","display_name":"The Mitochondrial Calcium Uniporter in Pancreatic Cancer Development, Metastasis, and Treatment","funder_award_id":"F32CA250144","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3041263631","display_name":null,"funder_award_id":"R01 HL152446","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4366644824","display_name":"Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer","funder_award_id":"K99CA252153","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5189791496","display_name":null,"funder_award_id":"F31 CA261041","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6013653176","display_name":null,"funder_award_id":"R37 GM056328","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000014044","display_name":null,"funder_award_id":"T32 HL007843","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000041331","display_name":null,"funder_award_id":"F31CA261041","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000044500","display_name":null,"funder_award_id":"R37GM56328","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000061651","display_name":null,"funder_award_id":"R01 DK060694","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000083365","display_name":null,"funder_award_id":"R01 CA248315","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000116989","display_name":null,"funder_award_id":"R37GM56328 R01CA250173 F32CA250144 R01DK060694 P30CA013696 T32HL007843 F31CA261041 K99CA252153 HL152446 R01CA248315","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000171907","display_name":null,"funder_award_id":"HL152446","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000313755","display_name":null,"funder_award_id":"T32-HL007843-24","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000867049","display_name":"Endoplasmic Reticulum-to-Mitochondria Calcium Transfer in Pancreatic Cancer Development, Metastasis, and Treatment","funder_award_id":"R01CA250173","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000916142","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA013696","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G951062505","display_name":null,"funder_award_id":"R01 CA248315","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320318473","display_name":"Hopper-Belmont Foundation","ror":"https://ror.org/02xtj4j63"},{"id":"https://openalex.org/F4320318896","display_name":"Emerson Collective","ror":"https://ror.org/04537p149"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332608","display_name":"Perelman School of Medicine, University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380052257.pdf","grobid_xml":"https://content.openalex.org/works/W4380052257.grobid-xml"},"referenced_works_count":126,"referenced_works":["https://openalex.org/W1483212110","https://openalex.org/W1523821352","https://openalex.org/W1553978925","https://openalex.org/W1575893559","https://openalex.org/W1622243645","https://openalex.org/W1825250204","https://openalex.org/W1832257936","https://openalex.org/W1932780354","https://openalex.org/W1967184808","https://openalex.org/W1980502224","https://openalex.org/W1984770187","https://openalex.org/W1986213783","https://openalex.org/W1988714320","https://openalex.org/W1991614275","https://openalex.org/W1991820222","https://openalex.org/W1996365670","https://openalex.org/W2002357266","https://openalex.org/W2005641666","https://openalex.org/W2006756372","https://openalex.org/W2009657046","https://openalex.org/W2014058353","https://openalex.org/W2014668921","https://openalex.org/W2019961716","https://openalex.org/W2023549669","https://openalex.org/W2026170688","https://openalex.org/W2028743750","https://openalex.org/W2029436635","https://openalex.org/W2034781878","https://openalex.org/W2037865099","https://openalex.org/W2043451976","https://openalex.org/W2046353863","https://openalex.org/W2055255976","https://openalex.org/W2059603427","https://openalex.org/W2067678773","https://openalex.org/W2067841051","https://openalex.org/W2070710923","https://openalex.org/W2081369737","https://openalex.org/W2081465448","https://openalex.org/W2081644238","https://openalex.org/W2084295225","https://openalex.org/W2086546138","https://openalex.org/W2091739490","https://openalex.org/W2092152920","https://openalex.org/W2093931854","https://openalex.org/W2095987251","https://openalex.org/W2101840868","https://openalex.org/W2102228853","https://openalex.org/W2111285897","https://openalex.org/W2115021528","https://openalex.org/W2116916145","https://openalex.org/W2117692326","https://openalex.org/W2129824771","https://openalex.org/W2132656753","https://openalex.org/W2133002620","https://openalex.org/W2140564760","https://openalex.org/W2149917889","https://openalex.org/W2149977873","https://openalex.org/W2162016905","https://openalex.org/W2165573061","https://openalex.org/W2167279371","https://openalex.org/W2167737594","https://openalex.org/W2189546716","https://openalex.org/W2223535266","https://openalex.org/W2269147622","https://openalex.org/W2277073486","https://openalex.org/W2291641483","https://openalex.org/W2337436076","https://openalex.org/W2345977715","https://openalex.org/W2530859476","https://openalex.org/W2557537936","https://openalex.org/W2570959155","https://openalex.org/W2586644082","https://openalex.org/W2592487518","https://openalex.org/W2610435987","https://openalex.org/W2617766232","https://openalex.org/W2643823353","https://openalex.org/W2738778195","https://openalex.org/W2739524607","https://openalex.org/W2745460555","https://openalex.org/W2786752277","https://openalex.org/W2810241447","https://openalex.org/W2891141193","https://openalex.org/W2897193648","https://openalex.org/W2901586290","https://openalex.org/W2903416169","https://openalex.org/W2906229934","https://openalex.org/W2913914680","https://openalex.org/W2915736024","https://openalex.org/W2920832140","https://openalex.org/W2924975078","https://openalex.org/W2943655244","https://openalex.org/W2948764282","https://openalex.org/W2959257877","https://openalex.org/W2959588548","https://openalex.org/W2974606989","https://openalex.org/W2982189315","https://openalex.org/W2982872965","https://openalex.org/W3006532142","https://openalex.org/W3008751896","https://openalex.org/W3016481540","https://openalex.org/W3022098300","https://openalex.org/W3022394898","https://openalex.org/W3042809529","https://openalex.org/W3085374376","https://openalex.org/W3092769144","https://openalex.org/W3094623602","https://openalex.org/W3101293635","https://openalex.org/W3113834486","https://openalex.org/W3153483716","https://openalex.org/W3153517561","https://openalex.org/W3154381759","https://openalex.org/W3164430512","https://openalex.org/W3167002553","https://openalex.org/W3167752044","https://openalex.org/W3175641414","https://openalex.org/W3183360408","https://openalex.org/W3184764602","https://openalex.org/W3186940301","https://openalex.org/W3210932179","https://openalex.org/W3213904362","https://openalex.org/W4220864023","https://openalex.org/W4226255852","https://openalex.org/W4289968706","https://openalex.org/W4297239275","https://openalex.org/W4361225334","https://openalex.org/W6684890163"],"related_works":["https://openalex.org/W2062811831","https://openalex.org/W2009164248","https://openalex.org/W3041103849","https://openalex.org/W2898640746","https://openalex.org/W2992157733","https://openalex.org/W1992887404","https://openalex.org/W2167378780","https://openalex.org/W2225852931","https://openalex.org/W2585203545","https://openalex.org/W4309093616"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"mitochondrial":[2,55,70,83,87,164,226],"uniporter":[3],"(MCU)":[4],"Ca":[5,14,56,78,88,166,209,227,234],"2+":[6,15,57,79,89,167,210,228,235],"ion":[7],"channel":[8],"represents":[9],"the":[10,141],"primary":[11,44],"means":[12],"for":[13,230,238],"uptake":[16,90,229],"into":[17],"mitochondria.":[18],"Here":[19],"we":[20],"employed":[21],"in":[22,25,46,106,125,132,155,185],"vitro":[23,47,133,156],"and":[24,40,72,102,121,128,152,175,194,202,205,233,241],"vivo":[26,126],"models":[27],"with":[28,50,135],"MCU":[29,35,52,95,144,184,190],"genetically":[30],"eliminated":[31],"to":[32,37,200],"understand":[33],"how":[34],"contributes":[36],"tumor":[38,111],"formation":[39,151],"progression.":[41],"Transformation":[42],"of":[43,60,62,68,76,82,86,94,99,103,117,140,160,183,217],"fibroblasts":[45,105],"was":[48,113],"associated":[49,134],"increased":[51],"expression,":[53],"enhanced":[54],"uptake,":[58],"suppression":[59],"inactivating-phosphorylation":[61],"pyruvate":[63],"dehydrogenase,":[64],"a":[65,73,115,215,223],"modest":[66],"increase":[67,75],"basal":[69],"respiration":[71,174],"significant":[74],"acute":[77],"-dependent":[80],"stimulation":[81],"respiration.":[84],"Inhibition":[85],"by":[91,180,222],"genetic":[92,181],"deletion":[93,145,182,191],"markedly":[96],"inhibited":[97,146],"growth":[98,112],"HEK293T":[100],"cells":[101,124],"transformed":[104,186],"mouse":[107],"xenograft":[108],"models.":[109],"Reduced":[110],"primarily":[114],"result":[116],"substantially":[118],"reduced":[119],"proliferation":[120,131,199],"fewer":[122],"mitotic":[123],",":[127,157],"slower":[129],"cell":[130,142,153,198,231,242],"delayed":[136],"progression":[137,240],"through":[138],"S-phase":[139],"cycle.":[143],"cancer":[147],"stem":[148],"cell-like":[149],"spheroid":[150],"invasion":[154],"both":[158],"predictors":[159],"metastatic":[161],"potential.":[162],"Surprisingly,":[163],"matrix":[165],"concentration,":[168],"membrane":[169],"potential,":[170],"global":[171],"dehydrogenase":[172],"activity,":[173],"ROS":[176],"production":[177],"were":[178],"unchanged":[179],"cells.":[187],"In":[188],"contrast,":[189],"elevated":[192],"glycolysis":[193],"glutaminolysis,":[195],"strongly":[196],"sensitized":[197],"glucose":[201],"glutamine":[203],"limitation,":[204],"altered":[206],"agonist-induced":[207],"cytoplasmic":[208],"signals.":[211],"Our":[212],"results":[213],"reveal":[214],"dependence":[216],"tumorigenesis":[218],"on":[219,225],"MCU,":[220],"mediated":[221],"reliance":[224],"metabolism":[232],"dynamics":[236],"necessary":[237],"cell-cycle":[239],"proliferation.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2023-06-10T00:00:00"}
