{"id":"https://openalex.org/W4380051958","doi":"https://doi.org/10.3390/curroncol30060418","title":"Estimating the Associated Burden of Illness and Healthcare Utilization of Newly Diagnosed Patients Aged \u226565 with Mantle Cell Lymphoma (MCL) in Ontario, Canada","display_name":"Estimating the Associated Burden of Illness and Healthcare Utilization of Newly Diagnosed Patients Aged \u226565 with Mantle Cell Lymphoma (MCL) in Ontario, Canada","publication_year":2023,"publication_date":"2023-06-08","ids":{"openalex":"https://openalex.org/W4380051958","doi":"https://doi.org/10.3390/curroncol30060418","pmid":"https://pubmed.ncbi.nlm.nih.gov/37366901","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10297405"},"language":"en","primary_location":{"id":"doi:10.3390/curroncol30060418","doi":"https://doi.org/10.3390/curroncol30060418","is_oa":true,"landing_page_url":"https://doi.org/10.3390/curroncol30060418","pdf_url":"https://www.mdpi.com/1718-7729/30/6/418/pdf?version=1686207648","source":{"id":"https://openalex.org/S113449754","display_name":"Current Oncology","issn_l":"1198-0052","issn":["1198-0052","1718-7729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1718-7729/30/6/418/pdf?version=1686207648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054496544","display_name":"Peter Anglin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802289008","display_name":"Southlake Regional Health Center","ror":"https://ror.org/05ayf4d73","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802289008"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter Anglin","raw_affiliation_strings":["Bayshore HealthCare, 2101 Hadwen Rd., Mississauga, ON L5K 2L3, Canada","Stronach Regional Cancer Centre, Southlake Regional Health Centre, Newmarket, ON L3Y 2P9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayshore HealthCare, 2101 Hadwen Rd., Mississauga, ON L5K 2L3, Canada","institution_ids":[]},{"raw_affiliation_string":"Stronach Regional Cancer Centre, Southlake Regional Health Centre, Newmarket, ON L3Y 2P9, Canada","institution_ids":["https://openalex.org/I2802289008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027159235","display_name":"Julia Elia-Pacitti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273451","display_name":"Janssen Canada (Canada)","ror":"https://ror.org/05v91av89","country_code":"CA","type":"company","lineage":["https://openalex.org/I4405273451"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julia Elia-Pacitti","raw_affiliation_strings":["Janssen Canada Inc., 19 Green Belt Drive, North York, ON M3C 1L9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Canada Inc., 19 Green Belt Drive, North York, ON M3C 1L9, Canada","institution_ids":["https://openalex.org/I4405273451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110448733","display_name":"Mar\u00eda Eberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Eberg","raw_affiliation_strings":["Real World Solutions, IQVIA, 16720 Rte Transcanadienne, Kirkland, QC H9H 5M3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Real World Solutions, IQVIA, 16720 Rte Transcanadienne, Kirkland, QC H9H 5M3, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110611731","display_name":"Sergey Muratov","orcid":"https://orcid.org/0000-0002-4105-4609","observed_orcids":["https://orcid.org/0000-0002-4105-4609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergey Muratov","raw_affiliation_strings":["Real World Solutions, IQVIA, 402-1875 Buckhorn Gate, Mississauga, ON L4W 5N9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Real World Solutions, IQVIA, 402-1875 Buckhorn Gate, Mississauga, ON L4W 5N9, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086606104","display_name":"ATIF A. KUKASWADIA","orcid":"https://orcid.org/0000-0002-9419-2415","observed_orcids":["https://orcid.org/0000-0002-9419-2415"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atif Kukaswadia","raw_affiliation_strings":["Real World Solutions, IQVIA, 402-1875 Buckhorn Gate, Mississauga, ON L4W 5N9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Real World Solutions, IQVIA, 402-1875 Buckhorn Gate, Mississauga, ON L4W 5N9, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101196475","display_name":"Arushi Sharma","orcid":"https://orcid.org/0009-0008-2089-356X","observed_orcids":["https://orcid.org/0009-0008-2089-356X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arushi Sharma","raw_affiliation_strings":["Real World Solutions, IQVIA, 301-300 March Rd., Kanata, ON K2K 2E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Real World Solutions, IQVIA, 301-300 March Rd., Kanata, ON K2K 2E2, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009449478","display_name":"Emmanuel M. Ewara","orcid":"https://orcid.org/0000-0001-5354-9329","observed_orcids":["https://orcid.org/0000-0001-5354-9329"]},"institutions":[{"id":"https://openalex.org/I4405273451","display_name":"Janssen Canada (Canada)","ror":"https://ror.org/05v91av89","country_code":"CA","type":"company","lineage":["https://openalex.org/I4405273451"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Emmanuel M. Ewara","raw_affiliation_strings":["Janssen Canada Inc., 19 Green Belt Drive, North York, ON M3C 1L9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Canada Inc., 19 Green Belt Drive, North York, ON M3C 1L9, Canada","institution_ids":["https://openalex.org/I4405273451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009449478"],"corresponding_institution_ids":["https://openalex.org/I4405273451"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2002},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2002},"fwci":0.5043,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60871594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"30","issue":"6","first_page":"5529","last_page":"5545"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":1.0},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8840000033378601},{"id":"https://openalex.org/keywords/healthcare-resource-utilization","display_name":"healthcare resource utilization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/health-care-costs","display_name":"health care costs","score":0.9959999918937683},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bendamustine-plus-rituximab","display_name":"bendamustine-rituximab","score":0.9010000228881836},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.4830000102519989},{"id":"https://openalex.org/keywords/ontario","display_name":"Ontario","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9082329273223877},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.8285041451454163},{"id":"https://openalex.org/C2781442060","wikidata":"https://www.wikidata.org/wiki/Q425745","display_name":"Bendamustine","level":4,"score":0.7100722193717957},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.5781358480453491},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.5275627970695496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5158021450042725},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4619925320148468},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4614627957344055},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4014272391796112},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3373154401779175},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09584730863571167},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069461","descriptor_name":"Bendamustine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009864","descriptor_name":"Ontario","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010342","descriptor_name":"Patient Acceptance of Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017281","descriptor_name":"Cost of Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/curroncol30060418","doi":"https://doi.org/10.3390/curroncol30060418","is_oa":true,"landing_page_url":"https://doi.org/10.3390/curroncol30060418","pdf_url":"https://www.mdpi.com/1718-7729/30/6/418/pdf?version=1686207648","source":{"id":"https://openalex.org/S113449754","display_name":"Current Oncology","issn_l":"1198-0052","issn":["1198-0052","1718-7729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10297405","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10297405","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10297405/pdf/curroncol-30-00418.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Oncol","raw_type":"Text"},{"id":"pmid:37366901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37366901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current oncology (Toronto, Ont.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d593ab355cd644919fb6a56f366013ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d593ab355cd644919fb6a56f366013ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Oncology, Vol 30, Iss 6, Pp 5529-5545 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/curroncol30060418","doi":"https://doi.org/10.3390/curroncol30060418","is_oa":true,"landing_page_url":"https://doi.org/10.3390/curroncol30060418","pdf_url":"https://www.mdpi.com/1718-7729/30/6/418/pdf?version=1686207648","source":{"id":"https://openalex.org/S113449754","display_name":"Current Oncology","issn_l":"1198-0052","issn":["1198-0052","1718-7729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320314607","display_name":"Government of Ontario","ror":"https://ror.org/015pzp858"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380051958.pdf","grobid_xml":"https://content.openalex.org/works/W4380051958.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W2001178238","https://openalex.org/W2023847862","https://openalex.org/W2472310215","https://openalex.org/W2590678262","https://openalex.org/W2803800538","https://openalex.org/W2896637894","https://openalex.org/W2943072932","https://openalex.org/W2963379299","https://openalex.org/W3008982966","https://openalex.org/W3011830237","https://openalex.org/W3014193429","https://openalex.org/W3085590528","https://openalex.org/W3089359485","https://openalex.org/W3116988381","https://openalex.org/W3127470524","https://openalex.org/W3138057721","https://openalex.org/W3161474882","https://openalex.org/W4221124092","https://openalex.org/W4225272251","https://openalex.org/W4280496528","https://openalex.org/W4287862649","https://openalex.org/W6783362625"],"related_works":["https://openalex.org/W4310107784","https://openalex.org/W4310108510","https://openalex.org/W6977109089","https://openalex.org/W4399614712","https://openalex.org/W4385295516","https://openalex.org/W4298139606","https://openalex.org/W6920736807","https://openalex.org/W4379981150","https://openalex.org/W4379508534","https://openalex.org/W2991171086"],"abstract_inverted_index":{"Background:":[0],"With":[1],"the":[2,12,116,143,203],"emergence":[3],"of":[4,17,182,209],"therapies":[5],"for":[6,64,145],"mantle":[7],"cell":[8],"lymphoma":[9],"(MCL),":[10],"understanding":[11],"treatment":[13,82],"patterns":[14],"and":[15,53,86,138],"burden":[16,201],"illness":[18],"among":[19,112],"older":[20],"patients":[21,103,114,156,169,184,211],"with":[22,47,57,155,171,206],"MCL":[23,48,102,113,151,183,197],"in":[24,69,115],"Canada":[25],"is":[26],"essential":[27],"to":[28,66,71,80,94,104,168,202,213],"inform":[29],"decision":[30],"making.":[31],"Methods:":[32],"A":[33],"retrospective":[34],"study":[35,99],"using":[36],"administrative":[37],"data":[38],"matched":[39,100],"individuals":[40],"aged":[41],"\u226565":[42],"who":[43],"were":[44,62,91,110,139],"newly":[45],"diagnosed":[46,196],"between":[49],"1":[50],"January":[51],"2013":[52],"31":[54],"December":[55],"2016":[56],"general":[58],"population":[59],"controls.":[60,106,146],"Cases":[61],"followed":[63],"up":[65],"3":[67,192,220],"years":[68],"order":[70],"assess":[72],"healthcare":[73,77,108,204],"resource":[74],"utilization":[75],"(HCRU),":[76],"costs,":[78],"time":[79],"next":[81],"or":[83,189,217],"death":[84,218],"(TTNTD),":[85],"overall":[87],"survival":[88],"(OS);":[89],"all":[90,210],"stratified":[92],"according":[93],"first-line":[95],"treatment.":[96],"Results:":[97],"This":[98],"159":[101],"636":[105],"Direct":[107],"costs":[109,144],"highest":[111],"first":[117],"year":[118],"following":[119],"diagnosis":[120,152],"(Y1:":[121],"CAD":[122,129,134],"77,555":[123],"\u00b1":[124,131,136],"40,789),":[125],"decreased":[126],"subsequently":[127],"(Y2:":[128],"40,093":[130],"28,720;":[132],"Y3:":[133],"36,059":[135],"36,303),":[137],"consistently":[140],"higher":[141,165],"than":[142],"The":[147],"3-year":[148],"OS":[149,166],"after":[150],"was":[153],"68.6%,":[154],"receiving":[157],"bendamustine":[158],"+":[159],"rituximab":[160],"(BR)":[161],"experiencing":[162],"a":[163,186,199,214],"significantly":[164],"compared":[167],"treated":[170],"other":[172],"regimens":[173],"(72.4%":[174],"vs.":[175],"55.6%,":[176],"p":[177],"=":[178],"0.041).":[179],"Approximately":[180],"40.9%":[181],"initiated":[185],"second-line":[187,215],"therapy":[188,216],"died":[190],"within":[191,219],"years.":[193,221],"Conclusion:":[194],"Newly":[195],"presents":[198],"substantial":[200],"system,":[205],"almost":[207],"half":[208],"progressing":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-10T00:00:00"}
