{"id":"https://openalex.org/W4380046271","doi":"https://doi.org/10.3390/cancers15123095","title":"Prevalence of Homologous Recombination Deficiency in First-Line PARP Inhibitor Maintenance Clinical Trials and Further Implication of Personalized Treatment in Ovarian Cancer","display_name":"Prevalence of Homologous Recombination Deficiency in First-Line PARP Inhibitor Maintenance Clinical Trials and Further Implication of Personalized Treatment in Ovarian Cancer","publication_year":2023,"publication_date":"2023-06-07","ids":{"openalex":"https://openalex.org/W4380046271","doi":"https://doi.org/10.3390/cancers15123095","pmid":"https://pubmed.ncbi.nlm.nih.gov/37370704","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10296621"},"language":"en","primary_location":{"id":"doi:10.3390/cancers15123095","doi":"https://doi.org/10.3390/cancers15123095","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15123095","pdf_url":"https://www.mdpi.com/2072-6694/15/12/3095/pdf?version=1686135661","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/15/12/3095/pdf?version=1686135661","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026167409","display_name":"E Sun Paik","orcid":"https://orcid.org/0000-0002-6172-5860","observed_orcids":["https://orcid.org/0000-0002-6172-5860"]},"institutions":[{"id":"https://openalex.org/I4210103535","display_name":"Kangbuk Samsung Hospital","ror":"https://ror.org/013e76m06","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4210103535"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"E Sun Paik","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-6172-5860","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea","institution_ids":["https://openalex.org/I4210103535","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076301937","display_name":"Ha Kyun Chang","orcid":"https://orcid.org/0000-0003-3138-1697","observed_orcids":["https://orcid.org/0000-0003-3138-1697"]},"institutions":[{"id":"https://openalex.org/I4405261856","display_name":"Korea University Ansan Hospital","ror":"https://ror.org/05yp5js06","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405261856"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ha Kyun Chang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si 15355, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si 15355, Republic of Korea","institution_ids":["https://openalex.org/I4405261856"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100320214","display_name":"Sang\u2010Hoon Lee","orcid":"https://orcid.org/0000-0003-1710-460X","observed_orcids":["https://orcid.org/0000-0003-1710-460X","https://orcid.org/0009-0002-2029-6024"]},"institutions":[{"id":"https://openalex.org/I4405260934","display_name":"Korea University Anam Hospital","ror":"https://ror.org/04gjj3027","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405260934"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sanghoon Lee","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Korea University Anam Hospital, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Korea University Anam Hospital, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea","institution_ids":["https://openalex.org/I4405260934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100320214"],"corresponding_institution_ids":["https://openalex.org/I4405260934"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":1.4438,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82127853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"12","first_page":"3095","last_page":"3095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/brca-mutations","display_name":"BRCA mutations","score":0.8980000019073486},{"id":"https://openalex.org/keywords/racial-differences","display_name":"racial differences","score":0.9380000233650208},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.7680000066757202},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9789999723434448},{"id":"https://openalex.org/keywords/niraparib","display_name":"niraparib","score":0.9850000143051147},{"id":"https://openalex.org/keywords/veliparib","display_name":"veliparib","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rucaparib","display_name":"rucaparib","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.8934140205383301},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.8748137354850769},{"id":"https://openalex.org/C2781312401","wikidata":"https://www.wikidata.org/wiki/Q7919041","display_name":"Veliparib","level":5,"score":0.808218240737915},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7789874076843262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6901042461395264},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.6332654356956482},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6011674404144287},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5066328644752502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5036513209342957},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4907549321651459},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.47121042013168335},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46961337327957153},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.28081607818603516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2036861777305603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14257043600082397},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09960132837295532}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers15123095","doi":"https://doi.org/10.3390/cancers15123095","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15123095","pdf_url":"https://www.mdpi.com/2072-6694/15/12/3095/pdf?version=1686135661","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10296621","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10296621","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10296621/pdf/cancers-15-03095.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:37370704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37370704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers15123095","doi":"https://doi.org/10.3390/cancers15123095","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15123095","pdf_url":"https://www.mdpi.com/2072-6694/15/12/3095/pdf?version=1686135661","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321373","display_name":"Korea University","ror":"https://ror.org/047dqcg40"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380046271.pdf","grobid_xml":"https://content.openalex.org/works/W4380046271.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1976385056","https://openalex.org/W2074952360","https://openalex.org/W2113122060","https://openalex.org/W2147629880","https://openalex.org/W2168409298","https://openalex.org/W2173456459","https://openalex.org/W2216554257","https://openalex.org/W2295085830","https://openalex.org/W2464880876","https://openalex.org/W2590203295","https://openalex.org/W2801496605","https://openalex.org/W2897430921","https://openalex.org/W2913584903","https://openalex.org/W2975141952","https://openalex.org/W2976139792","https://openalex.org/W2994977341","https://openalex.org/W3010654133","https://openalex.org/W3020771563","https://openalex.org/W3128646645","https://openalex.org/W3163378364","https://openalex.org/W3186310146","https://openalex.org/W4200266834","https://openalex.org/W4205309211","https://openalex.org/W4205969063","https://openalex.org/W4220932078","https://openalex.org/W4281666355","https://openalex.org/W4295225748","https://openalex.org/W4298127495","https://openalex.org/W4311934109"],"related_works":["https://openalex.org/W3166609661","https://openalex.org/W4312139709","https://openalex.org/W4392593808","https://openalex.org/W2325848599","https://openalex.org/W4280626699","https://openalex.org/W7214391856","https://openalex.org/W4391439005","https://openalex.org/W3048895372","https://openalex.org/W4207014167","https://openalex.org/W4286296846"],"abstract_inverted_index":{"Among":[0],"ovarian":[1,48,164,195],"cancer":[2,165,196],"patients":[3,125,166],"with":[4],"BRCA":[5,35],"mutation":[6,36],"or":[7],"homologous":[8],"recombination":[9],"deficiency":[10],"(HRD),":[11],"the":[12,138,142,188],"efficacy":[13],"of":[14,32,71,141],"Poly-ADP-ribose":[15],"polymerase":[16],"(PARP)":[17],"inhibitors":[18,122],"such":[19],"as":[20,63,85,156],"olaparib,":[21],"niraparib,":[22],"veliparib,":[23],"and":[24,37,90,162,180,191],"rucaparib":[25],"has":[26],"been":[27],"proven":[28],"in":[29,47,57,137,151,160,175,186,194],"a":[30,64,149],"number":[31,70],"clinical":[33],"trials.":[34,102],"HRD":[38,50,59,72,93,115,152,158,176],"are":[39,127,134,178],"currently":[40],"indicated":[41],"for":[42],"PARP":[43,99,121,143],"inhibitor":[44,100,144],"maintenance":[45,101,145],"treatment":[46,67,133,189,193],"cancer.":[49],"diagnostic":[51,73],"tests":[52,74],"examine":[53],"various":[54],"components,":[55],"resulting":[56],"different":[58,66,81,88,91],"status":[60],"definitions":[61],"and,":[62],"result,":[65],"decisions.":[68],"A":[69],"exist,":[75],"but":[76],"test":[77],"results":[78],"provided":[79],"by":[80,154],"companies":[82],"may":[83,182],"differ":[84],"they":[86],"use":[87],"methods":[89],"cutoffs.":[92],"prevalence":[94,153,159,177],"difference":[95,150],"was":[96,148,167],"shown":[97],"between":[98],"It":[103],"is":[104],"important":[105],"to":[106,117,120,130,184],"select":[107],"an":[108],"appropriate":[109],"method":[110],"that":[111,124],"can":[112],"present":[113],"accurate":[114],"phenotypes":[116],"predict":[118],"sensitivity":[119],"so":[123],"who":[126],"most":[128],"likely":[129],"benefit":[131],"from":[132],"selected.":[135],"Additionally,":[136],"subset":[139],"data":[140],"trials,":[146],"there":[147],"race":[155],"higher":[157],"Japanese":[161],"Chinese":[163],"shown.":[168],"Further":[169],"large-scale":[170],"investigations":[171],"on":[172],"racial":[173],"differences":[174],"needed":[179],"this":[181],"contribute":[183],"changes":[185],"determining":[187],"plan":[190],"personalized":[192],"patients.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-06-10T00:00:00"}
