{"id":"https://openalex.org/W4379981996","doi":"https://doi.org/10.1002/hon.3165_595","title":"PATTERNS OF IMMUNOGLOBULIN G TESTING AND INFECTION OUTCOMES IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA RECEIVING IMMUNOGLOBULIN REPLACEMENT THERAPY","display_name":"PATTERNS OF IMMUNOGLOBULIN G TESTING AND INFECTION OUTCOMES IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA RECEIVING IMMUNOGLOBULIN REPLACEMENT THERAPY","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379981996","doi":"https://doi.org/10.1002/hon.3165_595","pmid":"https://pubmed.ncbi.nlm.nih.gov/39112251"},"language":"en","primary_location":{"id":"doi:10.1002/hon.3165_595","doi":"https://doi.org/10.1002/hon.3165_595","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/hon.3165_595","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3165_595","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3165_595","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088343926","display_name":"Jacob Drobnyk Soumerai","orcid":"https://orcid.org/0000-0002-3062-6819","observed_orcids":["https://orcid.org/0000-0002-3062-6819"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. D. Soumerai","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center  Boston Massachusetts USA","Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001920308","display_name":"Z. Yousif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Yousif","raw_affiliation_strings":["Takeda Pharmaceuticals USA, Inc.  Lexington USA","Takeda Pharmaceuticals USA, Inc., Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceuticals USA, Inc.  Lexington USA","institution_ids":["https://openalex.org/I4210140176"]},{"raw_affiliation_string":"Takeda Pharmaceuticals USA, Inc., Lexington, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078044379","display_name":"Thais Gift","orcid":"https://orcid.org/0000-0001-5263-1283","observed_orcids":["https://orcid.org/0000-0001-5263-1283"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Gift","raw_affiliation_strings":["Takeda Pharmaceuticals USA, Inc.  Lexington USA","Takeda Pharmaceuticals USA, Inc., Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceuticals USA, Inc.  Lexington USA","institution_ids":["https://openalex.org/I4210140176"]},{"raw_affiliation_string":"Takeda Pharmaceuticals USA, Inc., Lexington, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Desai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79463011","display_name":"Analysis Group (United States)","ror":"https://ror.org/044jp1563","country_code":"US","type":"company","lineage":["https://openalex.org/I79463011"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Desai","raw_affiliation_strings":["Analysis Group, Inc.  Boston USA","Analysis Group, Inc., Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analysis Group, Inc.  Boston USA","institution_ids":["https://openalex.org/I79463011"]},{"raw_affiliation_string":"Analysis Group, Inc., Boston, USA","institution_ids":["https://openalex.org/I79463011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026542617","display_name":"Lynn Y Huynh","orcid":"https://orcid.org/0000-0003-3110-6775","observed_orcids":["https://orcid.org/0000-0003-3110-6775"]},"institutions":[{"id":"https://openalex.org/I79463011","display_name":"Analysis Group (United States)","ror":"https://ror.org/044jp1563","country_code":"US","type":"company","lineage":["https://openalex.org/I79463011"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Huynh","raw_affiliation_strings":["Analysis Group, Inc.  Boston USA","Analysis Group, Inc., Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analysis Group, Inc.  Boston USA","institution_ids":["https://openalex.org/I79463011"]},{"raw_affiliation_string":"Analysis Group, Inc., Boston, USA","institution_ids":["https://openalex.org/I79463011"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. G. Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. G. Hsieh","raw_affiliation_strings":["Harvard Medical School  Boston USA","Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School  Boston USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063896009","display_name":"Mei Sheng Duh","orcid":"https://orcid.org/0000-0001-5035-6687","observed_orcids":["https://orcid.org/0000-0001-5035-6687"]},"institutions":[{"id":"https://openalex.org/I79463011","display_name":"Analysis Group (United States)","ror":"https://ror.org/044jp1563","country_code":"US","type":"company","lineage":["https://openalex.org/I79463011"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. S. Duh","raw_affiliation_strings":["Analysis Group, Inc.  Boston USA","Analysis Group, Inc., Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analysis Group, Inc.  Boston USA","institution_ids":["https://openalex.org/I79463011"]},{"raw_affiliation_string":"Analysis Group, Inc., Boston, USA","institution_ids":["https://openalex.org/I79463011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058663911","display_name":"Marie E. Sanchirico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. E. Sanchirico","raw_affiliation_strings":["Takeda Pharmaceuticals USA, Inc.  Lexington USA","Takeda Pharmaceuticals USA, Inc., Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceuticals USA, Inc.  Lexington USA","institution_ids":["https://openalex.org/I4210140176"]},{"raw_affiliation_string":"Takeda Pharmaceuticals USA, Inc., Lexington, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087242254","display_name":"Shawn N. Murphy","orcid":"https://orcid.org/0000-0002-1905-8806","observed_orcids":["https://orcid.org/0000-0002-1905-8806"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. N. Murphy","raw_affiliation_strings":["Harvard Medical School  Boston USA","Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School  Boston USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08810167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"S2","first_page":"744","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/immunoglobulin-replacement-therapy","display_name":"immunoglobulin replacement therapy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hypogammaglobulinemia","display_name":"hypogammaglobulinemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/secondary-immunodeficiency","display_name":"secondary immunodeficiency","score":0.9089999794960022},{"id":"https://openalex.org/keywords/severe-infection","display_name":"serious infections","score":0.828000009059906},{"id":"https://openalex.org/keywords/infection-risk","display_name":"infection risk","score":0.671999990940094},{"id":"https://openalex.org/keywords/igg-levels","display_name":"IgG levels","score":0.7450000047683716},{"id":"https://openalex.org/keywords/infection-outcomes","display_name":"infection outcomes","score":0.3089999854564667},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.5210000276565552},{"id":"https://openalex.org/keywords/immunoglobulin-prophylaxis","display_name":"immunoglobulin prophylaxis","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9023557901382446},{"id":"https://openalex.org/C2777805810","wikidata":"https://www.wikidata.org/wiki/Q1047559","display_name":"Hypogammaglobulinemia","level":3,"score":0.8333976864814758},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6089075207710266},{"id":"https://openalex.org/C9267231","wikidata":"https://www.wikidata.org/wiki/Q15841445","display_name":"Image-guided radiation therapy","level":3,"score":0.6055279970169067},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.5383689403533936},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4841371476650238},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.43686744570732117},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.39204221963882446},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.33050623536109924},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3175860047340393},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.29567497968673706},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07530516386032104}],"mesh":[{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013557","descriptor_name":"Switzerland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hon.3165_595","doi":"https://doi.org/10.1002/hon.3165_595","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/hon.3165_595","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3165_595","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},{"id":"pmid:39112251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39112251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological oncology","raw_type":"Congress"}],"best_oa_location":{"id":"doi:10.1002/hon.3165_595","doi":"https://doi.org/10.1002/hon.3165_595","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/hon.3165_595","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3165_595","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379981996.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W174827180","https://openalex.org/W1962557339","https://openalex.org/W2964485441","https://openalex.org/W4394789926","https://openalex.org/W2394940576","https://openalex.org/W190211033","https://openalex.org/W2744428912","https://openalex.org/W2012897825","https://openalex.org/W2028012402","https://openalex.org/W3008750234"],"abstract_inverted_index":{"Introduction:":[0],"Infections":[1],"lead":[2],"to":[3,7,230,255],"mortality":[4],"in":[5,36,58,200,290,309,323],"up":[6],"50%":[8],"of":[9,51,56,87,97,117,140,167,186,276,333,354,402],"patients":[10],"(pts)":[11],"with":[12,38,48,80,119,134,213,221,233,245,273,292,325],"chronic":[13,302],"lymphocytic":[14,303],"leukemia":[15,304],"(CLL).":[16],"Immunoglobulin":[17],"G":[18],"(IgG)":[19],"testing":[20,45,206,269,286],"detects":[21],"hypogammaglobulinemia":[22],"(HGG;":[23],"<500":[24],"mg/dL),":[25],"a":[26,214],"secondary":[27],"immunodeficiency":[28],"and":[29,53,90,95,99,102,128,136,158,183,194,207,243,282,345,374,386,399],"risk":[30,55,218,275,280],"factor":[31],"for":[32,123],"severe":[33],"infections":[34],"(SI)":[35],"pts":[37,133,244,291],"CLL.":[39,59,293],"We":[40],"hypothesized":[41],"that":[42],"increased":[43,171],"IgG":[44,93,120,148,172,205,225,250,268,285],"is":[46],"associated":[47,212,272],"improved":[49],"identification":[50],"HGG":[52,98,187,234,246,279],"reduced":[54,184],"SI":[57,100,118,195,217,289],"Methods:":[60],"This":[61],"retrospective":[62],"study":[63,322],"used":[64],"de-identified":[65],"patient":[66],"data":[67,69,89],"(structured":[68],"only)":[70],"from":[71],"the":[72,115,201,331,334,400],"Mass":[73],"General":[74],"Brigham":[75],"Research":[76,376,431,444,458],"Registry.":[77],"Eligible":[78],"adults":[79],"CLL":[81,135],"(diagnosed":[82],"post-2010)":[83],"had":[84,152,248],"\u226512":[85],"months":[86,203],"clinical":[88],"\u22653":[91,222,249],"visits/year.":[92],"levels":[94,173],"rates":[96,185],"pre-":[101],"post-immunoglobulin":[103],"replacement":[104],"therapy":[105],"(IgRT)":[106],"were":[107,160,210,227,252,339,346],"compared.":[108],"A":[109],"multivariable":[110],"logistic":[111],"regression":[112],"model":[113],"examined":[114],"association":[116],"testing,":[121],"controlling":[122],"IgRT,":[124],"HGG,":[125],"treatment,":[126],"age,":[127],"sex.":[129],"Results:":[130],"Of":[131],"2842":[132],"median":[137],"(IQR)":[138],"follow-up":[139],"4.2":[141],"(2.2,":[142],"6.8)":[143],"years,":[144],"1352":[145],"(47.6%)":[146],"underwent":[147],"testing;":[149],"464":[150],"(34.3%)":[151],"HGG;":[153],"179":[154],"(6.3%)":[155],"received":[156],"IgRT;":[157],"75.2%":[159],"treatment-naive.":[161],"IgRT":[162,208,257],"use":[163,209],"(median":[164],"[IQR]":[165],"administrations":[166],"2.0":[168],"[1.0,":[169],"4.0])":[170],"(502.0":[174],"mg/dL":[175,180],"[397.0,":[176],"615.0]":[177],"vs.":[178,189,197,237,260],"367.0":[179],"[245.0,":[181],"454.0])":[182],"(38.0%":[188],"80.3%,":[190],"p":[191,240,263],"<":[192,241,264],"0.0001)":[193],"(33.7%":[196],"51.0%,":[198],"P=0.003)":[199],"12":[202],"post-IgRT.":[204],"independently":[211,271],"significantly":[215],"lower":[216,274],"(Table).":[219],"Pts":[220],"versus":[223],"1-2":[224],"tests":[226,251],"more":[228,253,283],"likely":[229,254],"be":[231],"identified":[232],"(51.5%":[235],"[321/623]":[236],"19.6%":[238],"[143/729],":[239],"0.0001),":[242],"who":[247],"receive":[256],"(32.7%":[258],"[105/321]":[259],"13.3%":[261],"[19/143],":[262],"0.0001).":[265],"Conclusions:":[266],"Increased":[267],"was":[270,314],"SI.":[277],"Greater":[278],"awareness":[281],"standardized":[284],"might":[287],"reduce":[288],"Study/writing":[294],"support":[295],"funder:":[296],"Takeda":[297,326,349,395,412,418,433,446,460,469,475],"Pharmaceuticals":[298,327,350,396,413,434,447,461,470],"USA,":[299,328,351,397,414,471],"Inc.":[300,319,329,352,398,415,427,430,472],"Keywords:":[301],"(CLL),":[305],"immunotherapy,":[306],"late":[307],"effects":[308],"lymphoma":[310],"survivors":[311],"The":[312],"research":[313],"funded":[315,347],"by:":[316],"Analysis":[317,425,428,441,455],"Group,":[318,426,429,442,456],"conducted":[320],"this":[321],"collaboration":[324],"Under":[330],"direction":[332],"authors,":[335],"medical":[336],"writing":[337],"services":[338],"provided":[340],"by":[341,348],"Oxford":[342],"PharmaGenesis":[343],"Inc.,":[344],"Conflict":[353],"interest:":[355],"J.":[356],"D.":[357],"Soumerai":[358],"Consultant":[359],"or":[360,392,409,422,438,452,466],"advisory":[361],"role:":[362],"Abbvie,":[363],"AstraZeneca,":[364],"Beigene,":[365,380],"Bristol":[366],"Myers":[367],"Squibb,":[368],"Roche,":[369],"Seattle":[370],"Genetics,":[371],"TG":[372,387],"Therapeutics,":[373],"Verastem":[375],"funding:":[377,432,445,459],"Adaptive":[378],"Biotechnologies,":[379],"BostonGene,":[381],"Genentech/Roche,":[382],"GlaxoSmithKline,":[383],"Moderna,":[384],"Takeda,":[385],"Therapeutics":[388],"Z.":[389],"Yousif":[390],"Employment":[391,408,421,437,451,465],"leadership":[393,410,423,439,453,467],"position:":[394,411,424,440,454,468],"University":[401],"California,":[403],"San":[404],"Diego.":[405],"T.":[406],"Gift":[407],"Stock":[416,473],"ownership:":[417,474],"R.":[419],"Desai":[420],"L.":[435],"Huynh":[436],"Inc":[443,457],"M.":[448,462],"S.":[449],"Duh":[450],"E.":[463],"Sanchirico":[464]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-06-10T00:00:00"}