{"id":"https://openalex.org/W4379967347","doi":null,"title":"The biogenesis, mechanism and function of the tRNA-derived small RNA (tsRNA): a review compared with microRNA.","display_name":"The biogenesis, mechanism and function of the tRNA-derived small RNA (tsRNA): a review compared with microRNA.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4379967347","pmid":"https://pubmed.ncbi.nlm.nih.gov/37293177","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10244104"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10244104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10244104","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10244104/pdf/ajcr0013-1656.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10244104/pdf/ajcr0013-1656.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yuxin Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Zhao","raw_affiliation_strings":["Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","Institute for Liver Diseases of Anhui Medical University Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","institution_ids":[]},{"raw_affiliation_string":"Institute for Liver Diseases of Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725265","display_name":"Xiaofeng Li","orcid":"https://orcid.org/0000-0001-5526-9961","observed_orcids":["https://orcid.org/0000-0001-5526-9961"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofeng Li","raw_affiliation_strings":["Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","Institute for Liver Diseases of Anhui Medical University Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","institution_ids":[]},{"raw_affiliation_string":"Institute for Liver Diseases of Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102521351","display_name":"Chong Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong Ye","raw_affiliation_strings":["Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I4210136596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112427522","display_name":"Cheng Huang","orcid":"https://orcid.org/0000-0003-1358-6293","observed_orcids":["https://orcid.org/0000-0003-1358-6293"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Huang","raw_affiliation_strings":["Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","Institute for Liver Diseases of Anhui Medical University Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","institution_ids":[]},{"raw_affiliation_string":"Institute for Liver Diseases of Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050950616","display_name":"Xiongwen Lv","orcid":"https://orcid.org/0000-0003-2354-0168","observed_orcids":["https://orcid.org/0000-0003-2354-0168","https://orcid.org/0000-0001-9357-4676"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiongwen Lv","raw_affiliation_strings":["Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","Institute for Liver Diseases of Anhui Medical University Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","institution_ids":[]},{"raw_affiliation_string":"Institute for Liver Diseases of Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100361773","display_name":"Jun Li","orcid":"https://orcid.org/0000-0002-1171-7141","observed_orcids":["https://orcid.org/0000-0002-1171-7141","https://orcid.org/0000-0001-7541-752X","https://orcid.org/0000-0001-5103-054X"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","Institute for Liver Diseases of Anhui Medical University Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education Hefei, China","institution_ids":[]},{"raw_affiliation_string":"Institute for Liver Diseases of Anhui Medical University Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7197,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92341715,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":"5","first_page":"1656","last_page":"1666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.13220000267028809,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trna-derived-small-rnas","display_name":"tRNA-derived small RNAs","score":0.996999979019165},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7549999952316284},{"id":"https://openalex.org/keywords/small-rna-biogenesis","display_name":"small RNA biogenesis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/microrna-biogenesis","display_name":"microRNA biogenesis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.9088401794433594},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7647473812103271},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6555560827255249},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6299302577972412},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6237533688545227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6221892237663269},{"id":"https://openalex.org/C2779341050","wikidata":"https://www.wikidata.org/wiki/Q24287527","display_name":"Small RNA","level":4,"score":0.5954056978225708},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.5855916142463684},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5748977661132812},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.42203816771507263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40298396348953247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.314414918422699},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.05979752540588379},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10244104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10244104","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10244104/pdf/ajcr0013-1656.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:37293177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37293177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10244104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10244104","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10244104/pdf/ajcr0013-1656.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1298480998","display_name":null,"funder_award_id":"GXXT-2020-025","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3251257482","display_name":null,"funder_award_id":"U19A2001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379967347.pdf","grobid_xml":"https://content.openalex.org/works/W4379967347.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1744683414","https://openalex.org/W1832399013","https://openalex.org/W1964493174","https://openalex.org/W1982131024","https://openalex.org/W2004271888","https://openalex.org/W2008255393","https://openalex.org/W2018342523","https://openalex.org/W2033724104","https://openalex.org/W2037313242","https://openalex.org/W2059117644","https://openalex.org/W2086535718","https://openalex.org/W2099517697","https://openalex.org/W2109920372","https://openalex.org/W2146642335","https://openalex.org/W2148224382","https://openalex.org/W2192997923","https://openalex.org/W2199951571","https://openalex.org/W2201382378","https://openalex.org/W2210080033","https://openalex.org/W2417123930","https://openalex.org/W2521810033","https://openalex.org/W2553826027","https://openalex.org/W2562613588","https://openalex.org/W2580344176","https://openalex.org/W2606698200","https://openalex.org/W2608190552","https://openalex.org/W2734686459","https://openalex.org/W2751526023","https://openalex.org/W2767370608","https://openalex.org/W2769036773","https://openalex.org/W2769399193","https://openalex.org/W2794279202","https://openalex.org/W2799656400","https://openalex.org/W2801429463","https://openalex.org/W2802402149","https://openalex.org/W2802787795","https://openalex.org/W2883487377","https://openalex.org/W2883890257","https://openalex.org/W2885650403","https://openalex.org/W2890244942","https://openalex.org/W2890701551","https://openalex.org/W2894563199","https://openalex.org/W2897690672","https://openalex.org/W2900204516","https://openalex.org/W2902370447","https://openalex.org/W2917184378","https://openalex.org/W2924349232","https://openalex.org/W2938403043","https://openalex.org/W2950847039","https://openalex.org/W2957001239","https://openalex.org/W2974302323","https://openalex.org/W2978006966","https://openalex.org/W2981981975","https://openalex.org/W2989473995","https://openalex.org/W3007202173","https://openalex.org/W3008698633","https://openalex.org/W3013012514","https://openalex.org/W3025007168","https://openalex.org/W3080803103","https://openalex.org/W3087104700","https://openalex.org/W3088975454","https://openalex.org/W3100777757","https://openalex.org/W3139572365","https://openalex.org/W3197265290","https://openalex.org/W3212484906","https://openalex.org/W3215423826"],"related_works":["https://openalex.org/W4200566690","https://openalex.org/W2978633787","https://openalex.org/W2802787795","https://openalex.org/W3164667537","https://openalex.org/W3083207651","https://openalex.org/W4292590376","https://openalex.org/W4410231088","https://openalex.org/W3160139315","https://openalex.org/W7119072150","https://openalex.org/W4282038118"],"abstract_inverted_index":{"Since":[0],"the":[1,4,26,45,84,90,101],"discovery":[2],"of":[3,22,52,71,86,93,103],"first":[5],"miRNA":[6,87,110],"in":[7],"1993,":[8],"numerous":[9],"studies":[10,72],"have":[11,40,58,67],"focused":[12],"on":[13,18,47],"their":[14,16,30,75,94,97],"biogenesis,":[15],"functions":[17,57],"regulating":[19],"a":[20,69],"diversity":[21],"cellular":[23],"processes,":[24],"and":[25,88,96,107,111],"molecular":[27,91],"mechanisms":[28,92],"underlying":[29],"regulatory":[31],"activity.":[32],"The":[33,105],"critical":[34],"roles":[35,99],"they":[36],"play":[37],"during":[38,100],"pathogenesis":[39],"also":[41,114],"been":[42,59],"explored.":[43],"With":[44],"advancement":[46],"next-generation":[48],"sequencing,":[49],"new":[50],"classes":[51],"small":[53],"RNA":[54],"with":[55],"distinct":[56],"discovered.":[60],"Among":[61],"them,":[62],"tRNA":[63],"derived":[64],"fragment":[65],"(tsRNAs)":[66],"become":[68],"center":[70],"due":[73],"to":[74,77],"similarity":[76,106],"miRNA.":[78],"In":[79],"this":[80],"review,":[81],"we":[82],"summarized":[83],"biogenesis":[85],"tsRNAs,":[89],"functions,":[95],"important":[98],"development":[102],"diseases.":[104],"difference":[108],"between":[109],"tsRNAs":[112],"were":[113],"discussed.":[115]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-06-10T00:00:00"}