{"id":"https://openalex.org/W4379967231","doi":null,"title":"High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway.","display_name":"High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4379967231","pmid":"https://pubmed.ncbi.nlm.nih.gov/37293151","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10244096"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10244096","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10244096","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10244096/pdf/ajcr0013-1884.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10244096/pdf/ajcr0013-1884.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100331277","display_name":"Nan Zhang","orcid":"https://orcid.org/0000-0002-4713-0908","observed_orcids":["https://orcid.org/0000-0002-4713-0908"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210122705","display_name":"Hebei University of Chinese Medicine","ror":"https://ror.org/02qxkhm81","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210122705"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","College of Integrative Chinese and Western Medicine, Hebei University of Chinese Medicine Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I111381250"]},{"raw_affiliation_string":"College of Integrative Chinese and Western Medicine, Hebei University of Chinese Medicine Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I4210122705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115592598","display_name":"Yaqi Wang","orcid":"https://orcid.org/0000-0002-6831-9742","observed_orcids":["https://orcid.org/0000-0002-6831-9742"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Qi Wang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","Department of Clinical Laboratory, Hebei Province Hospital of Chinese Medicine Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I111381250"]},{"raw_affiliation_string":"Department of Clinical Laboratory, Hebei Province Hospital of Chinese Medicine Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100677210","display_name":"Chao Sun","orcid":"https://orcid.org/0000-0003-4423-5285","observed_orcids":["https://orcid.org/0000-0003-4423-5285"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Sun","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080559983","display_name":"Yun Shi","orcid":"https://orcid.org/0000-0003-1925-4337","observed_orcids":["https://orcid.org/0000-0003-1925-4337"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Shi","raw_affiliation_strings":["Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110229850","display_name":"Lianguo Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian-Guo Hou","raw_affiliation_strings":["Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Yao","raw_affiliation_strings":["Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108616125","display_name":"Meng Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Hu","raw_affiliation_strings":["Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","Department of Complex Preparation, Shijiazhuang No. 4 Pharmaceutical Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I111381250"]},{"raw_affiliation_string":"Department of Complex Preparation, Shijiazhuang No. 4 Pharmaceutical Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377916","display_name":"Xiaoming Wang","orcid":"https://orcid.org/0000-0003-4559-7413","observed_orcids":["https://orcid.org/0000-0003-4559-7413"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210155055","display_name":"Beijing Hua Xin Hospital","ror":"https://ror.org/04k6zqn86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155055"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Ming Wang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","Department of Clinical Laboratory, The First Hospital of Tsinghua University Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I111381250"]},{"raw_affiliation_string":"Department of Clinical Laboratory, The First Hospital of Tsinghua University Beijing, China","institution_ids":["https://openalex.org/I4210155055"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pan-Pan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan-Pan Ma","raw_affiliation_strings":["Department of Blood Transfusion, Hebei General Hospital Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Transfusion, Hebei General Hospital Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I4210110525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408979","display_name":"Wenjie Li","orcid":"https://orcid.org/0000-0002-1413-0928","observed_orcids":["https://orcid.org/0000-0002-1413-0928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Jie Li","raw_affiliation_strings":["Department of Clinical Laboratory, Anyang Center for Disease Control and Prevention Anyang, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Anyang Center for Disease Control and Prevention Anyang, Henan, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101906839","display_name":"Lingling Jiang","orcid":"https://orcid.org/0000-0002-2713-7037","observed_orcids":["https://orcid.org/0000-0002-2713-7037"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Ling Jiang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Neural and Vascular Biology, Department of Biochemistry and Molecular Biology, Hebei Medical University Shijiazhuang, Hebei, China","institution_ids":["https://openalex.org/I111381250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2875,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.46259979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":"5","first_page":"1884","last_page":"1903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.7680000066757202},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.6539999842643738},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.9340000152587891},{"id":"https://openalex.org/keywords/glycogen","display_name":"glycogen","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mitochondrial-complex-iii","display_name":"mitochondrial complex III","score":0.7710000276565552},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.7110000252723694},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7910000085830688},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.704227089881897},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6129686832427979},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6121326088905334},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5545576214790344},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4738752543926239},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46815207600593567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45286813378334045},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4259946346282959},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4010166823863983},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3644106388092041},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2897779941558838},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13432812690734863},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10244096","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10244096","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10244096/pdf/ajcr0013-1884.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:37293151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37293151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10244096","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10244096","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10244096/pdf/ajcr0013-1884.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317799","display_name":"Health Commission of Hebei Province","ror":"https://ror.org/02g4yc525"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379967231.pdf","grobid_xml":"https://content.openalex.org/works/W4379967231.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1589023327","https://openalex.org/W1927760519","https://openalex.org/W1966902632","https://openalex.org/W1975925357","https://openalex.org/W1990607908","https://openalex.org/W1997846839","https://openalex.org/W2008080277","https://openalex.org/W2017298826","https://openalex.org/W2042996682","https://openalex.org/W2063156662","https://openalex.org/W2080878273","https://openalex.org/W2083859759","https://openalex.org/W2094390120","https://openalex.org/W2103013560","https://openalex.org/W2103880914","https://openalex.org/W2342093593","https://openalex.org/W2601256588","https://openalex.org/W2745366541","https://openalex.org/W2771424571","https://openalex.org/W2775369199","https://openalex.org/W2912451463","https://openalex.org/W2974441752","https://openalex.org/W2980251308","https://openalex.org/W3011324480","https://openalex.org/W3213048586"],"related_works":["https://openalex.org/W4288290371","https://openalex.org/W3044252905","https://openalex.org/W2767182882","https://openalex.org/W4413270573","https://openalex.org/W7151977883","https://openalex.org/W2102312214","https://openalex.org/W4205665935","https://openalex.org/W2952794342","https://openalex.org/W4412086774","https://openalex.org/W4415755517"],"abstract_inverted_index":{"Peroxisomal":[0],"D-bifunctional":[1],"protein":[2],"(DBP)":[3],"is":[4,25],"an":[5,121,212,257],"indispensable":[6],"enzyme":[7],"of":[8,16,21,49,70,125,138,178,195,209,226,247],"the":[9,14,19,47,68,76,132,160,193,206,220,224,234,242],"fatty":[10],"acid":[11],"\u03b2-oxidation":[12],"in":[13,23,51,92,131,152,157,211,228,241],"peroxisome":[15,133,151,229],"humans.":[17],"However,":[18],"role":[20,240],"DBP":[22,34,50,80,88,98,117,128,149,155,179,227,236],"oncogenesis":[24],"poorly":[26],"understood.":[27],"Our":[28],"previous":[29],"studies":[30],"have":[31],"demonstrated":[32],"that":[33,87,115,233],"overexpression":[35,156,177],"promotes":[36,81],"hepatocellular":[37],"carcinoma":[38],"(HCC)":[39],"cell":[40,83,167],"proliferation.":[41,84],"In":[42,72,175],"this":[43,217],"study,":[44],"we":[45,74],"evaluated":[46],"expression":[48,89,99,225],"75":[52],"primary":[53],"HCC":[54,82,93,166,248,258],"samples":[55],"using":[56],"RT-qPCR,":[57],"immunohistochemistry,":[58],"and":[59,96,106,134,136,164,183,230,232,245],"Western":[60],"blot,":[61],"as":[62,64,189,191],"well":[63,190],"its":[65],"correlation":[66],"with":[67,103],"prognosis":[69],"HCC.":[71,126],"addition,":[73,176],"explored":[75],"mechanisms":[77],"by":[78,147,169],"which":[79,250],"We":[85],"found":[86],"was":[90,100,120,129,145,219],"upregulated":[91],"tumor":[94,104,139,143],"tissues,":[95],"higher":[97],"positively":[101],"correlated":[102],"size":[105],"TNM":[107],"stage.":[108],"Multinomial":[109],"ordinal":[110],"logistic":[111],"regression":[112],"analysis":[113],"indicated":[114],"lower":[116],"mRNA":[118],"level":[119],"independent":[122],"protective":[123],"factor":[124],"Notably,":[127],"overexpressed":[130],"cytosol":[135,158],"mitochondria":[137],"tissue":[140],"cells.":[141],"Xenograft":[142],"growth":[144],"promoted":[146,165],"overexpressing":[148],"outside":[150],"vivo.":[153],"Mechanistically,":[154],"activated":[159],"PI3K/AKT":[161],"signaling":[162],"axis":[163],"proliferation":[168],"downregulating":[170],"apoptosis":[171],"via":[172,186,205],"AKT/FOXO3a/Bim":[173],"axis.":[174],"increased":[180],"glucose":[181],"uptake":[182],"glycogen":[184],"content":[185,204],"AKT/GSK3\u03b2":[187],"axis,":[188],"elevated":[192],"activity":[194],"mitochondrial":[196,207],"respiratory":[197],"chain":[198],"complex":[199],"III":[200],"to":[201,222],"increase":[202],"ATP":[203],"translocation":[208],"p-GSK3\u03b2":[210],"AKT-dependent":[213],"manner.":[214],"Taken":[215],"together,":[216],"study":[218],"first":[221],"report":[223],"cytosol,":[231],"cytosolic":[235],"has":[237],"a":[238,252],"critical":[239],"metabolic":[243],"reprogramming":[244],"adaptation":[246],"cells,":[249],"provides":[251],"valuable":[253],"reference":[254],"for":[255],"instituting":[256],"treatment":[259],"plan.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-06-10T00:00:00"}