{"id":"https://openalex.org/W4379928014","doi":"https://doi.org/10.1016/j.lanepe.2023.100665","title":"Optimal implementation of the 2019 ESC/EAS dyslipidaemia guidelines in patients with and without atherosclerotic cardiovascular disease across Europe: a simulation based on the DA VINCI study","display_name":"Optimal implementation of the 2019 ESC/EAS dyslipidaemia guidelines in patients with and without atherosclerotic cardiovascular disease across Europe: a simulation based on the DA VINCI study","publication_year":2023,"publication_date":"2023-06-08","ids":{"openalex":"https://openalex.org/W4379928014","doi":"https://doi.org/10.1016/j.lanepe.2023.100665","pmid":"https://pubmed.ncbi.nlm.nih.gov/37547279"},"language":"en","primary_location":{"id":"doi:10.1016/j.lanepe.2023.100665","doi":"https://doi.org/10.1016/j.lanepe.2023.100665","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lanepe.2023.100665","pdf_url":null,"source":{"id":"https://openalex.org/S4210196034","display_name":"The Lancet Regional Health - Europe","issn_l":"2666-7762","issn":["2666-7762"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Regional Health - Europe","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.lanepe.2023.100665","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052025629","display_name":"Julia Brandts","orcid":"https://orcid.org/0000-0002-1141-1126","observed_orcids":["https://orcid.org/0000-0002-1141-1126"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Julia Brandts","raw_affiliation_strings":["Department of Internal Medicine, University Hospital RWTH Aachen, Aachen, Germany","Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009121071","display_name":"Sarah L Bray","orcid":"https://orcid.org/0000-0002-4867-574X","observed_orcids":["https://orcid.org/0000-0002-4867-574X"]},"institutions":[{"id":"https://openalex.org/I4210117596","display_name":"Amgen (United Kingdom)","ror":"https://ror.org/02gvvc992","country_code":"GB","type":"company","lineage":["https://openalex.org/I1320553840","https://openalex.org/I4210117596"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Bray","raw_affiliation_strings":["Global Biostatistical Science, Amgen Ltd, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Biostatistical Science, Amgen Ltd, Cambridge, UK","institution_ids":["https://openalex.org/I4210117596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031997572","display_name":"Guillermo Villa","orcid":"https://orcid.org/0000-0003-4484-8858","observed_orcids":["https://orcid.org/0000-0003-4484-8858"]},"institutions":[{"id":"https://openalex.org/I4210139000","display_name":"Amgen (Switzerland)","ror":"https://ror.org/045wjte67","country_code":"CH","type":"company","lineage":["https://openalex.org/I1320553840","https://openalex.org/I4210139000"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Guillermo Villa","raw_affiliation_strings":["Health Economics & Outcomes Research, Amgen (Europe) GmbH, Risch-Rotkreuz, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics & Outcomes Research, Amgen (Europe) GmbH, Risch-Rotkreuz, Switzerland","institution_ids":["https://openalex.org/I4210139000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091523473","display_name":"Alberico Luigi Catapano","orcid":"https://orcid.org/0000-0002-7593-2094","observed_orcids":["https://orcid.org/0000-0002-7593-2094"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberico L. Catapano","raw_affiliation_strings":["Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy","IRCCS MultiMedica, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"IRCCS MultiMedica, Milan, Italy","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072011562","display_name":"Neil R Poulter","orcid":"https://orcid.org/0000-0002-6292-997X","observed_orcids":["https://orcid.org/0000-0002-6292-997X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil R. Poulter","raw_affiliation_strings":["Imperial Clinical Trials Unit, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Clinical Trials Unit, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056118217","display_name":"Antonio J. Vallejo\u2010Vaz","orcid":"https://orcid.org/0000-0001-7954-1253","observed_orcids":["https://orcid.org/0000-0001-7954-1253"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Antonio J. Vallejo-Vaz","raw_affiliation_strings":["Clinical Epidemiology and Vascular Risk, Institute of Biomedicine of Seville (IBiS), IBiS/Hospital Universitario Virgen del Roc\u00edo/University of Seville/CSIC, Seville, Spain","Department of Medicine, Faculty of Medicine, University of Seville, Seville, Spain","Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Epidemiology and Vascular Risk, Institute of Biomedicine of Seville (IBiS), IBiS/Hospital Universitario Virgen del Roc\u00edo/University of Seville/CSIC, Seville, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]},{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, University of Seville, Seville, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006206326","display_name":"Kausik Kumar Ray","orcid":"https://orcid.org/0000-0003-0508-0954","observed_orcids":["https://orcid.org/0000-0003-0508-0954","https://orcid.org/0000-0002-7166-060X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kausik K. Ray","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London, London, UK","Imperial Clinical Trials Unit, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-0508-0954","affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Imperial Clinical Trials Unit, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5006206326"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":10.6724,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.99074846,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"31","issue":null,"first_page":"100665","last_page":"100665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ldl-c-target-attainment","display_name":"LDL-C goal attainment","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/residual-cardiovascular-risk","display_name":"residual cardiovascular risk","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.7210000157356262},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.8989999890327454},{"id":"https://openalex.org/keywords/treatment-optimization","display_name":"treatment optimization","score":0.5759999752044678},{"id":"https://openalex.org/keywords/very-high-cardiovascular-risk","display_name":"very high cardiovascular risk","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.8712857961654663},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.7319557666778564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6582754850387573},{"id":"https://openalex.org/C152163801","wikidata":"https://www.wikidata.org/wiki/Q2146057","display_name":"Residual risk","level":2,"score":0.6431936025619507},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.6133412718772888},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.6051666140556335},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.5492168068885803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5351027250289917},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4758308231830597},{"id":"https://openalex.org/C3018284874","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Cardiovascular health","level":3,"score":0.41745632886886597},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4162151515483856},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3196759521961212},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.30948883295059204},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.26903483271598816},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1313873529434204}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1016/j.lanepe.2023.100665","doi":"https://doi.org/10.1016/j.lanepe.2023.100665","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lanepe.2023.100665","pdf_url":null,"source":{"id":"https://openalex.org/S4210196034","display_name":"The Lancet Regional Health - Europe","issn_l":"2666-7762","issn":["2666-7762"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Regional Health - Europe","raw_type":"journal-article"},{"id":"pmid:37547279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37547279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet regional health. Europe","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10398584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10398584","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10398584/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lancet Reg Health Eur","raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/352130","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/352130","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:doaj.org/article:d5519723bd9c486491d8b38aabbe1126","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d5519723bd9c486491d8b38aabbe1126","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Lancet Regional Health. Europe, Vol 31, Iss , Pp 100665- (2023)","raw_type":"article"},{"id":"pmh:oai:publications.rwth-aachen.de:969591","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-251581%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The lancet / Regional health. Europe 31, 100665 (2023). doi:10.1016/j.lanepe.2023.100665","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/130845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/37547279","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"doi:10.18154/rwth-conv-251581","doi":"https://doi.org/10.18154/rwth-conv-251581","is_oa":true,"landing_page_url":"https://doi.org/10.18154/rwth-conv-251581","pdf_url":null,"source":{"id":"https://openalex.org/S4306401033","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1016/j.lanepe.2023.100665","doi":"https://doi.org/10.1016/j.lanepe.2023.100665","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lanepe.2023.100665","pdf_url":null,"source":{"id":"https://openalex.org/S4210196034","display_name":"The Lancet Regional Health - Europe","issn_l":"2666-7762","issn":["2666-7762"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Regional Health - Europe","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5799999833106995}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320310967","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24"},{"id":"https://openalex.org/F7296444849","display_name":"Ministerio de Universidades","ror":"https://ror.org/03zcny908"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1962272706","https://openalex.org/W2024930123","https://openalex.org/W2043009290","https://openalex.org/W2072862124","https://openalex.org/W2077903945","https://openalex.org/W2115316104","https://openalex.org/W2164089346","https://openalex.org/W2740472173","https://openalex.org/W2761867837","https://openalex.org/W2771919228","https://openalex.org/W2888589263","https://openalex.org/W2905226841","https://openalex.org/W2942637256","https://openalex.org/W2948233520","https://openalex.org/W2953804067","https://openalex.org/W3008174927","https://openalex.org/W3011005820","https://openalex.org/W3014034202","https://openalex.org/W3029402664","https://openalex.org/W3037055026","https://openalex.org/W3093428474","https://openalex.org/W3120916025","https://openalex.org/W3183857127","https://openalex.org/W3193295997","https://openalex.org/W4213247255","https://openalex.org/W4220735712","https://openalex.org/W4242002391","https://openalex.org/W4293426420","https://openalex.org/W4294992476","https://openalex.org/W4307715479","https://openalex.org/W4315864622","https://openalex.org/W4362640332","https://openalex.org/W6640798808","https://openalex.org/W6851796101"],"related_works":["https://openalex.org/W4385378391","https://openalex.org/W2976066646","https://openalex.org/W2597380446","https://openalex.org/W2009560344","https://openalex.org/W3037994711","https://openalex.org/W2135340742","https://openalex.org/W4306173874","https://openalex.org/W2795313632","https://openalex.org/W2840365123","https://openalex.org/W2588240595"],"abstract_inverted_index":{"The":[0],"impact":[1],"of":[2,6,11,56,62,216,223],"the":[3,7,31,108],"stepwise":[4],"implementation":[5],"2019":[8,100],"European":[9],"Society":[10,15],"Cardiology":[12],"(ESC)/European":[13],"Atherosclerosis":[14],"(EAS)":[16],"treatment":[17,42,208],"algorithm":[18],"on":[19,46],"low-density":[20],"lipoprotein":[21],"cholesterol":[22],"(LDL-C)":[23],"goal":[24],"attainment":[25],"was":[26,38],"simulated":[27,214],"in":[28,86,107,212,255],"patients":[29,95,111,169,203,229],"from":[30],"DA":[32,92],"VINCI":[33],"study.":[34],"Monte":[35],"Carlo":[36],"simulation":[37],"used":[39],"to":[40,131,160,190,236,252],"evaluate":[41],"optimisation":[43,209,242],"scenarios,":[44],"based":[45],"a":[47,63,248],"patient's":[48],"risk":[49,75,81,148,233],"category:":[50],"statin":[51,241],"intensification":[52],"(step":[53,58,71],"1),":[54],"addition":[55,61],"ezetimibe":[57],"2),":[59],"and":[60,76,79,84,104,124,139,183,199,205,218,221,225,243,245],"proprotein":[64],"convertase":[65],"subtilisin/kexin":[66],"type":[67],"9":[68],"(PCSK9)":[69],"inhibitor":[70],"3).":[72],"Residual":[73],"cardiovascular":[74,87,114,232,256],"predicted":[77],"relative":[78],"absolute":[80],"reduction":[82,254],"(RRR":[83],"ARR)":[85],"events":[88],"were":[89,105],"assessed.":[90],"In":[91,110,168,202],"VINCI,":[93],"2482":[94],"did":[96],"not":[97],"achieve":[98,132,161,191,237],"their":[99,133,162,192],"ESC/EAS":[101],"LDL-C":[102,134,163,193,238],"goals":[103,135,164,194,239],"included":[106],"simulation.":[109],"without":[112,149,206],"atherosclerotic":[113],"disease":[115],"(ASCVD)":[116],"(n":[117,121,126,151,155,172,176,180,185],"=":[118,122,127,152,156,173,177,181,186],"962),":[119],"27.0%":[120],"259)":[123],"57.0%":[125],"548)":[128],"are":[129,158,188,234],"likely":[130,159,189],"at":[136,145,165,195,230],"step":[137,140,166],"1":[138],"2,":[141],"respectively.":[142,201,227],"Of":[143],"those":[144],"very":[146],"high":[147,231],"ASCVD":[150,171],"74),":[153],"88.1%":[154],"65)":[157],"3.":[167],"with":[170,204],"1520),":[174],"12.0%":[175],"183),":[178],"42.1%":[179],"641)":[182],"93.2%":[184],"1416)":[187],"steps":[196],"1,":[197],"2":[198],"3,":[200],"ASCVD,":[207],"may":[210],"result":[211],"mean":[213],"RRR":[215],"24.0%":[217],"17.7%,":[219],"respectively,":[220],"ARR":[222],"8.1%":[224],"2.6%,":[226],"Most":[228],"unlikely":[235],"through":[240],"ezetimibe,":[244],"will":[246],"require":[247],"PCSK9":[249],"inhibitor,":[250],"leading":[251],"greater":[253],"risk.":[257],"Amgen.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-06-09T00:00:00"}
