{"id":"https://openalex.org/W4379876323","doi":"https://doi.org/10.1038/s41556-023-01159-z","title":"The pyrimidinosome is cancer\u2019s Achilles\u2019 heel","display_name":"The pyrimidinosome is cancer\u2019s Achilles\u2019 heel","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379876323","doi":"https://doi.org/10.1038/s41556-023-01159-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/37291266"},"language":"en","primary_location":{"id":"doi:10.1038/s41556-023-01159-z","doi":"https://doi.org/10.1038/s41556-023-01159-z","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41556-023-01159-z","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},"volume":null,"type":"other","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031941069","display_name":"Matthew B. Dodson","orcid":"https://orcid.org/0000-0002-3743-5476","observed_orcids":["https://orcid.org/0000-0002-3743-5476"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Dodson","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA"],"raw_orcid":"https://orcid.org/0000-0002-3743-5476","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009033820","display_name":"Donna D. Zhang","orcid":"https://orcid.org/0000-0002-8972-697X","observed_orcids":["https://orcid.org/0000-0002-8972-697X","https://orcid.org/0000-0003-1468-6616"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donna D. Zhang","raw_affiliation_strings":["Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. dzhang@pharmacy.arizona.edu","Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA. dzhang@pharmacy.arizona.edu","Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA"],"raw_orcid":"https://orcid.org/0000-0002-8972-697X","affiliations":[{"raw_affiliation_string":"Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. dzhang@pharmacy.arizona.edu","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA. dzhang@pharmacy.arizona.edu","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009033820"],"corresponding_institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"],"apc_list":{"value":11690,"currency":"USD","value_usd":11690},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"6","first_page":"798","last_page":"799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/de-novo-pyrimidine-synthesis","display_name":"de novo pyrimidine biosynthesis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.903399646282196},{"id":"https://openalex.org/C2777248721","wikidata":"https://www.wikidata.org/wiki/Q174647","display_name":"Heel","level":2,"score":0.6547802686691284},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5904651284217834},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.562156081199646},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5129494071006775},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4865383207798004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46254369616508484},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4060709774494171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27408337593078613},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2578088641166687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23345810174942017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2014622688293457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15916070342063904},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1346237063407898}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41556-023-01159-z","doi":"https://doi.org/10.1038/s41556-023-01159-z","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41556-023-01159-z","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},{"id":"pmid:37291266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37291266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W146063059","https://openalex.org/W968652657","https://openalex.org/W1589007430","https://openalex.org/W1997183854","https://openalex.org/W2003677194","https://openalex.org/W2173108077","https://openalex.org/W2550324626","https://openalex.org/W2727828415","https://openalex.org/W2762087180","https://openalex.org/W2950781034","https://openalex.org/W3162306949","https://openalex.org/W4379878802"],"related_works":["https://openalex.org/W4379878802","https://openalex.org/W4413029512","https://openalex.org/W4248031987","https://openalex.org/W3026346985","https://openalex.org/W3005253578","https://openalex.org/W2743956515","https://openalex.org/W2998023201","https://openalex.org/W3125093083","https://openalex.org/W4386811379","https://openalex.org/W4392951752"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-06-09T00:00:00"}
