{"id":"https://openalex.org/W4379740561","doi":"https://doi.org/10.1038/s41598-023-35666-8","title":"The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae","display_name":"The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae","publication_year":2023,"publication_date":"2023-06-07","ids":{"openalex":"https://openalex.org/W4379740561","doi":"https://doi.org/10.1038/s41598-023-35666-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37286562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10247811"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-35666-8","doi":"https://doi.org/10.1038/s41598-023-35666-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-35666-8","pdf_url":"https://www.nature.com/articles/s41598-023-35666-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-35666-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027686370","display_name":"Rebecca Josefson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Rebecca Josefson","raw_affiliation_strings":["Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110943393","display_name":"Navinder Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Navinder Kumar","raw_affiliation_strings":["Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027018620","display_name":"Xinxin Hao","orcid":"https://orcid.org/0000-0001-5758-6290","observed_orcids":["https://orcid.org/0000-0001-5758-6290"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Xinxin Hao","raw_affiliation_strings":["Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-5758-6290","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027479268","display_name":"Beidong Liu","orcid":"https://orcid.org/0000-0001-6052-8411","observed_orcids":["https://orcid.org/0000-0001-6052-8411"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Beidong Liu","raw_affiliation_strings":["Department of Chemistry and Molecular Biology, Faculty of Science, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-6052-8411","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Molecular Biology, Faculty of Science, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041540706","display_name":"Thomas Nystr\u00f6m","orcid":"https://orcid.org/0000-0001-5489-2903","observed_orcids":["https://orcid.org/0000-0001-5489-2903"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Thomas Nystr\u00f6m","raw_affiliation_strings":["Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. thomas.nystrom@cmb.gu.se","Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-5489-2903","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. thomas.nystrom@cmb.gu.se","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041540706"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.3547,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47587569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"1","first_page":"9285","last_page":"9285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.2093999981880188,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/get-pathway","display_name":"GET pathway","score":0.8989999890327454},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.5410000085830688},{"id":"https://openalex.org/keywords/tail-anchored-proteins","display_name":"tail-anchored proteins","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hsp104","display_name":"Hsp104","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mitochondrial-aggregates","display_name":"mitochondrial aggregates","score":0.40799999237060547},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6840000152587891},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9300000071525574},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.8169999718666077},{"id":"https://openalex.org/keywords/genome-wide-screen","display_name":"genome-wide screen","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.9941009283065796},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.717560350894928},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6897843480110168},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6243366599082947},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.613074541091919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.579105019569397},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.550551176071167},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5032040476799011},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.30103105306625366},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2823497951030731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2780205011367798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2671065330505371},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.060870200395584106}],"mesh":[{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-023-35666-8","doi":"https://doi.org/10.1038/s41598-023-35666-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-35666-8","pdf_url":"https://www.nature.com/articles/s41598-023-35666-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10247811","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10247811","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10247811/pdf/41598_2023_Article_35666.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37286562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37286562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:598509b48e4c47faa1660b95e5db09da","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/598509b48e4c47faa1660b95e5db09da","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-35666-8","doi":"https://doi.org/10.1038/s41598-023-35666-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-35666-8","pdf_url":"https://www.nature.com/articles/s41598-023-35666-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3289492776","display_name":"Genetic interactions between the mitochondrial and the nuclear genomes to manage the proteome of aging cells","funder_award_id":"2019-03937","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323421","display_name":"G\u00f6teborgs Universitet","ror":"https://ror.org/01tm6cn81"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379740561.pdf"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W333722695","https://openalex.org/W1485116839","https://openalex.org/W1539776672","https://openalex.org/W1601640901","https://openalex.org/W1903209843","https://openalex.org/W1963578989","https://openalex.org/W1967025628","https://openalex.org/W1970353480","https://openalex.org/W1982296353","https://openalex.org/W2009476233","https://openalex.org/W2010292457","https://openalex.org/W2013429682","https://openalex.org/W2045929752","https://openalex.org/W2050837145","https://openalex.org/W2057505896","https://openalex.org/W2057813637","https://openalex.org/W2058546459","https://openalex.org/W2058746325","https://openalex.org/W2058775823","https://openalex.org/W2066168326","https://openalex.org/W2074273512","https://openalex.org/W2074828464","https://openalex.org/W2076159058","https://openalex.org/W2081233603","https://openalex.org/W2092587339","https://openalex.org/W2092986760","https://openalex.org/W2102472225","https://openalex.org/W2105375182","https://openalex.org/W2106728955","https://openalex.org/W2109283736","https://openalex.org/W2112660386","https://openalex.org/W2114030871","https://openalex.org/W2114083522","https://openalex.org/W2118418221","https://openalex.org/W2126525177","https://openalex.org/W2127073167","https://openalex.org/W2133102806","https://openalex.org/W2133465414","https://openalex.org/W2133992568","https://openalex.org/W2135532366","https://openalex.org/W2136201006","https://openalex.org/W2148176855","https://openalex.org/W2151697744","https://openalex.org/W2152231829","https://openalex.org/W2152770371","https://openalex.org/W2156576736","https://openalex.org/W2158217645","https://openalex.org/W2158224115","https://openalex.org/W2159460045","https://openalex.org/W2160779871","https://openalex.org/W2222857089","https://openalex.org/W2270560834","https://openalex.org/W2274155767","https://openalex.org/W2411562838","https://openalex.org/W2472093118","https://openalex.org/W2492182430","https://openalex.org/W2525451425","https://openalex.org/W2559731208","https://openalex.org/W2588507906","https://openalex.org/W2594299422","https://openalex.org/W2751981897","https://openalex.org/W2810613447","https://openalex.org/W2969479507","https://openalex.org/W2971839298","https://openalex.org/W2975586507","https://openalex.org/W3006584233","https://openalex.org/W3024496063","https://openalex.org/W3110645309","https://openalex.org/W3119242313","https://openalex.org/W3169531141","https://openalex.org/W3215296738","https://openalex.org/W4220858198","https://openalex.org/W4295138765"],"related_works":["https://openalex.org/W3217202979","https://openalex.org/W2797719377","https://openalex.org/W2189788457","https://openalex.org/W2594299422","https://openalex.org/W4410910343","https://openalex.org/W2102472225","https://openalex.org/W4390042377","https://openalex.org/W2678625059","https://openalex.org/W2768900507","https://openalex.org/W2768090743"],"abstract_inverted_index":{"A":[0],"hallmark":[1],"of":[2,7,12,18,66,96,120,154,157],"aging":[3,38],"in":[4,63,101,112,126,147,166,168],"a":[5,10,34,56,79,107,141,163],"variety":[6],"organisms":[8],"is":[9,25,105,162],"breakdown":[11,36],"proteostasis":[13,30,84,167],"and":[14,21,123,150],"an":[15],"ensuing":[16],"accumulation":[17,119],"protein":[19],"aggregates":[20,125],"inclusions.":[22],"However,":[23],"it":[24],"not":[26],"clear":[27],"if":[28,40],"the":[29,72,89,94,102,152],"network":[31],"suffers":[32],"from":[33],"uniform":[35],"during":[37],"or":[39,116],"some":[41],"distinct":[42],"components":[43],"act":[44],"as":[45,78,109],"bottlenecks":[46],"especially":[47],"sensitive":[48],"to":[49,70,81],"functional":[50],"decline.":[51],"Here,":[52],"we":[53],"report":[54],"on":[55],"genome-wide,":[57],"unbiased,":[58],"screen":[59,143],"for":[60,93],"single":[61,110],"genes":[62],"young":[64],"cells":[65,129],"budding":[67],"yeast":[68],"required":[69,92],"keep":[71],"proteome":[73],"aggregate-free":[74],"under":[75],"non-stress":[76],"conditions":[77],"means":[80],"identify":[82],"potential":[83],"bottlenecks.":[85],"We":[86],"found":[87],"that":[88,160,171],"GET":[90,148,169],"pathway,":[91],"insertion":[95],"tail-anchored":[97],"(TA)":[98],"membrane":[99],"proteins":[100,145,174],"endoplasmic":[103],"reticulum,":[104],"such":[106],"bottleneck":[108],"mutations":[111],"either":[113],"GET3,":[114],"GET2":[115],"GET1":[117],"caused":[118],"cytosolic":[121,155],"Hsp104-":[122],"mitochondria-associated":[124],"nearly":[127],"all":[128],"when":[130],"growing":[131],"at":[132],"30":[133],"\u00b0C":[134],"(non-stress":[135],"condition).":[136],"Further,":[137],"results":[138],"generated":[139],"by":[140],"second":[142],"identifying":[144],"aggregating":[146],"mutants":[149,170],"analyzing":[151],"behavior":[153],"reporters":[156],"misfolding,":[158],"suggest":[159],"there":[161],"general":[164],"collapse":[165],"affects":[172],"other":[173],"than":[175],"TA":[176],"proteins.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-08T00:00:00"}