{"id":"https://openalex.org/W4379740434","doi":"https://doi.org/10.1016/j.taap.2023.116582","title":"Thymic lymphoma detection in ROR\u03b3 knockout mice using 5-hydroxymethylcytosine profiling of circulating cell-free DNA","display_name":"Thymic lymphoma detection in ROR\u03b3 knockout mice using 5-hydroxymethylcytosine profiling of circulating cell-free DNA","publication_year":2023,"publication_date":"2023-06-07","ids":{"openalex":"https://openalex.org/W4379740434","doi":"https://doi.org/10.1016/j.taap.2023.116582","pmid":"https://pubmed.ncbi.nlm.nih.gov/37295732"},"language":"en","primary_location":{"id":"doi:10.1016/j.taap.2023.116582","doi":"https://doi.org/10.1016/j.taap.2023.116582","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.taap.2023.116582","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081048457","display_name":"Kelly Alana Fader","orcid":"https://orcid.org/0000-0002-8797-5577","observed_orcids":["https://orcid.org/0000-0002-8797-5577"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kelly A. Fader","raw_affiliation_strings":["Pfizer Worldwide Research, Development and Medical; Early Clinical Development; Groton, CT, USA. Electronic address: kelly.fader@pfizer.com","Early Clinical Development","Groton, CT, USA","Pfizer Worldwide Research, Development and Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical; Early Clinical Development; Groton, CT, USA. Electronic address: kelly.fader@pfizer.com","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Early Clinical Development","institution_ids":[]},{"raw_affiliation_string":"Groton, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003505976","display_name":"Mark M. Gosink","orcid":"https://orcid.org/0000-0003-3009-3941","observed_orcids":["https://orcid.org/0000-0003-3009-3941"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark M. Gosink","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Inc.; Ridgefield, CT, USA","Boehringer Ingelheim Pharmaceuticals, Inc","Ridgefield, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Inc.; Ridgefield, CT, USA","institution_ids":["https://openalex.org/I4210160255"]},{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Inc","institution_ids":[]},{"raw_affiliation_string":"Ridgefield, CT, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuhua Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuhua Xia","raw_affiliation_strings":["Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Groton, CT, USA","Drug Safety Research and Development","Groton, CT, USA","Pfizer Worldwide Research, Development and Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Drug Safety Research and Development","institution_ids":[]},{"raw_affiliation_string":"Groton, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088755018","display_name":"Thomas A. Lanz","orcid":"https://orcid.org/0000-0003-2483-3122","observed_orcids":["https://orcid.org/0000-0003-2483-3122"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Lanz","raw_affiliation_strings":["Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Groton, CT, USA","Drug Safety Research and Development","Groton, CT, USA","Pfizer Worldwide Research, Development and Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Drug Safety Research and Development","institution_ids":[]},{"raw_affiliation_string":"Groton, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058785315","display_name":"Charles Halsey","orcid":"https://orcid.org/0009-0004-6976-5578","observed_orcids":["https://orcid.org/0009-0004-6976-5578"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Halsey","raw_affiliation_strings":["Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Groton, CT, USA","Drug Safety Research and Development","Groton, CT, USA","Pfizer Worldwide Research, Development and Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Groton, CT, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Drug Safety Research and Development","institution_ids":[]},{"raw_affiliation_string":"Groton, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005111771","display_name":"Vishal S. Vaidya","orcid":"https://orcid.org/0000-0003-0553-9825","observed_orcids":["https://orcid.org/0000-0003-0553-9825"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishal S. Vaidya","raw_affiliation_strings":["Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Cambridge, MA, USA","Cambridge, MA, USA","Drug Safety Research and Development","Pfizer Worldwide Research, Development and Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Cambridge, MA, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Cambridge, MA, USA","institution_ids":[]},{"raw_affiliation_string":"Drug Safety Research and Development","institution_ids":[]},{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102911843","display_name":"Zaher A. Radi","orcid":"https://orcid.org/0000-0001-5849-5200","observed_orcids":["https://orcid.org/0000-0001-5849-5200"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaher A. Radi","raw_affiliation_strings":["Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Cambridge, MA, USA","Cambridge, MA, USA","Drug Safety Research and Development","Pfizer Worldwide Research, Development and Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical; Drug Safety Research and Development; Cambridge, MA, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Cambridge, MA, USA","institution_ids":[]},{"raw_affiliation_string":"Drug Safety Research and Development","institution_ids":[]},{"raw_affiliation_string":"Pfizer Worldwide Research, Development and Medical","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081048457"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":0.0755,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.24915863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"473","issue":null,"first_page":"116582","last_page":"116582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.26980000734329224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.26980000734329224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.24060000479221344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.14010000228881836,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymic-lymphoma","display_name":"thymic lymphoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/5-hydroxymethylcytosine","display_name":"5-hydroxymethylcytosine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.878000020980835},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6880000233650208},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.6819999814033508},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.7260000109672546},{"id":"https://openalex.org/keywords/rodent-carcinogenicity-testing","display_name":"rodent carcinogenicity testing","score":0.8069999814033508},{"id":"https://openalex.org/keywords/themis","display_name":"THEMIS","score":0.6539999842643738},{"id":"https://openalex.org/keywords/tox","display_name":"TOX","score":0.9919999837875366},{"id":"https://openalex.org/keywords/multi-organ-metastasis","display_name":"multiple organ metastasis","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.686846137046814},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6578112840652466},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5190609097480774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.502818763256073},{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.462999165058136},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.41839149594306946},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.41459769010543823},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40935614705085754},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3703477084636688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36950480937957764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3367117941379547},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32643580436706543},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.25507664680480957},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10871818661689758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057132","descriptor_name":"Nuclear Receptor Subfamily 1, Group F, Member 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.taap.2023.116582","doi":"https://doi.org/10.1016/j.taap.2023.116582","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.taap.2023.116582","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:37295732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37295732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1522731616","https://openalex.org/W1605900017","https://openalex.org/W1748436622","https://openalex.org/W1997825123","https://openalex.org/W2005103708","https://openalex.org/W2012034410","https://openalex.org/W2014677321","https://openalex.org/W2034773856","https://openalex.org/W2036859638","https://openalex.org/W2046903400","https://openalex.org/W2070050178","https://openalex.org/W2071424589","https://openalex.org/W2076316408","https://openalex.org/W2112822920","https://openalex.org/W2116635624","https://openalex.org/W2126098461","https://openalex.org/W2138207763","https://openalex.org/W2157395790","https://openalex.org/W2159529973","https://openalex.org/W2161541734","https://openalex.org/W2164899580","https://openalex.org/W2171143590","https://openalex.org/W2171808845","https://openalex.org/W2200884311","https://openalex.org/W2228143332","https://openalex.org/W2316415818","https://openalex.org/W2507330949","https://openalex.org/W2510134364","https://openalex.org/W2514915762","https://openalex.org/W2573002484","https://openalex.org/W2593179016","https://openalex.org/W2593499442","https://openalex.org/W2734629565","https://openalex.org/W2755906204","https://openalex.org/W2794713784","https://openalex.org/W2794789945","https://openalex.org/W2799975463","https://openalex.org/W2890984424","https://openalex.org/W2906602561","https://openalex.org/W2916911849","https://openalex.org/W2940964825","https://openalex.org/W2950512766","https://openalex.org/W2988402064","https://openalex.org/W2991616896","https://openalex.org/W2997569544","https://openalex.org/W3008543443","https://openalex.org/W3033670840","https://openalex.org/W3092918502","https://openalex.org/W3097551245","https://openalex.org/W3199333069","https://openalex.org/W4200459356","https://openalex.org/W4285386300","https://openalex.org/W4295077775","https://openalex.org/W4297198373","https://openalex.org/W6662068402"],"related_works":["https://openalex.org/W2112822920","https://openalex.org/W2946237908","https://openalex.org/W7162569626","https://openalex.org/W4403320630","https://openalex.org/W3181786794","https://openalex.org/W2058189041","https://openalex.org/W2481044522","https://openalex.org/W2783305251","https://openalex.org/W2912575843","https://openalex.org/W4306404919"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-08T00:00:00"}
