{"id":"https://openalex.org/W4379615286","doi":"https://doi.org/10.1038/s41598-026-77555-w","title":"Subacute carbon monoxide exposure alters AgNOR number and area ratio in the cerebral cortex of rats","display_name":"Subacute carbon monoxide exposure alters AgNOR number and area ratio in the cerebral cortex of rats","publication_year":2026,"publication_date":"2026-11-03","ids":{"openalex":"https://openalex.org/W4379615286","doi":"https://doi.org/10.1038/s41598-026-77555-w"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-77555-w","doi":"https://doi.org/10.1038/s41598-026-77555-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-77555-w","pdf_url":"https://www.nature.com/articles/s41598-026-77555-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-77555-w_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028981802","display_name":"Sedat \u00d6zbay","orcid":"https://orcid.org/0000-0002-8470-8529","observed_orcids":["https://orcid.org/0000-0002-8470-8529","https://orcid.org/0000-0001-7264-7442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tansu Gencer","raw_affiliation_strings":["Department of Emergency Medicine, Sivas Numune Education and Research Hospital, Sivas, Turkey","Sivas Numune Hospital, Department of Emergency Medicine, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-7264-7442","affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Sivas Numune Education and Research Hospital, Sivas, Turkey","institution_ids":[]},{"raw_affiliation_string":"Sivas Numune Hospital, Department of Emergency Medicine, Sivas, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028981802","display_name":"Sedat \u00d6zbay","orcid":"https://orcid.org/0000-0002-8470-8529","observed_orcids":["https://orcid.org/0000-0002-8470-8529","https://orcid.org/0000-0001-7264-7442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sedat Ozbay","raw_affiliation_strings":["Department of Emergency Medicine, Sivas Numune Education and Research Hospital, Sivas, Turkey","Sivas Numune Hospital, Department of Emergency Medicine, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-8470-8529","affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Sivas Numune Education and Research Hospital, Sivas, Turkey","institution_ids":[]},{"raw_affiliation_string":"Sivas Numune Hospital, Department of Emergency Medicine, Sivas, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013672528","display_name":"Esra Da\u011f \u015eeker","orcid":"https://orcid.org/0000-0001-6230-5529","observed_orcids":["https://orcid.org/0000-0001-6230-5529"]},"institutions":[{"id":"https://openalex.org/I121596126","display_name":"Aksaray University","ror":"https://ror.org/026db3d50","country_code":"TR","type":"education","lineage":["https://openalex.org/I121596126"]},{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seker Dag","raw_affiliation_strings":["Department of Biology, Faculty of Fen, Cumhuriyet University, Sivas, Turkey","Aksaray University, School of Medicine, Department of Medical Genetic, Aksaray, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-6230-5529","affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Fen, Cumhuriyet University, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Aksaray University, School of Medicine, Department of Medical Genetic, Aksaray, Turkey","institution_ids":["https://openalex.org/I121596126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026650459","display_name":"Ayhan Sar\u0131ta\u015f","orcid":"https://orcid.org/0000-0002-4302-1093","observed_orcids":["https://orcid.org/0000-0002-4302-1093","https://orcid.org/0000-0001-7623-504X"]},"institutions":[{"id":"https://openalex.org/I121596126","display_name":"Aksaray University","ror":"https://ror.org/026db3d50","country_code":"TR","type":"education","lineage":["https://openalex.org/I121596126"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Orhan Ozsoy","raw_affiliation_strings":["Department of Emergency Medicine, Sivas Numune Education and Research Hospital, Sivas, Turkey","Aksaray University, School of Medicine, Department of Emergency Medicine, Aksaray, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-7623-504X","affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Sivas Numune Education and Research Hospital, Sivas, Turkey","institution_ids":[]},{"raw_affiliation_string":"Aksaray University, School of Medicine, Department of Emergency Medicine, Aksaray, Turkey","institution_ids":["https://openalex.org/I121596126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026650459","display_name":"Ayhan Sar\u0131ta\u015f","orcid":"https://orcid.org/0000-0002-4302-1093","observed_orcids":["https://orcid.org/0000-0002-4302-1093","https://orcid.org/0000-0001-7623-504X"]},"institutions":[{"id":"https://openalex.org/I121596126","display_name":"Aksaray University","ror":"https://ror.org/026db3d50","country_code":"TR","type":"education","lineage":["https://openalex.org/I121596126"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ayhan Saritas","raw_affiliation_strings":["Department of Emergency Medicine, Faculty of Medicine, Aksaray University, Aksaray, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-4302-1093","affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Faculty of Medicine, Aksaray University, Aksaray, Turkey","institution_ids":["https://openalex.org/I121596126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040647289","display_name":"Cemil Kavalc\u0131","orcid":"https://orcid.org/0000-0003-2529-2946","observed_orcids":["https://orcid.org/0000-0003-2529-2946"]},"institutions":[{"id":"https://openalex.org/I4210109837","display_name":"Antalya E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/01ppcnz44","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210109837"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Cemil Kavalci","raw_affiliation_strings":["Emergency Department, Antalya Training and Research Hospital, Health Science University of Turkey, Antalya, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-2529-2946","affiliations":[{"raw_affiliation_string":"Emergency Department, Antalya Training and Research Hospital, Health Science University of Turkey, Antalya, Turkey","institution_ids":["https://openalex.org/I4210109837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083615493","display_name":"G\u00fcls\u00fcm Kavalc\u0131","orcid":"https://orcid.org/0000-0002-8245-4721","observed_orcids":["https://orcid.org/0000-0002-8245-4721"]},"institutions":[{"id":"https://openalex.org/I4210109837","display_name":"Antalya E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/01ppcnz44","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210109837"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gulsum Kavalci","raw_affiliation_strings":["Anesthesia Department, Antalya Training and Research Hospital, Antalya, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-8245-4721","affiliations":[{"raw_affiliation_string":"Anesthesia Department, Antalya Training and Research Hospital, Antalya, Turkey","institution_ids":["https://openalex.org/I4210109837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072781683","display_name":"Cihan Bedel","orcid":"https://orcid.org/0000-0002-3823-2929","observed_orcids":["https://orcid.org/0000-0002-3823-2929","https://orcid.org/0000-0002-4473-9427"]},"institutions":[{"id":"https://openalex.org/I4210109837","display_name":"Antalya E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/01ppcnz44","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210109837"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cihan bedel","raw_affiliation_strings":["Emergency Department, Antalya Training and Research Hospital, Health Science University of Turkey, Antalya, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3823-2929","affiliations":[{"raw_affiliation_string":"Emergency Department, Antalya Training and Research Hospital, Health Science University of Turkey, Antalya, Turkey","institution_ids":["https://openalex.org/I4210109837"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040647289"],"corresponding_institution_ids":["https://openalex.org/I4210109837"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00069612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-monoxide-poisoning","display_name":"carbon monoxide poisoning","score":0.9940000176429749},{"id":"https://openalex.org/keywords/brain-tissue-damage","display_name":"brain tissue damage","score":0.8569999933242798},{"id":"https://openalex.org/keywords/silver-nucleolar-organizer-regions","display_name":"silver nucleolar organizer regions","score":0.5889999866485596},{"id":"https://openalex.org/keywords/agnors","display_name":"AgNORs","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.925000011920929},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5860000252723694},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.5677552223205566},{"id":"https://openalex.org/C512735826","wikidata":"https://www.wikidata.org/wiki/Q2025","display_name":"Carbon monoxide","level":3,"score":0.5273146033287048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.435638427734375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42889130115509033},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.41038885712623596},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3906245231628418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3328256607055664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3156593441963196},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19106769561767578},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.13657280802726746},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07412683963775635},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41598-026-77555-w","doi":"https://doi.org/10.1038/s41598-026-77555-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-77555-w","pdf_url":"https://www.nature.com/articles/s41598-026-77555-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202306.0551.v1","doi":"https://doi.org/10.20944/preprints202306.0551.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.20944/preprints202306.0551.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/5eb6dbbd2cc9674099713b2baf981fcb/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-77555-w","doi":"https://doi.org/10.1038/s41598-026-77555-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-77555-w","pdf_url":"https://www.nature.com/articles/s41598-026-77555-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379615286.pdf","grobid_xml":"https://content.openalex.org/works/W4379615286.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W20881903","https://openalex.org/W1678699314","https://openalex.org/W1969984058","https://openalex.org/W1970027119","https://openalex.org/W1997967033","https://openalex.org/W2025047464","https://openalex.org/W2051847030","https://openalex.org/W2054798163","https://openalex.org/W2067083339","https://openalex.org/W2070922557","https://openalex.org/W2072502749","https://openalex.org/W2130100012","https://openalex.org/W2222755614","https://openalex.org/W2274574707","https://openalex.org/W2304975405","https://openalex.org/W2405385836","https://openalex.org/W2443498961","https://openalex.org/W2508096569","https://openalex.org/W2581288308","https://openalex.org/W2582517628","https://openalex.org/W2885435825","https://openalex.org/W2905948102","https://openalex.org/W2982719627","https://openalex.org/W3029066189","https://openalex.org/W3042167980","https://openalex.org/W3102406724","https://openalex.org/W3165808939","https://openalex.org/W3210617845","https://openalex.org/W4210662999","https://openalex.org/W4212954639","https://openalex.org/W4306247509","https://openalex.org/W4388311100"],"related_works":["https://openalex.org/W4210662999","https://openalex.org/W3216804372","https://openalex.org/W2161600779","https://openalex.org/W2443498961","https://openalex.org/W2905948102","https://openalex.org/W2051847030","https://openalex.org/W1773481289","https://openalex.org/W3165808939","https://openalex.org/W4414131609","https://openalex.org/W2028943498"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"aimed":[2],"to":[3,183,192,196,214],"evaluate":[4],"the":[5,20,86,109,198],"effects":[6],"of":[7,13,57,116,200],"hypoxia":[8],"induced":[9],"by":[10],"different":[11,203],"levels":[12],"subacute":[14],"carbon":[15,215],"monoxide":[16,216],"(CO)":[17],"exposure":[18],"on":[19],"total":[21],"AgNOR":[22,30,91,178,221],"area/total":[23],"nuclear":[24],"area":[25],"(TAA/TNA)":[26],"ratio":[27],"and":[28,54,64,99,126,136,155,166,190,205],"mean":[29,90,177],"number":[31,92],"in":[32,114,194,202],"rat":[33],"cerebral":[34],"cortical":[35],"tissue.":[36],"Eighteen":[37],"Albino":[38],"Wistar":[39],"adult":[40],"male":[41],"rats":[42],"were":[43,83,122,151],"randomly":[44],"divided":[45],"into":[46],"three":[47],"groups":[48,87,111],"(control":[49],"as":[50,61,72],"group":[51,62],"A,":[52],"1000ppm":[53,127],"3000ppm":[55],"concentration":[56],"CO":[58,67],"gas":[59,68],"exposed":[60,213],"B":[63],"C,":[65],"respectively).":[66],"was":[69],"chronically":[70],"given":[71],"30":[73],"min":[74],"a":[75],"day":[76],"during":[77],"seven":[78],"days.":[79],"Statistically":[80,148],"significant":[81,120,149],"differences":[82,121,150],"found":[84,152],"among":[85],"for":[88,145,176,225],"both":[89],"(\u03c72":[93,101],"=":[94,97,102,105,129,132,140,143,159,162,170,174],"12.051,":[95],"p":[96,104,131,142,161,173],"0.002)":[98],"TAA/TNA":[100,117,146],"12.316,":[103],"0.002),":[106],"respectively.":[107],"When":[108],"two":[110],"are":[112,211],"compared":[113],"terms":[115],"ratio,":[118],"statistically":[119],"detected":[123],"between":[124,134,153,164],"control":[125,135,154,165],"(Z":[128,139,158,169],"-2.882,":[130,141,160],"0.004),":[133,163],"3000":[137,167],"ppm":[138,157,168],"0.004)":[144,175],"ratio.":[147],"1000":[156],"-":[171],"2.887,":[172],"number.":[179],"It":[180,218],"is":[181],"important":[182],"determine":[184,197],"new":[185],"markers":[186],"with":[187],"high":[188],"sensitivity":[189],"easy":[191],"apply":[193],"order":[195],"effect":[199],"toxication":[201],"organs":[204],"tissues":[206],"(especially":[207],"brain":[208],"tissues)":[209],"that":[210,220],"subacutely":[212],"intoxication.":[217],"seems":[219],"may":[222],"be":[223],"used":[224],"this":[226],"purpose.":[227]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-06-08T00:00:00"}
