{"id":"https://openalex.org/W4379598183","doi":"https://doi.org/10.7150/thno.81388","title":"Nicotine exacerbates atherosclerosis and plaque instability via NLRP3 inflammasome activation in vascular smooth muscle cells","display_name":"Nicotine exacerbates atherosclerosis and plaque instability via NLRP3 inflammasome activation in vascular smooth muscle cells","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4379598183","doi":"https://doi.org/10.7150/thno.81388","pmid":"https://pubmed.ncbi.nlm.nih.gov/37284455","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10240824"},"language":"en","primary_location":{"id":"doi:10.7150/thno.81388","doi":"https://doi.org/10.7150/thno.81388","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.81388","pdf_url":"https://www.thno.org/v13p2825.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.thno.org/v13p2825.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054663109","display_name":"Junqing An","orcid":"https://orcid.org/0000-0003-0091-1501","observed_orcids":["https://orcid.org/0000-0003-0091-1501"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junqing An","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077322159","display_name":"Liu Ouyang","orcid":"https://orcid.org/0000-0002-3695-571X","observed_orcids":["https://orcid.org/0000-0002-3695-571X"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liu Ouyang","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091783408","display_name":"Changjiang Yu","orcid":"https://orcid.org/0000-0001-6395-5814","observed_orcids":["https://orcid.org/0000-0001-6395-5814"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changjiang Yu","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103047473","display_name":"Sean Michael Carr","orcid":"https://orcid.org/0000-0003-3643-7266","observed_orcids":["https://orcid.org/0000-0003-3643-7266"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Michael Carr","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052613023","display_name":"Tharmarajan Ramprasath","orcid":"https://orcid.org/0000-0002-2115-5875","observed_orcids":["https://orcid.org/0000-0002-2115-5875"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tharmarajan Ramprasath","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021842480","display_name":"Zhixue Liu","orcid":"https://orcid.org/0000-0001-7597-5337","observed_orcids":["https://orcid.org/0000-0001-7597-5337"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhixue Liu","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108493543","display_name":"Ping Song","orcid":"https://orcid.org/0000-0002-6143-4270","observed_orcids":["https://orcid.org/0000-0002-6143-4270","https://orcid.org/0000-0001-5947-4604"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Song","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055937253","display_name":"Ming\u2010Hui Zou","orcid":"https://orcid.org/0000-0002-3913-0617","observed_orcids":["https://orcid.org/0000-0002-3913-0617"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Hui Zou","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100624635","display_name":"Ding Ye","orcid":"https://orcid.org/0000-0001-6654-7832","observed_orcids":["https://orcid.org/0000-0001-6654-7832"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ye Ding","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100624635"],"corresponding_institution_ids":["https://openalex.org/I181565077"],"apc_list":{"value":2500,"currency":"AUD","value_usd":1671},"apc_paid":{"value":2500,"currency":"AUD","value_usd":1671},"fwci":3.1993,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.94055198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"13","issue":"9","first_page":"2825","last_page":"2842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-instability","display_name":"atherosclerotic plaque instability","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":1.0},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9890000224113464},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.9570000171661377},{"id":"https://openalex.org/keywords/brachiocephalic-artery","display_name":"brachiocephalic artery","score":0.9129999876022339},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.7749999761581421},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.9146987199783325},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6973181366920471},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.659679651260376},{"id":"https://openalex.org/C1918360","wikidata":"https://www.wikidata.org/wiki/Q5357720","display_name":"Electrical impedance myography","level":3,"score":0.45782408118247986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4371529817581177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4064956307411194},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.401427686214447},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39595550298690796},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20106366276741028},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.13392895460128784},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7150/thno.81388","doi":"https://doi.org/10.7150/thno.81388","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.81388","pdf_url":"https://www.thno.org/v13p2825.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10240824","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10240824","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Text"},{"id":"pmid:37284455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37284455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/thno.81388","doi":"https://doi.org/10.7150/thno.81388","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.81388","pdf_url":"https://www.thno.org/v13p2825.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6312438912","display_name":"Inflammasome in smoking-promoted atherosclerotic plaque rupture","funder_award_id":"19CDA34730035","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8624362539","display_name":"Inflammasome and unstable atherosclerotic plaques","funder_award_id":"R01HL089920","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000901132","display_name":"Elucidating Vascular Neuropilin 1 (NRP1) Functions in Response to Novel Interactions with Insulin Substrates","funder_award_id":"R01HL153333","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379598183.pdf","grobid_xml":"https://content.openalex.org/works/W4379598183.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1485896673","https://openalex.org/W1493025774","https://openalex.org/W1515994079","https://openalex.org/W1535175417","https://openalex.org/W1559813904","https://openalex.org/W1576530886","https://openalex.org/W1638567831","https://openalex.org/W1747142739","https://openalex.org/W1840986526","https://openalex.org/W1971915082","https://openalex.org/W1972483153","https://openalex.org/W1975261219","https://openalex.org/W1978488208","https://openalex.org/W1978644984","https://openalex.org/W1983084664","https://openalex.org/W1992402942","https://openalex.org/W2000249384","https://openalex.org/W2009385353","https://openalex.org/W2012100454","https://openalex.org/W2017593971","https://openalex.org/W2028923529","https://openalex.org/W2037141618","https://openalex.org/W2038568139","https://openalex.org/W2049885762","https://openalex.org/W2074954748","https://openalex.org/W2078027003","https://openalex.org/W2080878773","https://openalex.org/W2083084591","https://openalex.org/W2088755733","https://openalex.org/W2095819288","https://openalex.org/W2101486712","https://openalex.org/W2105541876","https://openalex.org/W2107505404","https://openalex.org/W2111549712","https://openalex.org/W2112360098","https://openalex.org/W2117975627","https://openalex.org/W2120439472","https://openalex.org/W2124860998","https://openalex.org/W2125738893","https://openalex.org/W2126374403","https://openalex.org/W2126978153","https://openalex.org/W2129033842","https://openalex.org/W2130904379","https://openalex.org/W2141470773","https://openalex.org/W2142441861","https://openalex.org/W2143076349","https://openalex.org/W2151749258","https://openalex.org/W2153575245","https://openalex.org/W2159767534","https://openalex.org/W2163582403","https://openalex.org/W2164455918","https://openalex.org/W2232984180","https://openalex.org/W2274924551","https://openalex.org/W2297988891","https://openalex.org/W2317197131","https://openalex.org/W2321849281","https://openalex.org/W2328099499","https://openalex.org/W2395305194","https://openalex.org/W2400444812","https://openalex.org/W2488479442","https://openalex.org/W2522054313","https://openalex.org/W2588546436","https://openalex.org/W2593542847","https://openalex.org/W2615751376","https://openalex.org/W2623226106","https://openalex.org/W2748400555","https://openalex.org/W2750587791","https://openalex.org/W2761784274","https://openalex.org/W2774588923","https://openalex.org/W2789997601","https://openalex.org/W2898698697","https://openalex.org/W2954782052","https://openalex.org/W2955387872","https://openalex.org/W3014839933","https://openalex.org/W4213174091","https://openalex.org/W4239417128","https://openalex.org/W4240900378","https://openalex.org/W4243074980","https://openalex.org/W4299117284"],"related_works":["https://openalex.org/W2789997601","https://openalex.org/W2889231069","https://openalex.org/W3044545104","https://openalex.org/W1929318247","https://openalex.org/W3193325237","https://openalex.org/W3022787402","https://openalex.org/W3016613650","https://openalex.org/W3197724789","https://openalex.org/W2988480815","https://openalex.org/W2393313469"],"abstract_inverted_index":{"Rationale:":[0],"Nicotine":[1,233],"has":[2],"been":[3],"reported":[4],"to":[5,32,138],"be":[6],"a":[7,153],"strong":[8],"risk":[9],"factor":[10],"for":[11,73,104],"atherosclerosis.However,":[12],"the":[13,34,59,71,85,113,188],"underlying":[14],"mechanism":[15],"by":[16,198,238],"which":[17],"nicotine":[18,88,125,214],"controls":[19],"atherosclerotic":[20,50,67,108,178,235],"plaque":[21,51,68,109,116,179,182,196,236],"stability":[22,54,69],"remain":[23],"largely":[24],"unknown.Objective:":[25],"The":[26],"aim":[27],"of":[28,36,66,115,120,151,157,164,190,205,226],"this":[29],"study":[30,210],"was":[31,136],"evaluate":[33],"impact":[35],"lysosomal":[37,216,239],"dysfunction":[38,217],"mediated":[39],"NLRP3":[40,140,158,165,192,206,241],"inflammasome":[41,81,141,159,193,231,242],"activation":[42,243],"in":[43,55,84,118,131,142,170,184,194,219,244],"vascular":[44,144,245],"smooth":[45,145,246],"muscle":[46,146,247],"cell":[47],"(VSMC)":[48],"on":[49],"formation":[52,110,180],"and":[53,63,70,111,133,135,161,172,181],"advanced":[56],"atherosclerosis":[57],"at":[58],"brachiocephalic":[60],"arteries":[61],"(BA).Methods":[62],"Results:":[64],"Features":[65],"markers":[72],"NLR":[74],"Family":[75],"Pyrin":[76],"Domain":[77],"Containing":[78],"3":[79],"(NLRP3)":[80],"were":[82],"monitored":[83],"BA":[86,119],"from":[87],"or":[89,224],"vehicle-treated":[90],"apolipoprotein":[91],"E":[92],"deficient":[93],"(Apoe":[94],"-/":[95,122],"-)":[96],"mice":[97],"fed":[98],"with":[99],"Western-type":[100],"diet":[101],"(WD).Nicotine":[102],"treatment":[103],"6":[105],"weeks":[106],"accelerated":[107],"enhanced":[112],"hallmarks":[114],"instability":[117,197,237],"Apoe":[121],"-":[123],"mice.Moreover,":[124],"elevated":[126],"interleukin":[127],"1":[128],"beta":[129],"(IL-1\u03b2)":[130],"serum":[132,171],"aorta":[134],"preferred":[137],"activate":[139],"aortic":[143],"cells":[147],"(VSMC).Importantly,":[148],"pharmacological":[149],"inhibition":[150],"Caspase1,":[152],"key":[154],"downstream":[155],"target":[156],"complex,":[160],"genetic":[162],"inactivation":[163],"significantly":[166],"restrained":[167],"nicotine-elevated":[168],"IL-1\u03b2":[169],"aorta,":[173],"as":[174,176],"well":[175],"nicotine-stimulated":[177],"destabilization":[183],"BA.We":[185],"further":[186,211],"confirmed":[187],"role":[189],"VSMC-derived":[191],"nicotine-induced":[195],"using":[199],"VSMC":[200],"specific":[201],"TXNIP":[202],"(upstream":[203],"regulator":[204],"inflammasome)":[207],"deletion":[208],"mice.Mechanistic":[209],"showed":[212],"that":[213],"induced":[215],"resulted":[218],"cathepsin":[220,227],"B":[221,228],"cytoplasmic":[222],"release.Inhibition":[223],"knockdown":[225],"blocked":[229],"nicotine-dependent":[230],"activation.Conclusions:":[232],"promotes":[234],"dysfunction-mediated":[240],"cells.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-08T00:00:00"}
