{"id":"https://openalex.org/W4379509745","doi":null,"title":"O. dentatum: a model for resistance to levamisole","display_name":"O. dentatum: a model for resistance to levamisole","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W4379509745"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-02746363v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02746363","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Membrane ion-channels in helminth parasites: resistance and sites of action for anthelmintics, Dec 2011, Philadelphie, United States. n.p","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033749081","display_name":"Richard J. Martin","orcid":"https://orcid.org/0000-0003-2422-1847","observed_orcids":["https://orcid.org/0000-0003-2422-1847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin, R.J.","raw_affiliation_strings":["Department of Biomedical Sciences, College of Veterinary Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Veterinary Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061632642","display_name":"Samuel Buxton","orcid":"https://orcid.org/0000-0001-8796-9284","observed_orcids":["https://orcid.org/0000-0001-8796-9284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Buxton, S.K.","raw_affiliation_strings":["Department of Biomedical Sciences, College of Veterinary Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Veterinary Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002068300","display_name":"Alan Patrick Robertson","orcid":"https://orcid.org/0000-0002-7980-1139","observed_orcids":["https://orcid.org/0000-0002-7980-1139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robertson, A.P.","raw_affiliation_strings":["Department of Biomedical Sciences, College of Veterinary Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Veterinary Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016852756","display_name":"C\u00e9dric Neveu","orcid":"https://orcid.org/0000-0003-4314-1850","observed_orcids":["https://orcid.org/0000-0003-4314-1850"]},"institutions":[{"id":"https://openalex.org/I4210147048","display_name":"Infectiologie et sant\u00e9 publique","ror":"https://ror.org/0454zjr22","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I4210088668","https://openalex.org/I4210147048"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Neveu, C\u00e9dric","raw_affiliation_strings":["Infectiologie Animale et Sant\u00e9 Publique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectiologie Animale et Sant\u00e9 Publique","institution_ids":["https://openalex.org/I4210147048"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083147221","display_name":"Claude Charvet","orcid":"https://orcid.org/0000-0002-0596-6598","observed_orcids":["https://orcid.org/0000-0002-0596-6598"]},"institutions":[{"id":"https://openalex.org/I4210147048","display_name":"Infectiologie et sant\u00e9 publique","ror":"https://ror.org/0454zjr22","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I4210088668","https://openalex.org/I4210147048"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charvet, Claude","raw_affiliation_strings":["Infectiologie Animale et Sant\u00e9 Publique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectiologie Animale et Sant\u00e9 Publique","institution_ids":["https://openalex.org/I4210147048"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54875283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"n.p.","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levamisole-resistance","display_name":"levamisole resistance","score":0.8360000252723694},{"id":"https://openalex.org/keywords/anthelmintic-resistance","display_name":"anthelmintic resistance","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9449999928474426},{"id":"https://openalex.org/keywords/nematode-model","display_name":"nematode model","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2781325985","wikidata":"https://www.wikidata.org/wiki/Q417097","display_name":"Levamisole","level":2,"score":0.6417980194091797},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5438429117202759},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3400615453720093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11322185397148132},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-02746363v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02746363","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Membrane ion-channels in helminth parasites: resistance and sites of action for anthelmintics, Dec 2011, Philadelphie, United States. n.p","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1571756799","https://openalex.org/W1538156864","https://openalex.org/W4302375064","https://openalex.org/W4360604505","https://openalex.org/W1978294750","https://openalex.org/W2095282287","https://openalex.org/W2072512054","https://openalex.org/W2064950764","https://openalex.org/W2802093561","https://openalex.org/W2033474948"],"abstract_inverted_index":{"Tractable":[0],"models":[1],"are":[2,27,223],"required":[3],"to":[4,128,220,229],"study":[5],"anthelmintic":[6],"resistance":[7],"in":[8,109,171,235],"the":[9,55,73,86,103,110,120,144,177],"laboratory.":[10],"Although":[11],"C.":[12,148],"elegans":[13],"is":[14,20,64,76],"a":[15,22,42,210],"very":[16],"useful":[17],"model,":[18],"it":[19],"not":[21,91,107],"parasitic":[23,39],"nematode":[24,34,58,63,233],"and":[25,35,51,72,93,153,159,183,214,227],"there":[26],"important":[28,232],"difference":[29],"between":[30],"this":[31],"Clade":[32,37,56],"V":[33,38,57],"other":[36,231],"nematodes.":[40],"For":[41],"number":[43],"of":[44,54,102,143,147,157,165,196,200,216],"years":[45],"we":[46,82,136],"have":[47,118,175,185],"worked":[48],"with":[49],"levamisole-sensitive":[50,158],"levamisole-resistant":[52,160],"isolates":[53,156],"0.":[59,121,161],"dentatum.":[60,162],"This":[61],"GI":[62],"relatively":[65],"easily":[66],"maintained":[67],"by":[68],"passage":[69],"through":[70],"pigs":[71],"adult":[74],"female":[75],"suitable":[77],"for":[78],"electrophysiology.":[79],"Under":[80],"patch-clamp,":[81],"had":[83],"found":[84],"that":[85],"levamisole":[87,130,145],"activated-receptor":[88],"channels":[89],"were":[90,169],"homogenous":[92],"could":[94],"be":[95],"separated":[96],"into":[97],"4":[98],"different":[99,188,198,236],"subtypes;":[100],"one":[101],"subtypes":[104,191],"(G35)":[105],"was":[106],"present":[108],"resistant":[111,172],"isolate":[112],"(Robertson":[113],"et":[114],"al.":[115],"1999).":[116],"We":[117,174,222],"pursed":[119],"dentatum":[122,203],"model":[123],"further":[124],"using":[125],"molecular":[126],"techniques":[127],"expressing":[129],"receptor":[131,146,190],"subunits":[132,168],"Xenopus":[133,178,193],"oocytes.":[134],"Here":[135],"report":[137],"our":[138],"success,":[139],"identifying":[140],"orthologous":[141],"genes":[142],"elegans:":[149],"unc-29,":[150],"unc-63,":[151],"unc-38":[152],"acr-8":[154],"from":[155],"Abbreviated":[163],"transcripts":[164],"Ode-ACR-8":[166,217],"AChR":[167,204],"detected":[170],"isolates.":[173],"used":[176],"laevis":[179],"oocyte":[180,194],"expression":[181],"system,":[182],"interestingly":[184],"observed":[186],"four":[187,197],"functional":[189],"following":[192],"injection":[195],"combinations":[199],"these":[201,225],"O.":[202],"subunits.":[205],"Each":[206],"subunit":[207],"appears":[208],"contribute":[209],"critical":[211],"pharmacological":[212],"role":[213],"lack":[215],"reduces":[218],"sensitivity":[219],"levamisole.":[221],"continuing":[224],"studies":[226],"intend":[228],"examine":[230],"parasites":[234],"Clades.":[237]},"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2023-06-07T00:00:00"}
